ES2050200T3 - Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente. - Google Patents

Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente.

Info

Publication number
ES2050200T3
ES2050200T3 ES89118917T ES89118917T ES2050200T3 ES 2050200 T3 ES2050200 T3 ES 2050200T3 ES 89118917 T ES89118917 T ES 89118917T ES 89118917 T ES89118917 T ES 89118917T ES 2050200 T3 ES2050200 T3 ES 2050200T3
Authority
ES
Spain
Prior art keywords
substance
marking
determined
determination
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89118917T
Other languages
English (en)
Inventor
Roland Dr Rer Nat Schenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2050200T3 publication Critical patent/ES2050200T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

PARA DETERMINAR UNA SUSTANCIA AGLUTINANTE ESPECIFICA, SE INCUBA UNA SOLUCION DE PRUEBA CON AL MENOS TRES RECEPTORES R , R Y R , DE LOS QUE R TIENE PODER AGLUTINANTE ESPECIFICO, RESPECTO A R , R Y A LA SUSTANCIA QUE SE ESTA DETERMINANDO, R CREA EL ENLACE/LA AGLUTINACION CON LA FASE SOLIDA Y R LLEVA UNA MARCACION. COMO RECEPTOR R SE UTILIZA UN RECEPTOR CON AL MENOS DOS PUNTOS DE AGLUTINACION ESPECIFICA CON UN EPITOPO DE LA SUSTANCIA A DETERMINAR, COMO R UN CONJUGADO DE UN ELEMENTO P1 DE UN PAR DE SUSTANCIAS AGLUTINANTES, Y UNA SUSTANCIA S QUE CORRESPONDE A LA SUSTANCIA A DETERMINAR O A UN DERIVADO CON AL MENOS UN EPITOPO DE LA MISMA. EL ELEMENTO P1 O ESTA ENLAZADO CON UNA FASE SOLIDA O ES INMOVILIZABLE. COMO R SE UTILIZA UN COMPLEJO QUE CONTIENE, AL MENOS, LA SUSTANCIA A DETERMINAR Y UNA MARCACION Y QUE SEPARA LA MARCACION ENLAZADA DE LA NO ENLAZADA. AL FINAL SE MIDE LA MARCACION EN UNA DE LAS DOS FASES.
ES89118917T 1988-10-12 1989-10-11 Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente. Expired - Lifetime ES2050200T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3834766A DE3834766A1 (de) 1988-10-12 1988-10-12 Verfahren zur bestimmung einer spezifisch bindefaehigen substanz

Publications (1)

Publication Number Publication Date
ES2050200T3 true ES2050200T3 (es) 1994-05-16

Family

ID=6364963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89118917T Expired - Lifetime ES2050200T3 (es) 1988-10-12 1989-10-11 Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente.

Country Status (10)

Country Link
US (1) US5126241A (es)
EP (1) EP0363942B1 (es)
JP (1) JPH0814579B2 (es)
KR (1) KR920005963B1 (es)
AT (1) ATE101723T1 (es)
AU (1) AU612907B2 (es)
CA (1) CA2000545C (es)
DE (2) DE3834766A1 (es)
ES (1) ES2050200T3 (es)
ZA (1) ZA897689B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3836348A1 (de) * 1988-10-25 1990-04-26 Boehringer Mannheim Gmbh Verfahren zur bestimmung von fuer ein antigen klassenspezifischen antikoerpern und dazu geeignetes reagenz
US5792606A (en) * 1990-02-26 1998-08-11 Boehringer Mannheim Gmbh Nucleic acid hybridization based assay for determining a substance of interest
US5437981A (en) * 1990-02-26 1995-08-01 Boehringer Mannheim Gmbh Method for the immunological determination of ligands
DE4006054A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Verfahren zur immunologischen bestimmung von liganden
US5556748A (en) * 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
DE4218257A1 (de) * 1992-06-03 1993-12-09 Behringwerke Ag Verfahren zur immunchemischen Bestimmung eines Analyten
DE4328070C1 (de) * 1993-08-20 1994-11-24 Henning Berlin Gmbh Verfahren zur Bestimmung eines Analyten in einem Volumen einer flüssigen Probe sowie seine Anwendung zur Bestimmung von anti-TSH-Rezeptor-Autoantikörpern in einem Patientenserum
US6627404B1 (en) 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US6991907B1 (en) * 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
WO1997006439A1 (en) 1995-08-09 1997-02-20 Quidel Corporation Test strip and method for one step lateral flow assay
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
DE19548375A1 (de) * 1995-12-27 1997-07-03 Behringwerke Ag Immunologische Bestimmungsmethode
DE19548028A1 (de) * 1995-12-21 1997-06-26 Bayer Ag Verfahren zur Herstellung eines synthetischen Kalibrators für den Einsatz in Sandwich-Immunoassays, bestehend aus einem Antikörper gegen einen der im Assay benutzten Antikörper und einer Sequenz des Analyten
US5798273A (en) * 1996-09-25 1998-08-25 Becton Dickinson And Company Direct read lateral flow assay for small analytes
DE19808226C1 (de) * 1998-02-27 2000-03-02 Bruker Analytik Gmbh Anordnung und Verfahren zur Untersuchung von hydrophilen Makromolekülen in wässriger Lösung
US6699722B2 (en) 2000-04-14 2004-03-02 A-Fem Medical Corporation Positive detection lateral-flow apparatus and method for small and large analytes
WO2002090961A2 (en) * 2001-05-03 2002-11-14 Immunetics, Inc. Systems and methods for detection of analytes in biological fluids
EP2058663A1 (en) 2007-11-12 2009-05-13 Euro-Diagnostica B.V. Method for the immobilization of an analyte on a solid support
US7842475B2 (en) * 2008-01-08 2010-11-30 Siemens Healthcare Diagnostics Inc. Stabilization of solid support assay reagents
US8673644B2 (en) 2008-05-13 2014-03-18 Battelle Memorial Institute Serum markers for type II diabetes mellitus
US8476008B2 (en) * 2008-07-23 2013-07-02 Diabetomics, Llc Methods for detecting pre-diabetes and diabetes
US8168396B2 (en) 2009-05-11 2012-05-01 Diabetomics, Llc Methods for detecting pre-diabetes and diabetes using differential protein glycosylation
EP2576806B1 (en) 2010-05-26 2017-03-08 The Board of Trustees of the University of Illionis Personal glucose meters for detection and quantification of a broad range of analytes
EP3418397B1 (en) 2012-01-24 2020-10-07 CD Diagnostics, Inc. System for detecting infection in synovial fluid
US9383352B2 (en) 2014-03-26 2016-07-05 Diabetomics, Inc. Salivary protein glycosylation test for diagnosis and monitoring of diabetes
US10584162B2 (en) 2015-04-23 2020-03-10 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Fungal detection using mannan epitope
AU2016301231A1 (en) 2015-08-04 2018-02-22 Cd Diagnostics, Inc. Methods for detecting adverse local tissue reaction (ALTR) necrosis
WO2017147186A1 (en) 2016-02-22 2017-08-31 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen
ES2866880T3 (es) 2016-04-13 2021-10-20 Inst Nat Sante Rech Med Métodos y kits para la detección rápida del clon O25B-ST131 de Escherichia Coli
US11300576B2 (en) 2019-01-29 2022-04-12 Arizona Board Of Regents On Behalf Of Arizona State University DARPin reagents that distinguish Alzheimer's disease and Parkinson's disease samples

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32696E (en) * 1975-09-04 1988-06-14 Akzona Incorporated Enzymatic immunological method for determination of antigens and antibodies
GB2084317B (en) * 1980-09-30 1984-01-18 Erba Farmitalia Antigen-linked competitive enzymeimmunoassay
US4737453A (en) * 1984-12-12 1988-04-12 Immunomedics, Inc. Sandwich immunoassay utilizing a separation specific binding substance
US4772550A (en) * 1986-02-10 1988-09-20 Miles Inc. Heterogeneous specific binding assay employing an aggregatable binding reagent
WO1988005538A1 (en) * 1987-01-15 1988-07-28 Hevey Richard C Method of detecting and quantifying ligands in liquids
DE3705686C2 (de) * 1987-02-23 1995-11-30 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Antikörpern

Also Published As

Publication number Publication date
KR900006778A (ko) 1990-05-08
DE58906981D1 (de) 1994-03-24
DE3834766A1 (de) 1990-04-26
AU612907B2 (en) 1991-07-18
CA2000545A1 (en) 1990-04-12
ATE101723T1 (de) 1994-03-15
ZA897689B (en) 1990-07-25
EP0363942B1 (de) 1994-02-16
KR920005963B1 (ko) 1992-07-25
US5126241A (en) 1992-06-30
AU4285589A (en) 1990-04-26
CA2000545C (en) 2000-05-09
EP0363942A3 (en) 1990-11-07
EP0363942A2 (de) 1990-04-18
JPH0814579B2 (ja) 1996-02-14
JPH02156155A (ja) 1990-06-15

Similar Documents

Publication Publication Date Title
ES2050200T3 (es) Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente.
DK150204C (da) Analogifremgangsmaade til fremstilling af dipeptidyl-agmatiner eller deres hydrochlorider
BR0013298A (pt) Métodos para simultaneamente detectar ambos os membros de um par de ligação
IT1065425B (it) Derivati indolici sostituiti consostituenti basici e processo per la loro preparazione
IT1130489B (it) Derivati chinonici particolarmente utili come medianti e procedimento per la loro preparazione
IT7821102A0 (it) Derivati cefemici e processo per la loro preparazione.
ES496753A0 (es) Procedimiento de obtencion de una composicion para detectar la presencia de un azucar en una muestra de ensayo
IT8067134A0 (it) Derivati dell alcool benzilico particolarmente utili come antidiabetici e procedimento per la loro preparazione
AR230431A1 (es) Compuesto de difenileter 3-hidrazin-4-nitro sustituidos y derivados 3-maleinimido,fenilmaleinimido y dihidroisoindolina,procedimiento para su preparacion y herbicidas que los contienen
GT199900011A (es) Nuevos derivados del acido dihidroxihexanoico
AR223194A1 (es) Composicion de ensayo para determinar la fuerza ionica o peso especifico de una muestra de ensayo acuosa
ES488717A0 (es) Procedimiento para la obtencion de derivados de pirazol
DK340178A (da) Fremgangsmaade til fremstilling af diotosubstituerede benzenderivater
ES2048047B1 (es) Procedimiento para la rehabilitacion de forjados deteriorados.
SV1997000010A (es) Nuevas heteroariloxazolidinonas ref. lea 31535-sv
AR220730A1 (es) Procedimiento para la preparacion de nuevos derivados de la i-((benzoxatiolil)-metil)-4-heterociclil-piperazina
AR220329A1 (es) Composicion de ensayo para determinar la presencia de sangre o peroxidasa en una muestra de ensayo,dispositivo que la comprende y procedimiento para preparar el dispositivo
IT1111484B (it) Composizioni collanti procedimento per la loro preparazione e carta collata con tali composizioni
DK198688D0 (da) Fremgangsmaade til maaling af polariserede fluorescensemissioner
ES488301A0 (es) Procedimiento para la obtencion de dehidropeptidos
ES2022865B3 (es) Compuestos azoicos que contienen grupos ciano, procedimientos para su obtencion y aplicacion de los mismos como colorantes.
DK119480A (da) Fremgangsmaade til fremstilling af organekstrakter med hoejt heparinindhold
AR224137A1 (es) Procedimiento para la elaboracion de 10-ciano-5h-dibenz(b,f)azepina 5-carboxamida
IT1212412B (it) Derivati della benzo-as-triazina e procedimento per la loro preparazione.
IT7867468A0 (it) Derivati dell urea procedimentoper la loro preparazione e composizione erbicida che li contiene

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 363942

Country of ref document: ES