ES2050200T3 - Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente. - Google Patents

Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente.

Info

Publication number
ES2050200T3
ES2050200T3 ES89118917T ES89118917T ES2050200T3 ES 2050200 T3 ES2050200 T3 ES 2050200T3 ES 89118917 T ES89118917 T ES 89118917T ES 89118917 T ES89118917 T ES 89118917T ES 2050200 T3 ES2050200 T3 ES 2050200T3
Authority
ES
Spain
Prior art keywords
substance
marking
determined
determination
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89118917T
Other languages
English (en)
Inventor
Roland Dr Rer Nat Schenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2050200T3 publication Critical patent/ES2050200T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

PARA DETERMINAR UNA SUSTANCIA AGLUTINANTE ESPECIFICA, SE INCUBA UNA SOLUCION DE PRUEBA CON AL MENOS TRES RECEPTORES R , R Y R , DE LOS QUE R TIENE PODER AGLUTINANTE ESPECIFICO, RESPECTO A R , R Y A LA SUSTANCIA QUE SE ESTA DETERMINANDO, R CREA EL ENLACE/LA AGLUTINACION CON LA FASE SOLIDA Y R LLEVA UNA MARCACION. COMO RECEPTOR R SE UTILIZA UN RECEPTOR CON AL MENOS DOS PUNTOS DE AGLUTINACION ESPECIFICA CON UN EPITOPO DE LA SUSTANCIA A DETERMINAR, COMO R UN CONJUGADO DE UN ELEMENTO P1 DE UN PAR DE SUSTANCIAS AGLUTINANTES, Y UNA SUSTANCIA S QUE CORRESPONDE A LA SUSTANCIA A DETERMINAR O A UN DERIVADO CON AL MENOS UN EPITOPO DE LA MISMA. EL ELEMENTO P1 O ESTA ENLAZADO CON UNA FASE SOLIDA O ES INMOVILIZABLE. COMO R SE UTILIZA UN COMPLEJO QUE CONTIENE, AL MENOS, LA SUSTANCIA A DETERMINAR Y UNA MARCACION Y QUE SEPARA LA MARCACION ENLAZADA DE LA NO ENLAZADA. AL FINAL SE MIDE LA MARCACION EN UNA DE LAS DOS FASES.
ES89118917T 1988-10-12 1989-10-11 Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente. Expired - Lifetime ES2050200T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3834766A DE3834766A1 (de) 1988-10-12 1988-10-12 Verfahren zur bestimmung einer spezifisch bindefaehigen substanz

Publications (1)

Publication Number Publication Date
ES2050200T3 true ES2050200T3 (es) 1994-05-16

Family

ID=6364963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89118917T Expired - Lifetime ES2050200T3 (es) 1988-10-12 1989-10-11 Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente.

Country Status (10)

Country Link
US (1) US5126241A (es)
EP (1) EP0363942B1 (es)
JP (1) JPH0814579B2 (es)
KR (1) KR920005963B1 (es)
AT (1) ATE101723T1 (es)
AU (1) AU612907B2 (es)
CA (1) CA2000545C (es)
DE (2) DE3834766A1 (es)
ES (1) ES2050200T3 (es)
ZA (1) ZA897689B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3836348A1 (de) * 1988-10-25 1990-04-26 Boehringer Mannheim Gmbh Verfahren zur bestimmung von fuer ein antigen klassenspezifischen antikoerpern und dazu geeignetes reagenz
US5792606A (en) * 1990-02-26 1998-08-11 Boehringer Mannheim Gmbh Nucleic acid hybridization based assay for determining a substance of interest
US5437981A (en) * 1990-02-26 1995-08-01 Boehringer Mannheim Gmbh Method for the immunological determination of ligands
DE4006054A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Verfahren zur immunologischen bestimmung von liganden
US5556748A (en) * 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
DE4218257A1 (de) * 1992-06-03 1993-12-09 Behringwerke Ag Verfahren zur immunchemischen Bestimmung eines Analyten
DE4328070C1 (de) * 1993-08-20 1994-11-24 Henning Berlin Gmbh Verfahren zur Bestimmung eines Analyten in einem Volumen einer flüssigen Probe sowie seine Anwendung zur Bestimmung von anti-TSH-Rezeptor-Autoantikörpern in einem Patientenserum
US6627404B1 (en) 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US6991907B1 (en) 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
AU6720096A (en) 1995-08-09 1997-03-05 Quidel Corporation Test strip and method for one step lateral flow assay
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
DE19548375A1 (de) * 1995-12-27 1997-07-03 Behringwerke Ag Immunologische Bestimmungsmethode
DE19548028A1 (de) * 1995-12-21 1997-06-26 Bayer Ag Verfahren zur Herstellung eines synthetischen Kalibrators für den Einsatz in Sandwich-Immunoassays, bestehend aus einem Antikörper gegen einen der im Assay benutzten Antikörper und einer Sequenz des Analyten
US5798273A (en) * 1996-09-25 1998-08-25 Becton Dickinson And Company Direct read lateral flow assay for small analytes
DE19808226C1 (de) * 1998-02-27 2000-03-02 Bruker Analytik Gmbh Anordnung und Verfahren zur Untersuchung von hydrophilen Makromolekülen in wässriger Lösung
US6699722B2 (en) 2000-04-14 2004-03-02 A-Fem Medical Corporation Positive detection lateral-flow apparatus and method for small and large analytes
WO2002090961A2 (en) * 2001-05-03 2002-11-14 Immunetics, Inc. Systems and methods for detection of analytes in biological fluids
EP2058663A1 (en) 2007-11-12 2009-05-13 Euro-Diagnostica B.V. Method for the immobilization of an analyte on a solid support
US7842475B2 (en) * 2008-01-08 2010-11-30 Siemens Healthcare Diagnostics Inc. Stabilization of solid support assay reagents
US8673644B2 (en) 2008-05-13 2014-03-18 Battelle Memorial Institute Serum markers for type II diabetes mellitus
WO2010011860A1 (en) * 2008-07-23 2010-01-28 Diabetomics, Llc Methods for detecting pre-diabetes and diabetes
US8168396B2 (en) 2009-05-11 2012-05-01 Diabetomics, Llc Methods for detecting pre-diabetes and diabetes using differential protein glycosylation
WO2011150186A1 (en) 2010-05-26 2011-12-01 The Board Of Trustees Of The University Of Illinois Personal glucose meters for detection and quantification of a broad range of analytes
US10139405B2 (en) 2012-01-24 2018-11-27 Cd Diagnostics, Inc. System for detecting infection in synovial fluid
US9383352B2 (en) 2014-03-26 2016-07-05 Diabetomics, Inc. Salivary protein glycosylation test for diagnosis and monitoring of diabetes
US10584162B2 (en) 2015-04-23 2020-03-10 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Fungal detection using mannan epitope
WO2017023929A1 (en) 2015-08-04 2017-02-09 Cd Diagnostics, Inc. Methods for detecting adverse local tissue reaction (altr) necrosis
WO2017147186A1 (en) 2016-02-22 2017-08-31 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen
WO2017178554A1 (en) 2016-04-13 2017-10-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for the rapid detection of the escherichia coli o25b-st131 clone
US11300576B2 (en) 2019-01-29 2022-04-12 Arizona Board Of Regents On Behalf Of Arizona State University DARPin reagents that distinguish Alzheimer's disease and Parkinson's disease samples

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32696E (en) * 1975-09-04 1988-06-14 Akzona Incorporated Enzymatic immunological method for determination of antigens and antibodies
GB2084317B (en) * 1980-09-30 1984-01-18 Erba Farmitalia Antigen-linked competitive enzymeimmunoassay
US4737453A (en) * 1984-12-12 1988-04-12 Immunomedics, Inc. Sandwich immunoassay utilizing a separation specific binding substance
US4772550A (en) * 1986-02-10 1988-09-20 Miles Inc. Heterogeneous specific binding assay employing an aggregatable binding reagent
AU1342488A (en) * 1987-01-15 1988-08-10 Richard C. Hevey Method of detecting and quantifying ligands in liquids
DE3705686C2 (de) * 1987-02-23 1995-11-30 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Antikörpern

Also Published As

Publication number Publication date
CA2000545C (en) 2000-05-09
DE58906981D1 (de) 1994-03-24
CA2000545A1 (en) 1990-04-12
ZA897689B (en) 1990-07-25
ATE101723T1 (de) 1994-03-15
JPH02156155A (ja) 1990-06-15
EP0363942B1 (de) 1994-02-16
AU4285589A (en) 1990-04-26
JPH0814579B2 (ja) 1996-02-14
DE3834766A1 (de) 1990-04-26
EP0363942A3 (en) 1990-11-07
EP0363942A2 (de) 1990-04-18
AU612907B2 (en) 1991-07-18
KR920005963B1 (ko) 1992-07-25
US5126241A (en) 1992-06-30
KR900006778A (ko) 1990-05-08

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