ES2049656B1 - GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. - Google Patents
GROUPS OF DRUG CONJUGATES WITH ANTIBODIES.Info
- Publication number
- ES2049656B1 ES2049656B1 ES09202001A ES9202001A ES2049656B1 ES 2049656 B1 ES2049656 B1 ES 2049656B1 ES 09202001 A ES09202001 A ES 09202001A ES 9202001 A ES9202001 A ES 9202001A ES 2049656 B1 ES2049656 B1 ES 2049656B1
- Authority
- ES
- Spain
- Prior art keywords
- antibodies
- groups
- pharmacy
- drug conjugates
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
LA INVENCION PROPORCIONA UN CONJUGADO FISIOLOGICAMENTE ACEPTABLE DE UN FARMACO DE FORMULA (I), EN LA QUE AC, R, RBS1 SC, X, Z, M, N, P, Q, R, S, Y, RBS2 SC, RBS3 SC Y RBS4 SC SE DEFINEN CON DETALLE EN LA MEMORIA DESCRIPTIVA. TAMBIEN PROPORCIONA COMPOSICIONES FARMACEUTICAS QUE CONTIENEN UN CONJUGADO DE LA INVENCION E INTERMEDIOS PARA PREPARAR LOS CONJUGADOS Y UN FARMACO MODIFICADO. REPRESENTA UN PROGRESO SIGNIFICATIVO EN EL CAMPO DE LOS FARMACOS DIRIGIDOS A UN OBJETIVO CONCRETO AL PERMITIR LA FIJACION DE MULTIPLES MOLECULAS DE FARMACO CITOTOXICO A UNA SOLA MOLECULA DE ANTICUERPO, TENIENDO APLICACION EN EL TRATAMIENTO DEL CANCER.THE INVENTION PROVIDES A PHYSIOLOGICALLY ACCEPTABLE CONJUGATE OF A PHARMACY OF FORMULA (I), IN WHICH AC, R, RBS1 SC, X, Z, M, N, P, Q, R, S, Y, RBS2 SC, RBS3 SC AND RBS4 SC ARE DEFINED IN DETAIL IN THE DESCRIPTIVE MEMORY. IT ALSO PROVIDES PHARMACEUTICAL COMPOSITIONS CONTAINING A CONJUGATE OF THE INVENTION AND INTERMEDIATES TO PREPARE THE CONJUGATES AND A MODIFIED PHARMACY. IT REPRESENTS SIGNIFICANT PROGRESS IN THE FIELD OF DRUGS AIMED AT A SPECIFIC OBJECTIVE BY ALLOWING THE ATTACHMENT OF MULTIPLE CYCLOTOXIC MOLECULES TO A SINGLE ANTIBODY MOLECULA, HAVING APPLICATION IN CANCER TREATMENT.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09202001A ES2049656B1 (en) | 1992-10-08 | 1992-10-08 | GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09202001A ES2049656B1 (en) | 1992-10-08 | 1992-10-08 | GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2049656A1 ES2049656A1 (en) | 1994-04-16 |
ES2049656B1 true ES2049656B1 (en) | 1994-11-16 |
Family
ID=8278354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09202001A Expired - Lifetime ES2049656B1 (en) | 1992-10-08 | 1992-10-08 | GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2049656B1 (en) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541435A (en) * | 1975-02-04 | 1979-02-28 | Searle & Co | Immunological materials |
US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
US4587046A (en) * | 1982-05-18 | 1986-05-06 | The Regents Of The University Of California | Drug-carrier conjugates |
JPS59116232A (en) * | 1982-12-24 | 1984-07-05 | Teijin Ltd | Cell toxicity complex and its preparation |
PT89504A (en) * | 1988-01-27 | 1989-10-04 | Lilly Co Eli | PROCESS FOR THE PREPARATION OF CONJUGATES OF ANTIBODIES WITH VINCA HYDRAULICS |
US5006652A (en) * | 1988-08-08 | 1991-04-09 | Eli Lilly And Company | Intermediates for antibody-vinca drug conjugates |
US5010176A (en) * | 1988-11-10 | 1991-04-23 | Eli Lilly And Company | Antibody-drug conjugates |
-
1992
- 1992-10-08 ES ES09202001A patent/ES2049656B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2049656A1 (en) | 1994-04-16 |
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