ES2049656A1 - New cluster conjugates of drugs with antibodies - for use with e.g. antineoplastic agents, can attach a large number of the cytotoxic drug molecules - Google Patents
New cluster conjugates of drugs with antibodies - for use with e.g. antineoplastic agents, can attach a large number of the cytotoxic drug moleculesInfo
- Publication number
- ES2049656A1 ES2049656A1 ES9202001A ES9202001A ES2049656A1 ES 2049656 A1 ES2049656 A1 ES 2049656A1 ES 9202001 A ES9202001 A ES 9202001A ES 9202001 A ES9202001 A ES 9202001A ES 2049656 A1 ES2049656 A1 ES 2049656A1
- Authority
- ES
- Spain
- Prior art keywords
- antibodies
- drugs
- attach
- drug molecules
- cytotoxic drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a combination that is physiologically acceptable from a drug with formula (I) in which Ac, R, R<1>, X, Z, M, N, P, Q, R, S, Y R<2>, R<3> Y R<4> are determined with details in descriptive memory. It also provides pharmaceutical compositions that contain a combination in the invention and intermediaries to prepare the combinations and a modified drug. It represents significant progress in the field of medicine directed at a concrete objective of enabling fixation of multiple cytotoxic drug molecules to a single antibody molecule, applicable in the treatment of cancer.<IMAGE>
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09202001A ES2049656B1 (en) | 1992-10-08 | 1992-10-08 | GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09202001A ES2049656B1 (en) | 1992-10-08 | 1992-10-08 | GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2049656A1 true ES2049656A1 (en) | 1994-04-16 |
ES2049656B1 ES2049656B1 (en) | 1994-11-16 |
Family
ID=8278354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09202001A Expired - Lifetime ES2049656B1 (en) | 1992-10-08 | 1992-10-08 | GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2049656B1 (en) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4046722A (en) * | 1975-02-04 | 1977-09-06 | G. D. Searle & Co. Limited | Immunological materials |
US4543211A (en) * | 1982-12-24 | 1985-09-24 | Teijin Limited | Conjugate having cytotoxicity and process for the preparation thereof |
US4587046A (en) * | 1982-05-18 | 1986-05-06 | The Regents Of The University Of California | Drug-carrier conjugates |
EP0326322A1 (en) * | 1988-01-27 | 1989-08-02 | Eli Lilly And Company | Antibody conjugates |
US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
EP0354728A2 (en) * | 1988-08-08 | 1990-02-14 | Eli Lilly And Company | Cytotoxic drug conjugates |
EP0368668A2 (en) * | 1988-11-10 | 1990-05-16 | Eli Lilly And Company | Antibody-drug conjugates |
-
1992
- 1992-10-08 ES ES09202001A patent/ES2049656B1/en not_active Expired - Lifetime
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4046722A (en) * | 1975-02-04 | 1977-09-06 | G. D. Searle & Co. Limited | Immunological materials |
US4587046A (en) * | 1982-05-18 | 1986-05-06 | The Regents Of The University Of California | Drug-carrier conjugates |
US4543211A (en) * | 1982-12-24 | 1985-09-24 | Teijin Limited | Conjugate having cytotoxicity and process for the preparation thereof |
US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
EP0326322A1 (en) * | 1988-01-27 | 1989-08-02 | Eli Lilly And Company | Antibody conjugates |
EP0354728A2 (en) * | 1988-08-08 | 1990-02-14 | Eli Lilly And Company | Cytotoxic drug conjugates |
US5006652A (en) * | 1988-08-08 | 1991-04-09 | Eli Lilly And Company | Intermediates for antibody-vinca drug conjugates |
EP0368668A2 (en) * | 1988-11-10 | 1990-05-16 | Eli Lilly And Company | Antibody-drug conjugates |
Also Published As
Publication number | Publication date |
---|---|
ES2049656B1 (en) | 1994-11-16 |
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ES2049656A1 (en) | New cluster conjugates of drugs with antibodies - for use with e.g. antineoplastic agents, can attach a large number of the cytotoxic drug molecules | |
RU94002476A (en) | MEDICINE |