ES2049636A1 - Quinoline carboxylic acid deriv prepn - by reacting boron complex of quinoline deriv with nucleophilic cpd - Google Patents

Quinoline carboxylic acid deriv prepn - by reacting boron complex of quinoline deriv with nucleophilic cpd

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Publication number
ES2049636A1
ES2049636A1 ES9200816A ES9200816A ES2049636A1 ES 2049636 A1 ES2049636 A1 ES 2049636A1 ES 9200816 A ES9200816 A ES 9200816A ES 9200816 A ES9200816 A ES 9200816A ES 2049636 A1 ES2049636 A1 ES 2049636A1
Authority
ES
Spain
Prior art keywords
deriv
quinoline
nucleophilic
carboxylic acid
boron complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9200816A
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Spanish (es)
Other versions
ES2049636B1 (en
Inventor
Coll Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro Genesis para la Investigacion SL
Original Assignee
Centro Genesis para la Investigacion SL
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Publication date
Application filed by Centro Genesis para la Investigacion SL filed Critical Centro Genesis para la Investigacion SL
Priority to ES9200816A priority Critical patent/ES2049636B1/en
Publication of ES2049636A1 publication Critical patent/ES2049636A1/en
Application granted granted Critical
Publication of ES2049636B1 publication Critical patent/ES2049636B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

Procedure for preparing quinoline carboxylic acid derivatives with formula I, (R<5> = nucleophile R = aliphatic or aromatic radical) based on the reaction of a nucleophile with a boron complex with formula II (R<1>, R<2> are halogen, methane sulphonate or trifluoro methane sulphonate R<3> = halogen or nitro R<4> = hydrogen or fluorine).These derivatives have outstanding antibacterial properties.< IMAGE >Quinoline carboxylic acid derivs. of formula (I), in which R5 is a nucleophilic gp. and R is an aliphatic or aromatic radical, are made by reaction of a nucleophilic with a boron complex of formula (II), in which R1 and R2 are halogen, methane sulphonate or trifluoromethane sulphonate, R3 is halogen or nitro and R4 is H or fluorine.
ES9200816A 1992-04-15 1992-04-15 PROCEDURE FOR THE PREPARATION OF QUINOLINCARBOXILIC ACID DERIVATIVES. Expired - Lifetime ES2049636B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9200816A ES2049636B1 (en) 1992-04-15 1992-04-15 PROCEDURE FOR THE PREPARATION OF QUINOLINCARBOXILIC ACID DERIVATIVES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9200816A ES2049636B1 (en) 1992-04-15 1992-04-15 PROCEDURE FOR THE PREPARATION OF QUINOLINCARBOXILIC ACID DERIVATIVES.

Publications (2)

Publication Number Publication Date
ES2049636A1 true ES2049636A1 (en) 1994-04-16
ES2049636B1 ES2049636B1 (en) 1994-12-16

Family

ID=8276755

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9200816A Expired - Lifetime ES2049636B1 (en) 1992-04-15 1992-04-15 PROCEDURE FOR THE PREPARATION OF QUINOLINCARBOXILIC ACID DERIVATIVES.

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ES (1) ES2049636B1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987003587A1 (en) * 1985-12-09 1987-06-18 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acids
ES2001464A6 (en) * 1986-12-19 1988-05-16 Chinoin Gyogyszer Es Vegyeszet Prepn. of oxo-di:hydroxy piperazino:quinoline carboxylic acid cpds.
WO1988007998A1 (en) * 1987-04-08 1988-10-20 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Quinoline carboxylic acid boric acid anhydrides and process for the preparation thereof
ES2006882A6 (en) * 1987-04-08 1989-05-16 Chinoin Gyogyszer Es Vegyeszet Procedure for the preparation of quinolincarboxilic acids. (Machine-translation by Google Translate, not legally binding)
ES2006994A6 (en) * 1987-06-24 1989-05-16 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of quinoline carboxylic acid derivatives.
ES2009402A6 (en) * 1988-11-23 1989-09-16 Salvat Procedure for obtaining the acid 1-ciclopropil-6-fluoro-7- (piperacinil) -1,4-dihidrido-4-oxo-quinolin-3-carboxilico. (Machine-translation by Google Translate, not legally binding)

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987003587A1 (en) * 1985-12-09 1987-06-18 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acids
ES2001464A6 (en) * 1986-12-19 1988-05-16 Chinoin Gyogyszer Es Vegyeszet Prepn. of oxo-di:hydroxy piperazino:quinoline carboxylic acid cpds.
WO1988007998A1 (en) * 1987-04-08 1988-10-20 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Quinoline carboxylic acid boric acid anhydrides and process for the preparation thereof
ES2006881A6 (en) * 1987-04-08 1989-05-16 Chinoin Gyogyszer Es Vegyeszet Quinoline carboxylic acid boric acid anhydrides and process for the preparation thereof.
ES2006882A6 (en) * 1987-04-08 1989-05-16 Chinoin Gyogyszer Es Vegyeszet Procedure for the preparation of quinolincarboxilic acids. (Machine-translation by Google Translate, not legally binding)
ES2006994A6 (en) * 1987-06-24 1989-05-16 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of quinoline carboxylic acid derivatives.
ES2009402A6 (en) * 1988-11-23 1989-09-16 Salvat Procedure for obtaining the acid 1-ciclopropil-6-fluoro-7- (piperacinil) -1,4-dihidrido-4-oxo-quinolin-3-carboxilico. (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
ES2049636B1 (en) 1994-12-16

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Effective date: 19950425