ES2036309T3 - Procedimiento y dispositivo para la sintesis simultanea y completamente automatica de varios polipeptidos. - Google Patents

Procedimiento y dispositivo para la sintesis simultanea y completamente automatica de varios polipeptidos.

Info

Publication number
ES2036309T3
ES2036309T3 ES198989114710T ES89114710T ES2036309T3 ES 2036309 T3 ES2036309 T3 ES 2036309T3 ES 198989114710 T ES198989114710 T ES 198989114710T ES 89114710 T ES89114710 T ES 89114710T ES 2036309 T3 ES2036309 T3 ES 2036309T3
Authority
ES
Spain
Prior art keywords
simultaneous
procedure
completely automatic
various polypeptides
automatic synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198989114710T
Other languages
English (en)
Inventor
Gerd Dr. Schnorrenberg
Wilhelm Knapp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Application granted granted Critical
Publication of ES2036309T3 publication Critical patent/ES2036309T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

LA PATENTE DESCRIBE UN PROCEDIMIENTO Y UN DISPOSITIVO PARA LA SINTESIS TOTAL Y AUTOMATICA DE VARIOS POLIPEPTIDOS. EL PROCEDIMIENTO CONSISTE EN SINTETIZAR SEGUN EL METODO DE SINTESIS FASES SOLIDAS , 96 TIPOS DIFERENTES DE POLIPEPTIDOS EN UN ROBOT-PIPETA.
ES198989114710T 1988-08-23 1989-08-09 Procedimiento y dispositivo para la sintesis simultanea y completamente automatica de varios polipeptidos. Expired - Lifetime ES2036309T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3828576A DE3828576A1 (de) 1988-08-23 1988-08-23 Verfahren und vorrichtung zur vollautomatischen simultanen synthese mehrerer polypeptide

Publications (1)

Publication Number Publication Date
ES2036309T3 true ES2036309T3 (es) 1993-05-16

Family

ID=6361418

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198989114710T Expired - Lifetime ES2036309T3 (es) 1988-08-23 1989-08-09 Procedimiento y dispositivo para la sintesis simultanea y completamente automatica de varios polipeptidos.

Country Status (8)

Country Link
EP (1) EP0355582B1 (es)
JP (1) JPH02167297A (es)
AT (1) ATE82983T1 (es)
AU (1) AU626315B2 (es)
DE (3) DE3828576A1 (es)
DK (1) DK173633B1 (es)
ES (1) ES2036309T3 (es)
GR (1) GR3006611T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4005518A1 (de) * 1990-02-22 1991-08-29 Boehringer Ingelheim Kg Verfahren und vorrichtung zur simultanen synthese mehrerer polypeptide
JPH0720546B2 (ja) * 1991-08-26 1995-03-08 株式会社島津製作所 多種品目同時化学反応装置
US5702672A (en) * 1992-10-08 1997-12-30 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
US5714127A (en) * 1992-10-08 1998-02-03 Warner-Lambert Company System for multiple simultaneous synthesis
US5567391A (en) * 1992-10-08 1996-10-22 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
JPH06220084A (ja) * 1993-01-23 1994-08-09 Shimadzu Corp ペプチド合成装置
AU4424496A (en) * 1995-03-27 1996-10-16 Warner-Lambert Company A method for the synthesis of mixtures of compounds
DE19844988A1 (de) * 1998-09-30 2000-04-13 Stefan Seeger Parallele Festphasensynthese
AU3191900A (en) * 1999-03-15 2000-10-04 Sankyo Company Limited Method for synthesizing peptide
US7272175B2 (en) * 2001-08-16 2007-09-18 Dsp Group Inc. Digital phase locked loop

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985032A (en) * 1975-11-13 1976-10-12 Centaur Chemical Co. Micropipette filter tips
US4059020A (en) * 1976-09-09 1977-11-22 Centaur Chemical Co. Filter for micropipettes
FR2485003A1 (fr) * 1980-06-23 1981-12-24 Clin Midy Appareillage automatise utilisable pour la synthese des peptides en phase solide
FR2582655B1 (fr) * 1985-06-03 1988-12-23 Centre Nat Rech Scient Multi-synthetiseur de peptides semi-automatique en phase solide
DE3631662A1 (de) * 1986-09-17 1988-03-24 Biotechnolog Forschung Gmbh Verfahren zur simultanen synthese mehrerer peptide an fester phase

Also Published As

Publication number Publication date
DK412789D0 (da) 1989-08-22
DE3828576A1 (de) 1990-03-08
DE58902869D1 (de) 1993-01-14
EP0355582B1 (de) 1992-12-02
DK412789A (da) 1990-02-24
DE3828576C2 (es) 1990-11-22
AU4013089A (en) 1990-03-01
EP0355582A2 (de) 1990-02-28
DE8816749U1 (de) 1990-05-10
GR3006611T3 (es) 1993-06-30
JPH02167297A (ja) 1990-06-27
DK173633B1 (da) 2001-05-14
AU626315B2 (en) 1992-07-30
EP0355582A3 (en) 1990-11-22
ATE82983T1 (de) 1992-12-15

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