AU4013089A - Process and apparatus for fully automatic simultaneous synthesis of a plurality of different polypeptides - Google Patents

Process and apparatus for fully automatic simultaneous synthesis of a plurality of different polypeptides

Info

Publication number
AU4013089A
AU4013089A AU40130/89A AU4013089A AU4013089A AU 4013089 A AU4013089 A AU 4013089A AU 40130/89 A AU40130/89 A AU 40130/89A AU 4013089 A AU4013089 A AU 4013089A AU 4013089 A AU4013089 A AU 4013089A
Authority
AU
Australia
Prior art keywords
different polypeptides
fully automatic
simultaneous synthesis
automatic simultaneous
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU40130/89A
Other versions
AU626315B2 (en
Inventor
Wilhelm Knapp
Gerd Schnorrenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU4013089A publication Critical patent/AU4013089A/en
Application granted granted Critical
Publication of AU626315B2 publication Critical patent/AU626315B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00364Pipettes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00423Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00691Automatic using robots
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00725Peptides
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Process and apparatus for the completely automatic simultaneous synthesis of several polypeptides, where up to 96 different polypeptides are synthesised by the solid-phase synthetic method in a robot pipetter.
AU40130/89A 1988-08-23 1989-08-22 Process and apparatus for fully automatic simultaneous synthesis of a plurality of different polypeptides Ceased AU626315B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3828576A DE3828576A1 (en) 1988-08-23 1988-08-23 METHOD AND DEVICE FOR THE FULLY AUTOMATIC SIMULTANEOUS SYNTHESIS OF SEVERAL POLYPEPTIDES
DE3828576 1988-08-23

Publications (2)

Publication Number Publication Date
AU4013089A true AU4013089A (en) 1990-03-01
AU626315B2 AU626315B2 (en) 1992-07-30

Family

ID=6361418

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40130/89A Ceased AU626315B2 (en) 1988-08-23 1989-08-22 Process and apparatus for fully automatic simultaneous synthesis of a plurality of different polypeptides

Country Status (8)

Country Link
EP (1) EP0355582B1 (en)
JP (1) JPH02167297A (en)
AT (1) ATE82983T1 (en)
AU (1) AU626315B2 (en)
DE (3) DE3828576A1 (en)
DK (1) DK173633B1 (en)
ES (1) ES2036309T3 (en)
GR (1) GR3006611T3 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565173A (en) * 1992-10-08 1996-10-15 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5582801A (en) * 1992-10-08 1996-12-10 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5702672A (en) * 1992-10-08 1997-12-30 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5714127A (en) * 1992-10-08 1998-02-03 Warner-Lambert Company System for multiple simultaneous synthesis

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4005518A1 (en) * 1990-02-22 1991-08-29 Boehringer Ingelheim Kg METHOD AND DEVICE FOR SIMULTANEOUS SYNTHESIS OF SEVERAL POLYPEPTIDES
JPH0720546B2 (en) * 1991-08-26 1995-03-08 株式会社島津製作所 Multi-item simultaneous chemical reactor
JPH06220084A (en) * 1993-01-23 1994-08-09 Shimadzu Corp Peptide synthesizer
AU4424496A (en) * 1995-03-27 1996-10-16 Warner-Lambert Company A method for the synthesis of mixtures of compounds
DE19844988A1 (en) * 1998-09-30 2000-04-13 Stefan Seeger Parallel solid phase synthesis
AU3191900A (en) * 1999-03-15 2000-10-04 Sankyo Company Limited Method for synthesizing peptide
US7272175B2 (en) * 2001-08-16 2007-09-18 Dsp Group Inc. Digital phase locked loop

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985032A (en) * 1975-11-13 1976-10-12 Centaur Chemical Co. Micropipette filter tips
US4059020A (en) * 1976-09-09 1977-11-22 Centaur Chemical Co. Filter for micropipettes
FR2485003A1 (en) * 1980-06-23 1981-12-24 Clin Midy AUTOMATED APPARATUS FOR USE IN THE SYNTHESIS OF SOLID-STATE PEPTIDES
FR2582655B1 (en) * 1985-06-03 1988-12-23 Centre Nat Rech Scient SOLID PHASE SEMI-AUTOMATIC PEPTIDE MULTI-SYNTHESIZER
DE3631662A1 (en) * 1986-09-17 1988-03-24 Biotechnolog Forschung Gmbh METHOD FOR SIMULTANEOUS SYNTHESIS OF SEVERAL PEPTIDES ON A SOLID PHASE

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565173A (en) * 1992-10-08 1996-10-15 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5567391A (en) * 1992-10-08 1996-10-22 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5582801A (en) * 1992-10-08 1996-12-10 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5593642A (en) * 1992-10-08 1997-01-14 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5612002A (en) * 1992-10-08 1997-03-18 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5702672A (en) * 1992-10-08 1997-12-30 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5714127A (en) * 1992-10-08 1998-02-03 Warner-Lambert Company System for multiple simultaneous synthesis

Also Published As

Publication number Publication date
DK412789D0 (en) 1989-08-22
DE3828576A1 (en) 1990-03-08
ES2036309T3 (en) 1993-05-16
DE58902869D1 (en) 1993-01-14
EP0355582B1 (en) 1992-12-02
DK412789A (en) 1990-02-24
DE3828576C2 (en) 1990-11-22
EP0355582A2 (en) 1990-02-28
DE8816749U1 (en) 1990-05-10
GR3006611T3 (en) 1993-06-30
JPH02167297A (en) 1990-06-27
DK173633B1 (en) 2001-05-14
AU626315B2 (en) 1992-07-30
EP0355582A3 (en) 1990-11-22
ATE82983T1 (en) 1992-12-15

Similar Documents

Publication Publication Date Title
AR244903A1 (en) Apparatus for classifying articles according to a variety of different criteria.
FI98192B (en) Process for preparing a nutritional composition
AU5333190A (en) Carton forming apparatus with servo control
EP0331145A3 (en) Process for producing amino acids
AU4013089A (en) Process and apparatus for fully automatic simultaneous synthesis of a plurality of different polypeptides
HUT43098A (en) Process for producing copolymeres from ethylene/carbon monoxide
HUT51304A (en) Process for production of cathalizator-component for polimerization of olefins
GB2221953B (en) Production plant for slide fasteners
GB2217731B (en) Process for producing a semi-finished leather product
GB8825248D0 (en) Method & apparatus for producing moulded articles
NZ230721A (en) A process for the conversion of a c 2 -c 6 aliphatic hydrocarbon into naphthenic hydrocarbons
AU3624689A (en) Centering apparatus for a gemstone
GB2218893B (en) Process for preparing a snack product
EP0379903A3 (en) Process for producing l-amino acids by fermentation
IL90749A0 (en) Fermentation process for producing carboxylic acids
AU2596288A (en) Method for producing a solid animal feed supplement
AU615295B2 (en) Method for controlling a process
AU3105689A (en) A culturing apparatus
GB2199333B (en) Process for producing shaped articles from vegetable particulate materials
GB8823533D0 (en) Method & apparatus for effecting bioreaction
AU7505987A (en) A process for producing L-lysine
GB8815612D0 (en) Novel grain-based animal feed material & method for production
AU4288789A (en) A process for forming ferrocement products
AU6336190A (en) Process for enriching a gas
GB8815148D0 (en) Process & means for plant cultivation