ES2035800A1 - Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados. - Google Patents
Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados.Info
- Publication number
- ES2035800A1 ES2035800A1 ES919102130A ES9102130A ES2035800A1 ES 2035800 A1 ES2035800 A1 ES 2035800A1 ES 919102130 A ES919102130 A ES 919102130A ES 9102130 A ES9102130 A ES 9102130A ES 2035800 A1 ES2035800 A1 ES 2035800A1
- Authority
- ES
- Spain
- Prior art keywords
- substd
- phenyl
- butyric acids
- derivs
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE DESCRIBE UN PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE FORMULA (I) FORMULA DONDE R REPRESENTA HIDROGENO, METILO, ETILO, TERBUTILO, BENCILO O TRIMETILSILILO Y R1 HIDROGENO, TRIMETILSILILO, ACILO O TRIFLUOROMETANSULFONILO, QUE RESULTAN DE LA RESOLUCION DEL ACIDO (R, S)-2-HIDROXI-4-FENILBUTIRICO CON LAS BASES D(-)TREO O L(+)TREO 1,P-NITROFENIL-2-AMINO-1, 3-PROPANODIOL DE DONDE SE AISLAN LOS ACIDOS (R) O (S) 2-HIDROXI-4-FENILBUTIRICOS, LOS CUALES SE ESTERIFICAN Y SE HACEN REACCIONAR SUS 2-TRIMETILSILILOXI DERIVADOS CON ANHIDRIDO TRIFLICO. LA CONVERSION DE (S)-HIDROXIACIDO (R)-HIDROXIACIDO SE REALIZA POR REACCION DE LOS TRIFLATOS CON ACETATO DE TRIETILAMINA CON INVERSION REGIO SELECTIVA Y LA HIDROLISIS DEL ACETATO CON RETENCION DE CONFIGURACION. COMPUESTOS DE APLICACION EN MEDICINA EN EL AREA DE LOS AGENTES ANTIHIPERTENSIVOS, Y EN AGRICULTURA COMO REGULADORES DEL CRECIMIENTO Y REPELENTES DE INSECTOS.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9102130A ES2035800B1 (es) | 1991-09-27 | 1991-09-27 | Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9102130A ES2035800B1 (es) | 1991-09-27 | 1991-09-27 | Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2035800A1 true ES2035800A1 (es) | 1993-04-16 |
ES2035800B1 ES2035800B1 (es) | 1994-02-01 |
Family
ID=8273638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9102130A Expired - Lifetime ES2035800B1 (es) | 1991-09-27 | 1991-09-27 | Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2035800B1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104496843A (zh) * | 2014-12-08 | 2015-04-08 | 山东益康药业股份有限公司 | 一种乌苯美司的合成方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0329156A1 (en) * | 1988-02-19 | 1989-08-23 | Kuraray Co., Ltd. | Process for the optical resolution of (+-)-2-hydroxy-4-phenylbutanoic acid |
-
1991
- 1991-09-27 ES ES9102130A patent/ES2035800B1/es not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0329156A1 (en) * | 1988-02-19 | 1989-08-23 | Kuraray Co., Ltd. | Process for the optical resolution of (+-)-2-hydroxy-4-phenylbutanoic acid |
Non-Patent Citations (2)
Title |
---|
CHEM. PHARM. BULL., Vol.37, n‘2, pßgs.280-283, 1989.G.IWASAKY et al. A practical and diastereoselective synthesis of angiotensin converting enzyme inhibitors. * |
PATENT ABSTRACTS OF JAPAN, Vol.13, n‘532, C-569,3880, 28-Nov.1989 &, JP-A-1216954 (DAICEL CHEM. IND.), 30-Agosto-1989. * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104496843A (zh) * | 2014-12-08 | 2015-04-08 | 山东益康药业股份有限公司 | 一种乌苯美司的合成方法 |
CN104496843B (zh) * | 2014-12-08 | 2017-02-22 | 山东益康药业股份有限公司 | 一种乌苯美司的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
ES2035800B1 (es) | 1994-02-01 |
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