ES2035800A1 - Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados. - Google Patents

Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados.

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Publication number
ES2035800A1
ES2035800A1 ES919102130A ES9102130A ES2035800A1 ES 2035800 A1 ES2035800 A1 ES 2035800A1 ES 919102130 A ES919102130 A ES 919102130A ES 9102130 A ES9102130 A ES 9102130A ES 2035800 A1 ES2035800 A1 ES 2035800A1
Authority
ES
Spain
Prior art keywords
substd
phenyl
butyric acids
derivs
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES919102130A
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English (en)
Other versions
ES2035800B1 (es
Inventor
Castellvi Juan Cabre
Coll Antonio Luis Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARGA INVESTIGACION
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MARGA INVESTIGACION
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MARGA INVESTIGACION filed Critical MARGA INVESTIGACION
Priority to ES9102130A priority Critical patent/ES2035800B1/es
Publication of ES2035800A1 publication Critical patent/ES2035800A1/es
Application granted granted Critical
Publication of ES2035800B1 publication Critical patent/ES2035800B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

LA INVENCION SE DESCRIBE UN PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE FORMULA (I) FORMULA DONDE R REPRESENTA HIDROGENO, METILO, ETILO, TERBUTILO, BENCILO O TRIMETILSILILO Y R1 HIDROGENO, TRIMETILSILILO, ACILO O TRIFLUOROMETANSULFONILO, QUE RESULTAN DE LA RESOLUCION DEL ACIDO (R, S)-2-HIDROXI-4-FENILBUTIRICO CON LAS BASES D(-)TREO O L(+)TREO 1,P-NITROFENIL-2-AMINO-1, 3-PROPANODIOL DE DONDE SE AISLAN LOS ACIDOS (R) O (S) 2-HIDROXI-4-FENILBUTIRICOS, LOS CUALES SE ESTERIFICAN Y SE HACEN REACCIONAR SUS 2-TRIMETILSILILOXI DERIVADOS CON ANHIDRIDO TRIFLICO. LA CONVERSION DE (S)-HIDROXIACIDO (R)-HIDROXIACIDO SE REALIZA POR REACCION DE LOS TRIFLATOS CON ACETATO DE TRIETILAMINA CON INVERSION REGIO SELECTIVA Y LA HIDROLISIS DEL ACETATO CON RETENCION DE CONFIGURACION. COMPUESTOS DE APLICACION EN MEDICINA EN EL AREA DE LOS AGENTES ANTIHIPERTENSIVOS, Y EN AGRICULTURA COMO REGULADORES DEL CRECIMIENTO Y REPELENTES DE INSECTOS.
ES9102130A 1991-09-27 1991-09-27 Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados. Expired - Lifetime ES2035800B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9102130A ES2035800B1 (es) 1991-09-27 1991-09-27 Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102130A ES2035800B1 (es) 1991-09-27 1991-09-27 Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados.

Publications (2)

Publication Number Publication Date
ES2035800A1 true ES2035800A1 (es) 1993-04-16
ES2035800B1 ES2035800B1 (es) 1994-02-01

Family

ID=8273638

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102130A Expired - Lifetime ES2035800B1 (es) 1991-09-27 1991-09-27 Procedimiento de preparacion de los acidos (5) y (r) 2-substituidos -4-fenilbutricos, sus sales y derivados.

Country Status (1)

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ES (1) ES2035800B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104496843A (zh) * 2014-12-08 2015-04-08 山东益康药业股份有限公司 一种乌苯美司的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329156A1 (en) * 1988-02-19 1989-08-23 Kuraray Co., Ltd. Process for the optical resolution of (+-)-2-hydroxy-4-phenylbutanoic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329156A1 (en) * 1988-02-19 1989-08-23 Kuraray Co., Ltd. Process for the optical resolution of (+-)-2-hydroxy-4-phenylbutanoic acid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEM. PHARM. BULL., Vol.37, n‘2, pßgs.280-283, 1989.G.IWASAKY et al. A practical and diastereoselective synthesis of angiotensin converting enzyme inhibitors. *
PATENT ABSTRACTS OF JAPAN, Vol.13, n‘532, C-569,3880, 28-Nov.1989 &, JP-A-1216954 (DAICEL CHEM. IND.), 30-Agosto-1989. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104496843A (zh) * 2014-12-08 2015-04-08 山东益康药业股份有限公司 一种乌苯美司的合成方法
CN104496843B (zh) * 2014-12-08 2017-02-22 山东益康药业股份有限公司 一种乌苯美司的合成方法

Also Published As

Publication number Publication date
ES2035800B1 (es) 1994-02-01

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