ES2035767A1 - Process for obtaining 4-substituted 2-hydroxymethyl-3,5- dimethyl pyridines - Google Patents

Process for obtaining 4-substituted 2-hydroxymethyl-3,5- dimethyl pyridines

Info

Publication number
ES2035767A1
ES2035767A1 ES9100890A ES9100890A ES2035767A1 ES 2035767 A1 ES2035767 A1 ES 2035767A1 ES 9100890 A ES9100890 A ES 9100890A ES 9100890 A ES9100890 A ES 9100890A ES 2035767 A1 ES2035767 A1 ES 2035767A1
Authority
ES
Spain
Prior art keywords
dimethyl
pyridine
hydroxymethyl
obtaining
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9100890A
Other languages
Spanish (es)
Other versions
ES2035767B1 (en
Inventor
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro Genesis para la Investigacion SL
Original Assignee
Centro Genesis para la Investigacion SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Genesis para la Investigacion SL filed Critical Centro Genesis para la Investigacion SL
Priority to ES9100890A priority Critical patent/ES2035767B1/en
Publication of ES2035767A1 publication Critical patent/ES2035767A1/en
Application granted granted Critical
Publication of ES2035767B1 publication Critical patent/ES2035767B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for obtaining 2-hydroxymethyl-3,5-dimethyl-4-R- pyridine of formula I where R is a nitro or methoxyl group which comprises: a) deoxygenation and introduction of a cyano group into the 2 position of 3,5-dimethyl-4-R- pyridine-N-oxide of formula III to obtain 3,5-dimethyl-4- R-pyridine-2-carbonitrile b) hydrolysis of the cyano group of the latter compound, yielding 3,5-dimethyl-4-R- pyridine-2-carboxylic acid, and c) reduction of the carboxyl radical of the above acid yielding the compound of formula I. The compound of formula I is an intermediate in the synthesis of omeprazole, which is a very effective drug.
ES9100890A 1991-04-05 1991-04-05 PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED. Expired - Fee Related ES2035767B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9100890A ES2035767B1 (en) 1991-04-05 1991-04-05 PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9100890A ES2035767B1 (en) 1991-04-05 1991-04-05 PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED.

Publications (2)

Publication Number Publication Date
ES2035767A1 true ES2035767A1 (en) 1993-04-16
ES2035767B1 ES2035767B1 (en) 1994-02-01

Family

ID=8271987

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9100890A Expired - Fee Related ES2035767B1 (en) 1991-04-05 1991-04-05 PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED.

Country Status (1)

Country Link
ES (1) ES2035767B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2097089A1 (en) * 1995-02-01 1997-03-16 Esteve Quimica Sa Process for the preparation of 2-hydroxymethyl-3,5- dimethyl-4-methoxypyridine

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9717849D0 (en) * 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0369208A1 (en) * 1988-11-15 1990-05-23 Hafslund Nycomed Pharma Aktiengesellschaft Process for the preparation of 3,5-dimethyl-4-methoxy pyridine derivatives, and intermediate therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0369208A1 (en) * 1988-11-15 1990-05-23 Hafslund Nycomed Pharma Aktiengesellschaft Process for the preparation of 3,5-dimethyl-4-methoxy pyridine derivatives, and intermediate therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2097089A1 (en) * 1995-02-01 1997-03-16 Esteve Quimica Sa Process for the preparation of 2-hydroxymethyl-3,5- dimethyl-4-methoxypyridine

Also Published As

Publication number Publication date
ES2035767B1 (en) 1994-02-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201