ES2035767A1 - Process for obtaining 4-substituted 2-hydroxymethyl-3,5- dimethyl pyridines - Google Patents
Process for obtaining 4-substituted 2-hydroxymethyl-3,5- dimethyl pyridinesInfo
- Publication number
- ES2035767A1 ES2035767A1 ES9100890A ES9100890A ES2035767A1 ES 2035767 A1 ES2035767 A1 ES 2035767A1 ES 9100890 A ES9100890 A ES 9100890A ES 9100890 A ES9100890 A ES 9100890A ES 2035767 A1 ES2035767 A1 ES 2035767A1
- Authority
- ES
- Spain
- Prior art keywords
- dimethyl
- pyridine
- hydroxymethyl
- obtaining
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Process for obtaining 2-hydroxymethyl-3,5-dimethyl-4-R- pyridine of formula I where R is a nitro or methoxyl group which comprises: a) deoxygenation and introduction of a cyano group into the 2 position of 3,5-dimethyl-4-R- pyridine-N-oxide of formula III to obtain 3,5-dimethyl-4- R-pyridine-2-carbonitrile b) hydrolysis of the cyano group of the latter compound, yielding 3,5-dimethyl-4-R- pyridine-2-carboxylic acid, and c) reduction of the carboxyl radical of the above acid yielding the compound of formula I. The compound of formula I is an intermediate in the synthesis of omeprazole, which is a very effective drug.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9100890A ES2035767B1 (en) | 1991-04-05 | 1991-04-05 | PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9100890A ES2035767B1 (en) | 1991-04-05 | 1991-04-05 | PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2035767A1 true ES2035767A1 (en) | 1993-04-16 |
ES2035767B1 ES2035767B1 (en) | 1994-02-01 |
Family
ID=8271987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9100890A Expired - Fee Related ES2035767B1 (en) | 1991-04-05 | 1991-04-05 | PROCEDURE FOR OBTAINING 2-HYDROXIMETIL-3,5-DIMETILPIRIDINAS 4-SUBSTITUTED. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2035767B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2097089A1 (en) * | 1995-02-01 | 1997-03-16 | Esteve Quimica Sa | Process for the preparation of 2-hydroxymethyl-3,5- dimethyl-4-methoxypyridine |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9717849D0 (en) * | 1997-08-23 | 1997-10-29 | Seal Sands Chemicals Limited | Preparation of pyridene derivatives |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0369208A1 (en) * | 1988-11-15 | 1990-05-23 | Hafslund Nycomed Pharma Aktiengesellschaft | Process for the preparation of 3,5-dimethyl-4-methoxy pyridine derivatives, and intermediate therefor |
-
1991
- 1991-04-05 ES ES9100890A patent/ES2035767B1/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0369208A1 (en) * | 1988-11-15 | 1990-05-23 | Hafslund Nycomed Pharma Aktiengesellschaft | Process for the preparation of 3,5-dimethyl-4-methoxy pyridine derivatives, and intermediate therefor |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2097089A1 (en) * | 1995-02-01 | 1997-03-16 | Esteve Quimica Sa | Process for the preparation of 2-hydroxymethyl-3,5- dimethyl-4-methoxypyridine |
Also Published As
Publication number | Publication date |
---|---|
ES2035767B1 (en) | 1994-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000201 |