ES2032726T1 - Un procedimiento para preparar micro-capsulas. - Google Patents

Un procedimiento para preparar micro-capsulas.

Info

Publication number
ES2032726T1
ES2032726T1 ES91905331T ES91905331T ES2032726T1 ES 2032726 T1 ES2032726 T1 ES 2032726T1 ES 91905331 T ES91905331 T ES 91905331T ES 91905331 T ES91905331 T ES 91905331T ES 2032726 T1 ES2032726 T1 ES 2032726T1
Authority
ES
Spain
Prior art keywords
microcapsules
oil
capsules
water
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES91905331T
Other languages
English (en)
Inventor
Lisbeth Illum
Clive Washington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albumedix Ltd
Original Assignee
Delta Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd
Publication of ES2032726T1 publication Critical patent/ES2032726T1/es
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Acoustics & Sound (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

MICROCAPSULAS HUECAS (ESTO ES, RELLENAS DE GAS O VAPOR), POR EJEMPLO DE ALBUMINA, SE PREPARAN FORMANDO UNA CORTEZA ALREDEDOR DE UN NUCLEO SOLIDO O LIQUIDO Y RETIRANDO POSTERIORMENTE EL NUCLEO. EL NUCLEO PUEDE SER DE UN ACEITE VOLATIL TAL COMO EL PERFLUOROHEXANO. LA CORTEZA SE PUEDE HACER POR COACERVACION SIMPLE O COMPLEJA, EMULSION DOBLE ACEITE/AGUA/ACEITE O POR MSIEP (MINIMIZACION DE LA SOLUBILIDAD EN EL PUNTO ISOELECTRICO) SEGUIDOS POR ENDURECIMIENTO QUIMICO O TERMICO PARA TORNARLA INSOLUBLE EN AGUA. CUANDO SE UTILIZA EL METODO DE DOBLE EMULSION, LAS MICROCAPSULAS TIENEN UN ASPECTO DE COLMENA CON MULTIPLES CAMARAS RELLENAS DE GAS. LAS MICROCAPSULAS SE PUEDEN UTILIZAR EN ECOCARDIOGRAFIA.
ES91905331T 1990-02-20 1991-02-19 Un procedimiento para preparar micro-capsulas. Pending ES2032726T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909003821A GB9003821D0 (en) 1990-02-20 1990-02-20 Diagnostic aid

Publications (1)

Publication Number Publication Date
ES2032726T1 true ES2032726T1 (es) 1993-03-01

Family

ID=10671314

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91905331T Pending ES2032726T1 (es) 1990-02-20 1991-02-19 Un procedimiento para preparar micro-capsulas.

Country Status (5)

Country Link
EP (1) EP0516732A1 (es)
JP (1) JPH05504573A (es)
ES (1) ES2032726T1 (es)
GB (1) GB9003821D0 (es)
WO (1) WO1991012823A1 (es)

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Also Published As

Publication number Publication date
EP0516732A1 (en) 1992-12-09
GB9003821D0 (en) 1990-04-18
WO1991012823A1 (en) 1991-09-05
JPH05504573A (ja) 1993-07-15

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