ES2019551A6 - Process for obtaining derivatives of 6-fluoro-1,4-dihydro-4-oxo-7-piperazinyl-3-quinolinecarboxylic acid and derivatives of acrylate used in said process - Google Patents

Process for obtaining derivatives of 6-fluoro-1,4-dihydro-4-oxo-7-piperazinyl-3-quinolinecarboxylic acid and derivatives of acrylate used in said process

Info

Publication number
ES2019551A6
ES2019551A6 ES9001050A ES9001050A ES2019551A6 ES 2019551 A6 ES2019551 A6 ES 2019551A6 ES 9001050 A ES9001050 A ES 9001050A ES 9001050 A ES9001050 A ES 9001050A ES 2019551 A6 ES2019551 A6 ES 2019551A6
Authority
ES
Spain
Prior art keywords
derivatives
fluoro
dihydro
oxo
quinolinecarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9001050A
Other languages
Spanish (es)
Inventor
Buron Enrique Dominguez
Arcilagos Anna Bosch
Moya Jose Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ercros SA
Original Assignee
Ercros SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ercros SA filed Critical Ercros SA
Priority to ES9001050A priority Critical patent/ES2019551A6/en
Priority to PCT/ES1991/000021 priority patent/WO1991015477A1/en
Priority to PT9732091A priority patent/PT97320B/en
Priority to MA22389A priority patent/MA22120A1/en
Publication of ES2019551A6 publication Critical patent/ES2019551A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Abstract

Process for obtaining derivatives of 6-fluoro-1,4-dihydro-4-oxo-7-piperazynil-3-quinolinecarboxylic acid of formula (I) wherein R1 is H, linear or branched alkyl or hydroxyalkyl having from 1 to 4 carbon atoms and R2 is a linear or cyclic alkyl with 1 to 4 carbon atoms. The process consists in the reaction of a compound (VI) wherein R3 is a linear or branched alkyl with 1 to 5 carbon atoms and R1 may be additionally acyl or alkoxycarbonyl, with HNa and subsequent acid hydrolysis of the cyclic ester obtained. Some of the starting compounds (VI) are new, in particular 3-cyclopropylamino-2-2-chloro-5-fluoro-4-(4-ethoxycarbonyl-1-piperazyn il)benzoylethylacrylate. Amongst the compounds (I) which may be obtained according to this process, cyprofloxazin, norfloxazin and enrofloxazin have the antibacterial activity which makes them appropriate in therapy.
ES9001050A 1990-04-11 1990-04-11 Process for obtaining derivatives of 6-fluoro-1,4-dihydro-4-oxo-7-piperazinyl-3-quinolinecarboxylic acid and derivatives of acrylate used in said process Expired - Lifetime ES2019551A6 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES9001050A ES2019551A6 (en) 1990-04-11 1990-04-11 Process for obtaining derivatives of 6-fluoro-1,4-dihydro-4-oxo-7-piperazinyl-3-quinolinecarboxylic acid and derivatives of acrylate used in said process
PCT/ES1991/000021 WO1991015477A1 (en) 1990-04-11 1991-04-10 Process for obtaining derivatives of 6-fluoro-1,4-dihydro-4-oxo-7-piperazinyl-3-quinolinecarboxylic acid and derivatives of acrylate used in said process
PT9732091A PT97320B (en) 1990-04-11 1991-04-10 PROCESS FOR THE PREPARATION OF ACID DERIVATIVES 6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINYL-KINOLINOCARBOXYL ACID
MA22389A MA22120A1 (en) 1990-04-11 1991-04-10 PROCESS FOR OBTAINING 6-FLUORO-I, 4-DEHYDRO-4-OXO-7-PIPERAZINYL-3-QUINOLEINE-CARBOXYLIC ACID DERIVATIVES AND ACRYLATE DERIVATIVES USED IN THIS PROCESS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9001050A ES2019551A6 (en) 1990-04-11 1990-04-11 Process for obtaining derivatives of 6-fluoro-1,4-dihydro-4-oxo-7-piperazinyl-3-quinolinecarboxylic acid and derivatives of acrylate used in said process

Publications (1)

Publication Number Publication Date
ES2019551A6 true ES2019551A6 (en) 1991-06-16

Family

ID=8266852

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9001050A Expired - Lifetime ES2019551A6 (en) 1990-04-11 1990-04-11 Process for obtaining derivatives of 6-fluoro-1,4-dihydro-4-oxo-7-piperazinyl-3-quinolinecarboxylic acid and derivatives of acrylate used in said process

Country Status (4)

Country Link
ES (1) ES2019551A6 (en)
MA (1) MA22120A1 (en)
PT (1) PT97320B (en)
WO (1) WO1991015477A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109574924A (en) * 2019-01-16 2019-04-05 浙江国邦药业有限公司 A kind of Enrofloxacin raffinate recoverying and utilizing method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
GB8612137D0 (en) * 1986-05-19 1986-06-25 Fujisawa Pharmaceutical Co Quinolone compounds

Also Published As

Publication number Publication date
WO1991015477A1 (en) 1991-10-17
PT97320B (en) 1998-08-31
MA22120A1 (en) 1991-12-31
PT97320A (en) 1992-01-31

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Legal Events

Date Code Title Description
RD1A Patent seized

Effective date: 19930915

PC1A Transfer granted
RD1A Patent seized

Effective date: 20010926

FD2A Announcement of lapse in spain

Effective date: 20180802