FI20001893A - (S) - (+) - 4- (4-t-butylphenyl) -2-pyrrolidone-4-methoxybenzoic acid, its use and processes for preparing the same - Google Patents
(S) - (+) - 4- (4-t-butylphenyl) -2-pyrrolidone-4-methoxybenzoic acid, its use and processes for preparing the same Download PDFInfo
- Publication number
- FI20001893A FI20001893A FI20001893A FI20001893A FI20001893A FI 20001893 A FI20001893 A FI 20001893A FI 20001893 A FI20001893 A FI 20001893A FI 20001893 A FI20001893 A FI 20001893A FI 20001893 A FI20001893 A FI 20001893A
- Authority
- FI
- Finland
- Prior art keywords
- same
- butylphenyl
- pyrrolidone
- preparing
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
Abstract
An optically active form of a compound represented by the following formula (II) below is useful as an agent for treating hyperlipidemia which has an activity to inhibit the synthesis of fatty acids and an activity to inhibit the synthesis of cholesterol <CHEM> wherein R' is a hydrogen atom or a lower alkyl group such as an alkyl group having 1 to 6 carbon atoms, and a synthesis method for same is described.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24288792 | 1992-09-11 | ||
JP24288792 | 1992-09-11 | ||
JP9301274 | 1993-09-08 | ||
PCT/JP1993/001274 WO1994006767A1 (en) | 1992-09-11 | 1993-09-08 | Optically active 1-phenylpyrrolidone derivative, intermediate for producing the same, and process for producing both |
Publications (2)
Publication Number | Publication Date |
---|---|
FI20001893A true FI20001893A (en) | 2000-08-28 |
FI108130B FI108130B (en) | 2001-11-30 |
Family
ID=17095708
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI942167A FI107605B (en) | 1992-09-11 | 1994-05-10 | Optically Active 2- [1- (4-t-Butyl-phenyl) -2-pyrrolidon-4-yl] -methoxycarbonyl-benzoic acid alpha-phenylethylamide, Intermediate and Process for its Preparation |
FI20001893A FI108130B (en) | 1992-09-11 | 2000-08-28 | A process for the preparation of pharmaceutically active (S) - (+) - 4- [1- (4-t-butylphenyl) -2-pyrrolidon-4-yl] methoxybenzoic acid or its ester |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI942167A FI107605B (en) | 1992-09-11 | 1994-05-10 | Optically Active 2- [1- (4-t-Butyl-phenyl) -2-pyrrolidon-4-yl] -methoxycarbonyl-benzoic acid alpha-phenylethylamide, Intermediate and Process for its Preparation |
Country Status (14)
Country | Link |
---|---|
US (1) | US5475118A (en) |
EP (2) | EP0627419B1 (en) |
JP (1) | JP2724634B2 (en) |
KR (1) | KR0141657B1 (en) |
AT (2) | ATE186907T1 (en) |
AU (1) | AU663233B2 (en) |
CA (1) | CA2122705C (en) |
DE (2) | DE69333903T2 (en) |
DK (1) | DK0627419T3 (en) |
ES (2) | ES2247657T3 (en) |
FI (2) | FI107605B (en) |
HU (1) | HU215598B (en) |
NO (1) | NO300130B1 (en) |
WO (1) | WO1994006767A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1000620B1 (en) * | 1998-02-24 | 2005-12-07 | Taiho Pharmaceutical Company, Limited | Lp(a)-LOWERING AGENTS AND APOPROTEIN (a) PRODUCTION INHIBITORS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2657324B2 (en) * | 1989-04-19 | 1997-09-24 | 大塚製薬株式会社 | Phenylcarboxylic acid derivatives having a hetero ring |
JPH06192221A (en) * | 1992-12-25 | 1994-07-12 | Taiho Yakuhin Kogyo Kk | Production of optically active 1-@(3754/24)4-t.-butylphenyl)-5-oxo-3-pyrrolidinecarboxylic acid |
-
1993
- 1993-09-08 WO PCT/JP1993/001274 patent/WO1994006767A1/en active IP Right Grant
- 1993-09-08 KR KR1019940701558A patent/KR0141657B1/en active
- 1993-09-08 DE DE69333903T patent/DE69333903T2/en not_active Expired - Fee Related
- 1993-09-08 US US08/211,950 patent/US5475118A/en not_active Expired - Fee Related
- 1993-09-08 DE DE69327092T patent/DE69327092T2/en not_active Expired - Fee Related
- 1993-09-08 JP JP6507962A patent/JP2724634B2/en not_active Expired - Lifetime
- 1993-09-08 AT AT93919628T patent/ATE186907T1/en not_active IP Right Cessation
- 1993-09-08 CA CA002122705A patent/CA2122705C/en not_active Expired - Fee Related
- 1993-09-08 AU AU49832/93A patent/AU663233B2/en not_active Ceased
- 1993-09-08 HU HU9401470A patent/HU215598B/en not_active IP Right Cessation
- 1993-09-08 EP EP93919628A patent/EP0627419B1/en not_active Expired - Lifetime
- 1993-09-08 ES ES98203959T patent/ES2247657T3/en not_active Expired - Lifetime
- 1993-09-08 AT AT98203959T patent/ATE309212T1/en not_active IP Right Cessation
- 1993-09-08 ES ES93919628T patent/ES2139670T3/en not_active Expired - Lifetime
- 1993-09-08 DK DK93919628T patent/DK0627419T3/en active
- 1993-09-08 EP EP98203959A patent/EP0916657B9/en not_active Expired - Lifetime
-
1994
- 1994-05-10 FI FI942167A patent/FI107605B/en active
- 1994-05-10 NO NO941757A patent/NO300130B1/en unknown
-
2000
- 2000-08-28 FI FI20001893A patent/FI108130B/en active
Also Published As
Publication number | Publication date |
---|---|
EP0627419A4 (en) | 1995-02-08 |
US5475118A (en) | 1995-12-12 |
AU663233B2 (en) | 1995-09-28 |
HUT70219A (en) | 1995-09-28 |
ATE186907T1 (en) | 1999-12-15 |
DK0627419T3 (en) | 2000-04-25 |
HU215598B (en) | 1999-01-28 |
DE69333903D1 (en) | 2005-12-15 |
CA2122705A1 (en) | 1994-03-31 |
FI942167A (en) | 1994-07-08 |
ES2139670T3 (en) | 2000-02-16 |
EP0916657B9 (en) | 2006-05-17 |
HU9401470D0 (en) | 1994-08-29 |
ES2247657T3 (en) | 2006-03-01 |
NO300130B1 (en) | 1997-04-14 |
NO941757L (en) | 1994-05-10 |
ATE309212T1 (en) | 2005-11-15 |
EP0916657B1 (en) | 2005-11-09 |
DE69327092D1 (en) | 1999-12-30 |
NO941757D0 (en) | 1994-05-10 |
FI942167A0 (en) | 1994-05-10 |
DE69327092T2 (en) | 2000-05-25 |
CA2122705C (en) | 1997-11-18 |
EP0627419B1 (en) | 1999-11-24 |
WO1994006767A1 (en) | 1994-03-31 |
DE69333903T2 (en) | 2006-07-27 |
FI107605B (en) | 2001-09-14 |
JP2724634B2 (en) | 1998-03-09 |
KR0141657B1 (en) | 1998-06-01 |
AU4983293A (en) | 1994-04-12 |
EP0916657A1 (en) | 1999-05-19 |
EP0627419A1 (en) | 1994-12-07 |
FI108130B (en) | 2001-11-30 |
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