ES2019029A6 - Procedimiento para la obtencion de 4-arilacoil-1-(3-piridilcianometil)piperazinas. - Google Patents
Procedimiento para la obtencion de 4-arilacoil-1-(3-piridilcianometil)piperazinas.Info
- Publication number
- ES2019029A6 ES2019029A6 ES9000245A ES9000245A ES2019029A6 ES 2019029 A6 ES2019029 A6 ES 2019029A6 ES 9000245 A ES9000245 A ES 9000245A ES 9000245 A ES9000245 A ES 9000245A ES 2019029 A6 ES2019029 A6 ES 2019029A6
- Authority
- ES
- Spain
- Prior art keywords
- chph
- arylalkoyl
- pyridylcyanomethyl
- piperazines
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 4-ARILALCOIL-1-(3-PIRIDILCIANOMETIL)PIPERAZINAS, DE FORMULA I, EN DONDE: AR ES FENILO Y NAFTILO; X ES ENCLACE COVALENTE, -CHSI2-, -CHSI2-CHSI2-, -CHSI2-CHSI2-CHSI2-, >CHME, >CHPH, >CMEPH, -CHPH-CHSI2-, CHSI2-CHPH-, -CHSI2-CHSI2-CHPH-, -CHSI2-CH(CHSI2PH)-, -CH=CH-, -CH=CPH-, O -CPH=CH-. DICHO PROCEDIMIENTO CONSISTE EN HACER REACCIONAR EL 2-PIPERAZINIL-2(3-PIRIDIL)ACETONITRILO CON: A) UN ACIDO DE FORMULA GENERAL AR-X-COOH (DONDE X Y AR TIENEN EL SIGNIFICADO ANTERIORMENTE DEFINIDO) EN PRESENCIA DE DICICLOHEXILCARBODIIMIDA Y 1-HIDROXIBENZOTRIAZOL EN EL SENO DE N,N-DIMETILFORMAMIDA; O BIEN B) EL CLORURO DE ACIDO DERIVADO DE UN ACIDO DE FORMULA GENERAL AR-X-COOOH (DONDE X Y AR TIENEN EL SIGNIFICADO ANTERIORMENTE DEFINIDO) EN PRESENCIA DE TRIETILAMINA, EN CLOROFORMO. DICHOS COMPUESTOS SON ANTAGONISTAS DEL PAF Y, POR LO TANTO, UTILES EN EL TRATAMIENTO DE LAS ENFERMEDADES EN LAS QUE DICHA SUSTANCIA SE HALLA IMPLICADA.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9000245A ES2019029A6 (es) | 1990-01-29 | 1990-01-29 | Procedimiento para la obtencion de 4-arilacoil-1-(3-piridilcianometil)piperazinas. |
EP91101126A EP0441226A1 (en) | 1990-01-29 | 1991-01-29 | (cyanomethyl)pyridines useful as PAF antagonists |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9000245A ES2019029A6 (es) | 1990-01-29 | 1990-01-29 | Procedimiento para la obtencion de 4-arilacoil-1-(3-piridilcianometil)piperazinas. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2019029A6 true ES2019029A6 (es) | 1991-05-16 |
Family
ID=8265659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9000245A Expired - Lifetime ES2019029A6 (es) | 1990-01-29 | 1990-01-29 | Procedimiento para la obtencion de 4-arilacoil-1-(3-piridilcianometil)piperazinas. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2019029A6 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2036926A1 (es) * | 1991-08-08 | 1993-06-01 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
-
1990
- 1990-01-29 ES ES9000245A patent/ES2019029A6/es not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2036926A1 (es) * | 1991-08-08 | 1993-06-01 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200201244A1 (ru) | Способы получения и промежуточные соединения для получения противораковых соединений | |
NZ275647A (en) | Tricyclic amide and urea derivatives and medicaments | |
NO913086D0 (no) | Fremgangsmaate for fremstilling av bifenylkarbonitriler ogvidere anvendelse av disse. | |
HU906494D0 (en) | Process for producing substituted 1,2,3-triazole derivatives and pharmaceutical preparatives containing these compounds | |
OA09982A (fr) | Derives heterocycliques leur procede de production et composition pharmaceutique les contenant | |
HUP0002893A2 (hu) | Szubsztituált kinazolinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények | |
HUT46708A (en) | Process for producing heterocyclic ketones and pharmaceutical compositions containing them as active components | |
HU910930D0 (en) | Process for the production of 2,8-dioxa-bicyclo/3.2.1/octane derivatives and medical preparations containing them | |
ATA170384A (de) | Verfahren zur herstellung von neuen 2-oxoazetidin-derivate | |
NO178544C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive tioalkyltiocefalosporinderivater | |
PT86708A (pt) | Nouveaux esters d:acides cyclopropanecarboxyliques apparentes a l:acide pyrethrique leur procede de preparation et leur application a la lutte contre les parasites | |
DE69024322D1 (de) | Dreizyklische Chinoline als antineoplastische Wirkstoffe | |
PT87277A (pt) | Process for the preparation of new bicyclic compounds and pharmaceutical compositions comprising same | |
ZA814540B (en) | Imidazole derivatives processes for their manufacture and pharmaceutical preparations containing them | |
JPS5681578A (en) | Novel thioalkyl amide derivative | |
ES2019029A6 (es) | Procedimiento para la obtencion de 4-arilacoil-1-(3-piridilcianometil)piperazinas. | |
JPS54160371A (en) | Novel piperidine derivative and hypotensive agents comprising it | |
EP0598910A4 (en) | METHOD FOR PRODUCING NUCLEOSIDE DERIVATIVES. | |
EA199900156A1 (ru) | Новые производные эритромицина, способ их получения и их применение в качестве медикаментов | |
DE69917668D1 (de) | Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung | |
EA200000924A2 (ru) | СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО[4,3-d]ПИРИМИДИН-7-ОН-3-ПИРИДИЛСУЛЬФОНИЛЬНЫХ СОЕДИНЕНИЙ И ИХ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ | |
HUT47266A (en) | Process for production of benzimidasole-derivatives and medical compositions containing them | |
YU48634B (sh) | Postupak za dobijanje 6-(supstituisanih aminopropionil) derivata forskolina i jedinjenja koja se dobijaju ovim postupkom | |
NO993154D0 (no) | FremgangsmÕte for fremstilling av imidazolderivater | |
NO179004C (no) | Analogifremgangsmåte til fremstilling av terapeutisk aktive imidazolderivater |