ES2013070A6 - Procedimiento para la preparacion de derivados de imidazol-2-ilo hipolipidemicos de compuestos biciclicos. - Google Patents

Procedimiento para la preparacion de derivados de imidazol-2-ilo hipolipidemicos de compuestos biciclicos.

Info

Publication number
ES2013070A6
ES2013070A6 ES8900800A ES8900800A ES2013070A6 ES 2013070 A6 ES2013070 A6 ES 2013070A6 ES 8900800 A ES8900800 A ES 8900800A ES 8900800 A ES8900800 A ES 8900800A ES 2013070 A6 ES2013070 A6 ES 2013070A6
Authority
ES
Spain
Prior art keywords
hypolipidaemic
imidazol
derivatives
preparation
bicyclic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8900800A
Other languages
English (en)
Inventor
Paolo Cozzi
Germano Carganico
Dino Severino
Pierpaolo Lovisolo
Augusto Chiari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of ES2013070A6 publication Critical patent/ES2013070A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IMIDAZOL-2-ILO HIPOLIPIDEMICOS DE COMPUESTOS BICICLICOS. COMPRENDE: A) HACER REACCIONAR (II) CON (III) PARA DAR (I); O B) HACER REACCIONAR (II) CON ACETONA Y CLOROFORMO, EN PRESENCIA DE UN HIDROXIDO DE METAL ALCALINO PARA DAR (I) EN QUE N = O, R = H, R1 = METILO, SIENDO LOS RESTANTES SIMBOLOS LOS DEFINIDOS MAS ADELANTE; Y, SI SE DESEA, INTERCONVERTIR UNOS COMPUESTOS EN OTROS, FORMAR LAS SALES U OBTENER DE ELLAS LOS COMPUESTOS LIBRES Y/O RESOLVER LAS MEZCLAS DE ISOMEROS. EN DICHAS FORMULAS EL SIMBOLO REPRESENTA UN ENLACE SENCILLO O DOBLE; Z = -O- O -CH2-; N = 0, 1, 2, O 3; R Y R1 SON, INDEPENDIENTEMENTE, HIDROGENO O ALQUILO C1-4; R2 Y R3 SON, INDEPENDIENTEMENTE, HIDROGENO O ALQUILO C1-8. ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTIDISLIPIDEMICOS Y ANTIATEROESCLEROTICOS. FORMULAS
ES8900800A 1988-03-09 1989-03-06 Procedimiento para la preparacion de derivados de imidazol-2-ilo hipolipidemicos de compuestos biciclicos. Expired - Fee Related ES2013070A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888805628A GB8805628D0 (en) 1988-03-09 1988-03-09 Hypolipidaemic imidazol-2-yl-derivatives of bicyclic compounds & process for their preparation

Publications (1)

Publication Number Publication Date
ES2013070A6 true ES2013070A6 (es) 1990-04-16

Family

ID=10633134

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900800A Expired - Fee Related ES2013070A6 (es) 1988-03-09 1989-03-06 Procedimiento para la preparacion de derivados de imidazol-2-ilo hipolipidemicos de compuestos biciclicos.

Country Status (15)

Country Link
US (1) US4985440A (es)
EP (1) EP0375746A1 (es)
JP (1) JPH02503432A (es)
KR (1) KR900700460A (es)
AU (1) AU616743B2 (es)
ES (1) ES2013070A6 (es)
FI (1) FI895277A0 (es)
GB (1) GB8805628D0 (es)
GR (1) GR1000277B (es)
HU (1) HUT55386A (es)
IL (1) IL89114A0 (es)
NZ (1) NZ227819A (es)
PT (1) PT89948A (es)
WO (1) WO1989008646A1 (es)
ZA (1) ZA891770B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9025848D0 (en) * 1990-11-28 1991-01-09 Erba Carlo Spa Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
DE60132920T2 (de) * 2000-12-26 2009-02-12 Pola Pharma Inc. Biphenylderivate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558645A (en) * 1968-07-08 1971-01-26 Sandoz Ag 2-(4-(4',5-diphenyl - 2 - imidazolyl)-phenoxy) lower aliphatic monocarboxylic acids
JPS4713909A (es) * 1971-12-03 1972-07-06
GB2122997B (en) * 1982-07-05 1985-08-14 Erba Farmitalia Imidazoles
EP0115142B1 (en) * 1982-12-23 1986-11-05 Ici Americas Inc. Chroman compounds
GB8323293D0 (en) * 1983-08-31 1983-10-05 Zyma Sa Substituted flavene and thioflavene derivatives

Also Published As

Publication number Publication date
HU892976D0 (en) 1990-02-28
FI895277A0 (fi) 1989-11-07
GB8805628D0 (en) 1988-04-07
EP0375746A1 (en) 1990-07-04
US4985440A (en) 1991-01-15
JPH02503432A (ja) 1990-10-18
GR1000277B (el) 1992-05-12
ZA891770B (en) 1989-11-29
AU616743B2 (en) 1991-11-07
PT89948A (pt) 1989-11-10
KR900700460A (ko) 1990-08-13
HUT55386A (en) 1991-05-28
AU3197189A (en) 1989-10-05
NZ227819A (en) 1990-12-21
IL89114A0 (en) 1989-08-15
GR890100122A (en) 1990-01-19
WO1989008646A1 (en) 1989-09-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108