ES2012307A6 - Perfeccionamientos en el objeto de la patente de invencion 8801824 por procedimiento para la obtencion de ciprofloxacina. - Google Patents
Perfeccionamientos en el objeto de la patente de invencion 8801824 por procedimiento para la obtencion de ciprofloxacina.Info
- Publication number
- ES2012307A6 ES2012307A6 ES8901945A ES8901945A ES2012307A6 ES 2012307 A6 ES2012307 A6 ES 2012307A6 ES 8901945 A ES8901945 A ES 8901945A ES 8901945 A ES8901945 A ES 8901945A ES 2012307 A6 ES2012307 A6 ES 2012307A6
- Authority
- ES
- Spain
- Prior art keywords
- ciprofloxacin
- procedure
- obtaining
- compound
- trimethyl orthoformate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003405 ciprofloxacin Drugs 0.000 title abstract 3
- PYOKUURKVVELLB-UHFFFAOYSA-N trimethyl orthoformate Chemical compound COC(OC)OC PYOKUURKVVELLB-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZPFNNJJRURYIGW-UHFFFAOYSA-N 1-(3,6-dichloro-3-fluorocyclohexa-1,5-dien-1-yl)butane-1,3-dione Chemical compound ClC=1C(=CC(CC1)(F)Cl)C(CC(C)=O)=O ZPFNNJJRURYIGW-UHFFFAOYSA-N 0.000 abstract 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 150000002084 enol ethers Chemical class 0.000 abstract 1
- LNOQURRKNJKKBU-UHFFFAOYSA-N ethyl piperazine-1-carboxylate Chemical compound CCOC(=O)N1CCNCC1 LNOQURRKNJKKBU-UHFFFAOYSA-N 0.000 abstract 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PERFECCIONAMIENTOS EN EL OBJETO DE LA PATENTE DE INVENCION 8801824 POR PROCEDIMIENTO PARA LA OBTENCION DE CIPROFLOXACINA (COMPUESTO DE FORMULA I), CONSISTENTES EN UTILIZAR ORTOFORMIATO DE TRIMETILO PARA SU REACCION CON LA 1-(2,5-DICLORO-5-FLUOROFENIL)1,3-BUTANODIONA, LO QUE DA LUGAR A UN ETER DE ENOL; CONVENCIONALMENTE EL PROCEDIMIENTO CONTINUA CON LA ADICION DE CICLOPROPILAMINA PARA OBTENER UNA ENAMINONA, QUE SE CICLA PARA DAR UN COMPUESTO QUE SE HACE REACCIONAR CON N-ETOXICARBONILPIPERACINA, CON LO QUE SE OBTIENE UN INTERMEDIO QUE SE OXIDA DE LO QUE RESULTA UN ACIDO QUE SE HIDROLIZA Y NEUTRALIZA. LA UTILIZACION DEL ORTOFORMIATO DE TRIMETILO MEJORA LOS RESULTADOS CONSEGUIDOS CON EL ORTOFORMIATO DE TRIETILO. LA CIPROFLOXACINA ES UN AGENTE BACTERICIDA DE GRAN EFICACIA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8901945A ES2012307A6 (es) | 1989-05-05 | 1989-05-05 | Perfeccionamientos en el objeto de la patente de invencion 8801824 por procedimiento para la obtencion de ciprofloxacina. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8901945A ES2012307A6 (es) | 1989-05-05 | 1989-05-05 | Perfeccionamientos en el objeto de la patente de invencion 8801824 por procedimiento para la obtencion de ciprofloxacina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2012307A6 true ES2012307A6 (es) | 1990-03-01 |
Family
ID=8262335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8901945A Expired - Lifetime ES2012307A6 (es) | 1989-05-05 | 1989-05-05 | Perfeccionamientos en el objeto de la patente de invencion 8801824 por procedimiento para la obtencion de ciprofloxacina. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2012307A6 (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2049640A1 (es) * | 1992-06-18 | 1994-04-16 | Genesis Para La Investigacion | Procedimiento paras la preparacion de acidos quinolin carboxilicos. |
| WO2003010144A3 (en) * | 2001-07-25 | 2003-10-16 | Farmaceutsko Hemijska Ind Zdra | A process for synthesis of fluoroquinolonic derivatives |
-
1989
- 1989-05-05 ES ES8901945A patent/ES2012307A6/es not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2049640A1 (es) * | 1992-06-18 | 1994-04-16 | Genesis Para La Investigacion | Procedimiento paras la preparacion de acidos quinolin carboxilicos. |
| WO2003010144A3 (en) * | 2001-07-25 | 2003-10-16 | Farmaceutsko Hemijska Ind Zdra | A process for synthesis of fluoroquinolonic derivatives |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20040614 |