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Laboratorios Salvat SA
Original Assignee
Laboratorios Salvat SA
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Filing date
Publication date
Application filed by Laboratorios Salvat SAfiledCriticalLaboratorios Salvat SA
Priority to ES8803574ApriorityCriticalpatent/ES2009402A6/es
Publication of ES2009402A6publicationCriticalpatent/ES2009402A6/es
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
EL PROCEDIMIENTO DE OBTENCION DEL ACIDO 1-CICLOPROPIL-6-FLUORO -7-(1-PIPERACINIL)-1, 4-DIHIDRO-4-OXO-QUINOLIN-3-CARBOXILICO I, Y SUS SALES DE ADICION ACEPTABLES FARMACEUTICAMENTE, CONSIGUE EVITAR TOTALMENTE LA FORMACION DEL ANALOGO 7-CLORO-6-(1-PIPERACINIL) COMO SUBPRODUCTO, ELIMINANDO UNA ETAPA DE PURIFICACION. EL PROCEDIMIENTO SE BASA EN LA REACCION DEL ACIDO 1-CICLOPROPIL-7-CLORO-6-FLUORO-1, 4-DIHIDRO-4-OXO-QUINOLIN-3-CARBOXILICO, O SUS ESTERES CON ACIDO TETRAFLUOROBORICO ACUOSO, PARA OBTENER UN INTERMEDIO ACIDO QUE SE TRATA CON UN EXCESO DE PIPERACINA PARA FORMAR OTRO INTERMEDIO ACIDO EL CUAL IN SITU O PREVIAMENTE AISLADO, SE SOMETE A HIDROLISIS BASICA, TRAS LA CUAL SE AISLA I POR NEUTRALIZACION Y PRECIPITACION. AMBOS INTERMEDIOS SON PRODUCTOS NUEVOS. EL PRODUCTO I ES UN ACTIVO ANTIBACTERIANO.
ES8803574A1988-11-231988-11-23Procedimiento de obtencion del acido 1-ciclopropil-6-fluoro-7-(piperacinil)-1,4-dihidrido-4-oxo-quinolin-3-carboxilico.
ExpiredES2009402A6
(es)
Process for producing piperazine derivatives and salts thereof, as well as pharmaceutical compositions comprising such piperazine deriatives and salts thereof
Anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof, process for preparing them and pharmaceutical compositions containing the same
Analogifremgangsmaate ved fremstilling av terapeutisk aktiv 1-etyl-6 fluor-1,4-dihydro-4-okso-7-(1-piperazinyl)-1,8-naftyridin-3-karboksylsyre. sesquihydrat.