ES2009147A6 - New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity - Google Patents
New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activityInfo
- Publication number
- ES2009147A6 ES2009147A6 ES8702020A ES8702020A ES2009147A6 ES 2009147 A6 ES2009147 A6 ES 2009147A6 ES 8702020 A ES8702020 A ES 8702020A ES 8702020 A ES8702020 A ES 8702020A ES 2009147 A6 ES2009147 A6 ES 2009147A6
- Authority
- ES
- Spain
- Prior art keywords
- famotidine
- prepd
- chlorinated hydrocarbon
- bio
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Craytalline famotidine polymorphs exhibiting a specified X-ray diffraction pattern, the crystals being stable, are claimed. They may be prepd. by (a) reacting a soln. in methanol of a salt of famotidine selected from hydrochloride, hydrobromide, sulphate, nitrate or phosphate with a tertiary organic base such as triethylamine, 1,8-diazabicyclo (5.40) undec-7-ene or diazabicyclo (4.3.0) non-5-ene, (b) diluting the resulting soln. at 50-65 deg. c with a chlorinated hydrocarbon pref. selected from CH2Cl2, CHCl3, CCl4, CH2Cl-CH2Cl and CCl2=CHCl2 and (c) cooling to ppt. or crystallise the polymorph of low m.pt. and low apparent density and isolating by filtration at 0-15 deg. C. High density polymorph can be obtd. by seeding the soln. from (b) with high density crystals.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8702020A ES2009147A6 (en) | 1987-06-22 | 1987-06-22 | New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity |
IL86330A IL86330A0 (en) | 1987-06-22 | 1988-05-10 | Famotidine polymorphic forms and their preparation |
NO882037A NO882037L (en) | 1987-06-22 | 1988-05-10 | FAMOTIDINE, POLYMERIC FORMS AND MANUFACTURING THEREOF. |
IS3342A IS3342A7 (en) | 1987-06-22 | 1988-05-11 | Famotidine (N-sulfamoyl-3-) 2-guanidionthiazol-4-yl) methylthioprooionamidine :) and a process for its preparation. |
FI882329A FI882329A (en) | 1987-06-22 | 1988-05-18 | POLYMORPHIC FORMER AV FAMOTIDIN OCH FOERFARANDE FOER FRAMSTAELLNING DAERAV. |
US07/197,329 US5021582A (en) | 1987-06-22 | 1988-05-23 | Famotidine polymorphic forms and their preparation process |
CN88103190A CN1030077A (en) | 1987-06-22 | 1988-05-25 | Famotidine pyridine polymorphic form and preparation method thereof |
JP63134279A JPH01100162A (en) | 1987-06-22 | 1988-05-31 | Famotidine polymorphisms and manufacture |
AT88500054T ATE69052T1 (en) | 1987-06-22 | 1988-06-01 | POLYMORPHOUS FORM OF FAMOTIDINE AND ITS PRODUCTION PROCESS. |
DE8888500054T DE3865899D1 (en) | 1987-06-22 | 1988-06-01 | POLYMORPHIC FORM OF FAMOTIDINE AND THEIR PRODUCTION PROCESS. |
EP88500054A EP0297019B1 (en) | 1987-06-22 | 1988-06-01 | Famotidine polymorphic form and preparation thereof |
AU17672/88A AU1767288A (en) | 1987-06-22 | 1988-06-14 | Famotidine polymorphic forms and their preparation process |
KR1019880007442A KR920000308B1 (en) | 1987-06-22 | 1988-06-20 | Famotidine polymorphic forms and their preparation process |
CA000569954A CA1322760C (en) | 1987-06-22 | 1988-06-21 | Famotidine polymorphic forms and their preparation process |
ZA884408A ZA884408B (en) | 1987-06-22 | 1988-06-21 | Famotidine polymorphic forms and their preparation process |
DK342988A DK342988A (en) | 1987-06-22 | 1988-06-22 | POLYMORPH PHAMOTIDE INFORMATION AND PROCEDURES FOR PREPARING IT |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8702020A ES2009147A6 (en) | 1987-06-22 | 1987-06-22 | New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2009147A6 true ES2009147A6 (en) | 1989-09-01 |
Family
ID=8251688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8702020A Expired ES2009147A6 (en) | 1987-06-22 | 1987-06-22 | New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity |
Country Status (3)
Country | Link |
---|---|
ES (1) | ES2009147A6 (en) |
IS (1) | IS3342A7 (en) |
ZA (1) | ZA884408B (en) |
-
1987
- 1987-06-22 ES ES8702020A patent/ES2009147A6/en not_active Expired
-
1988
- 1988-05-11 IS IS3342A patent/IS3342A7/en unknown
- 1988-06-21 ZA ZA884408A patent/ZA884408B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA884408B (en) | 1989-03-29 |
IS3342A7 (en) | 1988-12-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19991209 |