ES2009147A6 - New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity - Google Patents

New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity

Info

Publication number
ES2009147A6
ES2009147A6 ES8702020A ES8702020A ES2009147A6 ES 2009147 A6 ES2009147 A6 ES 2009147A6 ES 8702020 A ES8702020 A ES 8702020A ES 8702020 A ES8702020 A ES 8702020A ES 2009147 A6 ES2009147 A6 ES 2009147A6
Authority
ES
Spain
Prior art keywords
famotidine
prepd
chlorinated hydrocarbon
bio
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8702020A
Other languages
Spanish (es)
Inventor
Rodes Montserrat Ballester
Nicolau Francisco Eugen Palomo
Coll Antonio Luis Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro Marga Para la Investigacion SA
Original Assignee
Centro Marga Para la Investigacion SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Marga Para la Investigacion SA filed Critical Centro Marga Para la Investigacion SA
Priority to ES8702020A priority Critical patent/ES2009147A6/en
Priority to IL86330A priority patent/IL86330A0/en
Priority to NO882037A priority patent/NO882037L/en
Priority to IS3342A priority patent/IS3342A7/en
Priority to FI882329A priority patent/FI882329A/en
Priority to US07/197,329 priority patent/US5021582A/en
Priority to CN88103190A priority patent/CN1030077A/en
Priority to JP63134279A priority patent/JPH01100162A/en
Priority to AT88500054T priority patent/ATE69052T1/en
Priority to DE8888500054T priority patent/DE3865899D1/en
Priority to EP88500054A priority patent/EP0297019B1/en
Priority to AU17672/88A priority patent/AU1767288A/en
Priority to KR1019880007442A priority patent/KR920000308B1/en
Priority to CA000569954A priority patent/CA1322760C/en
Priority to ZA884408A priority patent/ZA884408B/en
Priority to DK342988A priority patent/DK342988A/en
Publication of ES2009147A6 publication Critical patent/ES2009147A6/en
Expired legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Craytalline famotidine polymorphs exhibiting a specified X-ray diffraction pattern, the crystals being stable, are claimed. They may be prepd. by (a) reacting a soln. in methanol of a salt of famotidine selected from hydrochloride, hydrobromide, sulphate, nitrate or phosphate with a tertiary organic base such as triethylamine, 1,8-diazabicyclo (5.40) undec-7-ene or diazabicyclo (4.3.0) non-5-ene, (b) diluting the resulting soln. at 50-65 deg. c with a chlorinated hydrocarbon pref. selected from CH2Cl2, CHCl3, CCl4, CH2Cl-CH2Cl and CCl2=CHCl2 and (c) cooling to ppt. or crystallise the polymorph of low m.pt. and low apparent density and isolating by filtration at 0-15 deg. C. High density polymorph can be obtd. by seeding the soln. from (b) with high density crystals.
ES8702020A 1987-06-22 1987-06-22 New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity Expired ES2009147A6 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ES8702020A ES2009147A6 (en) 1987-06-22 1987-06-22 New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity
IL86330A IL86330A0 (en) 1987-06-22 1988-05-10 Famotidine polymorphic forms and their preparation
NO882037A NO882037L (en) 1987-06-22 1988-05-10 FAMOTIDINE, POLYMERIC FORMS AND MANUFACTURING THEREOF.
IS3342A IS3342A7 (en) 1987-06-22 1988-05-11 Famotidine (N-sulfamoyl-3-) 2-guanidionthiazol-4-yl) methylthioprooionamidine :) and a process for its preparation.
FI882329A FI882329A (en) 1987-06-22 1988-05-18 POLYMORPHIC FORMER AV FAMOTIDIN OCH FOERFARANDE FOER FRAMSTAELLNING DAERAV.
US07/197,329 US5021582A (en) 1987-06-22 1988-05-23 Famotidine polymorphic forms and their preparation process
CN88103190A CN1030077A (en) 1987-06-22 1988-05-25 Famotidine pyridine polymorphic form and preparation method thereof
JP63134279A JPH01100162A (en) 1987-06-22 1988-05-31 Famotidine polymorphisms and manufacture
AT88500054T ATE69052T1 (en) 1987-06-22 1988-06-01 POLYMORPHOUS FORM OF FAMOTIDINE AND ITS PRODUCTION PROCESS.
DE8888500054T DE3865899D1 (en) 1987-06-22 1988-06-01 POLYMORPHIC FORM OF FAMOTIDINE AND THEIR PRODUCTION PROCESS.
EP88500054A EP0297019B1 (en) 1987-06-22 1988-06-01 Famotidine polymorphic form and preparation thereof
AU17672/88A AU1767288A (en) 1987-06-22 1988-06-14 Famotidine polymorphic forms and their preparation process
KR1019880007442A KR920000308B1 (en) 1987-06-22 1988-06-20 Famotidine polymorphic forms and their preparation process
CA000569954A CA1322760C (en) 1987-06-22 1988-06-21 Famotidine polymorphic forms and their preparation process
ZA884408A ZA884408B (en) 1987-06-22 1988-06-21 Famotidine polymorphic forms and their preparation process
DK342988A DK342988A (en) 1987-06-22 1988-06-22 POLYMORPH PHAMOTIDE INFORMATION AND PROCEDURES FOR PREPARING IT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8702020A ES2009147A6 (en) 1987-06-22 1987-06-22 New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity

Publications (1)

Publication Number Publication Date
ES2009147A6 true ES2009147A6 (en) 1989-09-01

Family

ID=8251688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8702020A Expired ES2009147A6 (en) 1987-06-22 1987-06-22 New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity

Country Status (3)

Country Link
ES (1) ES2009147A6 (en)
IS (1) IS3342A7 (en)
ZA (1) ZA884408B (en)

Also Published As

Publication number Publication date
ZA884408B (en) 1989-03-29
IS3342A7 (en) 1988-12-23

Similar Documents

Publication Publication Date Title
SU1650011A3 (en) Method of producing 1,4-dihydropyridine
HUP0004332A2 (en) 1,3-disubstituted ureas as acat inhibitors, and method of preparing thereof
DE69028605D1 (en) Aminocarbonyl carbamates related to physostigmine, processes for their preparation and their use as medicines
CH650506A5 (en) THERAPEUTICALLY ACTIVE ERGOL DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS.
ES2009147A6 (en) New polymorphic forms of famotidine - prepd. using chlorinated hydrocarbon solvent and having high purity, physical-chemical stability and bio:activity
RU93046065A (en) METHOD OF OBTAINING DERIVATIVES OF PHYSOSTYGMINCARBAMATE
ATE32068T1 (en) PROCESS FOR THE PREPARATION OF 6-METHYL-3,4DIHYDRO-1,2,3-OXATHIAZINE-4-ONE-2,2-DIOXIDE AND ITS NON-TOXIC SALTS.
AT391701B (en) METHOD FOR PRODUCING NEW 4,5,6,7TETRAHYDROTHIAZOLO (5,4-C) PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS
SU1122221A3 (en) Method of obtaining pyrazoline derivatives
ATE58532T1 (en) (2-AMINO-4-ARYL-THIAZOLE-5-YL)AETHANOL AND THEIR DERIVATIVES WITH DIURETIC ACTIVITY AND PROCESS FOR THEIR PRODUCTION.
ES427433A1 (en) A procedure for preparing a selected chemical compound of the group consisting of nitroimidazool-ethyl O-thiocarbamate. (Machine-translation by Google Translate, not legally binding)
YAMAGAMI et al. A quantitative structure-activity study of anticonvulsant benzyl N, N-dimethylcarbamates
DD283392A5 (en) PROCESS FOR PREPARING NEW 4-OXO-4H-PYRIDO [1,2-A] PYRIMIDIN-3-CARBONSAFEAMIDE DERIVATIVES AND THEIR USE
Klioze et al. Synthesis and antihypertensive activity of 2-benzamido-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizines
US4438133A (en) Therapeutically effective derivatives of cystine
RU93045705A (en) METHOD FOR PRODUCING DERIVATIVES OF PHYSOSTYGMIN
JPS6438072A (en) Production of 4-aminopyridines
DE3120450A1 (en) METHOD FOR PRODUCING CARBONIC ACID AMIDES
IL42714A (en) Thiourea derivatives,their production and pesticidal compositions containing them
DE2150267C3 (en) Process for the production of peptides
CA2003851A1 (en) Amine salts of 1,4,2-oxazaphospholidine-4-acetic acid, 2-alkoxy-2-oxides
KR890013076A (en) Method for preparing a compound having an imide bond and a flame retardant containing the compound
ATE223905T1 (en) METHOD FOR PRODUCING ARYLOXY- OR ALKOXYTRIAZOLINONES
JPS6429359A (en) 1,4-dihydropyridine derivative and production thereof
TH4059EX (en) Various compounds for the treatment of disease

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991209