ES2000591A6 - Un metodo de preparacion de un clon capaz de expresar anticuerpos monoclonales especificos para un determinante serotipico de un antigeno flagelar de un microorganismo - Google Patents

Un metodo de preparacion de un clon capaz de expresar anticuerpos monoclonales especificos para un determinante serotipico de un antigeno flagelar de un microorganismo

Info

Publication number
ES2000591A6
ES2000591A6 ES8600782A ES8600782A ES2000591A6 ES 2000591 A6 ES2000591 A6 ES 2000591A6 ES 8600782 A ES8600782 A ES 8600782A ES 8600782 A ES8600782 A ES 8600782A ES 2000591 A6 ES2000591 A6 ES 2000591A6
Authority
ES
Spain
Prior art keywords
protective antibodies
flagellar antigens
serotypic
determinants
serotypic determinants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600782A
Other languages
English (en)
Inventor
Richard L Rutherford
Richard C Harmon
Michael S Collins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/761,737 external-priority patent/US4772464A/en
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of ES2000591A6 publication Critical patent/ES2000591A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBE UN METODO DE PREPARACION DE UN CLON CAPAZ DE EXPRESAR ANTICUERPOS MONOCLONALES ESPECIFICOS PARA UN DETERMINANTE SEROTIPICO DE UN ANTIGENO FLAGELAR DE UN MICROORGANISMO QUE COMPRENDE LA FUSION DE CELULAS DE MIELOMA CON ESPLENOCITOS PREVIAMENTE INMUNIZADAS PARA PRODUCIR ANTICUERPOS FRENTE A UN DETERMINANTE SEROTIPICO DE UN ANTIGENO FLAGELAR DE UN MICROORGANISMO. LA INVENCION TAMBIEN PROPORCIONA UN METODO PARA LA PREPARACION DE DICHOS ANTICUERPOS MONOCLONALES, QUE INCLUYE LA ETAPA ADICIONAL DE INCUBAR EL CITADO CLON EN CONDICIONES ADECUADAS PARA ASEGURAR LA EXPRESION DEL MENCIONADO ANTICUERPO. ESTOS ANTICUERPOS SON ESPECIALMENTE UTILES PARA INHIBIR LA MOTILIDAD DE MICROORGANISMOS FLAGELADOS, PARTICULARMENTE BACTERIAS PATOGENAS GRAM-NEGATIVAS Y EN CONCRETO DEL GENERO PROTEUS.
ES8600782A 1985-08-01 1986-07-31 Un metodo de preparacion de un clon capaz de expresar anticuerpos monoclonales especificos para un determinante serotipico de un antigeno flagelar de un microorganismo Expired ES2000591A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/761,737 US4772464A (en) 1985-08-01 1985-08-01 Protective antibodies to serotypic determinants of flagellar antigens
US89191886A 1986-07-30 1986-07-30

Publications (1)

Publication Number Publication Date
ES2000591A6 true ES2000591A6 (es) 1988-03-01

Family

ID=27117032

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600782A Expired ES2000591A6 (es) 1985-08-01 1986-07-31 Un metodo de preparacion de un clon capaz de expresar anticuerpos monoclonales especificos para un determinante serotipico de un antigeno flagelar de un microorganismo

Country Status (3)

Country Link
EP (1) EP0211352B1 (es)
DE (1) DE3689713T2 (es)
ES (1) ES2000591A6 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
DK172840B1 (da) * 1986-07-03 1999-08-09 Genetic Systems Corp Monoklonale antistoffer mod Pseudomonas aeruginosa flagella, farmaceutiske præparater indeholdende sådanne antistoffer og c

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443549A (en) * 1981-10-19 1984-04-17 Molecular Genetics, Inc. Production of monoclonal antibodies against bacterial adhesins
DK219084D0 (da) * 1984-05-02 1984-05-02 Frederik Carl Peter Lindberg Antigen
GB8416841D0 (en) * 1984-07-03 1984-08-08 Technology Licence Co Ltd Monoclonal antibodies

Also Published As

Publication number Publication date
EP0211352A2 (en) 1987-02-25
DE3689713T2 (de) 1994-07-07
EP0211352B1 (en) 1994-03-16
DE3689713D1 (de) 1994-04-21
EP0211352A3 (en) 1989-02-08

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