EP4771024A1 - Verfahren zur herstellung von phosphonamidatverbindungen - Google Patents

Verfahren zur herstellung von phosphonamidatverbindungen

Info

Publication number
EP4771024A1
EP4771024A1 EP24776149.7A EP24776149A EP4771024A1 EP 4771024 A1 EP4771024 A1 EP 4771024A1 EP 24776149 A EP24776149 A EP 24776149A EP 4771024 A1 EP4771024 A1 EP 4771024A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
compound
formula
optionally substituted
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24776149.7A
Other languages
English (en)
French (fr)
Inventor
Marc-André KASPER
Olivier MARCQ
Paul MACHUI
Dominik SCHUMACHER
Jonas HELMA-SMETS
Marcus GERLACH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tubulis GmbH
Original Assignee
Tubulis GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tubulis GmbH filed Critical Tubulis GmbH
Publication of EP4771024A1 publication Critical patent/EP4771024A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4476—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aromatic amines (N-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/335—Polymers modified by chemical after-treatment with organic compounds containing phosphorus
    • C08G65/3356—Polymers modified by chemical after-treatment with organic compounds containing phosphorus having nitrogen in addition to phosphorus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP24776149.7A 2023-09-01 2024-08-30 Verfahren zur herstellung von phosphonamidatverbindungen Pending EP4771024A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23194788 2023-09-01
PCT/EP2024/074322 WO2025046090A1 (en) 2023-09-01 2024-08-30 Methods of preparing phosphonamidate compounds

Publications (1)

Publication Number Publication Date
EP4771024A1 true EP4771024A1 (de) 2026-07-08

Family

ID=87929188

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24776149.7A Pending EP4771024A1 (de) 2023-09-01 2024-08-30 Verfahren zur herstellung von phosphonamidatverbindungen

Country Status (9)

Country Link
EP (1) EP4771024A1 (de)
KR (1) KR20260065883A (de)
CN (1) CN122122162A (de)
AU (1) AU2024332412A1 (de)
CL (1) CL2026000575A1 (de)
CO (1) CO2026002501A2 (de)
IL (1) IL326614A (de)
MX (1) MX2026002319A (de)
WO (1) WO2025046090A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12521446B2 (en) 2024-02-27 2026-01-13 Bristol-Myers Squibb Company Anti-CEACAM5 antibody drug conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0401384B1 (de) 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemisch modifizierte granulocytenkolonie erregender faktor
JP2763020B2 (ja) 1995-04-27 1998-06-11 日本電気株式会社 半導体パッケージ及び半導体装置
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
EP1731174A3 (de) 1996-08-02 2007-01-17 Ortho-McNeil Pharmaceutical, Inc. Polypeptide mit durch Hydrazon oder Oxim Gruppe kovalent gebunden N-terminalen Polyethylen-glycol
WO2018041985A1 (en) 2016-09-01 2018-03-08 Forschungsverbund Berlin E.V. Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
US12453779B2 (en) 2018-03-07 2025-10-28 Forschungsverbund Berlin E.V. Chemoselective thiol-conjugation with alkene or alkyne-phosphonothiolates and -phosphonates
PE20242114A1 (es) 2021-11-09 2024-10-28 Tubulis Gmbh Conjugados que comprenden fosforo (v) y una fraccion molecular de camptotecina
US20230330258A1 (en) 2021-11-09 2023-10-19 Tubulis Gmbh Conjugates comprising a phosphorus (v) and a drug moiety

Also Published As

Publication number Publication date
CN122122162A (zh) 2026-05-29
CO2026002501A2 (es) 2026-05-19
CL2026000575A1 (es) 2026-06-05
KR20260065883A (ko) 2026-05-11
MX2026002319A (es) 2026-04-01
WO2025046090A1 (en) 2025-03-06
AU2024332412A1 (en) 2026-03-12
IL326614A (en) 2026-04-01

Legal Events

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