EP4761728A2 - Pde4-protein-abbauer, pharmazeutische zusammensetzungen und therapeutische anwendungen - Google Patents

Pde4-protein-abbauer, pharmazeutische zusammensetzungen und therapeutische anwendungen

Info

Publication number
EP4761728A2
EP4761728A2 EP24855034.5A EP24855034A EP4761728A2 EP 4761728 A2 EP4761728 A2 EP 4761728A2 EP 24855034 A EP24855034 A EP 24855034A EP 4761728 A2 EP4761728 A2 EP 4761728A2
Authority
EP
European Patent Office
Prior art keywords
compound
mixture
pyrimidin
certain embodiments
piperidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24855034.5A
Other languages
English (en)
French (fr)
Inventor
Eduardo Torres
Kyle W.H. Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katalytic Therapeutics Inc
Original Assignee
Katalytic Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katalytic Therapeutics Inc filed Critical Katalytic Therapeutics Inc
Publication of EP4761728A2 publication Critical patent/EP4761728A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP24855034.5A 2023-08-17 2024-08-19 Pde4-protein-abbauer, pharmazeutische zusammensetzungen und therapeutische anwendungen Pending EP4761728A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363520297P 2023-08-17 2023-08-17
PCT/US2024/042843 WO2025038987A2 (en) 2023-08-17 2024-08-19 Pde4 protein degraders, pharmaceutical compositions, and therapeutic applications

Publications (1)

Publication Number Publication Date
EP4761728A2 true EP4761728A2 (de) 2026-06-24

Family

ID=94632751

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24855034.5A Pending EP4761728A2 (de) 2023-08-17 2024-08-19 Pde4-protein-abbauer, pharmazeutische zusammensetzungen und therapeutische anwendungen

Country Status (4)

Country Link
EP (1) EP4761728A2 (de)
CN (1) CN122341613A (de)
AU (1) AU2024323358A1 (de)
WO (1) WO2025038987A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025245178A1 (en) * 2024-05-21 2025-11-27 Innovo Therapeutics, Inc. Pak4, cstf2, or cstf2t protein degraders, pharmaceutical compositions, and therapeutic applications

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2610258T1 (sl) * 2007-10-19 2014-12-31 Boehringer Ingelheim International Gmbh Substituirani piperidino-dihidrotienopirimidini
EP2215093B1 (de) * 2007-10-19 2011-12-14 Boehringer Ingelheim International GmbH Neue piperazino-dihydrothienopyrimidin-derivate
JP2012519160A (ja) * 2009-02-27 2012-08-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬
KR102438072B1 (ko) * 2012-01-12 2022-08-31 예일 유니버시티 E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법
WO2019115774A1 (en) * 2017-12-15 2019-06-20 Leo Pharma A/S Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
US20240124418A1 (en) * 2020-12-14 2024-04-18 Biotheryx, Inc. Pde4 degraders, pharmaceutical compositions, and therapeutic applications

Also Published As

Publication number Publication date
WO2025038987A2 (en) 2025-02-20
WO2025038987A3 (en) 2025-04-10
AU2024323358A1 (en) 2026-02-26
CN122341613A (zh) 2026-07-03

Legal Events

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