EP4739701A2 - Muteine des menschlichen interleukin 12 - Google Patents

Muteine des menschlichen interleukin 12

Info

Publication number
EP4739701A2
EP4739701A2 EP24748262.3A EP24748262A EP4739701A2 EP 4739701 A2 EP4739701 A2 EP 4739701A2 EP 24748262 A EP24748262 A EP 24748262A EP 4739701 A2 EP4739701 A2 EP 4739701A2
Authority
EP
European Patent Office
Prior art keywords
amino acid
subunit
mutein
sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24748262.3A
Other languages
English (en)
French (fr)
Inventor
Matthias Feige
Korbinian Liebl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Muenchen In Vertretung Des Freistaats Bayern
Original Assignee
Technische Universitaet Muenchen In Vertretung Des Freistaats Bayern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universitaet Muenchen In Vertretung Des Freistaats Bayern filed Critical Technische Universitaet Muenchen In Vertretung Des Freistaats Bayern
Publication of EP4739701A2 publication Critical patent/EP4739701A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP24748262.3A 2023-07-07 2024-07-05 Muteine des menschlichen interleukin 12 Pending EP4739701A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23184134 2023-07-07
PCT/EP2024/068967 WO2025012105A2 (en) 2023-07-07 2024-07-05 Muteins of human interleukin 12

Publications (1)

Publication Number Publication Date
EP4739701A2 true EP4739701A2 (de) 2026-05-13

Family

ID=87196222

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24748262.3A Pending EP4739701A2 (de) 2023-07-07 2024-07-05 Muteine des menschlichen interleukin 12

Country Status (2)

Country Link
EP (1) EP4739701A2 (de)
WO (1) WO2025012105A2 (de)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202103192RA (en) 2018-10-03 2021-04-29 Xencor Inc Il-12 heterodimeric fc-fusion proteins
IL297186A (en) * 2020-04-17 2022-12-01 Univ Leland Stanford Junior Engineered il-12 and il-23 polypeptides and uses thereof
WO2022094046A1 (en) * 2020-10-29 2022-05-05 Proviva Therapeutics (Hong Kong) Limited Il-12 compositions and methods of use thereof
US20250051413A1 (en) * 2021-01-12 2025-02-13 Askgene Pharma Inc. Chimeric molecules comprising il-12 agonist polypeptide
CA3226924A1 (en) * 2021-07-19 2023-01-26 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
WO2023023503A1 (en) 2021-08-16 2023-02-23 Yale University Interleukin-12 variants and methods of use
WO2023043978A2 (en) * 2021-09-17 2023-03-23 Bicara Therapeutics Inc. Caix targeting il-12 fusion proteins and methods of use thereof
EP4419545A4 (de) * 2021-10-20 2025-10-22 Synthekine Inc Heterodimere fc-zytokine und verwendungen davon
WO2023133540A1 (en) * 2022-01-07 2023-07-13 Lyell Immunopharma, Inc. Il-12 affinity variants

Also Published As

Publication number Publication date
WO2025012105A3 (en) 2025-03-20
WO2025012105A2 (en) 2025-01-16

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