EP4739656A1 - 2-phenoxy-1-(4-(alkylsulfonyl)piperidin-1-yl)ethan-1-on und 3-phenyl-1-(4-(alkylsulfonyl)piperidin-1-yl)prop-2-en-1-on-derivate als gpr183-antagonisten zur behandlung von chronischem schmerz - Google Patents

2-phenoxy-1-(4-(alkylsulfonyl)piperidin-1-yl)ethan-1-on und 3-phenyl-1-(4-(alkylsulfonyl)piperidin-1-yl)prop-2-en-1-on-derivate als gpr183-antagonisten zur behandlung von chronischem schmerz

Info

Publication number
EP4739656A1
EP4739656A1 EP24742983.0A EP24742983A EP4739656A1 EP 4739656 A1 EP4739656 A1 EP 4739656A1 EP 24742983 A EP24742983 A EP 24742983A EP 4739656 A1 EP4739656 A1 EP 4739656A1
Authority
EP
European Patent Office
Prior art keywords
piperidin
piperidine
sulfonamide
chlorophenoxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24742983.0A
Other languages
English (en)
French (fr)
Inventor
Marko Ahlmark
Anssi Haikarainen
Ari-Pekka Koivisto
Esa KUMPULAINEN
Aleksi SAHARI
Ainoleena TURKU
Emilia VÄISÄNEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Oyj filed Critical Orion Oyj
Publication of EP4739656A1 publication Critical patent/EP4739656A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
EP24742983.0A 2023-07-05 2024-07-04 2-phenoxy-1-(4-(alkylsulfonyl)piperidin-1-yl)ethan-1-on und 3-phenyl-1-(4-(alkylsulfonyl)piperidin-1-yl)prop-2-en-1-on-derivate als gpr183-antagonisten zur behandlung von chronischem schmerz Pending EP4739656A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20237131 2023-07-05
PCT/FI2024/050372 WO2025008574A1 (en) 2023-07-05 2024-07-04 2-phenoxy-1-(4-(alkylsulfonyl)piperidin-1-yl)ethan-1-one and 3-phenyl-1-(4-(alkylsulfonyl)piperidin-1-yl)prop-2-en-1-one derivatives as gpr183 antagonists for the treatment of chronic pain

Publications (1)

Publication Number Publication Date
EP4739656A1 true EP4739656A1 (de) 2026-05-13

Family

ID=91950461

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24742983.0A Pending EP4739656A1 (de) 2023-07-05 2024-07-04 2-phenoxy-1-(4-(alkylsulfonyl)piperidin-1-yl)ethan-1-on und 3-phenyl-1-(4-(alkylsulfonyl)piperidin-1-yl)prop-2-en-1-on-derivate als gpr183-antagonisten zur behandlung von chronischem schmerz

Country Status (11)

Country Link
EP (1) EP4739656A1 (de)
KR (1) KR20260035942A (de)
CN (1) CN121794256A (de)
AR (1) AR133165A1 (de)
AU (1) AU2024290016A1 (de)
CO (1) CO2026000808A2 (de)
IL (1) IL325730A (de)
MX (1) MX2025015183A (de)
PE (1) PE20260501A1 (de)
TW (1) TW202517611A (de)
WO (1) WO2025008574A1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1948597A1 (de) * 2005-10-21 2008-07-30 Vertex Pharmaceuticals Incorporated Derivate zur modulation von ionenkanälen
WO2015048570A2 (en) 2013-09-26 2015-04-02 Sanford-Burnham Medical Research Institute Ebi2 modulators
US11919895B2 (en) 2019-10-25 2024-03-05 Saint Louis University GPR183 antagonists for the treatment of pain
MX2024004722A (es) 2021-10-18 2024-07-24 Nanjing Immunophage Biotech Co Ltd Compuestos y sus usos como inhibidores de gpr183.

Also Published As

Publication number Publication date
AR133165A1 (es) 2025-09-03
TW202517611A (zh) 2025-05-01
CN121794256A (zh) 2026-04-03
MX2025015183A (es) 2026-02-03
KR20260035942A (ko) 2026-03-13
IL325730A (en) 2026-03-01
AU2024290016A1 (en) 2026-02-19
CO2026000808A2 (es) 2026-02-13
PE20260501A1 (es) 2026-02-27
WO2025008574A1 (en) 2025-01-09

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