EP4655591A4 - Nanopartikel mit polymerisiertem gammaglobulin sowie verfahren zur herstellung und verwendung davon - Google Patents

Nanopartikel mit polymerisiertem gammaglobulin sowie verfahren zur herstellung und verwendung davon

Info

Publication number
EP4655591A4
EP4655591A4 EP24747588.2A EP24747588A EP4655591A4 EP 4655591 A4 EP4655591 A4 EP 4655591A4 EP 24747588 A EP24747588 A EP 24747588A EP 4655591 A4 EP4655591 A4 EP 4655591A4
Authority
EP
European Patent Office
Prior art keywords
nanoparticles
polymerized
production
methods
gamma globulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24747588.2A
Other languages
English (en)
French (fr)
Other versions
EP4655591A1 (de
Inventor
Huey Lee
William Bedzyk
Michelle Son
Michael Sommer
Frank Vitzthum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Publication of EP4655591A1 publication Critical patent/EP4655591A1/de
Publication of EP4655591A4 publication Critical patent/EP4655591A4/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP24747588.2A 2023-01-26 2024-01-19 Nanopartikel mit polymerisiertem gammaglobulin sowie verfahren zur herstellung und verwendung davon Pending EP4655591A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363481710P 2023-01-26 2023-01-26
PCT/US2024/012254 WO2024158650A1 (en) 2023-01-26 2024-01-19 Nanoparticles comprising polymerized gamma globulin and methods of production and use thereof

Publications (2)

Publication Number Publication Date
EP4655591A1 EP4655591A1 (de) 2025-12-03
EP4655591A4 true EP4655591A4 (de) 2026-08-12

Family

ID=91970991

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24747588.2A Pending EP4655591A4 (de) 2023-01-26 2024-01-19 Nanopartikel mit polymerisiertem gammaglobulin sowie verfahren zur herstellung und verwendung davon

Country Status (5)

Country Link
EP (1) EP4655591A4 (de)
JP (1) JP2026504163A (de)
CN (1) CN120677383A (de)
AU (1) AU2024211287A1 (de)
WO (1) WO2024158650A1 (de)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6020149A (ja) * 1983-07-15 1985-02-01 Teikoku Hormone Mfg Co Ltd 免疫化学的測定方法及びその試薬
DE3640412A1 (de) * 1986-11-26 1988-06-09 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz
US4791067A (en) * 1987-06-25 1988-12-13 Fisher Scientific Co. Agglutination immunoassay for hapten involving monoclonal antibody of IgA class reagent
JP3300988B2 (ja) * 1992-01-31 2002-07-08 ダイナボット株式会社 凝集反応用担体粒子
US5432210A (en) * 1993-11-22 1995-07-11 Rohm And Haas Company Polymer particles and method for preparing by polymerization of encapsulated monomers
DE4343480A1 (de) * 1993-12-21 1995-07-06 Boehringer Mannheim Gmbh Acylierte Proteinaggregate und deren Verwendung zur Signalsteigerung in einem Immunoassay zum Nachweis von Antikörpern
US7172906B2 (en) * 2004-11-16 2007-02-06 Dade Behring Inc. Reduction of non-specific binding in assays
AU2006295515A1 (en) * 2005-09-27 2007-04-05 Polybatics Limited Polymer particles and uses thereof
JP2009514902A (ja) * 2005-11-11 2009-04-09 バイオラブ・サヌス・ファーマセウティカ・エルティーディーエー． 凝集ナノ粒子を含む固体医薬組成物及びその生成方法
JP2010096677A (ja) * 2008-10-17 2010-04-30 Toray Ind Inc 抗体／抗原結合能を有する高感度免疫学測定用ナノ粒子
GB201906331D0 (en) * 2019-05-03 2019-06-19 Governing Council Of The Univ Of Toronto Digital microfluidic agglutination assays

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HIGUCHI A ET AL: "Permeation of @c-globulin through microporous membranes in the presence of trace DNA", JOURNAL OF MEMBRANE SCIENCE,, vol. 186, no. 1, 15 May 2001 (2001-05-15), pages 9 - 18, XP004234544, DOI: 10.1016/S0376-7388(00)00658-X *
J. A. MOLINA?BOL?VAR ET AL: "Latex Immunoagglutination Assays", JOURNAL OF MACROMOLECULAR SCIENCE: PART C - POLYMER REVIEWS, vol. 45, no. 1, 1 January 2005 (2005-01-01), US, pages 59 - 98, XP055520776, ISSN: 1532-1797, DOI: 10.1081/MC-200045819 *
MCCARTHY D A ET AL: "The production of small IgG aggregates by glutaraldehyde cross-linking", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 82, no. 2, 1 January 1985 (1985-01-01), pages 349 - 358, XP023900542, ISSN: 0022-1759, [retrieved on 19850101], DOI: 10.1016/0022-1759(85)90367-9 *
See also references of WO2024158650A1 *

Also Published As

Publication number Publication date
JP2026504163A (ja) 2026-02-03
AU2024211287A1 (en) 2025-06-05
EP4655591A1 (de) 2025-12-03
WO2024158650A9 (en) 2024-09-12
CN120677383A (zh) 2025-09-19
WO2024158650A1 (en) 2024-08-02

Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20250821

AK Designated contracting states

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DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/543 20060101AFI20260417BHEP

Ipc: G01N 33/68 20060101ALI20260417BHEP

Ipc: C07K 16/28 20060101ALI20260417BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20260714

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/543 20060101AFI20260708BHEP

Ipc: G01N 33/68 20060101ALI20260708BHEP

Ipc: C07K 16/28 20060101ALI20260708BHEP