EP4608403A4 - MODULATORS AND USES OF THEM - Google Patents

MODULATORS AND USES OF THEM

Info

Publication number
EP4608403A4
EP4608403A4 EP23882103.7A EP23882103A EP4608403A4 EP 4608403 A4 EP4608403 A4 EP 4608403A4 EP 23882103 A EP23882103 A EP 23882103A EP 4608403 A4 EP4608403 A4 EP 4608403A4
Authority
EP
European Patent Office
Prior art keywords
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23882103.7A
Other languages
German (de)
French (fr)
Other versions
EP4608403A1 (en
Inventor
Itay Chowers
Sarah Elbaz-Hayoun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hadasit Medical Research Services and Development Co
Original Assignee
Hadasit Medical Research Services and Development Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hadasit Medical Research Services and Development Co filed Critical Hadasit Medical Research Services and Development Co
Publication of EP4608403A1 publication Critical patent/EP4608403A1/en
Publication of EP4608403A4 publication Critical patent/EP4608403A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP23882103.7A 2022-10-24 2023-10-24 MODULATORS AND USES OF THEM Pending EP4608403A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263380675P 2022-10-24 2022-10-24
PCT/IL2023/051103 WO2024089691A1 (en) 2022-10-24 2023-10-24 Modulators and uses thereof

Publications (2)

Publication Number Publication Date
EP4608403A1 EP4608403A1 (en) 2025-09-03
EP4608403A4 true EP4608403A4 (en) 2026-04-01

Family

ID=90830247

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23882103.7A Pending EP4608403A4 (en) 2022-10-24 2023-10-24 MODULATORS AND USES OF THEM

Country Status (3)

Country Link
EP (1) EP4608403A4 (en)
IL (1) IL320391A (en)
WO (1) WO2024089691A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0966443B1 (en) * 1997-02-26 2009-01-28 Pfizer Inc. Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
CN103357017A (en) * 2013-03-07 2013-10-23 首都医科大学附属北京同仁医院 Application of met-RANTES in preparing medicine used for treating inherited retinal degeneration
JP2018127498A (en) * 2011-01-11 2018-08-16 ディメリックス バイオサイエンス プロプライアタリー リミテッド Combination therapy
CN112386696A (en) * 2019-08-13 2021-02-23 贵州百灵企业集团制药股份有限公司 Target for treating insulin resistance and application thereof
WO2022079322A1 (en) * 2020-10-16 2022-04-21 Fundació Centre De Regulació Genòmica Therapy for degenerative disease and tissue damage

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0966443B1 (en) * 1997-02-26 2009-01-28 Pfizer Inc. Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
JP2018127498A (en) * 2011-01-11 2018-08-16 ディメリックス バイオサイエンス プロプライアタリー リミテッド Combination therapy
CN103357017A (en) * 2013-03-07 2013-10-23 首都医科大学附属北京同仁医院 Application of met-RANTES in preparing medicine used for treating inherited retinal degeneration
CN112386696A (en) * 2019-08-13 2021-02-23 贵州百灵企业集团制药股份有限公司 Target for treating insulin resistance and application thereof
WO2022079322A1 (en) * 2020-10-16 2022-04-21 Fundació Centre De Regulació Genòmica Therapy for degenerative disease and tissue damage

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2024089691A1 *
ZENG HUI-YANG ET AL: "The Role of CCR1 Expression in the Retinal Degeneration in rd Mice", CURRENT EYE RESEARCH, vol. 36, no. 3, 28 January 2011 (2011-01-28), pages 264 - 269, XP093367508, ISSN: 0271-3683, DOI: 10.3109/02713683.2010.535133 *

Also Published As

Publication number Publication date
EP4608403A1 (en) 2025-09-03
WO2024089691A1 (en) 2024-05-02
IL320391A (en) 2025-06-01

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