EP4486923A4 - Verfahren für multimodale epigenetische sequenzierungstests - Google Patents

Verfahren für multimodale epigenetische sequenzierungstests

Info

Publication number
EP4486923A4
EP4486923A4 EP23764100.6A EP23764100A EP4486923A4 EP 4486923 A4 EP4486923 A4 EP 4486923A4 EP 23764100 A EP23764100 A EP 23764100A EP 4486923 A4 EP4486923 A4 EP 4486923A4
Authority
EP
European Patent Office
Prior art keywords
sequalization
epigenetic
multimodal
tests
procedures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23764100.6A
Other languages
English (en)
French (fr)
Other versions
EP4486923A2 (de
Inventor
Wei Li
Yumei Li
Jianfeng Xu
David Taggart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of EP4486923A2 publication Critical patent/EP4486923A2/de
Publication of EP4486923A4 publication Critical patent/EP4486923A4/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Epidemiology (AREA)
  • Bioethics (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP23764100.6A 2022-03-03 2023-03-01 Verfahren für multimodale epigenetische sequenzierungstests Pending EP4486923A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263316277P 2022-03-03 2022-03-03
PCT/US2023/063522 WO2023168297A2 (en) 2022-03-03 2023-03-01 Methods for multimodal epigenetic sequencing assays

Publications (2)

Publication Number Publication Date
EP4486923A2 EP4486923A2 (de) 2025-01-08
EP4486923A4 true EP4486923A4 (de) 2026-03-11

Family

ID=87884349

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23764100.6A Pending EP4486923A4 (de) 2022-03-03 2023-03-01 Verfahren für multimodale epigenetische sequenzierungstests

Country Status (6)

Country Link
US (1) US20230323473A1 (de)
EP (1) EP4486923A4 (de)
JP (1) JP2025508977A (de)
CN (1) CN118922563A (de)
AU (1) AU2023228901A1 (de)
WO (1) WO2023168297A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025251032A1 (en) * 2024-05-31 2025-12-04 Helio Health Inc. Liver cancer methylation markers and machine models

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190352695A1 (en) * 2018-01-10 2019-11-21 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190287645A1 (en) * 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
US20220251640A1 (en) * 2019-05-17 2022-08-11 The Broad Institute, Inc. Methods of determination of genome architecture and epigenetic profile
AU2020283042B2 (en) * 2019-05-31 2026-02-19 Freenome Holdings, Inc. Methods and systems for high-depth sequencing of methylated nucleic acid
GB2612447B (en) * 2020-04-24 2025-08-13 Univ Cornell Methods for detecting tissue damage, graft versus host disease, and infections using cell-free DNA profiling
WO2022147420A1 (en) * 2020-12-30 2022-07-07 Guardant Health, Inc. Detection of epigenetic status using sequence-specific degradation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190352695A1 (en) * 2018-01-10 2019-11-21 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CRISTIANO STEPHEN ET AL: "Genome-wide cell-free DNA fragmentation in patients with cancer", NATURE,, vol. 570, no. 7761, 29 May 2019 (2019-05-29), pages 385 - 389, XP036814426, [retrieved on 20190529], DOI: 10.1038/S41586-019-1272-6 *
ERGER FLORIAN ET AL: "cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA", GENOME MEDICINE, vol. 12, no. 1, 24 June 2020 (2020-06-24), XP093354440, ISSN: 1756-994X, DOI: 10.1186/s13073-020-00750-5 *
SIEJKA-ZIELINSKA PAULINA ET AL: "Cell-free DNA TAPS provides multimodal information for early cancer detection", SCI. ADV, vol. 7, no. 36, 1 September 2021 (2021-09-01), XP055978148 *

Also Published As

Publication number Publication date
JP2025508977A (ja) 2025-04-10
WO2023168297A3 (en) 2023-11-30
WO2023168297A2 (en) 2023-09-07
AU2023228901A1 (en) 2024-09-12
US20230323473A1 (en) 2023-10-12
EP4486923A2 (de) 2025-01-08
CN118922563A (zh) 2024-11-08

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