EP4294354A1 - Compositions de soins buccodentaires hydratantes comprenant du peroxyde - Google Patents

Compositions de soins buccodentaires hydratantes comprenant du peroxyde

Info

Publication number
EP4294354A1
EP4294354A1 EP22708721.0A EP22708721A EP4294354A1 EP 4294354 A1 EP4294354 A1 EP 4294354A1 EP 22708721 A EP22708721 A EP 22708721A EP 4294354 A1 EP4294354 A1 EP 4294354A1
Authority
EP
European Patent Office
Prior art keywords
peroxide
oral care
care composition
combinations
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP22708721.0A
Other languages
German (de)
English (en)
Inventor
Michael David Curtis
Robert Scott Leonard
Paul Albert Sagel
Jayanth Rajaiah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/577,405 external-priority patent/US20220265533A1/en
Priority claimed from US17/577,399 external-priority patent/US20220265530A1/en
Priority claimed from US17/577,402 external-priority patent/US20220265531A1/en
Priority claimed from US17/577,404 external-priority patent/US20220265532A1/en
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP4294354A1 publication Critical patent/EP4294354A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate

Definitions

  • an oral care composition comprising (a) from about 1% to about 5%, by weight of the oral care composition, of peroxide; and (b) water, wherein the oral care composition releases at least about 1 % of the peroxide within about 120 seconds according to the Peroxide Release Method.
  • a hydrating oral care composition comprising (a) from about 1% to about 5%, by weight of the oral care composition, of peroxide; and (b) water, wherein the oral care composition releases at least about 1 % of the peroxide into an oral cavity of a user within about 120 seconds of initial application to the oral cavity.
  • a jammed oil-in-water emulsion comprising (a) hydrophobic phase; (b) aqueous phase; and (c) peroxide, wherein the jammed oil-in-water emulsion releases at least about 1 % of the peroxide within about 120 seconds according to the Peroxide Release Method.
  • Disclosed herein is a method of delivering peroxide to an oral cavity of a user comprising (a) directing the user to apply any of the disclosed oral care compositions to the oral cavity; (b) directing the user to continue application of the oral care composition to the oral cavity for at least 120 seconds.
  • Disclosed herein is a method of delivering a majority of peroxide to an oral cavity of a user instead of a sink comprising (a) directing the user to a apply any of the disclosed oral care compositions to the oral cavity; (b) directing the user to continue application of the oral care composition to the oral cavity for at least 120 seconds; and (c) directing the user to expectorate the oral care composition.
  • Fig. 1 shows the peroxide release over time for Composition A, B, C, and D.
  • the present invention is directed to hydrating oral care compositions comprising peroxide and water. While not wishing to being bound by theory, it is believed that peroxide that is stabilized through complexation and placed in an anhydrous chassis can lead to lower amounts of available of peroxide to provide health and cosmetic benefits. Additionally, anhydrous compositions can be dehydrating, leading to additional sensitivity challenges.
  • oral care composition includes a product, which in the ordinary course of usage, is not intentionally swallowed for purposes of systemic administration of particular therapeutic agents, but is rather retained in the oral cavity for a time sufficient to contact dental surfaces or oral tissues.
  • oral care compositions include dentifrice, tooth gel, subgingival gel, mouth rinse, mousse, foam, mouth spray, lozenge, chewable tablet, chewing gum, tooth whitening strips, floss and floss coatings, breath freshening dissolvable strips, or denture care or adhesive product.
  • the oral care composition may also be incorporated onto strips or films for direct application or attachment to oral surfaces.
  • dentifrice composition includes tooth or subgingival -paste, gel, or liquid formulations unless otherwise specified.
  • the dentifrice composition may be a singlephase composition or may be a combination of two or more separate dentifrice compositions.
  • the dentifrice composition may be in any desired form, such as deep striped, surface striped, multilayered, having a gel surrounding a paste, or any combination thereof.
  • Each dentifrice composition in a dentifrice comprising two or more separate dentifrice compositions may be contained in a physically separated compartment of a dispenser and dispensed side-by-side.
  • Active and other ingredients useful herein may be categorized or described herein by their cosmetic and/or therapeutic benefit or their postulated mode of action or function. However, it is to be understood that the active and other ingredients useful herein can, in some instances, provide more than one cosmetic and/or therapeutic benefit or function or operate via more than one mode of action. Therefore, classifications herein are made for the sake of convenience and are not intended to limit an ingredient to the particularly stated fimction(s) or activities listed.
  • substantially free refers to the presence of no more than 0.05%, preferably no more than 0.01%, and more preferably no more than 0.001%, of an indicated material in a composition, by total weight of such composition.
  • essentially free means that the indicated material is not deliberately added to the composition, or preferably not present at analytically detectable levels. It is meant to include compositions whereby the indicated material is present only as an impurity of one of the other materials deliberately added.
  • oral hygiene regimen or “regimen” can be for the use of two or more separate and distinct treatment steps for oral health, e.g. toothpaste, mouth rinse, floss, toothpicks, spray, water irrigator, massager.
  • total water content means both free water and water that is bound by other ingredients in the oral care composition.
  • the relevant molecular weight (MW) to be used is that of the material added when preparing the composition e.g., if the chelant is a citrate species, which can be supplied as citric acid, sodium citrate or indeed other salt forms, the MW used is that of the particular salt or acid added to the composition but ignoring any water of crystallization that may be present. While compositions and methods are described herein in terms of “comprising” various components or steps, the compositions and methods can also “consist essentially of’ or “consist of’ the various components or steps, unless stated otherwise.
  • the word "or" when used as a connector of two or more elements is meant to include the elements individually and in combination; for example, X or Y, means X or Y or both.
  • groups of elements are indicated using the numbering scheme indicated in the version of the periodic table of elements published in Chemical and Engineering News, 63(5), 27, 1985.
  • a group of elements can be indicated using a common name assigned to the group; for example, alkali metals for Group 1 elements, alkaline earth metals for Group 2 elements, and so forth.
  • the dentifrice composition can be in any suitable form, such as a solid, liquid, powder, paste, or combinations thereof.
  • the oral care composition can be dentifrice, tooth gel, subgingival gel, mouth rinse, mousse, foam, mouth spray, lozenge, chewable tablet, chewing gum, tooth whitening strips, floss and floss coatings, breath freshening dissolvable strips, or denture care or adhesive product.
  • the components of the dentifrice composition can be incorporated into a film, a strip, a foam, or a fiber-based dentifrice composition.
  • the oral care compositions as described herein, comprise peroxide and peroxide compatible abrasive, such as calcium pyrophosphate. Additionally, the oral care compositions can comprise other optional ingredients, as described below.
  • the section headers below are provided for convenience only. In some cases, a compound can fall within one or more sections.
  • stannous fluoride can be a tin compound and/or a fluoride compound.
  • the oral care composition comprises peroxide.
  • the peroxide can include any suitable source of peroxide, such as solubilized peroxide compounds and/or solid peroxide sources. Suitable peroxides include solid peroxides, hydrogen peroxide, urea peroxide, calcium peroxide, benzoyl peroxide, sodium peroxide, barium peroxide, inorganic peroxides, hydroperoxides, organic peroxides, polyvinylpyrrolidone-peroxide complex, crosslinked polyvinylpyrrolidone- peroxide complex, and/or combinations thereof.
  • the peroxide can comprise solubilized peroxide compounds, such as aqueous hydrogen peroxide.
  • oral care compositions include oral care compositions comprising at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, from about 90% to about 99%, or from about 88% to about 99% of hydrogen peroxide remaining in the oral care composition the oral care composition is stored at 50 °C for 20 days.
  • the oral care composition can comprise from about 0.01% to about 20%, from about 0.01% to about 10%, from about 1% to about 5%, at least about 1%, at least about 2%, at least about 3%, at least about 3.5%, at least about 4%, or greater than 3%, by weight of the oral care composition, of the peroxide.
  • Desirable oral care compositions include oral care compositions that have a peroxide release of at least about 10%, at least about 15%, at least about 25%, at least about 35%, at least about 50%, at least about 60 %, at least about 70%, at least about 75%, at least about 80%, at least about 90%, at least about 95%, from about 10% to about 95%, from about 25% to about 75%, from about 20% to about 95%, from about 35% to about 90%, from about 40% to about 95%, from about 50% to about 90%, and from about 60% to about 99% in a defined period of time corresponding to a single oral care session, such as 30 second, 45 second, 60 seconds, 75 seconds, 90 seconds, 120 seconds, and/or 5 minutes.
  • the oral care composition can comprise abrasive, such as a peroxide-compatible abrasive.
  • Abrasives can be added to oral care formulations to help remove surface stains from teeth.
  • the abrasive can comprise calcium abrasive, silica abrasive, carbonate abrasive, phosphate abrasive, alumina abrasive, other suitable abrasives, and/or combinations thereof.
  • the calcium abrasive can comprise calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcium orthophosphate, calcium metaphosphate, calcium pyrophosphate, calcium polyphosphate, calcium hydroxyapatite, and combinations thereof.
  • the calcium abrasive can comprise calcium carbonate.
  • the calcium-containing abrasive can be selected from the group consisting of fine ground natural chalk, ground calcium carbonate, precipitated calcium carbonate, and combinations thereof.
  • the calcium abrasive can comprise calcium pyrophosphate. While not wishing to be bound by theory, it is believed that particular sources of calcium pyrophosphate can be sufficiently compatible with peroxide to be used in an oral care composition comprising peroxide. Calcium pyrophosphate has at least three polymorphic phases: alpha (a), beta (b), and gamma (g). It has been unexpectedly found that calcium pyrophosphate with a higher proportion of the g phase are more compatible with peroxide, such as hydrogen peroxide. Suitable sources of calcium pyrophosphate can comprise a ratio of gamma phase calcium pyrophosphate to beta phase calcium pyrophosphate of at least about 0.75, at least about 0.8. at least about 0.9, at least about 1, from about 0.75 to about 1.5, from about 0.9 to about 1.5, or from about 1 to about 1.5.
  • abrasives that include high amounts of soluble metal ions are less compatible with peroxide due to reactivity between peroxide and metal ions.
  • suitable sources of abrasives such as calcium pyrophosphate, can comprise less than about 0.001%, less than about 0.00075%, less than about 0.0006%, less than about 0.0005%, or less than about 0.0001%, by weight of the abrasive.
  • the abrasive can be free of, substantially free of, or essentially free of soluble metal ions.
  • abrasives with a slurry pH of from about 5.4 to about 7 were more compatible with peroxide.
  • the slurry pH was determined by creating a 1:3 abrasive: water slurry and determining the pH.
  • the carbonate abrasive can comprise sodium carbonate, sodium bicarbonate, calcium carbonate, strontium carbonate, and/or combinations thereof.
  • the phosphate abrasive can comprise calcium phosphate, sodium hexametaphosphate, dicalcium phosphate, tricalcium phosphate, calcium orthophosphate, calcium metaphosphate, calcium polyphosphate, a polyphosphate, a pyrophosphate, and/or combinations thereof.
  • the alumina abrasive can comprise polycrystalline alumina, calcined alumina, uncalcined alumina, fused alumina, levigated alumina, hydrated alumina, and/or combinations thereof.
  • Suitable abrasives include diatomaceous earth, barium sulfate, wollastonite, perlite, polymethylmethacrylate particles, tospearl, and combinations thereof.
  • the oral care composition can comprise from about 0.01% to about 30%, from about 0.01% to about 15%, from about 0.01% to less than 15%, from about 1% to about 30%, from about 1% to less than 15%, from about 1% to about 12%, or from about 0.01% to about 10%, by weight of the oral care composition of the abrasive.
  • the oral care composition can have a Pellicle Cleaning Ratio (PCR) of at least about 75, at least about 90, at least about 100, from about 75 to about 250, or from about 100 to about 250.
  • PCR Pellicle Cleaning Ratio
  • the oral care composition can have a Relative Dentin Abrasion value of up to about 250, up to about 150, from about 70 to about 150, or from about 50 to about 250.
  • the oral care composition can include alumina as an abrasive.
  • the alumina can be the sole abrasive or used in combination with other abrasives, as described herein.
  • the abrasivity of alumina can be higher than silica, thus a lower amount of alumina abrasive can be added.
  • An oral care composition comprising alumina can have a pellicle cleaning ratio (PCR) of at least about 75, at least about 100, from about 75 to about 250, from about 50 to about 175, from about 50 to about 150, or rom about 65 to about 155.
  • PCR pellicle cleaning ratio
  • An oral care composition comprising alumina can have a Relative Dentin Abrasion (RDA) of less than about 150, less than about 125, less than about 100, or less than about 90. While not wishing to be bound by theory, it is believed that alumina can be reactive with peroxide and/or fluoride. Thus, desirable alumina abrasives include those that are compatible with peroxide and/or fluoride.
  • RDA Relative Dentin Abrasion
  • oral care compositions include oral care compositions that comprise peroxide and alumina and have % loss of peroxide after 30 days and/or 90 days at 40 °C of less than about 10%, less than about 5%, less than about 4%, less than about 3%, from about 0.5% to about 10%, from about 0.5% to about 5%, or from about 0.1% to about 5%. While not wishing to being bound by theory, it is believed that alumina is unexpectedly stable with alumina, such that only a minimal amount of peroxide is lost to peroxide decomposition and/or degradation.
  • oral care compositions include oral care compositions that comprise peroxide, fluoride, and alumina and have % loss of fluoride after 30 days and/or 90 days at 40 °C of less than about 20%, less than about 18%, less than about 15%, less than about 10%, less than about 5%, from about 0.5% to about 10%, from about 0.5% to about 20%, or from about 0.1% to about 15%. While not wishing to being bound by theory, it is believed that alumina and peroxide are unexpectedly stable with certain fluoride sources, such that only a minimal loss of fluoride is observed.
  • the oral care composition of the present invention can be a dentifrice composition that is anhydrous, a low water formulation, or a high water formulation.
  • the oral care composition can comprise from 0% to about 99%, from about 5% to about 60%, from about 5% to about 75%, about 20% or greater, about 30% or greater, about 50% or greater, up to about 45%, or up to about 75%, by weight of the composition, of water.
  • the water is USP water.
  • the oral care composition of the present invention can include water. While not wishing to be bound by theory, it is believed that including water in the oral care composition can lead to greater availability of peroxide to provide oral health benefits, such as whitening, while also hydrating the oral cavity. While one option to stabilize peroxide is to provide a complexed peroxide in an anhydrous dentifrice composition, it is believed that peroxide can be more effectively delivered through the selection of the other ingredients of the oral care composition while simultaneously hydrating the oral cavity.
  • the dentifrice composition comprises from about 45% to about 75%, by weight of the composition, of water.
  • the high water dentifrice composition can comprise from about 45% to about 65%, from about 45% to about 55%, or from about 46% to about 54%, by weight of the composition, of water.
  • the water may be added to the high water dentifrice formulation and/or may come into the composition from the inclusion of other ingredients.
  • the dentifrice composition can also comprise other orally acceptable carrier materials, such as alcohol, humectants, polymers, surfactants, and acceptance improving agents, such as flavoring, sweetening, coloring and/or cooling agents.
  • carrier materials such as alcohol, humectants, polymers, surfactants, and acceptance improving agents, such as flavoring, sweetening, coloring and/or cooling agents.
  • the oral care composition can also be a mouth rinse formulation.
  • a mouth rinse formulation can comprise from about 75% to about 99%, from about 75% to about 95%, or from about 80% to about 95% of water.
  • peroxide can be effectively delivered in an aqueous chassis if the other components are designed to minimize reactivity with the peroxide.
  • amphiphilic polymer it is desirable for the amphiphilic polymer to not strongly react with the peroxide.
  • amphiphilic polymer it is desirable for the amphiphilic polymer to not form an isolatable complex with the peroxide.
  • the amphiphilic polymer can include polymers that are at least partially soluble and/or fully soluble in water.
  • Suitable amphiphilic polymers include 2-acrylamido-2-methylpropane sulfonic acid (AMPS) polymer, copolymer, cross-polymer, or combination thereof.
  • AMPS 2-acrylamido-2-methylpropane sulfonic acid
  • the oral care composition can contain polyacrylate crosspolymer-6 (commercially available as SepiMAXTM ZEN from SEPPIC S.A., a subsidiary of the Air Liquide group, Puteaux Cedex, France).
  • the oral care composition can comprise alkyl alcohol. While not wishing to be bound by theory, it is believed that the addition of alkyl alcohol in combination with the amphiphilic polymer can lead to oral care compositions with unexpectedly high viscosities.
  • the alkyl alcohol can be provided through commercial mixtures of alkyl alcohols, such as Lanette ® W, which includes cetyl alcohol: stearyl alcohol: sodium lauryl sulfate at a 45:45:10 ratio (available from BASF, Florham Park, NJ).
  • Lanette ® W which includes cetyl alcohol: stearyl alcohol: sodium lauryl sulfate at a 45:45:10 ratio (available from BASF, Florham Park, NJ).
  • the oral care composition can comprise from about 0.01% to about 10%, from about 0.1% to about 5%, from about 1% to about 10%, or from about 1% to about 5%, by weight of the oral care composition, of the alkyl alcohol.
  • the pH of the disclosed composition can be from about 4 to about 10, from about 4 to about 7, from about 4 to about 8, or from about 7 to about 10.
  • the oral care composition can comprise a fluoride ion source capable of providing from about 50 ppm to about 5000 ppm, and preferably from about 500 ppm to about 3000 ppm of free fluoride ions.
  • the fluoride ion source may be present in the oral care composition at an amount of from about 0.0025% to about 5%, from about 0.01% to about 10%, from about 0.2% to about 1%, from about 0.5% to about 1.5%, or from about 0.3% to about 0.6%, by weight of the oral care composition.
  • the oral care composition can comprise less than 0.1%, less than 0.01%, be essentially free of, be substantially free of, or free of a fluoride ion source.
  • the oral care composition can comprise from about 0.01% to about 10%, from about 1% to about 5%, or from about 0.5% to about 15% of metal and/or a metal ion source.
  • the oral care composition of the present invention can comprise tin, which can be provided by a tin ion source.
  • the tin ion source can be any suitable compound that can provide tin ions in an oral care composition and/or deliver tin ions to the oral cavity when the oral care composition is applied to the oral cavity.
  • the tin ion source can comprise one or more tin containing compounds, such as stannous fluoride, stannous chloride, stannous bromide, stannous iodide, stannous oxide, stannous oxalate, stannous sulfate, stannous sulfide, stannic fluoride, stannic chloride, stannic bromide, stannic iodide, stannic sulfide, and/or mixtures thereof.
  • Tin ion source can comprise stannous fluoride, stannous chloride, and/or mixture thereof.
  • the tin ion source can also be a fluoride-free tin ion source, such as stannous chloride.
  • the oral care composition can comprise from about 0.0025% to about 5%, from about 0.01% to about 10%, from about 0.2% to about 1%, from about 0.4% to about 1%, or from about 0.3% to about 0.6%, by weight of the oral care composition, of tin and/or a tin ion source.
  • the oral care composition can be essentially free of, substantially free of, or free of tin.
  • the zinc and/or zinc ion source may be present in the total oral care composition at an amount of from about 0.01% to about 10%, from about 0.2% to about 1%, from about 0.4% to about 1 %, or from about 0.3% to about 0.6%, by weight of the dentifrice composition.
  • the oral care composition can be essentially free of, substantially free of, or free of zinc.
  • Preferred polyphosphates are those having an average of two or more phosphate groups so that surface adsorption at effective concentrations produces sufficient non-bound phosphate functions, which enhance the anionic surface charge as well as hydrophilic character of the surfaces.
  • Preferred in this invention are the linear polyphosphates having the formula: XO(XPO 3 ) n X, wherein X is sodium, potassium, ammonium, or any other alkali metal cations and n averages from about 2 to about 21.
  • Alkali earth metal cations, such as calcium are not preferred because they tend to form insoluble fluoride salts from aqueous solutions comprising a fluoride ions and alkali earth metal cations.
  • the oral care compositions disclosed herein can be free of or substantially free of calcium pyrophosphate.
  • the oral care composition can comprise from about 0,01 % to about 15%, from about 0.1% to about 10%, from about 0.5% to about 5%, from about 1 to about 20%, or about 10% or less, by weight of the oral care composition, of the polyphosphate source.
  • the oral care composition can be essentially free of, substantially free of, or free of polyphosphate.
  • the oral care composition can comprise orthophosphate, which can be provided by an orthophosphate source.
  • An orthophosphate source can comprise a salt including the orthophosphate anion, a salt including a phosphate anion (H 2 PO 4 , HPO 4 2- , and PO 4 3- ), a phosphoric acid compound, a polyphosphate source, which can breakdown into orthophosphate under a variety of conditions, and/or another suitable orthophospha te source.
  • the oral care composition can comprise from about 0.01% to about 15%, from about 0.1% to about 10%, from about 0.5% to about 5%, from about 1 to about 20%, or about 10% or less, by weight of the oral care composition, of the orthophosphate.
  • the oral care composition can be essentially free of, substantially free of, or free of orthophosphate.
  • the oral care composition can comprise one or more surfactants.
  • the surfactants can be used to make the compositions more cosmetically acceptable.
  • the surfactant is preferably a detersive material which imparts to the composition detersive and foaming properties.
  • Suitable surfactants are safe and effective amounts of anionic, cationic, nonionic, zwitterionic, amphoteric and betaine surfactants, such as sodium lauryl sulfate, sodium lauryl isethionate, sodium lauroyl methyl isethionate, sodium cocoyl glutamate, sodium dodecyl benzene sulfonate, alkali metal or ammonium salts of lauroyl sarcosinate, myristoyl sarcosinate, palmitoyl sarcosinate, stearoyl sarcosinate and oleoyl sarcosinate, polyoxyethylene sorbitan monostearate, isostearate and laurate, sodium
  • the oral care composition can comprise one or more surfactants each at a level from about 0.01% to about 15%, from about 0.3% to about 10%, or from about 0.3% to about 2.5 %, by weight of the oral care composition.
  • compositions that comprise at least about 1.5%, greater than 1.5%, from about 1.5% to about 10%, or greater than 1.5% to about 10%, by weight of the oral care composition, of anionic surfactant.
  • the oral care composition can comprise amino acid.
  • the amino acid can comprise one or more amino acids, peptide, and/or polypeptide, as described herein.
  • Suitable amino acids also include, for example, arginine, histidine, lysine, aspartic acid, glutamic acid, serine, threonine, asparagine, glutamine, cysteine, selenocysteine, glycine, proline, alanine, valine, isoleucine, leucine, methionine, phenylalanine, tyrosine, tryptophan, citrulline, ornithine, creatine, diaminobutanoic acid, diaminoproprionic acid, salts thereof, and/or combinations thereof.
  • Suitable amino acids include the compounds described by Formula I, either naturally occurring or synthetically derived.
  • the amino acid can be zwitterionic, neutral, positively charged, or negatively charged based on the R group and the environment.
  • the charge of the amino acid, and whether particular functional groups, can interact with tin at particular pH conditions, would be well known to one of ordinary skill in the art.
  • Suitable amino acids include one or more basic amino acids, one or more acidic amino acids, one or more neutral amino acids, or combinations thereof.
  • neutral amino acids include not only naturally occurring neutral amino acids, such as alanine, asparagine, cysteine, glutamine, glycine, isoleucine, leucine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, but also biologically acceptable amino acids which have an isoelectric point in range of pH 5.0 to 7.0.
  • the biologically preferred acceptable neutral amino acid has a single amino group and carboxyl group in the molecule or a functional derivative hereof, such as functional derivatives having an altered side chain albeit similar or substantially similar physio chemical properties.
  • the amino acid would be at minimum partially water soluble and provide a pH of less than 7 in an aqueous solution of lg/1000ml at 25°C.
  • neutral amino acids suitable for use in the invention include, but are not limited to, alanine, aminobutyrate, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, salts thereof, or mixtures thereof.
  • neutral amino acids used in the composition of the present invention may include asparagine, glutamine, glycine, salts thereof, or mixtures thereof.
  • the neutral amino acids may have an isoelectric point of 5.0, or 5.1, or 5.2, or 5.3, or 5.4, or 5.5, or 5.6, or 5.7, or 5.8, or 5.9, or 6.0, or 6.1, or 6.2, or 6.3, or 6.4, or 6.5, or 6.6, or 6.7, or 6.8, or 6.9, or 7.0, in an aqueous solution at 25°C.
  • the neutral amino acid is selected from proline, glutamine, or glycine, more preferably in its free form (i.e. uncomplexed).
  • suitable salts include salts known in the art to be pharmaceutically acceptable salts considered to be physiologically acceptable in the amounts and concentrations provided.
  • Humectant include salts known in the art to be pharmaceutically acceptable salts considered to be physiologically acceptable in the amounts and concentrations provided.
  • the oral care composition can comprise one or more humectants, have low levels of a humectant, or be free of a humectant.
  • Humectants serve to add body or “mouth texture” to an oral care composition or dentifrice as well as preventing the dentifrice from drying out.
  • Suitable humectants include polyethylene glycol (at a variety of different molecular weights), propylene glycol, glycerin (glycerol), erythritol, xylitol, sorbitol, mannitol, butylene glycol, lactitol, hydrogenated starch hydrolysates, and/or mixtures thereof.
  • the oral care composition can comprise one or more humectants each at a level of from 0 to about 70%, from about 5% to about 50%, from about 10% to about 60%, or from about 20% to about 80%, by weight of the oral care composition.
  • the oral care composition can comprise one or more thickening agents in addition to the amphiphilic polymer and alkyl alcohol, as described herein.
  • Thickening agents can be useful in the oral care compositions to provide a gelatinous structure that stabilizes the dentifrice and/or toothpaste against phase separation.
  • Suitable thickening agents include polysaccharides, polymers, and/or silica thickeners.
  • the thickening agent can comprise one or more polysaccharides.
  • polysaccharides include starch; glycerite of starch; gums such as gum karaya (sterculia gum), gum tragacanth, gum arabic, gum ghatti, gum acacia, xanthan gum, guar gum and cellulose gum; magnesium aluminum silicate (Veegum); carrageenan; sodium alginate; agar-agar; pectin; gelatin; cellulose compounds such as cellulose, microcrystalline cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethyl cellulose, hydroxymethyl carboxypropyl cellulose, methyl cellulose, ethyl cellulose, and sulfated cellulose; natural and synthetic clays such as hectorite clays; and mixtures thereof.
  • Carageenans is a polysaccharide derived from seaweed. There are several types of carageenan that may be distinguished by their seaweed source and/or by their degree of and position of sulfation.
  • the thickening agent can comprise kappa carageenans, modified kappa carageenans, iota carageenans, modified iota carageenans, lambda carrageenan, and mixtures thereof.
  • Carageenans suitable for use herein include those commercially available from the FMC Company under the series designation “Viscarin,” including but not limited to Viscarin TP 329, Viscarin TP 388, and Viscarin TP 389.
  • the thickening agent can comprise one or more polymers.
  • the polymer can be a polyethylene glycol (PEG), a polyvinylpyrrolidone (PVP), polyacrylic acid, a polymer derived from at least one acrylic acid monomer, a copolymer of maleic anhydride and methyl vinyl ether, a crosslinked polyacrylic acid polymer, of various weight percentages of the oral care composition as well as various ranges of average molecular ranges.
  • the oral care composition can be free of, essentially free of, or substantially free of a copolymer of maleic anhydride and methyl vinyl ether.
  • the thickening agent can comprise one or more inorganic thickening agents.
  • suitable inorganic thickening agents include colloidal magnesium aluminum silicate, silica thickeners.
  • Useful silica thickeners include, for example, include, as a non-limiting example, an amorphous precipitated silica such as ZEODENT® 165 silica.
  • Other non-limiting silica thickeners include ZEODENT® 153, 163, and 167, and ZEOFREE® 177 and 265 silica products, all available from Evonik Corporation, and AEROSIL® fumed silicas.
  • the oral care composition can comprise from 0.01% to about 15%, from 0.1% to about 10%, from about 0.2% to about 5%, or from about 0.5 % to about 2% of one or more thickening agents.
  • R can be null, alkyl, alkenyl, allyl, phenyl, benzyl, aliphatic, aromatic, polyethylene glycol, polymer, O, N, P, or combinations thereof.
  • the dicarboxylic acid can comprise oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azerlaic acid, sebacic acid, undecanedioic acid, dodecanedioic acid, brassylic acid, thapsic acid, japanic acid, phellogenic acid, equisetolic acid, malic acid, tartaric acid, salts thereof, or combinations thereof.
  • the oral care composition can comprise from about 0.01% to about 10%, from about 0.1% to about 15%, from about 1% to about 5%, or from about 0.0001 to about 25%, of dicarboxylic acid.
  • Coolants may also be part of the flavor system.
  • Preferred coolants in the present compositions are the paramenthan carboxyamide agents such as N-ethyl-p-menthan-3 -carboxamide (known commercially as “WS-3”) or N-(Ethoxycarbonylmethyl)-3-p-menthanecarboxamide (known commercially as “WS-5”), and mixtures thereof.
  • a flavor system is generally used in the compositions at levels of from about 0.001 % to about 5%, by weight of the oral care composition.
  • These flavoring agents generally comprise mixtures of aldehydes, ketones, esters, phenols, acids, and aliphatic, aromatic and other alcohols.
  • Titanium dioxide may also be added to the present composition. Titanium dioxide is a white powder which adds opacity to the compositions. Titanium dioxide generally comprises from about 0.25% to about 5%, by weight of the oral care composition.
  • Suitable oral care compositions include dentifrice compositions, toothpaste compositions, and/or jammed oil-in-water emulsions.
  • the oral care composition can comprise multi-phase oral composition.
  • the multi-phase oral composition can comprise multi-phase compositions, such as in U.S. Patent Application Publication Number 2018/0133121, U.S. Patent Number 10,849,729, and/or U.S. Patent Application Publication Number 10,780,032, which are each herein incorporated by reference in their entirety.
  • a jammed emulsion may be an unexpectedly stable high internal phase emulsion.
  • regions of discontinuous phase can become sufficiently crowded, such that they can jam against each other with a region of continuous phase between them and deform each other with a region of continuous phase between them.
  • both the continuous phase and discontinuous phase are liquids, the emulsion can transition into an at least a partially semisolid structure when the jamming transition occurs.
  • the jammed emulsion, as described herein can be prepared by the portion-wise addition or gradual addition or slow addition of the discontinuous phase to the continuous phase. Simply combining the entire discontinuous phase to the continuous phase will not necessarily result in jammed emulsion.
  • the aqueous phase can be at least partially continuous, essentially continuous, or preferably continuous.
  • the multi-phase oral care composition and/or jammed oil-in-water emulsion can comprise from about 0.01% to about 25%, from about 1% to about 20%, from about 2.5% to about 20 %, or preferably from about 5% to about 15%, by weight or volume of the multi-phase oral care composition and/or jammed oil-in-water emulsion, of the aqueous phase.
  • the hydrophobic phase can comprise a non-toxic oil, such as non-toxic edible oil.
  • the hydrophobic phase can comprise non-toxic edible oils, saturated or unsaturated fatty alcohols, aliphatic hydrocarbons, long chain triglycerides, fatty esters, and combinations thereof.
  • the hydrophobic phase may also comprise silicones, polysiloxanes, and mixtures thereof.
  • the hydrophobic phase may be preferably selected from mineral oil, petrolatum, and combinations thereof.
  • the multi-phase oral care composition and/or jammed oil-in-water emulsion can comprise one or more emulsifiers.
  • the hydrophobic phase can have emulsifying properties.
  • the emulsifier and the hydrophobic phase can comprise the same compound.
  • the multi-phase oral care composition and/or jammed oil-in-water emulsion, as described herein, can comprise from about 0.001% to about 20%, from about 0.01% to about 10%, up to about 10%, up to about 5%, or preferably from about 0.1% to about 10%, by weight of the multi- phase oral care composition or jammed oil-in-water emulsion, of the emulsifier.
  • Classes of surfactants useful as emulsifiers include nonionic, anionic, cationic, amphoteric, polymeric, synthetic emulsifiers, and mixtures thereof. Many suitable nonionic and amphoteric surfactants are disclosed by U.S. Pat. No. 3,988,433; U.S. Pat. No. 4,051,234, and many suitable nonionic surfactants are also disclosed by U.S. Pat. No. 3,959,458.
  • the emulsifier can comprise a polysorbate, an alkyl sulfate, Lipowax® D, or combinations thereof.
  • Suitable polysorbate compounds include, polysorbate 20, 40, 60, 80, or combinations thereof, such as Tween® 20, 40, 60, 80, or combinations thereof.
  • the emulsifier can comprise natural emulsifiers, such as acacia, gelatin, lecithin and cholesterol; finely dispersed solids, such as colloidal clays, bentonite, veegum (magnesium aluminum silicate; and synthetic emulsifiers, such as salts of fatty acids, sulfates such as sorbitan trioleate, sorbitan tristearate, sucrose distearate, propylene glycol monostearate, glycerol monostearate, propylene glycol monolaurate, sorbitan monostearate, sorbitan monolaurate, polyoxyethylene-4-lauryl ether, sodium lauryl sulfate, sulfonates such as dioctyl sosium sulfosuccinate, glyceryl esters, polyoxyethylene glycol esters and ethers, diethylene glycol monostearate, PEG 200 distearate, and sorbitan fatty acid
  • the emulsifier can be a surfactant that is non-reactive with a bleaching agent.
  • surfactants that are non-reactive with a bleaching agent may be substantially free of hydroxy groups, nitrogen groups and linkages, double or triple covalent bonds between adjacent carbon atoms, metals such as Zn, etc., or combinations thereof.
  • compositions with a high % peroxide diffusion according to the Peroxide Release Rate Method, as described herein, will also release a high amount of peroxide to the oral cavity.
  • a 15 mL dialysis cell (2K MWCO, Slide-A-Lyzer G2 Dialysis Cassette) was filled with WFI MilliQ Water (16 grams) and the cap affixed.
  • a test product was applied covering the entire cell membrane surface at a depth defined by the cell plastic housing by leveling the applied product with a spatula.
  • a piece of parafilm was applied over the product composition to protect it during cassette mixing during sampling.
  • the cell was placed either vertically or horizontally product facing down on a tared balanced.
  • a timer was started post product application and samples of the WFI MilliQ water within the cassette were taken at the defined time points.
  • the cell was taken and inverted 180 degrees twice, the lid removed and a sample (0.3 - 0.50g) pulled via a pipet. Following sampling, the dialysis cell was returned to the balance until the next sample was required. Each sample was assayed for percent peroxide as outlined below.
  • a Reflectoquant RQ Flex peroxide test strip reader (Millipore Sigma) was calibrated using both 0.2 - 0.20 mg/L (604) and 100 - 1000 mg/L (609) test strips (Supelco) with peroxide standard solutions as follows:
  • test strip was inserted into a RQ Flex 10 with the 0.2 - 20.0 mg/L test strip program loaded and the measurement recorded. Note total strip development and program is 15 seconds in duration. 5. 2 grams from solution (1) were diluted to 500 grams with WFI MilliQ water and steps (3) and (4) were repeated.
  • test strip was inserted into a RQ Flex 10 with the 100 - 1000 mg/L test strip program loaded and the measurement recorded.
  • the diffused peroxide concentration defined the appropriate strip to use. If concentrations exceeded the respective strip concentration ranges, serial dilutions were performed to bring the concentration into range.
  • composition A TABLE 1
  • Composition B TABLE 2A
  • inventive compositions Compositions B
  • Composition C and Composition D TABLE 3
  • commercial products marketed by the Colgate-Palmolive Company Composition C is Colgate Optic White Renewal Toothpaste, which is marketed to include hydrogen peroxide at 3% wt%.
  • Composition D is Colgate Optic White Overnight, which is also marketed to include hydrogen peroxide at 4 wt%. TABLE 1.
  • Composition A TABLE 1
  • Composition B TABLE 2A
  • inventive compositions inventive compositions.
  • Composition C and Composition D TABLE 3
  • commercial products marketed by the Colgate-Palmolive Company Composition C is Colgate Optic White Renewal Toothpaste, which is marketed to include hydrogen peroxide at 3% wt%.
  • Composition D is Colgate Optic White Overnight, which is also marketed to include hydrogen peroxide at 4 wt%.
  • Composition A a jammed oil-in-water emulsion.
  • Composition A was produced by combining polysorbate 20, water, sucralose and the aqueous solution of H 2 O 2 in a 20 gallon premix tank. The premix mixture was transferred to a 400L vessel and agitated while mineral oil was slowly added over 30 minutes. Flavor was added next and the batch stirred for 5 minutes. An oil-in-water emulsion was formed during this step, and the composition developed a lotion-like, semisolid consistency.
  • TABLE 2A shows the formulation of Composition B, a dentifrice composition including fluoride, 4 wt% peroxide, water, and abrasive. The release of peroxide into the dialysis cell is shown in TABLE 5, and additionally shown in Fig. 1.
  • TABLE 2B shows a variety of exemplary compositions that include different amounts of amphiphilic polymer (from 1.25 wt% to 2.25 wt%) and alkyl alcohol (from 0.75 wt% to 1.25 wt%).
  • Ex. 1-6 include sodium monofluorophosphate (1.14 wt%) , sodium lauryl sulfate (1.4 wt%), calcium pyrophosphate (10 wt%), and hydrogen peroxide (4 wt%).
  • Comparative Compositions include sodium monofluorophosphate (1.14 wt%) , sodium lauryl sulfate (1.4 wt%), calcium pyrophosphate (10 wt%), and hydrogen peroxide (4 wt%).
  • TABLE 3 shows the ingredients listed on the carton for comparative examples and commercial products Composition C, Colgate Optic White Renewal toothpaste, and Composition D, Colgate Optic White Overnight whitening pen.
  • Composition A Peroxide Release Rate Sampling TABLE 4 shows an example of the procedure utilized to calculate the amount of peroxide (ppm) in the dialysis cell. As shown in TABLE 4, Composition A led to 717 ppm of peroxide after 120 seconds, 1525 ppm of peroxide after 300 seconds, and 3263 ppm peroxide after 900 seconds. The same method of quantification shown in TABLE 4, was used to determine the concentration of the dialysis cell at various times with Composition B, Composition C, and Composition D.
  • TABLE 5 shows the peroxide concentration of each dialysis cell after a loading of Composition A-D after a defined period of time.
  • Composition A and Composition B resulted in 717 ppm and 150 ppm, respectively, of hydrogen peroxide in the dialysis cell after 120 seconds.
  • Compositions C and D resulted in less than 1 ppm and 2 pm, respectively, of peroxide in the dialysis cell after 120 seconds.
  • Composition A and Composition B resulted in 3263 ppm and 1529 ppm, respectively, of peroxide in the dialysis cell after 900 seconds.
  • Composition C and Composition D resulted in 219 ppm and 252 ppm, respectively, of peroxide in the dialysis cell after 900 seconds.
  • membranes loaded with Compositions A and Composition B, both including hydrogen peroxide in solution led to increased delivery of hydrogen peroxide across the membrane. TABLE 6. % Peroxide Diffused after 2 Minutes
  • TABLE 6 shows the relative amount of peroxide that diffused into the dialysis cell after a defined period of time. 9.3-10.8% of the total amount of peroxide in Compositions A diffused into the dialysis cell after 2 minutes. 49% of the total amount of peroxide in Composition A diffused into the dialysis cell after 15 minutes. 1.5% of the total amount of peroxide in Composition B diffused into the dialysis cell after 2 minutes. 16% of the total amount of peroxide in Composition B diffused into the dialysis cell after 15 minutes. In contrast, 0.001% and 0.13% of Composition C and Composition D diffused into the dialysis cell after 2 minutes and 2.5% and 13% of Composition C and Composition D diffused into the dialysis cell after 15 minutes.
  • compositions such as toothpaste compositions and jammed oil-in-water emulsion compositions, that included peroxide and water led to an increased diffusion of peroxide into the dialysis cell. It has been surprisingly found that peroxide in composition including water can have a high peroxide release rate, as shown in TABLE 6 with Composition A and Composition B, and hydrate the oral cavity. While not wishing to being bound by theory, it is believed that by minimizing reactivity with the remaining components in the oral care composition, including the abrasive, peroxide can be formulated in a composition including water.

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Abstract

Compositions de soins buccodentaires hydratantes comprenant du peroxyde et de l'eau. Compositions de dentifrice hydratantes comprenant du peroxyde et de l'eau. Ces compositions de soins buccodentaires hydratantes comprenant du peroxyde et de l'eau peuvent libérer au moins environ 1 % du peroxyde en 120 secondes. Ces compositions de soins buccodentaires hydratantes comprenant du peroxyde et de l'eau peuvent libérer au moins environ 15 % du peroxyde en 15 minutes.
EP22708721.0A 2021-02-19 2022-02-18 Compositions de soins buccodentaires hydratantes comprenant du peroxyde Withdrawn EP4294354A1 (fr)

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US202163151091P 2021-02-19 2021-02-19
US202163151099P 2021-02-19 2021-02-19
US202163151096P 2021-02-19 2021-02-19
US202163219929P 2021-07-09 2021-07-09
US17/577,405 US20220265533A1 (en) 2021-02-19 2022-01-18 Hydrating oral care compositions comprising peroxide
US17/577,399 US20220265530A1 (en) 2021-02-19 2022-01-18 Oral care compositions comprising peroxide and polymer
US17/577,402 US20220265531A1 (en) 2021-02-19 2022-01-18 Oral care compositions comprising peroxide and compatible abrasive
US17/577,404 US20220265532A1 (en) 2021-02-19 2022-01-18 Oral care compositions comprising peroxide and alumina
PCT/US2022/070717 WO2022178530A1 (fr) 2021-02-19 2022-02-18 Compositions de soins buccodentaires hydratantes comprenant du peroxyde

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US3959458A (en) 1973-02-09 1976-05-25 The Procter & Gamble Company Oral compositions for calculus retardation
US3988433A (en) 1973-08-10 1976-10-26 The Procter & Gamble Company Oral compositions for preventing or removing stains from teeth
US4051234A (en) 1975-06-06 1977-09-27 The Procter & Gamble Company Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies
US20050143274A1 (en) * 2003-12-17 2005-06-30 Ghosh Chanchal K. Compositions and methods of delivering bleaching agents to teeth
US20090081136A1 (en) * 2007-09-24 2009-03-26 Deepak Sharma Compositions Useful For Tooth Whitening
US20130108559A1 (en) * 2011-11-01 2013-05-02 The Procter & Gamble Company Hydrogen Peroxide Toothpaste With Improved Stability
EP3328347A1 (fr) * 2015-07-28 2018-06-06 The Procter and Gamble Company Compositions d'hygiène buccale contenant des polymères, des copolymères ou des polymères réticulés amps
MX2019001584A (es) * 2016-08-09 2019-07-01 Symrise Ag Mezclas que comprenden (e)-3-benzo[1,3]dioxol-5-il-n,n-difenil-2-p ropenamida.
CA3041126A1 (fr) 2016-10-26 2018-05-03 The Procter & Gamble Company Kit pour le blanchiment des dents
US10849729B2 (en) 2019-04-16 2020-12-01 The Procter & Gamble Company Multi-phase oral care compositions
JP2022529190A (ja) 2019-04-25 2022-06-17 ザ プロクター アンド ギャンブル カンパニー 活性剤送達のための口腔ケア組成物
MX2021011297A (es) * 2019-04-25 2021-10-13 Procter & Gamble Composiciones para el cuidado bucal para el suministro de agente activo.

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