EP4228407A1 - Antimikrobielle zusammensetzung, insbesondere bakterizid, viruzides, fungizides und mykobakterielles mittel zur reinigung von kontaminierten oberflächen und verwendung - Google Patents
Antimikrobielle zusammensetzung, insbesondere bakterizid, viruzides, fungizides und mykobakterielles mittel zur reinigung von kontaminierten oberflächen und verwendungInfo
- Publication number
- EP4228407A1 EP4228407A1 EP21802420.6A EP21802420A EP4228407A1 EP 4228407 A1 EP4228407 A1 EP 4228407A1 EP 21802420 A EP21802420 A EP 21802420A EP 4228407 A1 EP4228407 A1 EP 4228407A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- copper
- composition
- based compounds
- antimicrobial composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 61
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 37
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 12
- 238000004140 cleaning Methods 0.000 title claims abstract description 11
- 230000000855 fungicidal effect Effects 0.000 title claims abstract description 9
- 230000003253 viricidal effect Effects 0.000 title claims abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 23
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910052802 copper Inorganic materials 0.000 claims abstract description 22
- 239000010949 copper Substances 0.000 claims abstract description 22
- 239000004094 surface-active agent Substances 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims abstract description 9
- 239000000645 desinfectant Substances 0.000 claims description 20
- 238000011012 sanitization Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 241000894006 Bacteria Species 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 7
- 241000233866 Fungi Species 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 239000003599 detergent Substances 0.000 claims description 6
- 239000002738 chelating agent Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 claims description 4
- 238000005202 decontamination Methods 0.000 claims description 3
- 230000003588 decontaminative effect Effects 0.000 claims description 3
- 241000186359 Mycobacterium Species 0.000 claims description 2
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000000047 product Substances 0.000 description 24
- 238000011109 contamination Methods 0.000 description 9
- 239000004599 antimicrobial Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 6
- 238000005507 spraying Methods 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- 241000305071 Enterobacterales Species 0.000 description 4
- 239000003570 air Substances 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 239000000344 soap Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229910001431 copper ion Inorganic materials 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 229910052572 stoneware Inorganic materials 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical class ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 241000700141 Rotifera Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- -1 e.g. Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/046—Salts
Definitions
- the present invention relates to an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces and to the use of the same.
- the surfaces of objects and articles ranging from floors, ceilings, door panels, glass windows to, e.g., medical devices, systems, machinery, kitchen worktops, kitchen equipment, can all be contaminated or colonized by microorganisms such as viruses, bacteria, mold, fungi, and in fact, if left dirty, are almost always contaminated with microbes to some degree.
- Known antimicrobial compositions such as, e.g., commercially available disinfectants, soaps, detergents and sanitizing agents used to fight against contamination of solutions and surfaces with pathogens such as viruses or bacteria are only partly effective in reducing or preventing contamination of any nature, whether viral, microbial, fungal or mycobacterial.
- DBPs Disinfection Byproducts
- QACs quaternary ammonium compounds
- QACs are highly toxic to numerous aquatic organisms, comprising fish, daphnids, algae, rotifers, and other utilized microorganisms, as well as to the environment and humans.
- Improved or new antimicrobial compositions and disinfectants, soaps, detergents and sanitizing agents are more efficient, more effective and/or safer when considering the duration of prevention against contamination and/or when considering the degree of decontamination and/or when considering the risk to human health or to the environment.
- a first object of the invention is to provide an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces and its use, with an improved antimicrobial activity against microbes such as viruses, bacteria, fungi and mycobacteria, without posing an unacceptable risk to the environment or human health.
- a second object of the invention is to provide an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces, which has improved as far as killing microbes, preferably viruses, bacteria, fungi and mycobacteria is concerned, and/or the prevention of the microbial growth on a surface, which, in contrast to known state-of-the-art antimicrobial compositions, does not contain compounds which may cause adverse consequences for the environment and human health, and which is sufficiently effective at eliminating contamination.
- Another object of the present invention is to devise an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces and its use which allows the mentioned drawbacks of the prior art to be overcome within a simple, rational, easy and effective to use as well as affordable solution.
- Figures 1-3 are representative graphs of bactericidal efficacy tests and of the duration of the bactericidal action over time.
- the present invention relates to an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces.
- antimicrobial activity has its normal scientific meaning throughout the text, and here relates to the activity that kills or blocks the growth of microorganisms.
- carrier as used herein has its normal scientific meaning throughout the text and here relates to anything in which or on which contaminants, such as microorganisms, i.e. microbes such as bacteria, may be present and/or grow.
- such a carrier is an aqueous solution, a gas such as air, an object, or a surface such as the surface of an object, such as, e.g., the surface of a ceiling, wall, floor, table, kitchen worktop, machinery, etc.
- surface has its normal scientific meaning throughout the text, and here relates to any part of an object that constitutes its outer layer, comprising the flat surfaces such as e.g. floors, ceilings, door panels, glass panes, etc., but also other objects such as, e.g., medical devices, systems, machinery, kitchen equipment, etc.
- contamination as used herein relates to the undesirable presence of pathogens inside or on an object, in an aqueous solution or in a gas such as air.
- infectious agent has its normal scientific meaning throughout the text, and herein relates to a biocidal antimicrobial agent or an antimicrobial or biocidal solution which is, e.g., applied to the surface of inanimate objects or to a gas such as air, or, in order to destroy living microorganisms on such objects or to prevent contamination of such objects by microbes such as bacteria, viruses, fungi and mycobacteria.
- the composition comprises: one or more copper-based compounds; one or more surfactants; and an aqueous solution.
- one or more copper-based compounds indicates that the composition may comprise a plurality of copper-based compounds, either belonging to the same chemical type or belonging to different chemical types.
- one or more surfactants indicates that the composition may comprise a plurality of surfactants, either belonging to the same chemical type or belonging to different chemical types.
- the one or more copper-based compounds are present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 0.0001% and 50%.
- the one or more copper-based compounds are present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 5% and 20%.
- the one or more copper-based compounds are present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 10% and 15%.
- each of the one or more copper-based compounds comprise a concentration by weight of copper metal, estimated with respect to the total weight of the one or more copper-based compounds, comprised between 0.0001% and 50%.
- the one or more copper-based compounds comprise copper sulfate.
- the one or more copper-based compounds comprise pentahydrate copper sulfate.
- the one or more surfactants are present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 1% and 40%.
- composition according to the present invention comprises at least one surfactant present in a concentration by weight comprised between 10% and 20%.
- the latter comprises a mixture of surfactants present in an overall concentration by weight comprised between 20% and 35%.
- the aforementioned surfactants are of the ionic and/or non-ionic type.
- composition according to the invention comprises hydrochloric acid present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 0.5% and 15%.
- composition according to the invention comprises one or more chelating agents of the one or more copper-based compounds.
- the presence of the aforementioned chelating agents is adapted to allow avoiding the precipitation of the one or more copper-based compounds inside the antimicrobial composition and, at the same time, to allow the maintenance thereof in solution.
- the present invention relates to a disinfectant product, comprising: a) the antimicrobial composition as described above; and b) a thinner, preferably water.
- the disinfectant product comprises the antimicrobial composition in a concentration by weight, estimated with respect to the total weight of the product, comprised between 0.01% and 5%.
- the antimicrobial composition according to the present invention has a concentration comprised between 10 mL/L of water and 17 mL/L of water, preferably 15 mL/L of water.
- the disinfectant product has a pH comprised between 0 and 14.
- the disinfectant product has a pH comprised between 3 and 6.
- the aforementioned acid pH allows, in combination with the chelating agents, chelating only a minimum percentage of copper ions, thus ensuring that the latter remain active and persistent on the treated surfaces.
- the disinfectant product comprises at least one of: one or more antifoaming agents or one or more pH adjusting agents.
- the present invention relates to the use of the antimicrobial composition in the decontamination of a surface contaminated by a microbe such as a bacterium, virus, or fungus, or a mycobacterium in which the antimicrobial composition is added to the aqueous solution at a concentration of at least 0.01% by weight of the antimicrobial composition based on the total weight of the aqueous solution.
- a microbe such as a bacterium, virus, or fungus
- mycobacterium in which the antimicrobial composition is added to the aqueous solution at a concentration of at least 0.01% by weight of the antimicrobial composition based on the total weight of the aqueous solution.
- the aforementioned protocol was set up by employing the disinfectant product (PRODUCT) with three different concentrations of the antimicrobial composition (COMPOSITION) according to the present invention.
- the antimicrobial composition employed in the aforementioned experimental protocol comprises: pentahydrate copper sulfate present in a concentration by weight substantially equal to 13.5%; surfactants present in an overall concentration by weight substantially equal to 33.6%; hydrochloric acid present in a concentration by weight substantially equal to 8.9%; water present in a concentration by weight substantially equal to 43.2%.
- the disinfectant product thus prepared was sprayed as follows: a surface (worktop) made of monolithic stoneware has been artificially contaminated by spraying with waste water (the same water and the same level of spraying will be used);
- the copper ions released in water, by means of ionic bonds form the protective film having considerable effectiveness and duration over time compared to the currently known antimicrobial compositions and disinfectant products.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102020000024271A IT202000024271A1 (it) | 2020-10-14 | 2020-10-14 | Composizione antimicrobica, particolarmente battericida, virucida, fungicida e micobatterica per la detersione di superfici contaminate e relativo uso |
PCT/IB2021/059393 WO2022079626A1 (en) | 2020-10-14 | 2021-10-13 | Antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces and its use |
Publications (1)
Publication Number | Publication Date |
---|---|
EP4228407A1 true EP4228407A1 (de) | 2023-08-23 |
Family
ID=74068488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21802420.6A Pending EP4228407A1 (de) | 2020-10-14 | 2021-10-13 | Antimikrobielle zusammensetzung, insbesondere bakterizid, viruzides, fungizides und mykobakterielles mittel zur reinigung von kontaminierten oberflächen und verwendung |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP4228407A1 (de) |
IT (1) | IT202000024271A1 (de) |
WO (1) | WO2022079626A1 (de) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6923991B2 (en) * | 2002-02-20 | 2005-08-02 | Global Microbio Products, L.L.C. | Bactericide solution and method of making same |
US20040033916A1 (en) * | 2002-06-28 | 2004-02-19 | Kuzmin Vladimir Semenovich | Disinfecting composition |
US7465697B1 (en) * | 2006-11-02 | 2008-12-16 | Ohsoclean, Inc. | Essential oils based cleaning and disinfecting compositions |
US10440958B1 (en) * | 2014-12-05 | 2019-10-15 | Pen Inc. | Disinfectant material comprising a copper halide salt and surfactant |
MA41546A (fr) * | 2015-02-12 | 2017-12-26 | Cremona Christian | Désinfectant à base d'eau |
-
2020
- 2020-10-14 IT IT102020000024271A patent/IT202000024271A1/it unknown
-
2021
- 2021-10-13 WO PCT/IB2021/059393 patent/WO2022079626A1/en unknown
- 2021-10-13 EP EP21802420.6A patent/EP4228407A1/de active Pending
Also Published As
Publication number | Publication date |
---|---|
IT202000024271A1 (it) | 2022-04-14 |
WO2022079626A1 (en) | 2022-04-21 |
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