Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/76—Salicaceae (Willow family), e.g. poplar
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
  • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
  • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D11/00—Solvent extraction
  • B01D11/02—Solvent extraction of solids
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D11/00—Solvent extraction
  • B01D11/02—Solvent extraction of solids
  • B01D11/0203—Solvent extraction of solids with a supercritical fluid
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D11/00—Solvent extraction
  • B01D11/02—Solvent extraction of solids
  • B01D11/0288—Applications, solvents

Definitions

• the present group of inventions relates to healthcare, more specifically concerns dentistry and is intended for the treatment and/or prevention of the oral diseases.
• the group of inventions includes a composition for the treatment and/or prevention of the oral diseases comprising an effective amount of aqueous and lipophilic extracts of aspen bark and at least one or more auxiliary compounds for the treatment and/or prevention.
• the group of inventions also includes the use of a composition for the manufacture of a product for the treatment and/or prevention of the oral diseases.
• the oral diseases are among the most common non-communicable diseases and affect people throughout their lives, causing pain and discomfort, leading to tooth loss and the occurrence of concomitant diseases.
• Products comprising active substances in their composition are characterized by a narrowly directed action and a short duration of action after use, which generally indicates their low therapeutic effectiveness.
• Preventive and therapeutic products for home use do not provide sufficiently effective prevention.
• the purpose of the present invention is to create a composition that is effective in the treatment and/or prevention of various the oral diseases, having a complex effect and a long-lasting effect even at home.
• composition of preventive and/or therapeutic action comprising an effective amount of aqueous and lipophilic extracts of aspen bark for treatment and/or prevention, and at least one or more acceptable carriers and/or auxiliary agents.
• Dental compositions comprising a separate aqueous extract of aspen bark are known from the prior art.
• a dental elixir comprising ethyl alcohol, polyatomic alcohol, extracts of vegetable raw materials, essential oils, a flavor additive and drinking water, wherein it additionally comprises lignans from lignan-containing plants, selenocysteine, as extracts of vegetable raw materials - water extracts of bog strawberry, stevia leaves, turnip leaves, cerapadus leaves, aspen bark, as essential oils - oils tea tree and myrrh, and as a flavoring additive - rebaudioside A.
• compositions for the prevention of periodontal diseases comprising a plant extract, ethyl alcohol, menthol, flavoring agent and water, characterized in that, in order to increase activity by improving the permeability of the oral mucosa, it additionally comprises polyvinylpyrrolidone, sodium lauryl sulfate, an antiseptic, and as a plant extract - an aqueous extract of aspen bark with the following component content, wt.
• % an aqueous extract of aspen bark 20.0-25.0; polyvinylpyrrolidone 4.0-6.0; sodium lauryl sulfate 1.0-3.0; antiseptic preservative (propyl ether of paraoxybenzoic acid or sodium benzoate) 0.2-0.5; ethyl alcohol (96 °) 10.0-20.0; menthol 1.0-1.8; flavoring agent 0.7-1.5; water up to 100.
• the water extract of aspen bark comprises glycosides (salicin, salicortin, etc.), up to 10% of tannins, essential oils, phytoncites, amino acids, macro - and microelements, substances with P-vitamin activity (coumarins and flavonoids) and other biologically active substances. They have anti-inflammatory, anti-radiation, antiseptic and hemostatic, as well as astringent effect. Due to the latter, the permeability of the oral mucosa to biologically active substances increases, which improves the trophism of periodontal tissues, has a therapeutic and preventive and healing effect.
• Therapeutic and prophylactic toothpaste "Osinka”, known from the patent of the RU 2090183, comprises plant extracts, chalk, glycerin, sodium carboxymethylcellulose, flavoring agent, aerosil, sodium lauryl sulfate, perfume oil, antiseptic preservative and water, gliderinine sodium salt, polyvinylpyrrolidone, xylitol-sorbitol syrup and an aqueous extract of aspen bark.
• the products disclosed above comprise only an aqueous extract of aspen bark as an active agent.
• aspen bark comprise substances that are soluble in organic solvents.
• tannins, organic acids, mineral salts, etc. are released.
• Extraction with organic solvents allows to isolate fats, resins, waxes, essential oils, vitamins that are not available during water extraction, as well as phenol glycosides and flavonoids.
• the extract of diethyl ether of the aspen bark crust is active against such bacterial species as Bacillus subtilus, Escherichia coli; Clavibacter m.s. michiganensis, Xanthomonas compestris, etc. (Natalia Mikhailovna Faustova, thesis submitted in partial fulfillment of the requirements for the degree of candidate of chemical sciences, Chemical composition of aspen bark and wood, St. Louis 2005, p. 7).
• the fractions of phenol glycosides and flavonoids isolated from the ethanol extract exhibit anti-ulcer activity: they reduce the prevalence of the ulcerative process by 40% and 50%, respectively.
• dry aspen bark extract obtained by extracting raw materials with 40% ethanol is used (Chalmers, R. A.
• composition according to the present invention uses an aqueous extract and a lipophilic one prepared by extraction of aspen bark with liquefied carbon dioxide, which allows the most complete use of the components of aspen bark that are useful in the prevention of the oral diseases.
• the resulting composition is characterized by high efficiency in the treatment and/or prevention of various the oral diseases compared to compositions that include only an aqueous extract of aspen bark, action against various pathogens of the oral diseases and a long-lasting effect.
• composition reduces the likelihood of the occurrence and/or elimination of inflammation, as well as ulcers and erosions of the oral cavity in situations that contribute to their formation.
• Such situations include the action of the causative agent of a bacterial infection, chemical or thermal bum of the oral cavity, injury of the oral cavity with a sharp object, etc.
• the present invention also concerns the use of the described composition for the treatment and/or prevention of the oral diseases. Moreover, when using this composition simultaneously with the effect of treatment and/or prevention, a high quality of hygienic cleaning of the surface of the teeth and the oral cavity as a whole is ensured.
• the use of the claimed composition allows to increase the buffer capacity of saliva, normalize its pH and increase its mineralizing potential. These properties allow the composition to be used in patients with non-removable orthodontic equipment who are on long-term orthodontic treatment.
• Conditions and/or diseases for which the proposed compositions have a preventive effect include acute and chronic forms of stomatitis, periodontal diseases, for example, gingivitis, periodontitis or parodontosis, dental caries, pulpitis.
• compositions of the invention also prevent the formation of plaque and/or dental calculus.
• compositions of the invention also contribute to the healing of injuries of the oral cavity and teeth.
• Alcohol extraction does not provide the lipophilic extract used in this composition, since it has a significant drawback: before alcohol extraction, the lipid complex is not extracted, which creates certain difficulties in isolating the target products and requires the introduction of a purification stage (Natalia Mikhailovna Faustova, issertation submitted in partial fulfillment of the requirements for the degree of candidate of chemical sciences, Chemical composition of aspen bark and wood, St. Louis 2005).
• liquefied carbon dioxide is used for the preparation of a lipophilic extract according to the present invention.
• Liquefied carbon dioxide is a colorless, easily mobile liquid, the viscosity is 14 times less than the viscosity of water, 5 times less than ethyl alcohol. Such properties of carbon dioxide distinguish it as an extractant with the best diffusion properties.
• Low values of the heat of vaporization (condensation) indicate a relatively small energy consumption required for evaporation and condensation of the solvent when using it in the technological cycle.
• Liquefied CO2 is a strong and inert substance that exhibits complete chemical indifference to processed raw materials, recoverable substances, and structural materials of equipment.
• the dielectric constant for liquefied CO2 at 10°C is 2.6. This value of the dielectric constant is characteristic of nonpolar solvents, which makes it possible to extract nonpolar or weakly polar substances from the crust. These include essential and fatty oils; carbonyl compounds; fat-soluble vitamins (A, D, K, F, E); sterols; alkaloids in the form of bases, etc.
• Extraction and distillation of the solvent at a low temperature makes it possible to extract essential oils and biologically active components in the native state.
• Liquid CO2 does not support the vital activity of microorganisms and mold fungi, which makes it possible to obtain sterile extracts.
• Extraction in a liquid CO2 environment completely eliminates oxidation due to the absence of aeration.
• the physico-chemical features of the solvent used contribute to the extraction of substances from plant raw materials practically without changing their properties. Distillation is provided by a pressure reduction that turns liquid CO2 into a gaseous state, while a CO2 extract (lipophilic extract) is released.
• the water extract is obtained using standard methods. Extraction can be carried out at room or elevated temperature, extraction can also be carried out using boiling water or aqueous solutions and standard containers and connecting equipment. If necessary, water or an aqueous solution of alkali or an aqueous solution of acid can be used as an extractant, the pH of the solution can be adjusted if necessary, the values and methods are standard and known to specialists in this field.
• Extracts according to the invention can be obtained by using suitable techniques, including those known to specialists in this field. If necessary, extracts can be separated from negative compounds by filtration, chromatography, extraction or other standard techniques.
• the quantitative ratio of the aqueous and lipophilic extract of aspen bark in the mixture is 1:1-100:1.
• the quantitative ratio can be represented by the ratios 1:1, 2:1, 5:1, 10:1, 20:1, 30:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1, 100:1, as well as ratios close to this (within the error of the corresponding measurements).
• the extracts can be pre-mixed or added to the composition separately.
• the proposed composition is used for the manufacture of cosmetic, preventive and/or therapeutic product.
• the product can be made in the form of a toothpaste, a non-abrasive gel or a mouthwash.
• auxiliary agents such as thickeners, binding agents, abrasive agents (for toothpaste), wetting agents, foaming agents, flavorings, sweeteners, stabilizers, preservatives, anti-caries additives can be used.
• An auxiliary substance or auxiliary agent is a substance that contributes to giving the composition an acceptable form and properties for cosmetic, preventive and/or therapeutic use.
• Thickeners can be various cellulose derivatives, for example, carboxymethylcellulose, hydroxypropylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, alginates, for example, sodium alginate, carrageenan, xanthan gum, guar gum.
• composition in the form of a toothpaste according to the invention can be prepared using abrasive agents, for example, the following: hydroxyapatites, calcium phosphates, calcium, magnesium, aluminum silicates, silicon oxides, calcium, magnesium carbonates, sodium bicarbonate (baking soda).
• abrasive agents for example, the following: hydroxyapatites, calcium phosphates, calcium, magnesium, aluminum silicates, silicon oxides, calcium, magnesium carbonates, sodium bicarbonate (baking soda).
• the wetting agents in the composition can be glycerin, sorbitol, xylitol, polyethylene glycol or mixtures thereof.
• Alkylamidobetaines laurylsarcosinate salts, methyl cocoyltaurate salts, non-ionic surfactants, for example, PEG-40 hydrogenated castor oil or Polysorbate-20 can be used as surfactants in the composition.
• the following flavors can be used in the composition: essential oils or extracts of mint, lemon balm, clove, eucalyptus, orange, lemon, sage, lavender, sandalwood, cypress, etc.
• Acceptable sweeteners in the composition of the proposed compositions are, without limitation, saccharin or its derivatives, aspartame or its derivatives, stevioside, neohesperidin dihydrohalcone, glycyrrhizinates, acesulfame potassium, perillartin, p-methoxycoric aldehyde, xylitol.
• Vitamins E, C or their derivatives can be used as stabilizers in the composition.
• Hydroxybenzoic acid esters, alkyldiaminoethylglycine hydrochloride, parabens, for example, methylparaben, ethylparaben, propylparaben, sodium benzoate, potassium sorbate, ortho-5-cumen-ol can be used as preservatives in the composition.
• Calcium glycerophosphate, magnesium glycerophosphate, sodium fluoride, potassium fluoride, sodium monofluorophosphate, potassium monofluorophosphate can be used as anticaries additives in the composition.
• Auxiliary components and/or carriers may be present in the composition from about 0.1% to about 99% wt., in some cases - from about 0.1% to about 1% wt., in some cases - from about 1% to about 10% wt. in some cases - from about 10% to about 99% wt.
• the recommended doses of active components for adults are 0.02-3%.
• the recommended dose of the extract is up to 65% of the adult dose, for infants and young children - up to 10%, for children from 7 to 14 years - 50%.
• Fig. 1. shows the cultivation of S. mutans with the studied samples of toothpastes.
• compositions in the form of toothpaste are prepared as follows.
• the required amount of water is weighed in a measuring dispenser, then the water is loaded into a mixer, if necessary, heated to a temperature of 50-60°C. Thickener, wetting agents, sweetener, preservatives, anti-caries additives are added to the water. The mixture is mixed until a homogeneous gel is obtained, if necessary, homogenized and vacuumed. An abrasive filler is added to the resulting gel, mixed until a homogeneous mass is obtained, if necessary, homogenized and vacuumed. If necessary, the resulting mass is cooled to a temperature of 30-40°C, and surfactants, an aqueous extract of aspen bark, stabilizers, and a mixture of fragrance with CO2 extract of aspen bark are added. Mix, homogenize and vacuum if necessary. The manufactured toothpaste is pumped into storage tanks and packed into tubes on filling machines.
• compositions in the form of a non-abrasive gel are prepared as follows.
• the required amount of water is weighed in a measuring dispenser, then the water is loaded into a mixer, if necessary, heated to a temperature of 50-60°C. Thickener, wetting agents, sweetener, preservatives, anti-caries additives are added to the water. The mixture is mixed until a homogeneous gel is obtained, if necessary, homogenized and vacuumed. If necessary, the resulting mass is cooled to a temperature of 30-40°C, and surfactants, an aqueous extract of aspen bark, stabilizers, and a mixture of fragrance with CO2 extract of aspen bark are added. Mix, homogenize and vacuum if necessary. The manufactured gel is pumped into storage tanks and packed into tubes on filling machines.
• compositions according to the invention can be prepared using standard techniques.
• compositions according to the present invention are illustrative in nature and are not restrictive. It is clear to the specialist that compositions with the properties of the invention can be implemented in other formulations that meet the characteristics of the invention.
• Non- abrasive gel
• the water extract of aspen used in the preparation of compositions is characterized by a mass fraction of water and volatile substances - 86.6 %; a mass fraction of tannins - 2.0%.
• Lipophilic (fat-soluble) CO2 extract comprises 4.35% water and volatile substances, 4.0% tannins.
• the mixture of extracts is characterized by the presence in its formulation of phenolic glycosides (salicin, salicortin, tremuloicin), tannins, organic acids (oleic, linoleic, palmitic, capric, lauric, arachin, begenic), triterpenoids, pectin, glycine betaine, flavonoids, wax, sterols, carotenoids, polysaccharides, anthocyanins, glycolipids, phospholipids.
• phenolic glycosides salicin, salicortin, tremuloicin
• tannins organic acids (oleic, linoleic, palmitic, capric, lauric, arachin, begenic), triterpenoids, pectin, glycine betaine, flavonoids, wax, sterols, carotenoids, polysaccharides, anthocyanins, glycolipids, phospholipids.
• a liquid nutrient medium - Todd Hewitt Broth (M313) - was used.
• 50 ml tubes with a membrane filter (TubeSpin SW) were used.
• a bacterial suspension in the amount of 5 ml was prepared separately in sterile test tubes with a volume of 15 ml.
• the optical density of the resulting suspension was measured using a DEB- IB densitometer (BioSan, Lithuania).
• the concentration of the test sample was 0.1 g/1 ml.
• the adaptive phase When cultivating a clinical S. mutans isolate, in a control sample, the adaptive phase lasted up to 8 hours. This phase corresponds to the period of physiological adaptation, including the induction of enzymes, synthesis and assembly of ribosomes.
• the initial stationary period lasted up to 4 hours, 4-6 hours - the period of initial cell growth, 6-8 hours-the period of accelerated development.
• the exponential phase was marked by a classical jump in the optical density at the interval of 8-16 hours, after which a period of growth delay with a sharp transition to stationary equilibrium is traced.
• the peak optical density index at the end of true logarithmic development is 4.51+0.3 mcf (16 hours)
• the total indicator for the entire period of culture development is 5.25+0.3 mcf (16 hours).
• the stationary phase characterized by the equilibrium between cell growth and division and the process of cell death, was short (18-24 hours), followed by a gradual transition of the culture into the dying phase.
• the average optical density in stationary equilibrium is 5.28+0.3 mcf.
• Cultivation of the bacterial population of S. mutans with the addition of the studied samples of pastes 1 and 2 showed the following: Sample 2 - the adaptive phase is significantly prolonged compared to the control sample: up to 6 hours - the initial stationary period; up to 8 hours - the period of initial cell growth; up to 14 hours - the period of accelerated cell development.
• the period of accelerated cell development is characterized by the beginning of cell division, an increase in the total mass of the population and a constant increase in the growth rate of the culture, but exponential signs of growth were noted only after 15 hours of the experiment.
• the duration of logarithmic cell development was shortened compared to the control sample, and the rate of generation of new populations, therefore, the change in the optical density index was an order of magnitude lower.
• the indicator a is 4.15+0.3 mcf (22 hours)
• the indicator P is 4.25+0.3 mcf (24 hours).
• the stationary equilibrium phase was longer than in the control sample, with an average optical density of 4.25+0.3 mcf (24 hours).
• Example 5 The effectiveness of toothpaste in patients undergoing orthodontic treatment.
• the first group carried out oral hygiene using a toothpaste comprising an aqueous and lipophilic extract of aspen bark, (the composition of the paste corresponds to sample 4, disclosed in Example 3);
• the second group carried out oral hygiene using a toothpaste comprising only an aqueous extract of aspen bark, (the composition of the paste corresponds to sample 1, disclosed in Example 4);
• the third group (control) carried out oral hygiene using a toothpaste that does not comprise aspen extracts, attention was not focused on the specific composition of the paste.
• the hygiene efficiency index O'Leary
• PMA the index of the state of periodontal tissues
• the conducted studies have shown the following. During the study period, there was no significant change in the rate of salivation for patients of all groups. In the subjects of the first and second groups, the hygiene index significantly decreased, which corresponds to a decrease in the amount of plaque and dental calculus. A slight decrease in the O'Leary index is also observed in patients of the control group. The subjects of the first and second groups also have a significant improvement in the condition of the gums at the teeth. In patients of the first and second groups, a decrease in the viscosity of saliva was also observed, which leads to a more complete cleaning of the surfaces of the teeth and oral cavity, and contributes to an increase in its remineralizing potential. The use of a paste comprising extracts of aspen bark leads to a shift in the pH of saliva to a more neutral area.
• composition characterized by the presence of two aspen extracts: lipophilic and aqueous, demonstrates excellent properties not only in comparison with the control compositions, but also in comparison with a paste comprising only an aqueous extract of aspen bark.
• a method for the prevention and treatment of oral diseases using the composition of the present invention consists in applying it to the surface of the teeth and finding the composition in the oral cavity and on the surface of the teeth for 5 seconds to 5 minutes of time. Preferably from 30 seconds to 4 minutes. Preferably from 1 minute to 4 minutes.
• a brush can be additionally used.
• composition proposed in the scope of the present invention can be used in healthcare, providing effective prevention and/or treatment of the oral diseases.

Landscapes

• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• Animal Behavior & Ethology (AREA)
• Natural Medicines & Medicinal Plants (AREA)
• Engineering & Computer Science (AREA)
• Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Epidemiology (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Mycology (AREA)
• Biotechnology (AREA)
• Microbiology (AREA)
• Botany (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• General Chemical & Material Sciences (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Birds (AREA)
• Alternative & Traditional Medicine (AREA)
• Medical Informatics (AREA)
• Dermatology (AREA)
• Cosmetics (AREA)
• Medicines Containing Plant Substances (AREA)
• Medicinal Preparation (AREA)

Applications Claiming Priority (2)

Publications (2)

Family

ID=75919738

Family Applications (1)

Country Status (8)

Family Cites Families (10)

• 2020
  • 2020-08-24 RU RU2020128107A patent/RU2747983C1/ru active
• 2021
  • 2021-08-23 KR KR1020237009886A patent/KR20230054713A/ko active Pending
  • 2021-08-23 BR BR112023003283A patent/BR112023003283A2/pt unknown
  • 2021-08-23 US US18/023,264 patent/US20230320976A1/en active Pending
  • 2021-08-23 JP JP2023505933A patent/JP2023537868A/ja active Pending
  • 2021-08-23 CN CN202180052351.5A patent/CN115968305A/zh active Pending
  • 2021-08-23 WO PCT/RU2021/050275 patent/WO2022045933A1/en not_active Ceased
  • 2021-08-23 CN CN202511189178.XA patent/CN120860116A/zh active Pending
  • 2021-08-23 EP EP21862183.7A patent/EP4199944A4/de active Pending
• 2025
  • 2025-01-30 JP JP2025013706A patent/JP2025072430A/ja active Pending

Also Published As

Similar Documents

Legal Events