EP4161547A4 - Methanol-based extraction of psychoactive compounds from fungus - Google Patents

Methanol-based extraction of psychoactive compounds from fungus Download PDF

Info

Publication number
EP4161547A4
EP4161547A4 EP21825822.6A EP21825822A EP4161547A4 EP 4161547 A4 EP4161547 A4 EP 4161547A4 EP 21825822 A EP21825822 A EP 21825822A EP 4161547 A4 EP4161547 A4 EP 4161547A4
Authority
EP
European Patent Office
Prior art keywords
fungus
methanol
based extraction
psychoactive compounds
psychoactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21825822.6A
Other languages
German (de)
French (fr)
Other versions
EP4161547A1 (en
Inventor
Benjamin Lightburn
Ryan Moss
Lisa Ranken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psilo Scientific Ltd
Original Assignee
Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA3088384A external-priority patent/CA3088384C/en
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Publication of EP4161547A1 publication Critical patent/EP4161547A1/en
Publication of EP4161547A4 publication Critical patent/EP4161547A4/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0253—Fluidised bed of solid materials
    • B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B01D11/0284—Multistage extraction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP21825822.6A 2020-06-17 2021-06-16 Methanol-based extraction of psychoactive compounds from fungus Pending EP4161547A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063040317P 2020-06-17 2020-06-17
US202063046089P 2020-06-30 2020-06-30
CA3088384A CA3088384C (en) 2020-06-17 2020-07-29 Extraction of psychoactive compounds from psilocybin fungus
CA3089455A CA3089455C (en) 2020-06-17 2020-08-07 Methanol-based extraction of psychoactive compounds from fungus
PCT/CA2021/050823 WO2021253124A1 (en) 2020-06-17 2021-06-16 Methanol-based extraction of psychoactive compounds from fungus

Publications (2)

Publication Number Publication Date
EP4161547A1 EP4161547A1 (en) 2023-04-12
EP4161547A4 true EP4161547A4 (en) 2023-11-01

Family

ID=82309500

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21825822.6A Pending EP4161547A4 (en) 2020-06-17 2021-06-16 Methanol-based extraction of psychoactive compounds from fungus

Country Status (6)

Country Link
US (1) US20220305402A1 (en)
EP (1) EP4161547A4 (en)
AU (1) AU2021291726B2 (en)
BR (1) BR112022025778A2 (en)
CA (1) CA3163795C (en)
MX (1) MX2022016530A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB911946A (en) * 1958-02-21 1962-12-05 Sandoz Ltd Psilocybin and psilocin and processes for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550166A (en) * 1995-03-17 1996-08-27 Ostlund; Richard E. Pinitol and derivatives thereof for the treatment of metabolic disorders
WO2019099745A1 (en) * 2017-11-16 2019-05-23 CaaMTech, LLC Compositions comprising a psilocybin derivative and a cannabinoid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB911946A (en) * 1958-02-21 1962-12-05 Sandoz Ltd Psilocybin and psilocin and processes for their preparation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JANIS FRICKE ET AL: "Production Options for Psilocybin: Making of the Magic", CHEMISTRY - A EUROPEAN JOURNAL, vol. 25, no. 4, 18 January 2019 (2019-01-18), DE, pages 897 - 903, XP055766088, ISSN: 0947-6539, DOI: 10.1002/chem.201802758 *
PELLEGRINI MANUELA ET AL: "Magic truffles or Philosopher's stones: a legal way to sell psilocybin?", vol. 5, no. 3, 28 February 2013 (2013-02-28), pages 182 - 185, XP009547892, ISSN: 1942-7611, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdta.1400> [retrieved on 20120809], DOI: 10.1002/DTA.1400 *
PIOTR PAWEL WIECZOREK ET AL: "Bioactive Alkaloids of Hallucinogenic Mushrooms", 30 November 2015 (2015-11-30), XP009545779, ISBN: 978-0-444-63462-7, Retrieved from the Internet <URL:https://ebookcentral.proquest.com/lib/epo-ebooks/reader.action?docID=2036175&ppg=148> [retrieved on 20150427] *
See also references of WO2021253124A1 *
TSUJIKAWA KENJI ET AL: "Morphological and chemical analysis of magic mushrooms in Japan", vol. 138, no. 1-3, 30 November 2003 (2003-11-30), pages 85 - 90, XP009547895, ISSN: 0379-0738, Retrieved from the Internet <URL:https://api.elsevier.com/content/article/PII:S0379073803003785?httpAccept=text/plain> [retrieved on 20230919], DOI: 10.1016/J.FORSCIINT.2003.08.009 *

Also Published As

Publication number Publication date
MX2022016530A (en) 2023-04-05
AU2021291726A1 (en) 2023-02-02
CA3163795C (en) 2023-06-13
EP4161547A1 (en) 2023-04-12
US20220305402A1 (en) 2022-09-29
AU2021291726B2 (en) 2023-12-21
CA3163795A1 (en) 2021-12-23
BR112022025778A2 (en) 2023-01-10

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Owner name: PSILO SCIENTIFIC LTD

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RIC1 Information provided on ipc code assigned before grant

Ipc: C12P 17/10 20060101ALI20230928BHEP

Ipc: A61P 25/00 20060101ALI20230928BHEP

Ipc: A61K 45/06 20060101ALI20230928BHEP

Ipc: C12P 17/00 20060101ALI20230928BHEP

Ipc: C07F 9/572 20060101ALI20230928BHEP

Ipc: C07D 209/16 20060101ALI20230928BHEP

Ipc: B01D 11/02 20060101ALI20230928BHEP

Ipc: A61K 31/675 20060101ALI20230928BHEP

Ipc: A61K 31/4045 20060101ALI20230928BHEP

Ipc: A23L 31/00 20160101ALI20230928BHEP

Ipc: A61K 36/07 20060101AFI20230928BHEP