EP4138904A4 - Rekombinantes rotavirus-expressionssystem und rekombinante rotaviren - Google Patents

Rekombinantes rotavirus-expressionssystem und rekombinante rotaviren Download PDF

Info

Publication number
EP4138904A4
EP4138904A4 EP21792557.7A EP21792557A EP4138904A4 EP 4138904 A4 EP4138904 A4 EP 4138904A4 EP 21792557 A EP21792557 A EP 21792557A EP 4138904 A4 EP4138904 A4 EP 4138904A4
Authority
EP
European Patent Office
Prior art keywords
recombinant rotavirus
expression system
rotavirus
recombinant
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21792557.7A
Other languages
English (en)
French (fr)
Other versions
EP4138904A1 (de
Inventor
John Thomas Patton
Asha Ann Philip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University
Indiana University Bloomington
Original Assignee
Indiana University
Indiana University Bloomington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University, Indiana University Bloomington filed Critical Indiana University
Publication of EP4138904A1 publication Critical patent/EP4138904A1/de
Publication of EP4138904A4 publication Critical patent/EP4138904A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12341—Use of virus, viral particle or viral elements as a vector
    • C12N2720/12343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP21792557.7A 2020-04-20 2021-04-20 Rekombinantes rotavirus-expressionssystem und rekombinante rotaviren Pending EP4138904A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063012870P 2020-04-20 2020-04-20
PCT/US2021/028195 WO2021216575A1 (en) 2020-04-20 2021-04-20 Recombinant rotavirus expression system and recombinant rotaviruses

Publications (2)

Publication Number Publication Date
EP4138904A1 EP4138904A1 (de) 2023-03-01
EP4138904A4 true EP4138904A4 (de) 2024-10-09

Family

ID=78270067

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21792557.7A Pending EP4138904A4 (de) 2020-04-20 2021-04-20 Rekombinantes rotavirus-expressionssystem und rekombinante rotaviren

Country Status (6)

Country Link
EP (1) EP4138904A4 (de)
JP (1) JP2023523411A (de)
CN (1) CN115942955A (de)
BR (1) BR112022021259A2 (de)
CA (1) CA3180688A1 (de)
WO (1) WO2021216575A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12173032B2 (en) 2018-07-13 2024-12-24 The Trustees Of Indiana University Recombinant rotavirus expression system and recombinant rotaviruses
EP4323383A4 (de) * 2021-04-15 2025-08-13 Merck Sharp & Dohme Llc Rotavirusvektoren zur heterologen genverabreichung
CN116694578A (zh) * 2023-04-29 2023-09-05 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 稳定表达t7聚合酶细胞系、轮状病毒反向遗传系统及其构建方法和应用
WO2025059470A1 (en) * 2023-09-15 2025-03-20 Board Of Regents, The University Of Texas System Stabilized sars-cov-2 s antigens
CN117866858B (zh) * 2023-11-30 2024-06-21 吉林农业大学 一种表达猪轮状病毒抗原的重组植物乳杆菌及其应用
CN117947096B (zh) * 2024-01-16 2024-08-30 伊诺维康(北京)生物科技有限公司 一种羊轮状病毒重组质粒、反向遗传病毒学拯救系统及其构建方法和应用
CN117904197B (zh) * 2024-01-16 2024-08-27 伊诺维康(北京)生物科技有限公司 一种羊轮状病毒感染性克隆质粒和构建方法、羊轮状病毒的反向遗传病毒拯救系统及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022005503A1 (en) * 2020-06-29 2022-01-06 The Scripps Research Institute Stabilized coronavirus spike (s) protein immunogens and related vaccines
WO2022221159A1 (en) * 2021-04-15 2022-10-20 Merck Sharp & Dohme Llc Rotavirus vectors for heterologous gene delivery

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1618127B1 (de) * 2003-04-10 2014-12-10 Novartis Vaccines and Diagnostics, Inc. Immunogenische Zusammensetzung einer Spikeprotein des SARS Coronavirus
US12173032B2 (en) * 2018-07-13 2024-12-24 The Trustees Of Indiana University Recombinant rotavirus expression system and recombinant rotaviruses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022005503A1 (en) * 2020-06-29 2022-01-06 The Scripps Research Institute Stabilized coronavirus spike (s) protein immunogens and related vaccines
WO2022221159A1 (en) * 2021-04-15 2022-10-20 Merck Sharp & Dohme Llc Rotavirus vectors for heterologous gene delivery

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PHILIP ASHA A. ET AL: "Rotavirus as an Expression Platform of the SARS-CoV-2 Spike Protein", BIORXIV, 18 February 2021 (2021-02-18), XP093194339, Retrieved from the Internet <URL:https://www.biorxiv.org/content/10.1101/2021.02.18.431835v1> [retrieved on 20240815], DOI: 10.1101/2021.02.18.431835 *
See also references of WO2021216575A1 *

Also Published As

Publication number Publication date
WO2021216575A1 (en) 2021-10-28
EP4138904A1 (de) 2023-03-01
CN115942955A (zh) 2023-04-07
CA3180688A1 (en) 2021-10-28
BR112022021259A2 (pt) 2022-12-27
JP2023523411A (ja) 2023-06-05

Similar Documents

Publication Publication Date Title
EP4138904A4 (de) Rekombinantes rotavirus-expressionssystem und rekombinante rotaviren
EP4082451A4 (de) Verschluss und system
DE112022004033A5 (de) Leuchte und Leuchtenanordnung
EP4017424A4 (de) Interspinös-interlaminare stabilisierungssysteme und -verfahren
EP3915883A4 (de) Raumfahrzeug und steuerungssystem
DK3619324T3 (da) Rekombinante modificerede fibroblast-vækstfaktorer og terapeutiske anvendelser heraf
EP4117594A4 (de) Mobilitätssysteme und -verfahren
EP3672443A4 (de) Koffer und koffersystem
EP4294790A4 (de) Smarca-abbauer und verwendungen davon
EP4392454A4 (de) Anti-psma-antikörper und verwendungen davon
EP4097696C0 (de) Vorrichtungen und system
EP4452934A4 (de) Ionisierbare disulfidlipide und daraus gewonnene lipidnanopartikel
EP4305160A4 (de) Neuartige crispr-cas12i-systeme und verwendungen davon
EP3950559A4 (de) Kransteuerverfahren und kran
EP4418711A4 (de) Roaming-verfahren und -system
EP4405487A4 (de) Il-2-varianten und fusionsproteine davon
EP4166417A4 (de) Führungssystem und führungsverfahren
EP4187090A4 (de) Verdichter und verdichtersystem
EP4187089A4 (de) Verdichter und verdichtersystem
EP4198040C0 (de) Pt-dpephos-iod-komplex und pt-dpephos-brom-komplex
EP4200479C0 (de) Schnellwechsler und schnellwechselsystem
EP4083678A4 (de) Endoskop und endoskopsystem
EP4457877A4 (de) Mikro-led-struktur und mikro-led-projektor
EP4106781A4 (de) Rekombinante myxomaviren und verwendungen davon
EP4580176A4 (de) Regelsystem und regelverfahren

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20221118

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20240910

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/86 20060101ALI20240904BHEP

Ipc: C07K 14/005 20060101ALI20240904BHEP

Ipc: A61K 39/00 20060101ALI20240904BHEP

Ipc: A61K 39/12 20060101ALI20240904BHEP

Ipc: C07K 14/14 20060101ALI20240904BHEP

Ipc: A61P 31/14 20060101ALI20240904BHEP

Ipc: A61K 39/215 20060101AFI20240904BHEP