EP4121050A4 - Compositions polymorphes stables de bréquinar sodium et procédés d'utilisation et de fabrication de celles-ci - Google Patents
Compositions polymorphes stables de bréquinar sodium et procédés d'utilisation et de fabrication de celles-ciInfo
- Publication number
- EP4121050A4 EP4121050A4 EP21770978.1A EP21770978A EP4121050A4 EP 4121050 A4 EP4121050 A4 EP 4121050A4 EP 21770978 A EP21770978 A EP 21770978A EP 4121050 A4 EP4121050 A4 EP 4121050A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- manufacture
- methods
- brequinar sodium
- stable polymorphic
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PZOHOALJQOFNTB-UHFFFAOYSA-M brequinar sodium Chemical group [Na+].N1=C2C=CC(F)=CC2=C(C([O-])=O)C(C)=C1C(C=C1)=CC=C1C1=CC=CC=C1F PZOHOALJQOFNTB-UHFFFAOYSA-M 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062992720P | 2020-03-20 | 2020-03-20 | |
US202063020460P | 2020-05-05 | 2020-05-05 | |
US202063030677P | 2020-05-27 | 2020-05-27 | |
US202063043384P | 2020-06-24 | 2020-06-24 | |
US202063043382P | 2020-06-24 | 2020-06-24 | |
US202063043388P | 2020-06-24 | 2020-06-24 | |
US202063043386P | 2020-06-24 | 2020-06-24 | |
PCT/US2021/023350 WO2021189017A1 (fr) | 2020-03-20 | 2021-03-19 | Compositions polymorphes stables de bréquinar sodium et procédés d'utilisation et de fabrication de celles-ci |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4121050A1 EP4121050A1 (fr) | 2023-01-25 |
EP4121050A4 true EP4121050A4 (fr) | 2024-04-17 |
Family
ID=77771654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21770978.1A Pending EP4121050A4 (fr) | 2020-03-20 | 2021-03-19 | Compositions polymorphes stables de bréquinar sodium et procédés d'utilisation et de fabrication de celles-ci |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP4121050A4 (fr) |
JP (1) | JP2023518419A (fr) |
AU (1) | AU2021236757A1 (fr) |
CA (1) | CA3175964A1 (fr) |
WO (1) | WO2021189017A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023043830A1 (fr) * | 2021-09-15 | 2023-03-23 | Clear Creek Bio, Inc. | Polythérapies pour traiter des infections virales |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2335503C2 (ru) * | 2003-04-30 | 2008-10-10 | Ниппон Синяку Ко., Лтд. | Кристаллы сольвата производного хинолинкарбоновой кислоты |
ES2768651T3 (es) * | 2013-04-25 | 2020-06-23 | Kyorin Seiyaku Kk | Composición farmacéutica sólida |
CA2996632C (fr) * | 2015-09-01 | 2023-10-17 | Bayer Pharma Aktiengesellschaft | Composes et methodes utiles pour le traitement ou la prevention de cancers hematologiques |
US20190290634A1 (en) * | 2018-03-26 | 2019-09-26 | Clear Creek Bio, Inc. | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
MX2021000143A (es) * | 2018-06-22 | 2021-08-05 | Ohio State Innovation Foundation | Metodos y composiciones para la inhibicion de dihidroorotato deshidrogenasa. |
-
2021
- 2021-03-19 WO PCT/US2021/023350 patent/WO2021189017A1/fr active Application Filing
- 2021-03-19 EP EP21770978.1A patent/EP4121050A4/fr active Pending
- 2021-03-19 CA CA3175964A patent/CA3175964A1/fr active Pending
- 2021-03-19 AU AU2021236757A patent/AU2021236757A1/en active Pending
- 2021-03-19 JP JP2022556043A patent/JP2023518419A/ja active Pending
Non-Patent Citations (3)
Title |
---|
HARWOOD L M ET AL: "Experimental organic chemistry - Principles and practice", 1 January 1989, EXPERIMENTAL CHEMISTRY - ORGANIC CHEMISTRY AND REACTION,, PAGE(S) 127 - 132, ISBN: 978-0-632-02016-4, XP003025361 * |
See also references of WO2021189017A1 * |
WU LEI-SHU ET AL: "The impact of crystallinity on brequinar sodium hygroscopicity", vol. 1, no. 1, 1 January 1996 (1996-01-01), pages 43 - 49, XP009552418, ISSN: 1083-7450, Retrieved from the Internet <URL:http://www.tandfonline.com/doi/full/10.3109/10837459609031417> [retrieved on 20080927], DOI: 10.3109/10837459609031417 * |
Also Published As
Publication number | Publication date |
---|---|
WO2021189017A1 (fr) | 2021-09-23 |
CA3175964A1 (fr) | 2021-09-23 |
AU2021236757A1 (en) | 2022-10-13 |
EP4121050A1 (fr) | 2023-01-25 |
JP2023518419A (ja) | 2023-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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17P | Request for examination filed |
Effective date: 20220914 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0031450000 Ipc: A61K0031470000 |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20240320 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 215/52 20060101ALI20240314BHEP Ipc: A61K 31/47 20060101AFI20240314BHEP |