EP4121050A4 - STABLE POLYMORPHOUS COMPOSITIONS OF BREQUINA SODIUM, METHODS OF USE AND PRODUCTION THEREOF - Google Patents

STABLE POLYMORPHOUS COMPOSITIONS OF BREQUINA SODIUM, METHODS OF USE AND PRODUCTION THEREOF Download PDF

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Publication number
EP4121050A4
EP4121050A4 EP21770978.1A EP21770978A EP4121050A4 EP 4121050 A4 EP4121050 A4 EP 4121050A4 EP 21770978 A EP21770978 A EP 21770978A EP 4121050 A4 EP4121050 A4 EP 4121050A4
Authority
EP
European Patent Office
Prior art keywords
making
methods
same
brequinar sodium
stable polymorphic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21770978.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP4121050A1 (en
Inventor
Abdolsamad Tadayon
Ping Huang
Chaoyi DENG
Jinsuo YANG
Siyi Jiang
Qingqing LU
Lin Cui
Mo JIA
Xianjun You
David P. Hesson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clear Creek Bio Inc
Original Assignee
Clear Creek Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clear Creek Bio Inc filed Critical Clear Creek Bio Inc
Publication of EP4121050A1 publication Critical patent/EP4121050A1/en
Publication of EP4121050A4 publication Critical patent/EP4121050A4/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP21770978.1A 2020-03-20 2021-03-19 STABLE POLYMORPHOUS COMPOSITIONS OF BREQUINA SODIUM, METHODS OF USE AND PRODUCTION THEREOF Pending EP4121050A4 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202062992720P 2020-03-20 2020-03-20
US202063020460P 2020-05-05 2020-05-05
US202063030677P 2020-05-27 2020-05-27
US202063043384P 2020-06-24 2020-06-24
US202063043382P 2020-06-24 2020-06-24
US202063043386P 2020-06-24 2020-06-24
US202063043388P 2020-06-24 2020-06-24
PCT/US2021/023350 WO2021189017A1 (en) 2020-03-20 2021-03-19 Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof

Publications (2)

Publication Number Publication Date
EP4121050A1 EP4121050A1 (en) 2023-01-25
EP4121050A4 true EP4121050A4 (en) 2024-04-17

Family

ID=77771654

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21770978.1A Pending EP4121050A4 (en) 2020-03-20 2021-03-19 STABLE POLYMORPHOUS COMPOSITIONS OF BREQUINA SODIUM, METHODS OF USE AND PRODUCTION THEREOF

Country Status (5)

Country Link
EP (1) EP4121050A4 (enExample)
JP (1) JP2023518419A (enExample)
AU (1) AU2021236757A1 (enExample)
CA (1) CA3175964A1 (enExample)
WO (1) WO2021189017A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022159763A1 (en) * 2021-01-22 2022-07-28 Model Medicines, Inc. Sars-cov-2 therapeutics
WO2023043830A1 (en) * 2021-09-15 2023-03-23 Clear Creek Bio, Inc. Combination therapies to treat viral infections
CN120131690A (zh) * 2025-03-24 2025-06-13 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种布喹那在制备抑制流感病毒的制剂中的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05011525A (es) * 2003-04-30 2005-12-12 Nippon Shinyaku Co Ltd Cristales de solvato de derivado de acido quinolincarboxilico.
CA2910112C (en) * 2013-04-25 2021-02-16 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
US11096934B2 (en) * 2015-09-01 2021-08-24 The Broad Institute, Inc. Compounds and methods useful for treating or preventing hematological cancers
EP3773579A4 (en) * 2018-03-26 2022-03-09 Clear Creek Bio, Inc. COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE
US20190290634A1 (en) * 2018-03-26 2019-09-26 Clear Creek Bio, Inc. Compositions and methods for inhibiting dihydroorotate dehydrogenase
WO2019246603A1 (en) * 2018-06-22 2019-12-26 Ohio State Innovation Foundation Methods and compositions for inhibition of dihydroorotate dehydrogenase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HARWOOD L M ET AL: "Experimental organic chemistry - Principles and practice", 1 January 1989, EXPERIMENTAL CHEMISTRY - ORGANIC CHEMISTRY AND REACTION,, PAGE(S) 127 - 132, ISBN: 978-0-632-02016-4, XP003025361 *
HEINRICH STAHL P ED - WERMUTH C G: "The Practice of Medicinal Chemistry; 35 Preparation of water-soluble compounds through salt formation", 1 January 2003, THE PRACTICE OF MEDICINAL CHEMISTRY, ELSEVIER, NL, PAGE(S) 601 - 615, ISBN: 978-0-12-744481-9, XP002566271 *
See also references of WO2021189017A1 *
WU LEI-SHU ET AL: "The impact of crystallinity on brequinar sodium hygroscopicity", vol. 1, no. 1, 1 January 1996 (1996-01-01), pages 43 - 49, XP009552418, ISSN: 1083-7450, Retrieved from the Internet <URL:http://www.tandfonline.com/doi/full/10.3109/10837459609031417> [retrieved on 20080927], DOI: 10.3109/10837459609031417 *

Also Published As

Publication number Publication date
JP2023518419A (ja) 2023-05-01
EP4121050A1 (en) 2023-01-25
CA3175964A1 (en) 2021-09-23
WO2021189017A1 (en) 2021-09-23
AU2021236757A1 (en) 2022-10-13

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