EP4018991A1 - Adaptiver clip zum durchstechen des verschlusses für medizinische flaschen - Google Patents

Adaptiver clip zum durchstechen des verschlusses für medizinische flaschen Download PDF

Info

Publication number
EP4018991A1
EP4018991A1 EP21211218.9A EP21211218A EP4018991A1 EP 4018991 A1 EP4018991 A1 EP 4018991A1 EP 21211218 A EP21211218 A EP 21211218A EP 4018991 A1 EP4018991 A1 EP 4018991A1
Authority
EP
European Patent Office
Prior art keywords
cap
clip
bottle
adaptive
cannula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21211218.9A
Other languages
English (en)
French (fr)
Inventor
Gaëtan REY
Maxime CLAVEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Raymond SARL
Original Assignee
A Raymond SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Raymond SARL filed Critical A Raymond SARL
Publication of EP4018991A1 publication Critical patent/EP4018991A1/de
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents

Definitions

  • the present invention relates to the field of medicine and more particularly that of sampling. It relates in particular to an adaptive cap piercing clip for a medical bottle, the cap being held together with the bottle by a cap.
  • the clip is adaptive in that it can be used with caps of different nature and dimensions, in particular in height.
  • a stopper-piercing clip In the field of medicine, it is common practice to use a stopper-piercing clip to access the contents of a bottle closed by said stopper, and to take a sample of the medical solution stored in the bottle.
  • the stopper of this bottle is typically held in position by a cap provided with a central opening to expose a central portion of the stopper and allow it to be drilled.
  • a cannula ending in a tip is formed on the inner surface of the clip to puncture the exposed portion of the stopper and access the contents of the vial.
  • the cannula comprises, close to its end, a slit opening inside the cannula similar to that of a medical needle.
  • a syringe without a needle, the cannula of the clip replacing the needle of the syringe can then be assembled and/or screwed onto the clip to withdraw the contents of the vial.
  • Caps of the capsule type are formed from a single element, typically an aluminum foil with a thickness of the order of a few tenths of a millimeter covering the stopper and the head of the bottle.
  • Caps of the locking cap type have a larger size, in particular in height, and can reach a total height of between 10 and 20 millimeters, depending on the dimensions of the bottle, because of the various elements constituting it.
  • a clip is generally not suitable for clipping onto different types of cap, more particularly on caps of different heights. Indeed, these retaining means being intended to be clipped under the cap, their position on the clip is then dependent on the height of the cap. A conventional clip therefore cannot generally be used indiscriminately on these two types of cap while ensuring the attachment of the clip to the cap.
  • these two types of caps also have a difference in thickness at the level of the portion of the cap partially covering the stopper. In the case of a cap of the capsule type, this is a thickness typically between 1 and 5 tenths of a millimeter, i.e. the thickness of the aluminum sheet, while in the case of a cap of the locking cap type this thickness is typically between 2 and 6 mm.
  • This difference in thickness, at the stopper, has a disadvantage for conventional clips because it can result in a different depression of the cannula depending on the type of cap and can thus lead to differences in dead volume during sampling.
  • the dead volume corresponds to the volume of solution which cannot be sampled and which is therefore lost during sampling. Indeed, the samples of liquid being made by turning the bottle upside down, if the cannula sinks too deeply there then exists a dead volume of solution which cannot be sampled because it is located below the slit of the cannula. If the cannula does not go deep enough, there may be a risk of leakage or contamination, part of the slit may protrude from the stopper and connect the inside of the bottle to its outside. It is desirable to maintain the same collection efficiency, ie an equivalent dead volume as well as an absence of leakage, whether the clip is used on a cap of the capsule type or of the locking cap type.
  • the plugs have a thinner zone in their center to optimize sampling. This area of lesser thickness forms the lowest point of the cap when it is turned over. Thus if the tip of the clip does not penetrate precisely at the level of this low point for sampling, it will be impossible to recover the solution there. finding, no portion of the cannula and therefore of the slot having access to it.
  • the locking cap having a thickness at the level of the stopper as well as a greater total height than those of a cap of the capsule type.
  • An object of the invention is to propose an adaptive clip for piercing a stopper for a medical bottle addressing all or part of the aforementioned objectives.
  • This is in particular a clip providing similar performance on caps of the capsule type or of the locking cap type, while ensuring the attachment of the clip to the cap.
  • the adaptive clip being further remarkable in that the internal surface of the head comprises at least one abutment intended to come into contact with the central portion of the stopper.
  • the figure 1 represents an overall view of an adaptive clip 1 for piercing a cap for a medical bottle 2, in accordance with the invention.
  • cap 3 held together with the bottle 2 by a cap 4.
  • the cap 4 has a central opening 41, the size of which is typically between 5 and 10 mm depending on the diameter of the bottle, to expose a central portion 31 of the cap 3. It will be noted that in the case of caps 4 of the locking cap type, the latter may comprise a capsule blocking access to the central opening 41, which is removed before using the adaptive clip 1 for drilling .
  • the stopper 3 has, in its center in the central portion 31, a zone of less thickness forming the low point 32 of the stopper. It is usually formed of an easily piercable material such as rubber.
  • the cap 4 for its part can be of a varied nature as has already been introduced; it may be a cap of the capsule type ( figure 2a ), typically formed of an aluminum foil covering the stopper 3 as well as the head of the bottle, or of a locking cap ( figure 2b ) composed of several elements and covering the cap 3 and the neck of the bottle 2.
  • the locking cap has larger dimensions, in height and in thickness, typically in the case of a bottle with a diameter of 20mm it is a height between 14 and 20mm.
  • the thickness of the part of the cap in contact with the upper face of the stopper 3 will be designated by the expression “thickness e1, e2 of the top of the cap”, the thickness e1 of the top of a capsule-type cap being less important than that e2 of a locking cap-type cap.
  • the thickness e1 of caps of the capsule type is typically of the order of a tenth of a millimeter while, for locking caps, this thickness e2 is of the order of a millimeter, for example between 2 and 6mm in the case of a 20mm diameter bottle.
  • the figure 2a and 2b show cross-sectional views of an adaptive clip 1 assembled on a medical bottle 2 provided respectively with a cap of the capsule type and of the locking cap type.
  • the adaptive clip 1 is formed from a plastic material, such as polycarbonate.
  • the adaptive clip 1 has the shape of a cap to be inserted and clipped onto the cap 4.
  • the clip 1 comprises a head 10a as well as a side wall 10b of cylindrical shape to surround the cap 4.
  • the head 10a extends along a main plane P and is provided in its center, and on an internal surface, with a cannula 11 ending in a point 12 intended to pierce the stopper 3 of the bottle 2.
  • internal surface we mean the surface intended to come in vis-à-vis or in contact with the cap 4 of the medical bottle 2.
  • the head 10a also comprises, arranged on its internal surface ( picture 3 ) at least one abutment 15 intended to come into contact with the central portion of the stopper 3 to control the depression of the cannula 11 through the stopper 3 by coming into abutment against the latter as is clearly visible on the figure 2a and 2b .
  • the peripheral wall 10b comprises a first end 10' connected to the head 10a of the clip 1 and a second free end 10'.
  • First and second legs 16a, 16b, distinct, are delimited by grooves formed on the peripheral wall 10b and opening at the second end 10".
  • Each lug 16a, 16b therefore has a free end, on the side of the second end 10" of the peripheral wall 10b.
  • the first 16a and second 16b lugs are arranged alternately along the periphery of the wall 10b; in other words, each first leg 16a is close to two second legs 16b, and each second leg 16b is adjacent to two first legs 16a.
  • the first lugs 16a each comprise a deformable tab 17 extending radially from an inner face of the peripheral wall 10b and oriented towards the head 10a of the clip 1.
  • the second lugs 16b are flexible and comprise on their inner face notches 18.
  • the peripheral wall 10b may comprise third legs, distinct from the first and second legs, comprising no deformable tab 17 or notch 18, but participating in forming the cylindrical peripheral wall of the clip 1.
  • the first legs 16a, or even the third legs can also be flexible. In the figures are shown three first legs 16a and three second legs 16b. Nevertheless, these numbers of legs are not restrictive and it could very well be a different number, in particular depending on the diameter of the bottle, such as four or two legs of each type.
  • the picture 3 shows a bottom view of a clip 1 according to the invention to illustrate the internal surface of the head 10a of the clip 1.
  • stops 15 are represented in the form of ribs arranged on either side of the cannula 11 in a circle having said cannula 11 as its center.
  • the number of stops 15 as well as their nature can vary and the invention is in no way reduced to the example illustrated.
  • the (at least one) stop 15 be placed at a distance from the cannula 11 that is less than the radius of the central opening 41 of the cap 4, or for example less than a distance of 4.2 mm in the case of a bottle with a diameter of 20 mm, in order to be able to pass through this opening 41 and come into abutment against the exposed central portion 31 of the cap 3.
  • the stops 15 are arranged at a distance from the cannula 11 comprised between 1 and 4mm.
  • the height of the stops 15 is determined so as to be greater, by a few tenths of a millimeter, or equal to the thickness e2 of the head of a cap 4 of the locking cap type in order to control the depression of the cannula 11 at through the cap 3, so that it is identical regardless of the type of cap used.
  • the height of the stops 15 is generally greater than or equal to 3.3 mm in the case of a bottle with a diameter of 20 mm.
  • the cannula 11 extends along a central axis A perpendicular to the main plane P.
  • the cannula 11 is hollow and comprises, close to its tip 12, a slot 13 opening inside the cannula 11 to allow aspiration, at through the cannula 11, of the medical solution contained in the bottle 2.
  • the length of the cannula 11 is defined, taking into account the existence of the stops 15, so as to be able to expose the slot 13 of the cannula 11 to the inside the bottle 1 without a portion of the slot 13 opening out of the bottle 2, to prevent leaks.
  • the dimensions of the slot 13 it is also possible to adjust the dimensions of the slot 13 to achieve this result, the main thing being that no portion of the slot 13 opens outside of the bottle 2 and that at least a portion of the slot 13 opens inside the bottle, preferably as close as possible to the internal surface of the stopper 3 to limit the dead volumes.
  • the dimensions of the portion of the slot 13 exposed inside the bottle 2 condition the suction speed, the greater this exposed portion, the greater the suction, and therefore the sampling speed, will be important.
  • the head 10a of the clip 1 comprises on its outer surface, in the extension of the cannula 11, a junction element 14 communicating with the inside of the cannula 11, to allow the connection of a needleless syringe (not represented on the figures) on the clip 1.
  • the junction element 14 thus forms a fluid connection between the syringe and the bottle 2 to transfer the contents of the medical bottle 2 to the syringe.
  • the junction element 14 can comprise an internal or external thread to interact with a complementary thread on the syringe and/or comprise a particular geometry, such as a shoulder, to allow the clipping of the syringe.
  • the connection of the syringe to the clip 1 can also be a simple wedging cone on cone.
  • the figure 4 illustrates a hybrid sectional view of a clip according to the invention, the right half of the figure 4 showing a sectional view at a flexible tab 17 and the left half showing a sectional view at a notch 18.
  • the first tabs 16a include a window 19 surmounting the deformable tab 17 to accommodate its deformation.
  • the thickness of the tabs 17 is chosen to be less than or equal to the thickness of the peripheral wall 10b to prevent the tabs 17 from protruding too much out of this wall 10b, through the window 19, when their deformation. This is typically a thickness between 0.5 and 2 mm.
  • these tabs 17 are intended to be clipped under said cap 4, and more particularly under the neck of the bottle 2, to retain the clip 1 assembled with the cap 4.
  • these tabs 17 are intended to flatten and come into contact against the peripheral wall of said cap 4 while at least partially occupying the windows 19.
  • the tabs 17 are initially inclined and their inner surface thus defines frustoconical surface sections.
  • the notches 18 are advantageously arranged close to the free end 10" of the second flexible tabs 16b and at a distance from the head 10a greater than or equal to the height of a cap 4 of the locking cap type, typically greater than or equal to 17mm in the case of a bottle with a diameter of 20 mm.
  • the notches 18 also have a radial dimension chosen so that the radial distance between the central axis A and the notches 18 is less than the radius of a cap of the locking cap type to allow the notches to come and clip under said cover 4 (see figure 2b ).
  • the notches 18 have a radial dimension to have a grip of at least 0.5 mm, once clipped under the cap 4, i.e. for example a radial dimension between 0.75 and 1.75 mm in the case of a bottle with a diameter of 20 mm .
  • the radial dimension of the notches 18 can be chosen so that the radial distance between the central axis A and the notches 18 is less than the radius of a cap 4 of the capsule type so that the notches 18 can also come into contact against this type of cap during the insertion of the clip 1.
  • the notches 18 advantageously have an inclined plane 18' to facilitate the insertion of the clip 1 on the cap 4 by guiding the deformation of the second flexible tabs 16b.
  • the fact that the notches 18 are formed on flexible elements, here on the second legs 16b, makes it possible to insert the clip 1 on the cap 4. Indeed, in the absence of this flexible character, the notches 18 would come into abutment against the cap 4 without the possibility of deforming to deviate and thus allow the insertion of the clip 1 on the cap 4.
  • the notches 18 define a first plane P1 parallel to the main plane P and the deformable tabs 17 define a second plane P2, different from the first plane P1, also parallel to the main plane P and intended to form a plane of contact with the cap 4 during the insertion of the clip 1 on the bottle 2 as shown in the figure 4 (the bottle provided with the stopper 3 and its cap 4 being schematized by the rectangle delimited in dotted line).
  • This second plane P2 corresponds to the first intersection between the frustoconical surface formed by the tabs 17 and a disk of radius equal to that of the cap 4 and parallel to the main plane P along the direction of insertion of the clip 1 on the cap 4.
  • the deformable tongues 17 also have the role of centering the clip 1 during its insertion on the cap 4, in particular in the case of cap 4 of the capsule type.
  • the caps 4 of the capsule type having a smaller diameter than that of the caps of the locking cap type, there is a clearance of the order of several millimeters ( figure 2a ), typically between 1 and 5 mm, between the peripheral wall 10b of the clip and the cap 4.
  • figure 2a millimeters
  • the tongues 17 are configured, thanks to their length and their initial inclination, so that the plane of contact with the cap 4, during the insertion of the clip 1 on the bottle 2, is done in same time as, or preferably before, the contact of the tip 12 of the cannula 11 with the stopper 3.
  • the second plane P2 is between the first plane P1 and the tip 12 of the cannula 11.
  • the radial dimension of the notches 18 can be chosen so that a contact can be made between the notches 18 and a cap 4 of the capsule type to achieve a pre-centering of the clip 1 on the cap 4, before cap 4 comes into contact with tabs 17 at second plane P2.
  • the notches 18 come into contact against the cap 4 at the level of the first plane P1.
  • the inclined plane 18' facilitates the insertion of the clip 1 on the cap 4 by guiding the deformation of the second flexible legs 16b and also contributes to the centering of the clip 1 on the cap 4 and consequently to the centering of the clip 1 on the stopper 3.
  • the deformable tabs 17 come into contact against the cap 4, at the level of the second plane P2, and deform in the windows 19 to flatten against the wall of the cap 4.
  • the tip 12 of the cannula 11 comes into contact with the exposed central portion 31 of the stopper 3 and pierces the stopper 3 at its low point 32 thanks to the centering carried out by the notches 18 and tabs 17.
  • the clip 1 continues its depression on the cap 4, the stops 15 pass through the central opening 41 of the cap 4 until they come to rest against the central portion 31 of the cap 3.
  • the notches 18 fold under the cap 4 simultaneously or slightly before the contact between the stops 15 and the cap 3.
  • the clip 1 is then firmly retained assembled to the cap 4 and the cap 3 pierced in its center.
  • a syringe can then be assembled to the clip 1 to take the sample.
  • the notches 18 can, similar to the case of a cap 4 of the locking cap type, come into contact and deform with the cap 4 at the level of the first plane P1 and allow to carry out a pre-centering of the clip 1 on the cap 4, before the contact between the tongues 17 and the cap 4.
  • the deformable tongues 17 come into contact against the cap 4 at the level of the plane P2, before or simultaneously with the contact between the tip 12 of the cannula 11 and the stopper 3, to center the clip 1 on the cap 4 and therefore on cap 3 before drilling it. Then the tabs 17 gradually deform in the windows 19 to allow the passage of the cap 4.
  • a third step which can be simultaneous with the second step, the tip 12 of the cannula 11 comes into contact with the exposed central portion 31 of the stopper 3 at its low point 32 thanks to the centering carried out by the tabs 17 and optionally the notches 18 , to pierce it in its center. Tabs 17 continue to deform in windows 19 to allow passage of cap 4, while cannula 11 passes through stopper 3.
  • the clip 1 continues its depression on the cap 4, the stops 15 pass through the central opening 41 of the cap 4 until they come to rest against the central portion 31 of the cap 3 and the tabs 17 return to position to be housed under the cap 4 simultaneously or slightly before the contact between the stops 15 and the cap 3.
  • the clip 1 is then securely retained assembled to the cap 4 and the cap 3 pierced in its center. A syringe can then be assembled to the clip 1 to take the sample.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Devices For Opening Bottles Or Cans (AREA)
EP21211218.9A 2020-12-23 2021-11-30 Adaptiver clip zum durchstechen des verschlusses für medizinische flaschen Pending EP4018991A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR2014098A FR3117774B1 (fr) 2020-12-23 2020-12-23 Clip adaptatif de perçage de bouchon pour flacon medical

Publications (1)

Publication Number Publication Date
EP4018991A1 true EP4018991A1 (de) 2022-06-29

Family

ID=75746761

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21211218.9A Pending EP4018991A1 (de) 2020-12-23 2021-11-30 Adaptiver clip zum durchstechen des verschlusses für medizinische flaschen

Country Status (5)

Country Link
US (1) US20220192924A1 (de)
EP (1) EP4018991A1 (de)
CN (1) CN114732725A (de)
CA (1) CA3143064A1 (de)
FR (1) FR3117774B1 (de)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5772652A (en) * 1997-05-14 1998-06-30 Comar, Inc. Stab cap for a vial having a puncturable seal
EP1474201A2 (de) 2002-02-08 2004-11-10 Alaris Medical Systems, Inc. Phiolenadapter mit nadelfreiem ventil zur benutzung mit phiolenverschlüssen mit verschiedenen grössen
WO2011039004A1 (fr) 2009-10-01 2011-04-07 A. Raymond Et Cie Coiffe de verrouillage pour recipient a col avec une capsule a pattes de fixation
US20120123381A1 (en) * 2003-10-30 2012-05-17 Teva Medical Ltd. Safety drug handling device
WO2013150956A1 (ja) * 2012-04-04 2013-10-10 株式会社ジェイ・エム・エス オス部材用フード及びオスコネクタ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425209B2 (en) * 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
US20020173748A1 (en) * 1998-10-29 2002-11-21 Mcconnell Susan Reservoir connector
FR2878737B1 (fr) * 2004-12-07 2007-03-16 Maptech Soc Par Actions Simpli Dispositif de securite pour flacon a usage medical
FR2912384B1 (fr) * 2007-02-09 2009-04-10 Biocorp Rech Et Dev Sa Dispositif de bouchage pour un recipient, recipient equipe d'un tel dispositif et procede de fermeture d'un lot de tel recipient
RU2487738C1 (ru) * 2011-11-25 2013-07-20 Федеральное государственное бюджетное учреждение "Пятигорский государственный научно-исследовательский институт курортологии Федерального медико-биологического агентства" (ФГБУ ПГНИИК ФМБА России) Способ лечения синдрома мальабсорбции у детей с применением дифференцированной магнитотерапии
EP3065692B1 (de) * 2013-11-06 2019-06-05 Becton Dickinson and Company Limited System mit einem adapter für geschlossenen flüssigkeitstransfer
US11224555B2 (en) * 2018-04-23 2022-01-18 Hospira, Inc. Access and vapor containment system for a drug vial and method of making and using same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5772652A (en) * 1997-05-14 1998-06-30 Comar, Inc. Stab cap for a vial having a puncturable seal
EP1474201A2 (de) 2002-02-08 2004-11-10 Alaris Medical Systems, Inc. Phiolenadapter mit nadelfreiem ventil zur benutzung mit phiolenverschlüssen mit verschiedenen grössen
US20120123381A1 (en) * 2003-10-30 2012-05-17 Teva Medical Ltd. Safety drug handling device
WO2011039004A1 (fr) 2009-10-01 2011-04-07 A. Raymond Et Cie Coiffe de verrouillage pour recipient a col avec une capsule a pattes de fixation
WO2013150956A1 (ja) * 2012-04-04 2013-10-10 株式会社ジェイ・エム・エス オス部材用フード及びオスコネクタ

Also Published As

Publication number Publication date
FR3117774A1 (fr) 2022-06-24
FR3117774B1 (fr) 2023-03-31
US20220192924A1 (en) 2022-06-23
CN114732725A (zh) 2022-07-12
CA3143064A1 (fr) 2022-06-23

Similar Documents

Publication Publication Date Title
EP1226077B1 (de) Einsatzbereite verbindungsvorrichtung
EP1663102B1 (de) Vorrichtung zur oralen verabreichung eines medikaments
CA2345649C (fr) Dispositif d'injection a usage unique destine a etre pre-rempli
EP1890760B1 (de) Steckverbinder zur medizinischen verwendung
EP1973592B1 (de) Vorgefüllte hypodermische spritze mit einer verschlussvorrichtung
FR3050184A1 (fr) Bouchon perforateur notamment pour tube souple
WO2012168235A1 (fr) Dispositif de connexion entre un récipient et un contenant, procédé d'assemblage et d'utilisation d'un tel dispositif
EP0114145A2 (de) Spritze zum medizinischen Gebrauch
WO2011101389A1 (fr) Ensemble de connecteurs facilement nettoyable pour un circuit liquide
EP1117453B1 (de) Vorgefüllte injektionsvorrichtung für einmalverwendung
WO1989000432A2 (fr) Seringue de haute securite non reutilisable
WO2016001599A1 (fr) Dispositif de distribution de produit fluide
EP2308452B1 (de) Perforierende Nadel
EP1918214B1 (de) Ampulle bestehend aus einem Hohlkörper und einem Kopf mit Bruchmöglichkeit zwischen Körper und Kopf
EP3235754B1 (de) System für das schliessen einer tube und tube damit
FR2821827A1 (fr) Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
CA2866559C (fr) Dispositif de bouchage et recipient equipe d'un tel dispositif
EP4018991A1 (de) Adaptiver clip zum durchstechen des verschlusses für medizinische flaschen
FR2644349A1 (fr) Seringue a utilisation unique
WO2009118417A1 (fr) Connecteur a usage medical ameliore
WO2010031812A1 (fr) Site implantable avec septum à précontrainte bidirectionnelle
FR3050187A1 (fr) Bouchon perforateur, notamment pour tube souple
EP3302650A1 (de) Gehäuse zur montage eines behälters auf einem injektionsstift
EP3173114B1 (de) Vorrichtung zur herstellung einer hermetisch geschlossenen verbindung zwischen einer nadel und einem behälter
EP4051601A1 (de) Äussere sicherheitskappe für einen behälter

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20211202

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR