EP4017598A1 - Cosmetic o/w emulsion containing succinoglucan and lipophilic uv filter substances - Google Patents

Cosmetic o/w emulsion containing succinoglucan and lipophilic uv filter substances

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Publication number
EP4017598A1
EP4017598A1 EP20760785.4A EP20760785A EP4017598A1 EP 4017598 A1 EP4017598 A1 EP 4017598A1 EP 20760785 A EP20760785 A EP 20760785A EP 4017598 A1 EP4017598 A1 EP 4017598A1
Authority
EP
European Patent Office
Prior art keywords
emulsion
weight
emulsifiers
emulsions according
lipophilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20760785.4A
Other languages
German (de)
French (fr)
Inventor
Keti Piradashvili
Thomas Raschke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP4017598A1 publication Critical patent/EP4017598A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966—Triazines or their condensed derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides

Definitions

  • the present invention relates to a cosmetic preparation containing succinoglucan and lipophilic UV filter substances.
  • Emulsions are generally understood to mean heterogeneous systems which consist of two liquids which are immiscible or only partially miscible with one another, which are usually referred to as phases and in which one of the two liquids is dispersed in the other liquid in the form of very fine droplets. Externally and with the naked eye, emulsions appear homogeneous.
  • the two liquids are water and oil and if oil droplets are finely distributed in water, then it is an oil-in-water emulsion (O / W emulsion, e.g. milk).
  • O / W emulsion oil-in-water emulsion
  • the basic character of an O / W emulsion is shaped by the water.
  • W / O emulsion water-in-oil emulsion, e.g. butter
  • so-called emulsifiers are added to the emulsions.
  • Emulsifiers are usually molecules with a polar, lipophilic structural element and a non-polar, lipophilic structural element.
  • a so-called HLB value (a dimensionless number between 0 and 20) is assigned to each emulsifier, which indicates whether the water or oil solubility is preferred. Numbers under 8 indicate oil-soluble, more hydrophobic emulsifiers, numbers above 8 water-soluble, more hydrophilic emulsifiers.
  • the water phase is combined with the lipid phase (oil phase) with stirring, the droplets of the inner phase of the emulsion having to be broken down to a size of less than 10 ⁇ m so that the emulsion becomes stable.
  • UVA and UVB filters are summarized in most industrialized countries in the form of positive lists such as Annex 7 of the Cosmetics Ordinance.
  • O / W emulsions cosmetic oil-in-water emulsions (O / W emulsions) containing, in addition to a water phase, one or more oil phases dispersed therein and a) one or more succinoglucans and b) one or more lipophilic UV filter substances.
  • Succinoglucan is a polysaccharide partially esterified with succinic acid, which can be obtained, for example, as a fermentation product of Agrobacterium tumefaciens. Succinoglucan is released into the surrounding medium as a microbial exopolysaccharide.
  • the backbone of the succinoglucan is mainly formed by glucose monomers, but galactose can advantageously also be polymerized.
  • a particularly advantageous succino glucan has molar ratios of glucose to galactose such as 8-6: 1, in particular about 7: 1.
  • every eighth to twelfth sugar molecule of the polymeric backbone is advantageously esterified with a molecule of succinic acid, preferably about every tenth sugar molecule.
  • sugar molecules for example pyruvic acid, which can be coupled via acetal formation.
  • every fifth to twentieth sugar molecule of the polymeric backbone is coupled to a pyruvic acid molecule, preferably about every eighth sugar molecule.
  • succinoglucan The chemical structure of succinoglucan is illustrated as follows:
  • succinoglucan is readily soluble in water and can be used as a thickener.
  • the use of succinoglucan in cosmetic emulsions is known per se to the person skilled in the art, but the prior art could not point the way to the present invention.
  • the emulsion according to the invention is characterized in that the content of succinoglucan in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.01 and 1.5% by weight, particularly preferably between 0.1 and 1.0% by weight, each based on the total weight of the emulsion.
  • the emulsion has one or more oil-in-water emulsifiers (O / W emulsifiers) in a total concentration of 0.05 to 5.0% by weight and preferably in a total concentration of 2.0 to 4.0% by weight, based in each case on the total weight of the emulsion.
  • O / W emulsifiers oil-in-water emulsifiers
  • the emulsion according to the invention is characterized in that the content of one or more anionic emulsifiers in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.05 and 2% by weight, particularly preferably between 0.1 and 1.0% by weight, based in each case on the total weight of the emulsion.
  • the emulsion according to the invention is characterized in that the content of one or more nonionic emulsifiers in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.05 and 3% by weight, particularly preferably between 0.1 and 2% by weight, based in each case on the total weight of the emulsion.
  • the emulsion according to the invention is characterized in that the content of one or more lipophilic UV- Filter substances in the emulsion from 0.001 to 20% by weight and preferably between 0.05 and 15% by weight, particularly preferably between 0.1 and 10% by weight, in each case based on the total weight of the emulsion.
  • Advantageous lipophilic UV-A filter substances for the purposes of the present invention are, for. B.
  • Advantageous UV-A filter substances for the purposes of the present invention are dibenzoyl methane derivatives, especially 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol ® 1789 brand and sold by Merck under the trade name Eusolex ® 9020.
  • Advantageous UV filter substances for the purposes of the present invention are also so-called broadband filters, i.e. filter substances that absorb both UV-A and UV-B radiation.
  • Advantageous broadband filters or UV-B filter substances are, for example, bis-resorcinyl triazine derivatives with the following structure: where R 1 , R 2 and R 3 are independently selected from the group of the branched and unbranched alkyl groups with 1 to 10 carbon atoms or represent a single hydrogen atom.
  • 2,4-Bis - ⁇ [4- (2-ethylhexyloxy) -2-hydroxy] -phenyl ⁇ -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: Aniso Triazine) are particularly preferred ), which is available under the trade name Tinosorb® S from BASF AG, and the 4,4 ', 4 "- (1,3,5-triazine-2,4,6-triyltriimino) -tris-benzoic acid-tris ( 2-ethylhexyl ester), synonym: 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: Octyl Triazone), which is sold by BASF Aktiengesellschaft under the trade name UVINUL® T 150.
  • UV filter substances which the structural motif have, are advantageous UV filter substances for the purposes of the present invention, for example the s-triazine derivatives described in the European patent application EP 570838 A1, whose chemical structure is given by the generic formula is played back, where
  • R represents a branched or unbranched Ci-Cis-alkyl radical, a C5-Ci2-cycloalkyl radical, optionally substituted with one or more C1-C4-alkyl groups,
  • X represents an oxygen atom or an NH group
  • Ri is a branched or unbranched Ci-Cis-alkyl radical, a C5-Ci2-cycloalkyl radical, optionally substituted by one or more C1-C4-alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula means in which
  • A represents a branched or unbranched C 1 -C 4 -alkyl radical, a C 5 -C 2 -cycloalkyl or aryl radical, optionally substituted by one or more C 1 -C 4 alkyl groups,
  • R 3 represents a hydrogen atom or a methyl group, n represents a number from 1 to 10,
  • R 2 is a branched or unbranched C 1 -C 4 -alkyl radical, a C 5 -C 2 -cycloalkyl radical, optionally substituted by one or more C 1 -C 4 -alkyl groups, when X represents the NH group, and a branched or unbranched C 1 -Cis- Alkyl radical, a C 5 -C 2 cycloalkyl radical, optionally substituted by one or more C 1 -C 4 alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula means in which
  • A represents a branched or unbranched C 1 -C 4 -alkyl radical, a C 5 -C 2 -cycloalkyl or aryl radical, optionally substituted by one or more C 1 -C 4 alkyl groups,
  • R 3 represents a hydrogen atom or a methyl group
  • n represents a number from 1 to 10 when X represents an oxygen atom.
  • a particularly preferred UV filter substance for the purposes of the present invention is also an asymmetrically substituted s-triazine, the chemical structure of which is given by the formula
  • Dioctylbutylamidotriazon (INCI: Dioctylbutamidotriazone) and is available under the trade name UVASORB HEB from Sigma 3V.
  • An advantageous broadband filter for the purposes of the present invention is 2,2'-methylene bis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol), which through the chemical structural formula and is available under the trade name Tinosorb® M from CIBA-Nahrungsstoff GmbH.
  • Another advantageous broadband filter for the purposes of the present invention is 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [( trimethylsilyl) oxy] disiloxanyl] propyl] -phenol (CAS-No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane, which by the chemical structural formula is marked.
  • the UV-B filters can be oil-soluble or water-soluble.
  • Advantageous oil-soluble UV-B filter substances are z.
  • 3-benzylidene camphor derivatives preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor; 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4-
  • benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-di
  • Another light protection filter substance to be used advantageously according to the invention is ethylhexyl-2-cyano-3,3-diphenyl acrylate (octocrylene), which is available from BASF under the name Uvinul ® N 539 and is characterized by the following structure:
  • UV light absorbing substance or substances are selected or are selected from the group butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, octocrylene, ethylhexyl salicylate, phenylbenzimidazolesulfonic acid, disodium phenyldibenzimidazole tetrasul- fonate, benzophenone-3, drometrizol trisiloxane, benzophenone-4, homosalates, benzene-1,4-di (2- oxo-3-bornylidenemethyl-10-sulfonic acid, polysilicone-15, ethylhexyl triazone, diethylhexylbutamidotriazone, isoamyl p-methoxycinnamate , Diethyla ino Hydroxybenzoyl Hexyl Benzoate
  • the emulsion according to the invention is characterized in that lipophilic emulsifiers with an HLB value of greater than / equal to 8 are used as O / W emulsifiers.
  • the HLB value of emulsifiers can be found in the usual standard works (e.g. Fiedler, Lexicon of Auxiliaries for Pharmacy, Cosmetics and Neighboring Areas, Editio Cantor Verlag, Aulendorf).
  • the emulsion according to the invention is characterized in that, as O / W emulsifiers, glyceryl stearate citrate (CAS 39175-72-9, INCI Glyceryl Stearate Citrate, e.g. Imwitor 370 from Hüls), polyglyceryl-3 methylglucose distearate (INCI Polyglyceryl Methyl Glucose Distearate, e.g. Tego Care 450 from Evonik) and / or polyethylene glycol (2000) monostearate (INCI; PEG-40 stearate) can be used.
  • O / W emulsifiers glyceryl stearate citrate (CAS 39175-72-9, INCI Glyceryl Stearate Citrate, e.g. Imwitor 370 from Hüls), polyglyceryl-3 methylglucose distearate (INCI Polyglyceryl Methyl Glucose Distearate, e
  • the emulsion according to the invention contains potassium cetyl phosphate, sodium cetearyl sulfate, sodium stearyl glutamate, alkali salts of saturated fatty acids of chain length C14-C22, in particular sodium stearate, as an anionic emulsifier.
  • the emulsion according to the invention contains one or more polyglyceryl fatty acid esters as nonionic emulsifiers.
  • the polyglyceryl fatty acid ester particularly preferred according to the invention is polyglyceryl-10 stearate (INCI polyglyceryl-10 stearate).
  • the emulsion according to the invention is characterized in that the content of one or more anionic emulsifiers in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.05 and 2% by weight, be particularly preferably between 0.1 and 1.0% by weight, based in each case on the total weight of the emulsion.
  • the emulsion according to the invention is characterized in that the content of one or more nonionic emulsifiers, in particular one or more polyglyceryl fatty acid esters, especially polyglyceryl-10 stearate, in the emulsion is from 0.001 to 5.0% by weight and is preferably between 0.05 and 3% by weight, particularly preferably between 0.1 and 2.0% by weight, in each case based on the total weight of the emulsion.
  • the emulsion according to the invention can have the consistency of an ointment, cream or low-viscosity lotion or represent an ointment, cream or low-viscosity lotion.
  • the process according to the invention is carried out in the form of the hot-hot process.
  • a hot oil and water phase are combined with one another.
  • the emulsion can advantageously be in the form of an ointment, cream or lotion (optionally sprayable).
  • the emulsion can advantageously also be used as a spray or as a soaking medium for a plaster or cloth. Therefore, plasters and tissues impregnated with the emulsion according to the invention are also according to the invention.
  • the water phase of the emulsion according to the invention can advantageously contain customary cosmetic auxiliaries, such as alcohols, especially those with a low carbon number, preferably ethanol and / or isopropanol, diols or polyols with a low carbon number, and their ethers, preferably propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl - or monobutyl ether, hexanediol, octanediol, glyceryl caprylate, ethylhexylglycerol, methylpropanediol, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether, and analogous products, as well as phenoxyethanol, hydrochloride, benzethylacetophenol, benzethonium alcohol , Foam stabilizers, electrolytes, self-tanner
  • the oil phase according to the invention can contain all conventional constituents of oil, fat and wax components used in cosmetics.
  • the emulsion according to the invention can advantageously contain cosmetic active and care substances, for example the UV light protection filters approved according to the Cosmetics Ordinance.
  • cosmetic active and care substances for example the UV light protection filters approved according to the Cosmetics Ordinance.
  • active ingredients can advantageously be contained therein in concentrations of 0.01 to 30% by weight, based on the total weight of the preparation.
  • Additional care substances that can be used are niacinamide, panthenol, aloe vera, vitamin E, vitamin A, vitamin A palmitate, vitamin C, vitamin C phosphate, vitamin C palmitate, vitamin C glucoside, coenzyme Q10 (ubiquinone), creatine, creatinine, taurine, Folic acid, alpha-glycosyl rutin, amino acids (e.g. glycine, histidine, alanine, arginine), carnosine, unsaturated fatty acids and their esters, especially di- and triglycerides (e.g.
  • g-linolenic acid, linoleic acid, oleic acid), mannose, magnolia bark extract, magnolol, Honokiol, dihydromyricetin, burdock fruit extract, arctiin, milk thistle extracts, silymarin, ingredients of liquorice extracts such as glycyrrhetinic acid and licochalcone A can be used in concentrations of 0.001 to 5% by weight, based on the total weight of the preparation.
  • the preparation according to the invention particularly preferably contains alpha-hydroxy acids and / or their salts as further constituents.
  • lactic acid / lactates or citric acid / citrates are preferably used in a concentration of 0.01 to 5% by weight, based on the total weight of the preparation.
  • the preparation according to the invention can contain perfumes in any desired composition and amount.

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Abstract

The invention relates to cosmetic oil-in-water emulsions (O/W emulsions) containing, in addition to a water phase, one or more oil phases dispersed therein and a) optionally one or more anionic emulsifiers and/or b) optionally one or more non-ionic emulsifiers and c) one or more succinoglucans and d) one or more lipophilic UV filter substances.

Description

Beschreibung description
Kosmetische O/W-Emulsion mit Succinoglucan und lipophilen UV-Filtersubstanzen Cosmetic O / W emulsion with succinoglucan and lipophilic UV filter substances
Die vorliegende Erfindung betrifft eine kosmetische Zubereitung enthaltend Succinoglucan und lipophile UV-Filtersubstanzen. The present invention relates to a cosmetic preparation containing succinoglucan and lipophilic UV filter substances.
Der Wunsch, schön und attraktiv auszusehen, ist von Natur aus im Menschen verwurzelt. Auch wenn das Schönheitsideal im Laufe der Zeit Wandlungen erfahren hat, so ist das Stre ben nach einem makellosen Äußeren immer das Ziel der Menschen gewesen. Einen wesent lichen Anteil an einem schönen und attraktiven Äußeren haben dabei der Zustand und das Aussehen der Haut. The desire to look beautiful and attractive is inherently rooted in people. Even if the ideal of beauty has changed in the course of time, striving for a flawless appearance has always been the goal of people. The condition and appearance of the skin play a key role in a beautiful and attractive appearance.
Damit die Haut ihre biologischen Funktionen im vollen Umfang erfüllen kann, bedarf sie der regelmäßigen Reinigung und Pflege. Die Reinigung der Haut dient dabei der Entfernung von Schmutz, Schweiß und Resten abgestorbener Hautpartikel, die einen idealen Nährboden für Krankheitserreger und Parasiten aller Art bilden. Hautpflegeprodukte dienen meist der Be feuchtung und Rückfettung der Haut. Häufig sind ihnen Wirkstoffe zugesetzt, welche die Haut regenerieren und beispielsweise ihre vorzeitige Alterung (z. B. das Entstehen von Fält- chen, Falten) verhindern und vermindern sollen. In order for the skin to be able to fully fulfill its biological functions, it needs regular cleaning and care. The cleaning of the skin serves to remove dirt, sweat and residues of dead skin particles, which form an ideal breeding ground for pathogens and parasites of all kinds. Skin care products are mostly used to moisturize and re-oil the skin. Often, active ingredients are added to them that regenerate the skin and, for example, are intended to prevent and reduce its premature aging (eg the appearance of fine lines and wrinkles).
Hautpflegeprodukte bestehen in der Regel aus Emulsionen. Unter Emulsionen versteht man im Allgemeinen heterogene Systeme, die aus zwei nicht oder nur begrenzt miteinander mischbaren Flüssigkeiten bestehen, die üblicherweise als Phasen bezeichnet werden und bei denen eine der beiden Flüssigkeiten in Form feinster Tröpfchen in der anderen Flüssig keit dispergiert ist. Äußerlich und mit bloßem Auge betrachtet erscheinen Emulsionen homo gen. Skin care products are usually made up of emulsions. Emulsions are generally understood to mean heterogeneous systems which consist of two liquids which are immiscible or only partially miscible with one another, which are usually referred to as phases and in which one of the two liquids is dispersed in the other liquid in the form of very fine droplets. Externally and with the naked eye, emulsions appear homogeneous.
Sind die beiden Flüssigkeiten Wasser und Öl und liegen Öltröpfchen fein verteilt in Wasser vor, so handelt es sich um eine ÖI-in-Wasser-Emulsion (O/W-Emulsion, z. B. Milch). Der Grundcharakter einer O/W-Emulsion ist durch das Wasser geprägt. Bei einer Wasser-in-ÖI- Emulsion (W/O-Emulsion, z. B. Butter) handelt es sich um das umgekehrte Prinzip, wobei der Grundcharakter hier durch das Öl bestimmt wird. Um Emulsionen über einen längeren Zeitraum stabil zu halten und eine Entmischung der Phasen zu verhindern, werden den Emulsionen sogenannte Emulgatoren zugesetzt. Bei Emulgatoren handelt es sich in der Regel um Moleküle mit einem polaren, lipophilen Struktu relement und einem unpolaren, lipophilen Strukturelement. Ende der vierziger Jahre wurde ein System entwickelt, das die Auswahl von Emulgatoren erleichtern sollte. Jedem Emulga tor wird ein so genannter HLB-Wert (eine dimensionslose Zahl zwischen 0 und 20) zuge schrieben, der angibt, ob eine bevorzugte Wasser- oder Öllöslichkeit vorliegt. Zahlen unter 8 kennzeichnen öllösliche, hydrophobere Emulgatoren, Zahlen über 8 wasserlösliche, hydro philere. If the two liquids are water and oil and if oil droplets are finely distributed in water, then it is an oil-in-water emulsion (O / W emulsion, e.g. milk). The basic character of an O / W emulsion is shaped by the water. In the case of a water-in-oil emulsion (W / O emulsion, e.g. butter), the principle is reversed, the basic character being determined here by the oil. In order to keep emulsions stable over a longer period of time and to prevent the phases from separating, so-called emulsifiers are added to the emulsions. Emulsifiers are usually molecules with a polar, lipophilic structural element and a non-polar, lipophilic structural element. At the end of the 1940s a system was developed to make the selection of emulsifiers easier. A so-called HLB value (a dimensionless number between 0 and 20) is assigned to each emulsifier, which indicates whether the water or oil solubility is preferred. Numbers under 8 indicate oil-soluble, more hydrophobic emulsifiers, numbers above 8 water-soluble, more hydrophilic emulsifiers.
Bei der Herstellung einer Emulsion wird die Wasserphase mit der Lipidphase (Ölphase) unter Rühren vereinigt, wobei die Tröpfchen der inneren Phase der Emulsion auf eine Größe von unter 10 pm zerkleinert werden müssen, damit die Emulsion stabil wird. In the production of an emulsion, the water phase is combined with the lipid phase (oil phase) with stirring, the droplets of the inner phase of the emulsion having to be broken down to a size of less than 10 μm so that the emulsion becomes stable.
Der Trend weg von der vornehmen Blässe hin zur „gesunden, sportlich braunen Haut“ ist seit Jahren ungebrochen. Um diese zu erzielen setzen die Menschen ihre Haut der Sonnenstrah lung aus, da diese eine Pigmentbildung im Sinne einer Melaninbildung hervorruft. Die ultra violette Strahlung des Sonnenlichtes hat jedoch auch eine schädigende Wirkung auf die Haut. Neben der akuten Schädigung (Sonnenbrand) treten Langzeitschäden wie ein erhöh tes Risiko an Hautkrebs zu erkranken bei übermäßiger Bestrahlung mit Licht aus dem UVB- Bereich (Wellenlänge: 280-320 nm) auf. Die übermäßige Einwirkung der UVB- und UVA- Strahlung (Wellenlänge: 320-400 nm) führt darüber hinaus zu einer Schwächung der elasti schen und kollagenen Fasern des Bindegewebes. Dies führt zu zahlreichen phototoxischen und photoallergischen Reaktionen und hat eine vorzeitige Hautalterung zur Folge. The trend away from elegant paleness towards "healthy, sporty brown skin" has been unbroken for years. In order to achieve this, people expose their skin to solar radiation, as this causes pigment formation in the form of melanin. However, the ultra violet radiation of sunlight also has a damaging effect on the skin. In addition to acute damage (sunburn), long-term damage such as an increased risk of developing skin cancer occurs when exposed to excessive exposure to light from the UVB range (wavelength: 280-320 nm). The excessive exposure to UVB and UVA radiation (wavelength: 320-400 nm) also leads to a weakening of the elastic and collagen fibers of the connective tissue. This leads to numerous phototoxic and photoallergic reactions and leads to premature aging of the skin.
Zum Schutz der Haut wurde daher eine Reihe von Lichtschutzfiltersubstanzen entwickelt, die in kosmetischen Zubereitungen eingesetzt werden können. Diese UVA- und UVB-Filter sind in den meisten Industrieländern in Form von Positivlisten wie der Anlage 7 der Kosmetikver ordnung zusammengefasst. To protect the skin, a number of light protection filter substances have therefore been developed that can be used in cosmetic preparations. These UVA and UVB filters are summarized in most industrialized countries in the form of positive lists such as Annex 7 of the Cosmetics Ordinance.
Der Einsatz von lipophilen UV-Filtern in Emulsionen führt häufig zu einer Destabilisierung dieser Systeme und einer daraus resultierenden Trennung der Phasen. Eine Langzeitstabi- liserung von O/W Emulsionen mit UV-Filtern auch bei erhöhter Temperatur ist daher wün schenswert. Überraschend gelöst wird die Aufgabe durch kosmetische ÖI-in-Wasser-Emulsionen (O/W- Emulsionen) enthaltend neben einer Wasserphase eine oder mehrere darin dispergierte Öl phasen sowie a) ein oder mehrere Succinoglucane und b) eine oder mehrere lipophile UV-Filtersubstanzen. The use of lipophilic UV filters in emulsions often leads to a destabilization of these systems and a resulting separation of the phases. Long-term stabilization of O / W emulsions with UV filters, even at elevated temperatures, is therefore desirable. The object is surprisingly achieved by cosmetic oil-in-water emulsions (O / W emulsions) containing, in addition to a water phase, one or more oil phases dispersed therein and a) one or more succinoglucans and b) one or more lipophilic UV filter substances.
Succinoglucan ist ein mit Bernsteinsäure teilweise verestertes Polysaccharid, welches bei spielsweise als Fermentationsproduct von Agrobacterium tumefaciens gewonnen werden kann. Succinoglucan wird dabei) als mikrobielles Exopolysaccharid in das umgebende Medi um abgegeben. Succinoglucan is a polysaccharide partially esterified with succinic acid, which can be obtained, for example, as a fermentation product of Agrobacterium tumefaciens. Succinoglucan is released into the surrounding medium as a microbial exopolysaccharide.
Das Rückgrat des Succinoglucans bilden dabei vorwiegend Glucosemonomere, vorteilhaft kann allerdings auch Galactose einpolymerisiert sein. Ein besonders vorteilhaftes Succino glucan weist molare Verhältnisse von Glucose zu Galactose wie 8 - 6 : 1, insbesondere un gefähr wie 7 : 1 auf. The backbone of the succinoglucan is mainly formed by glucose monomers, but galactose can advantageously also be polymerized. A particularly advantageous succino glucan has molar ratios of glucose to galactose such as 8-6: 1, in particular about 7: 1.
Erfindungsgemäß vorteilhaft ist im statistischen Mittel jedes achte bis zwölfte Zuckermolekül des polymeren Rückgrates mit einem Molekül Bernsteinsäure verestert, bevorzugt etwa je des zehnte Zuckermolekül. According to the invention, on a statistical average, every eighth to twelfth sugar molecule of the polymeric backbone is advantageously esterified with a molecule of succinic acid, preferably about every tenth sugar molecule.
Es kann auch vorteilhaft sein, zuzüglich weitere funktionelle Moleküle an die Zuckermoleküle zu binden, beispielsweise Brenztraubensäure, die über eine Acetalbildung angekoppelt wer den kann. It can also be advantageous to bind additional functional molecules to the sugar molecules, for example pyruvic acid, which can be coupled via acetal formation.
Erfindungsgemäß vorteilhaft ist im statistischen Mittel jedes fünfte bis zwanzigste Zuckermo lekül des polymeren Rückgrates an ein Molekül Brenztraubensäure gekoppelt, bevorzugt etwa jedes achte Zuckermolekül. Advantageously according to the invention, on a statistical average, every fifth to twentieth sugar molecule of the polymeric backbone is coupled to a pyruvic acid molecule, preferably about every eighth sugar molecule.
Die chemische Struktur des Succinoglucans wird wie folgt veranschaulicht: The chemical structure of succinoglucan is illustrated as follows:
Succinoglucan ist in Wasser gut löslich und kann als Verdicker eingesetzt werden. Der Ein satz von Succinoglucan in kosmetischen Emulsionen ist dem Fachmann an sich bekannt, doch konnte der Stand der Technik nicht den Weg zur vorliegenden Erfindung weisen. Succinoglucan is readily soluble in water and can be used as a thickener. The use of succinoglucan in cosmetic emulsions is known per se to the person skilled in the art, but the prior art could not point the way to the present invention.
Es ist erfindungsgemäß vorteilhaft, wenn die erfindungsgemäße Emulsion dadurch gekenn zeichnet ist, dass der Gehalt an Succinoglucan in der Emulsion von 0,001 bis 5,0 Gew.-% und bevorzugt zwischen 0,01 und 1,5 Gew.-%, besonders bevorzugt zwischen 0,1 und 1,0 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Emulsion, beträgt. According to the invention it is advantageous if the emulsion according to the invention is characterized in that the content of succinoglucan in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.01 and 1.5% by weight, particularly preferably between 0.1 and 1.0% by weight, each based on the total weight of the emulsion.
Es ist erfindungsgemäß vorteilhaft, wenn die Emulsion einen oder mehrere Öl-in-Wasser- Emulgatoren (O/W-Emulgatoren) in einer Gesamtkonzentration von 0,05 bis 5,0 Gew.-% und bevorzugt in einer Gesamtkonzentration von 2,0 bis 4,0 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Emulsion, beträgt. It is advantageous according to the invention if the emulsion has one or more oil-in-water emulsifiers (O / W emulsifiers) in a total concentration of 0.05 to 5.0% by weight and preferably in a total concentration of 2.0 to 4.0% by weight, based in each case on the total weight of the emulsion.
Es ist erfindungsgemäß besonders vorteilhaft, wenn die erfindungsgemäße Emulsion dadurch gekennzeichnet ist, dass der Gehalt an einem oder mehreren anionischen Emulga toren in der Emulsion von 0,001 bis 5,0 Gew.-% und bevorzugt zwischen 0,05 und 2 Gew-%, besonders bevorzugt zwischen 0,1 und 1,0 Gew.-%, jeweils bezogen auf das Gesamtge wicht der Emulsion, beträgt. According to the invention, it is particularly advantageous if the emulsion according to the invention is characterized in that the content of one or more anionic emulsifiers in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.05 and 2% by weight, particularly preferably between 0.1 and 1.0% by weight, based in each case on the total weight of the emulsion.
Es ist erfindungsgemäß besonders vorteilhaft, wenn die erfindungsgemäße Emulsion dadurch gekennzeichnet ist, dass der Gehalt an einem oder mehreren nichtionischen Emul gatoren in der Emulsion von 0,001 bis 5,0 Gew.-% und bevorzugt zwischen 0,05 und 3 Gew.-%, besonders bevorzugt zwischen 0,1 und 2 Gew.-%, jeweils bezogen auf das Ge samtgewicht der Emulsion, beträgt. According to the invention, it is particularly advantageous if the emulsion according to the invention is characterized in that the content of one or more nonionic emulsifiers in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.05 and 3% by weight, particularly preferably between 0.1 and 2% by weight, based in each case on the total weight of the emulsion.
Es ist erfindungsgemäß besonders vorteilhaft, wenn die erfindungsgemäße Emulsion dadurch gekennzeichnet ist, dass der Gehalt an einem oder mehreren lipophilen UV- Filtersubstanzen in der Emulsion von 0,001 bis 20 Gew.-% und bevorzugt zwischen 0,05 und 15 Gew.-%, besonders bevorzugt zwischen 0,1 und 10 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Emulsion, beträgt. According to the invention, it is particularly advantageous if the emulsion according to the invention is characterized in that the content of one or more lipophilic UV- Filter substances in the emulsion from 0.001 to 20% by weight and preferably between 0.05 and 15% by weight, particularly preferably between 0.1 and 10% by weight, in each case based on the total weight of the emulsion.
Vorteilhafte lipophile UV-A-Filtersubstanzen im Sinne der vorliegenden Erfindung sind z. B. Vorteilhafte UV-A-Filtersubstanzen im Sinne der vorliegenden Erfindung sind Dibenzoyl- methanderivate, insbesondere das 4-(tert.-Butyl)-4’-methoxydibenzoylmethan (CAS-Nr. 70356-09-1), welches von Givaudan unter der Marke Parsol® 1789 und von Merck unter der Handelsbezeichnung Eusolex® 9020 verkauft wird. Advantageous lipophilic UV-A filter substances for the purposes of the present invention are, for. B. Advantageous UV-A filter substances for the purposes of the present invention are dibenzoyl methane derivatives, especially 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol ® 1789 brand and sold by Merck under the trade name Eusolex ® 9020.
Vorteilhafte UV-Filtersubstanzen im Sinne der vorliegenden Erfindung sind ferner soge nannte Breitbandfilter, d.h. Filtersubstanzen, die sowohl UV-A- als auch UV-B-Strahlung ab sorbieren. Advantageous UV filter substances for the purposes of the present invention are also so-called broadband filters, i.e. filter substances that absorb both UV-A and UV-B radiation.
Vorteilhafte Breitbandfilter oder UV-B-Filtersubstanzen sind beispielsweise Bis-Resorcinyl- triazinderivate mit der folgenden Struktur: wobei R1, R2 und R3 unabhängig voneinander gewählt werden aus der Gruppe der ver zweigten und unverzweigten Alkylgruppen mit 1 bis 10 Kohlenstoffatomen bzw. ein einzelnes Wasserstoffatom darstellen. Insbesondere bevorzugt sind das 2,4-Bis-{[4-(2-Ethyl-hexyloxy)- 2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin (INCI: Aniso Triazin), welches unter der Handelsbezeichnung Tinosorb® S bei der BASF AG erhältlich ist, und das 4,4',4"-(1,3,5- Triazin-2,4,6-triyltriimino)-tris-benzoesäure-tris(2-ethylhexylester), synonym: 2,4,6-Tris- [anilino-(p-carbo-2'-ethyl-1'-hexyloxy)]-1,3,5-triazin (INCI: Octyl Triazone), welches von der BASF Aktiengesellschaft unter der Warenbezeichnung UVINUL® T 150 vertrieben wird. Auch andere UV-Filtersubstanzen, welche das Strukturmotiv aufweisen, sind vorteilhafte UV-Filtersubstanzen im Sinne der vorliegenden Erfindung, bei spielsweise die in der Europäischen Offenlegungsschrift EP 570838 A1 beschriebenen s- Triazinderivate, deren chemische Struktur durch die generische Formel wiedergegeben wird, wobei Advantageous broadband filters or UV-B filter substances are, for example, bis-resorcinyl triazine derivatives with the following structure: where R 1 , R 2 and R 3 are independently selected from the group of the branched and unbranched alkyl groups with 1 to 10 carbon atoms or represent a single hydrogen atom. 2,4-Bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: Aniso Triazine) are particularly preferred ), which is available under the trade name Tinosorb® S from BASF AG, and the 4,4 ', 4 "- (1,3,5-triazine-2,4,6-triyltriimino) -tris-benzoic acid-tris ( 2-ethylhexyl ester), synonym: 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: Octyl Triazone), which is sold by BASF Aktiengesellschaft under the trade name UVINUL® T 150. Also other UV filter substances, which the structural motif have, are advantageous UV filter substances for the purposes of the present invention, for example the s-triazine derivatives described in the European patent application EP 570838 A1, whose chemical structure is given by the generic formula is played back, where
R einen verzweigten oder unverzweigten Ci-Cis-Alkylrest, einen C5-Ci2-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C1-C4- Alkylgruppen, darstellt,R represents a branched or unbranched Ci-Cis-alkyl radical, a C5-Ci2-cycloalkyl radical, optionally substituted with one or more C1-C4-alkyl groups,
X ein Sauerstoffatom oder eine NH-Gruppe darstellt, X represents an oxygen atom or an NH group,
Ri einen verzweigten oder unverzweigten Ci-Cis-Alkylrest, einen C5-Ci2-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C1-C4- Alkylgruppen, oder ein Wasserstoffatom, ein Alkalimetallatom, eine Ammoniumgruppe oder eine Gruppe der Formel bedeutet, in welcher Ri is a branched or unbranched Ci-Cis-alkyl radical, a C5-Ci2-cycloalkyl radical, optionally substituted by one or more C1-C4-alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula means in which
A einen verzweigten oder unverzweigten CrCis-Alkylrest, einen C5-Ci2-Cycloalkyl- oder Arylrest darstellt, gegebenenfalls substituiert mit einer oder mehreren C1-C4- Alkylgrup pen, A represents a branched or unbranched C 1 -C 4 -alkyl radical, a C 5 -C 2 -cycloalkyl or aryl radical, optionally substituted by one or more C 1 -C 4 alkyl groups,
R3 ein Wasserstoffatom oder eine Methylgruppe darstellt, n eine Zahl von 1 bis 10 darstellt, R 3 represents a hydrogen atom or a methyl group, n represents a number from 1 to 10,
R2 einen verzweigten oder unverzweigten CrCis-Alkylrest, einen C5-Ci2-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C1-C4- Alkylgruppen, darstellt, wenn X die NH-Gruppe darstellt, und einen verzweigten oder unverzweigten CrCis-Alkylrest, einen C5-Ci2-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C1-C4- Alkylgruppen, oder ein Wasserstoffatom, ein Alkalimetallatom, eine Ammoniumgruppe oder eine Gruppe der Formel bedeutet, in welcher R 2 is a branched or unbranched C 1 -C 4 -alkyl radical, a C 5 -C 2 -cycloalkyl radical, optionally substituted by one or more C 1 -C 4 -alkyl groups, when X represents the NH group, and a branched or unbranched C 1 -Cis- Alkyl radical, a C 5 -C 2 cycloalkyl radical, optionally substituted by one or more C 1 -C 4 alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula means in which
A einen verzweigten oder unverzweigten CrCis-Alkylrest, einen C5-Ci2-Cycloalkyl- oder Arylrest darstellt, gegebenenfalls substituiert mit einer oder mehreren C1-C4- Alkylgrup pen, A represents a branched or unbranched C 1 -C 4 -alkyl radical, a C 5 -C 2 -cycloalkyl or aryl radical, optionally substituted by one or more C 1 -C 4 alkyl groups,
R3 ein Wasserstoffatom oder eine Methylgruppe darstellt, n eine Zahl von 1 bis 10 darstellt, wenn X ein Sauerstoffatom darstellt. R 3 represents a hydrogen atom or a methyl group, n represents a number from 1 to 10 when X represents an oxygen atom.
Besonders bevorzugte UV-Filtersubstanz im Sinne der vorliegenden Erfindung ist ferner ein unsymmetrisch substituiertes s-Triazin, dessen chemische Struktur durch die Formel A particularly preferred UV filter substance for the purposes of the present invention is also an asymmetrically substituted s-triazine, the chemical structure of which is given by the formula
wiedergegeben wird, welches im Folgenden auch als Dioctylbutylamidotriazon (INCI: Dio- ctylbutamidotriazone) bezeichnet wird und unter der Handelsbezeichnung UVASORB HEB bei Sigma 3V erhältlich ist. is reproduced, which is also referred to below as Dioctylbutylamidotriazon (INCI: Dioctylbutamidotriazone) and is available under the trade name UVASORB HEB from Sigma 3V.
Auch in der Europäischen Offenlegungsschrift 775698 werden bevorzugt einzusetzende Bis- Resorcinyltriazinderivate beschrieben, deren chemische Struktur durch die generische For mel wiedergegeben wird, wobei Ri , R2 und Ai verschiedenste organische Reste repräsentieren. In the European laid-open specification 775698 bis-resorcinyltriazine derivatives to be used are also described, the chemical structure of which is given by the generic formula is reproduced, where Ri, R2 and Ai represent a wide variety of organic radicals.
Vorteilhaft im Sinne der vorliegenden Erfindung sind ferner das 2,4-Bis-{[4-(3-sulfonato)-2- hydroxy-propyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1 ,3,5-triazin Natriumsalz, das 2,4-Bis-{[4-(3-(2-Propyloxy)-2-hydroxy-propyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)- 1 ,3,5-triazin, das 2,4-Bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-[4-(2-methoxyethyl- carboxyl)-phenylamino]-1 ,3,5-triazin, das 2,4-Bis-{[4-(3-(2-propyloxy)-2-hydroxy-propyloxy)- 2-hydroxy]-phenyl}-6-[4-(2-ethyl-carboxyl)-phenylamino]-1 ,3,5-triazin, das 2,4-Bis-{[4-(2- ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(1-methyl-pyrrol-2-yl)-1,3,5-triazin, das 2,4-Bis-{[4- tris(trimethylsiloxy-silylpropyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin, das 2,4-Bis-{[4-(2“-methylpropenyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin und das 2,4-Bis-{[4-(1 1 1 ’,3’,5’,5’,5’-Heptamethylsiloxy-2“-methyl-propyloxy)-2-hydroxy]-phenyl}- 6-(4-methoxyphenyl)-1,3,5-triazin. The 2,4-bis - {[4- (3-sulfonato) -2-hydroxy-propyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1, are also advantageous for the purposes of the present invention. 3,5-triazine sodium salt, the 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxy-propyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) - 1,3,5-triazine, 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- [4- (2-methoxyethyl-carboxyl) -phenylamino] -1, 3,5-triazine, 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxy-propyloxy) -2-hydroxy] -phenyl} -6- [4- ( 2-ethyl-carboxyl) phenylamino] -1, 3,5-triazine, the 2,4-bis - {[4- (2- ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (1-methyl-pyrrol-2-yl) -1,3,5-triazine, the 2,4-bis - {[4- tris (trimethylsiloxy- silylpropyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine, the 2,4-bis - {[4- (2 “-methylpropenyloxy) -2-hydroxy] - phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine and the 2,4-bis - {[4- (1 1 1 ', 3', 5 ', 5', 5'-heptamethylsiloxy- 2 “-methyl-propyloxy) -2-hydroxy] -phenyl} - 6- (4-methoxyphenyl) -1,3,5-triazine.
Ein vorteilhafter Breitbandfilter im Sinne der vorliegenden Erfindung ist das 2,2’-Methylen- bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-phenol), welches durch die chemi sche Strukturformel gekennzeichnet ist und unter der Handelsbezeichnung Tinosorb® M bei der CIBA- Chemikalien GmbH erhältlich ist. An advantageous broadband filter for the purposes of the present invention is 2,2'-methylene bis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol), which through the chemical structural formula and is available under the trade name Tinosorb® M from CIBA-Nahrungsmittel GmbH.
Vorteilhafter Breitbandfilter im Sinne der vorliegenden Erfindung ist ferner das 2-(2H- benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxa- nyl]propyl]-phenol (CAS-Nr.: 155633-54-8) mit der INCI-Bezeichnung Drometrizole Trisiloxa- ne, welches durch die chemische Strukturformel gekennzeichnet ist. Die UV-B-Filter können öllöslich oder wasserlöslich sein. Vorteilhafte öllösliche UV-B- Filtersubstanzen sind z. B.: 3-Benzylidencampher-Derivate, vorzugsweise 3-(4- Methylbenzyliden)campher, 3-Benzylidencampher; 4-Aminobenzoesäure-Derivate, vorzugs weise 4-(Dimethylamino)-benzoesäure(2-ethylhexyl)ester, 4-Another advantageous broadband filter for the purposes of the present invention is 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [( trimethylsilyl) oxy] disiloxanyl] propyl] -phenol (CAS-No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane, which by the chemical structural formula is marked. The UV-B filters can be oil-soluble or water-soluble. Advantageous oil-soluble UV-B filter substances are z. For example: 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor; 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4-
(Dimethylamino)benzoesäureamylester; 2,4,6-Trianilino-(p-carbo-2'-ethyl-1'-hexyloxy)-1,3,5-- triazin; Ester der Benzalmalonsäure, vorzugsweise 4-Methoxybenzalmalonsäuredi(2-ethylhe- xyl)ester; Ester der Zimtsäure, vorzugsweise 4-Methoxyzimtsäure(2-ethylhexyl)ester, 4- Methoxyzimtsäureisopentylester; Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4- methoxybenzophenon, 2-Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2'-Dihydroxy-4- methoxybenzophenon sowie an Polymere gebundene UV-Filter. Amyl (dimethylamino) benzoate; 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine; Esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) ester; Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester; Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, and UV filters bound to polymers.
Eine weiterere erfindungsgemäß vorteilhaft zu verwendende Lichtschutzfiltersubstanz ist das Ethylhexyl-2-cyano-3,3-diphenylacrylat (Octocrylen), welches von BASF unter der Bezeich nung Uvinul® N 539 erhältlich ist und sich durch folgende Struktur auszeichnet: Another light protection filter substance to be used advantageously according to the invention is ethylhexyl-2-cyano-3,3-diphenyl acrylate (octocrylene), which is available from BASF under the name Uvinul ® N 539 and is characterized by the following structure:
Es kann auch von erheblichem Vorteil sein, polymergebundene oder polymere UV-Filter- substanzen in Zubereitungen gemäß der vorliegenden Erfindung zu verwenden, insbe sondere solche, wie sie in der WO-A-92/20690 beschrieben werden. It can also be of considerable advantage to use polymer-bound or polymeric UV filter substances in preparations according to the present invention, in particular those as described in WO-A-92/20690.
Ferner kann es gegebenenfalls von Vorteil sein, erfindungsgemäß weitere UV-A- und/oder UV-B-Filter in kosmetische oder dermatologische Zubereitungen einzuarbeiten, bei spielsweise bestimmte Salicylsäurederivate wie 4-lsopropylbenzylsalicylat, 2-Ethylhexyl- salicylat (= Octylsalicylat), Homomenthylsalicylat. It may also be advantageous to incorporate further UV-A and / or UV-B filters into cosmetic or dermatological preparations according to the invention, for example certain salicylic acid derivatives such as 4-isopropylbenzyl salicylate, 2-ethylhexyl salicylate (= octyl salicylate), homomenthyl salicylate.
Ganz besonders vorteilhaft sind erfindungsgemäße Zubereitungen, dadurch gekennzeichnet, daß die UV-Licht absorbierenden Substanz oder die Substanzen gewählt wird oder werden aus der Gruppe Butylmethoxydibenzoylmethan, Ethylhexylmethoxycinnamat, Octocrylen, Ethylhexylsalicylat, Phenylbenzimidazolsulfonsäure, Dinatriumphenyldibenzimidazoltetrasul- fonat, Benzophenon-3, Drometrizol trisiloxan, Benzophenon-4, Homosalate, Benzol-1,4-di(2- oxo-3-bornylidenmethyl-10-sulfonsäure, Polysilicone-15, Ethylhexyl Triazone, Diethylhexyl- Butamidotriazone, Isoamyl p-Methoxycinnamate, Diethyla ino Hydroxybenzoyl Hexyl Ben zoate, Methylen-bis-benzotriazolyltetramethylbutylphenol, Bis-Ethylhexyloxyphenolmethoxy- phenyltriazin, 4-Methylbenzylidencampher, 2,4-Bis-[5-](dimethylpropyl)benzoxazol-2-yl-(4- phenyl)-i ino]-6-(2-ethylhexyl)-i ino-1 ,3,5-triazin und/oder (2-{4-[2-(4-Diethylamino-2- hydroxy-benzoyl)-benzoyl]-piperazin-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)- ethanon. Preparations according to the invention, characterized in that the UV light absorbing substance or substances are selected or are selected from the group butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, octocrylene, ethylhexyl salicylate, phenylbenzimidazolesulfonic acid, disodium phenyldibenzimidazole tetrasul- fonate, benzophenone-3, drometrizol trisiloxane, benzophenone-4, homosalates, benzene-1,4-di (2- oxo-3-bornylidenemethyl-10-sulfonic acid, polysilicone-15, ethylhexyl triazone, diethylhexylbutamidotriazone, isoamyl p-methoxycinnamate , Diethyla ino Hydroxybenzoyl Hexyl Benzoate, Methylen-bis-benzotriazolyltetramethylbutylphenol, Bis-ethylhexyloxyphenolmethoxyphenolmethoxyphenyltriazin, 4-Methylbenzylidencamphor, 2,4-Bis- [5 -] (dimethylpropyl) -benzoxazol-2-phenyl) -i- ( ino] -6- (2-ethylhexyl) -i ino-1, 3,5-triazine and / or (2- {4- [2- (4-diethylamino-2-hydroxy-benzoyl) -benzoyl] -piperazine- 1-carbonyl} -phenyl) - (4-diethylamino-2-hydroxyphenyl) - ethanone.
Es ist erfindungsgemäß vorteilhaft, wenn die erfindungsgemäße Emulsion dadurch gekenn zeichnet ist, dass als O/W-Emulgatoren lipophile Emulgatoren mit einem HLB-Wert von grö ßer/gleich 8 eingesetzt werden. Der HLB-Wert von Emulgatoren kann dabei den üblichen Standartwerken (z. B. Fiedler, Lexikon der Hilfsstoffe für Pharmazie, Kosmetik und angren zende Gebiete, Editio Cantor Verlag, Aulendorf) entnommen werden. It is advantageous according to the invention if the emulsion according to the invention is characterized in that lipophilic emulsifiers with an HLB value of greater than / equal to 8 are used as O / W emulsifiers. The HLB value of emulsifiers can be found in the usual standard works (e.g. Fiedler, Lexicon of Auxiliaries for Pharmacy, Cosmetics and Neighboring Areas, Editio Cantor Verlag, Aulendorf).
Es ist erfindungsgemäß bevorzugt, wenn die erfindungsgemäße Emulsion dadurch gekenn zeichnet ist, dass als O/W-Emulgatoren Glycerylstearatcitrat (CAS 39175-72-9, INCI Glyceryl Stearate Citrate, z. B. Imwitor 370 der Firma Hüls), Polyglyceryl-3 Methylglucosedistearat (INCI Polyglyceryl Methyl Glucose Distearate, z. B. Tego Care 450 der Firma Evonik) und/oder Polyethylenglycol(2000)monostearat (INCI; PEG-40 stearate) eingesetzt werden. It is preferred according to the invention if the emulsion according to the invention is characterized in that, as O / W emulsifiers, glyceryl stearate citrate (CAS 39175-72-9, INCI Glyceryl Stearate Citrate, e.g. Imwitor 370 from Hüls), polyglyceryl-3 methylglucose distearate (INCI Polyglyceryl Methyl Glucose Distearate, e.g. Tego Care 450 from Evonik) and / or polyethylene glycol (2000) monostearate (INCI; PEG-40 stearate) can be used.
In einer erfindungsgemäß bevorzugten Ausführungsform enthält die erfindungsgemäße Emulsion Kalium Cetylphosphat, Natrium Cetearylsulfat, Natrium Stearylglutamat, Alkalisal ze von gesättigten Fettsäuren der Kettenlänge C14-C22, insbesondere Natrium Stearat als anionischen Emulgator. In a preferred embodiment according to the invention, the emulsion according to the invention contains potassium cetyl phosphate, sodium cetearyl sulfate, sodium stearyl glutamate, alkali salts of saturated fatty acids of chain length C14-C22, in particular sodium stearate, as an anionic emulsifier.
In einerweiteren erfindungsgemäß bevorzugten Ausführungsform enthält die erfindungsge mäße Emulsion einen oder mehrere Polyglycerylfettsäureester als nichtionische Emulgato ren. Der erfindungsgemäß besonders bevorzugte Polyglycerylfettsäureester ist dabei Poly- glyceryl-10 Stearat (INCI Polyglyceryl-10 Stearate). In a further embodiment preferred according to the invention, the emulsion according to the invention contains one or more polyglyceryl fatty acid esters as nonionic emulsifiers. The polyglyceryl fatty acid ester particularly preferred according to the invention is polyglyceryl-10 stearate (INCI polyglyceryl-10 stearate).
Es ist erfindungsgemäß besonders vorteilhaft, wenn die erfindungsgemäße Emulsion dadurch gekennzeichnet ist, dass der Gehalt an ein oder mehreren anionischen Emulgatoren in der Emulsion von 0,001 bis 5,0 Gew.-% und bevorzugt zwischen 0,05 und 2 Gew.-%, be sonders bevorzugt zwischen 0,1 und 1,0 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Emulsion, beträgt. Es ist erfindungsgemäß besonders vorteilhaft, wenn die erfindungsgemäße Emulsion dadurch gekennzeichnet ist, dass der Gehalt an ein oder mehreren nichtionischen Emulgato ren, insbesondere einen oder mehrere Polyglycerylfettsäureester, besonders Polyglyceryl-10 Stearat in der Emulsion von 0,001 bis 5,0 Gew.-% und bevorzugt zwischen 0,05 und 3 Gew-%, besonders bevorzugt zwischen 0,1 und 2,0 Gew.-%, jeweils bezogen auf das Ge samtgewicht der Emulsion, beträgt. According to the invention, it is particularly advantageous if the emulsion according to the invention is characterized in that the content of one or more anionic emulsifiers in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.05 and 2% by weight, be particularly preferably between 0.1 and 1.0% by weight, based in each case on the total weight of the emulsion. According to the invention, it is particularly advantageous if the emulsion according to the invention is characterized in that the content of one or more nonionic emulsifiers, in particular one or more polyglyceryl fatty acid esters, especially polyglyceryl-10 stearate, in the emulsion is from 0.001 to 5.0% by weight and is preferably between 0.05 and 3% by weight, particularly preferably between 0.1 and 2.0% by weight, in each case based on the total weight of the emulsion.
Die erfindungsgemäße Emulsion kann die Konsistenz einer Salbe, Creme oder dünnflüssi gen Lotion aufweisen bzw. eine Salbe, Creme oder dünnflüssige Lotion darstellen. The emulsion according to the invention can have the consistency of an ointment, cream or low-viscosity lotion or represent an ointment, cream or low-viscosity lotion.
Es ist erfindungsgemäß bevorzugt, wenn das erfindungsgemäße Verfahren in Form des Hot- Hot-Verfahrens durchgeführt wird. Bei diesem Verfahren werden eine heiße Öl- und Was serphase miteinander vereinigt. It is preferred according to the invention if the process according to the invention is carried out in the form of the hot-hot process. In this process, a hot oil and water phase are combined with one another.
Dabei ist es erfindungsgemäß besonders bevorzugt, wenn das Verfahren bei einer Tempera tur nicht über 85 °C durchgeführt wird. It is particularly preferred according to the invention if the process is carried out at a temperature not above 85.degree.
Die Emulsion kann erfindungsgemäß vorteilhaft als Salbe, Creme oder Lotion (ggf. sprühbar) vorliegen. According to the invention, the emulsion can advantageously be in the form of an ointment, cream or lotion (optionally sprayable).
Die Emulsion kann erfindungsgemäß vorteilhaft auch als Spray oder als Tränkungsmedium für ein Pflaster oder Tuch eingesetzt werden. Daher sind auch Pflaster und Tücher getränkt mit der erfindungsgemäßen Emulsion, erfindungsgemäß. According to the invention, the emulsion can advantageously also be used as a spray or as a soaking medium for a plaster or cloth. Therefore, plasters and tissues impregnated with the emulsion according to the invention are also according to the invention.
Die Wasserphase der erfindungsgemäßen Emulsion kann vorteilhaft übliche kosmetische Hilfsstoffe enthalten, wie beispielsweise Alkohole, insbesondere solche niedriger C-Zahl, vorzugsweise Ethanol und/oder Isopropanol, Diole oder Polyole niedriger C-Zahl sowie de ren Ether, vorzugsweise Propylenglykol, Glycerin, Ethylenglykol, Ethylenglykolmonoethyl- oder -monobutylether, Hexandiol, Octandiol, Glycerylcaprylat, Ethylhexylglycerin, Methylpro- pandiol, Propylenglykolmonomethyl, -monoethyl- oder -monobutylether, Diethylenglykolmo- nomethyl- oder monoethylether, und analoge Produkte, außerdem Phenoxyethanol, Hydro- xyacetophenone, Benzylalkohol, Benzethonium Chlorid, Polymere, Schaumstabilisatoren, Elektrolyte, Selbstbräuner, Repellentien sowie insbesondere ein oder mehrere Verdickungs mittel, welches oder welche vorteilhaft gewählt werden können aus der Gruppe der Polysac charide bzw. deren Derivate, z. B. Xanthangummi, Carrageenan, Gellangummi, Sclerogluca- ne, Stärken und Cellulosen, Hyaluronsäure. Die erfindungsgemäße Ölphase kann alle herkömmlichen Bestandteile von in der Kosmetik eingesetzten Öl-, Fett- und Wachskomponenten enthalten. The water phase of the emulsion according to the invention can advantageously contain customary cosmetic auxiliaries, such as alcohols, especially those with a low carbon number, preferably ethanol and / or isopropanol, diols or polyols with a low carbon number, and their ethers, preferably propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl - or monobutyl ether, hexanediol, octanediol, glyceryl caprylate, ethylhexylglycerol, methylpropanediol, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether, and analogous products, as well as phenoxyethanol, hydrochloride, benzethylacetophenol, benzethonium alcohol , Foam stabilizers, electrolytes, self-tanners, repellants and, in particular, one or more thickening agents, which or which can advantageously be selected from the group of Polysac charides or their derivatives, eg. B. xanthan gum, carrageenan, gellan gum, scleroglucans, starches and celluloses, hyaluronic acid. The oil phase according to the invention can contain all conventional constituents of oil, fat and wax components used in cosmetics.
Die erfindungsgemäße Emulsion kann erfindungsgemäß vorteilhaft kosmetische Wirk- und Pflegestoffe enthalten, beispielsweise die nach der Kosmetikverordnung zugelassenen UV- Lichtschutzfilter. Derartige Wirkstoffe können erfindungsgemäß vorteilhaft in Konzentrationen von 0,01 bis 30 Gew.-%, bezogen auf das Gesamtgewicht der Zubereitung in dieser enthal ten sein. According to the invention, the emulsion according to the invention can advantageously contain cosmetic active and care substances, for example the UV light protection filters approved according to the Cosmetics Ordinance. According to the invention, such active ingredients can advantageously be contained therein in concentrations of 0.01 to 30% by weight, based on the total weight of the preparation.
Als weitere Pflegestoffe können insbesondere Niacinamid, Panthenol, Aloe vera, Vitamin E, Vitamin A, Vitamin A-Palmitat, Vitamin C, Vitamin C Phosphat, Vitamin C Palmitat, Vitamin C Glucosid, Coenzym Q10 (Ubiquinone), Kreatin, Kreatinin, Taurin, Folsäure, Alpha- Glycosylrutin, Aminosäuren (z.B. Glycin, Histidin, Alanin, Arginin), Carnosin, ungesättigte Fettsäuren und deren Ester, insbesondere Di- und Triglyceride (z.B. g-Linolensäure, Linol säure, Ölsäure), Mannose, Magnolia Rindenextrakt, Magnolol, Honokiol, Dihydromyricetin, Klettenfruchtextrakt, Arctiin, Extrakte der Mariendistel, Silymarin, Inhaltstoffe von Süßholzex trakten wie zum Beispiel Glycyrrhetinsäure und Licochalcone A in Konzentrationen von 0,001 bis 5 Gew.-%, bezogen auf das Gesamtgewicht der Zubereitung eingesetzt werden. Additional care substances that can be used are niacinamide, panthenol, aloe vera, vitamin E, vitamin A, vitamin A palmitate, vitamin C, vitamin C phosphate, vitamin C palmitate, vitamin C glucoside, coenzyme Q10 (ubiquinone), creatine, creatinine, taurine, Folic acid, alpha-glycosyl rutin, amino acids (e.g. glycine, histidine, alanine, arginine), carnosine, unsaturated fatty acids and their esters, especially di- and triglycerides (e.g. g-linolenic acid, linoleic acid, oleic acid), mannose, magnolia bark extract, magnolol, Honokiol, dihydromyricetin, burdock fruit extract, arctiin, milk thistle extracts, silymarin, ingredients of liquorice extracts such as glycyrrhetinic acid and licochalcone A can be used in concentrations of 0.001 to 5% by weight, based on the total weight of the preparation.
Erfindungsgemäß besonders bevorzugt enthält die erfindungsgemäße Zubereitung als weite re Bestandteile Alpha-Hydroxysäuren und/oder deren Salze. Dabei werden erfindungsgemäß bevorzugt Milchsäure/Lactate oder Zitronensäure/Citrate in einer Konzentration von 0,01 bis 5 Gew.-%, bezogen auf das Gesamtgewicht der Zubereitung eingesetzt. According to the invention, the preparation according to the invention particularly preferably contains alpha-hydroxy acids and / or their salts as further constituents. According to the invention, lactic acid / lactates or citric acid / citrates are preferably used in a concentration of 0.01 to 5% by weight, based on the total weight of the preparation.
Die erfindungsgemäße Zubereitung kann Parfümstoffe in beliebiger Zusammensetzung und Menge enthalten. The preparation according to the invention can contain perfumes in any desired composition and amount.
Die nachfolgenden Beispiele sollen die vorliegende Erfindung verdeutlichen ohne sie einzu schränken. Die Angaben beziehen sich stets auf Gew.-%, sofern nicht andere Angaben ge macht werden. The following examples are intended to illustrate the present invention without restricting it. The data always relate to% by weight, unless otherwise stated.
Rezepturbeispiele Recipe examples

Claims

Patentansprüche Claims
1. Kosmetische ÖI-in-Wasser-Emulsionen (O/W-Emulsionen) enthaltend neben einer Wasserphase eine oder mehrere darin dispergierte Ölphasen sowie a) ein oder mehrere Succinoglucane und b) ein oder mehrere lipophile UV-Filtersubstanzen. 1. Cosmetic oil-in-water emulsions (O / W emulsions) containing, in addition to a water phase, one or more oil phases dispersed therein and a) one or more succinoglucans and b) one or more lipophilic UV filter substances.
2. O/W-Emulsionen nach Anspruch 1, dadurch gekennzeichnet, dass der Gehalt an Suc- cinoglucan in der Emulsion von 0,01 bis 1,0 Gew.-%, bezogen auf das Gesamtgewicht der Emulsion, beträgt. 2. O / W emulsions according to claim 1, characterized in that the content of suc- cinoglucan in the emulsion is from 0.01 to 1.0% by weight, based on the total weight of the emulsion.
3. O/W-Emulsionen nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass der Gehalt an einem oder mehreren lipophilen UV-Filtersubstanzen in der Emul sion von 0,001 bis 20 Gew.-% und bevorzugt zwischen 0,05 und 15 Gew.-%, beson ders bevorzugt zwischen 0,1 und 10 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Emulsion, beträgt. 3. O / W emulsions according to one of the preceding claims, characterized in that the content of one or more lipophilic UV filter substances in the emul sion of 0.001 to 20 wt .-% and preferably between 0.05 and 15 wt. %, particularly preferably between 0.1 and 10% by weight, based in each case on the total weight of the emulsion.
4. O/W-Emulsionen nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass die lipophile UV-A-Filtersubstanz oder die -Substanzen gewählt wird oder werden aus der Gruppe der Dibenzoylmethanderivate, insbesondere das 4-(tert.-Butyl)-4’- methoxydibenzoylmethan und der Triazine, insbesondere das Bis-ethylhexyloxyphenol methoxyphenyl triazin. 4. O / W emulsions according to one of the preceding claims, characterized in that the lipophilic UV-A filter substance or substances is or are selected from the group of dibenzoylmethane derivatives, in particular 4- (tert-butyl) -4 '- methoxydibenzoylmethane and the triazines, especially the bis-ethylhexyloxyphenol methoxyphenyl triazine.
5. O/W-Emulsionen nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass die Emulsion einen oder mehrere ÖI-in-Wasser-Emulgatoren (O/W-Emulgatoren) in einer Gesamtkonzentration von 0,05 bis 5,0%, bezogen auf das Gesamtgewicht der Emulsion, beträgt. 5. O / W emulsions according to one of the preceding claims, characterized in that the emulsion is based on one or more oil-in-water emulsifiers (O / W emulsifiers) in a total concentration of 0.05 to 5.0% based on the total weight of the emulsion.
6. O/W-Emulsionen nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass der Gehalt an einem oder mehreren anionischen Emulgatoren in der Emulsion von 0,001 bis 5,0 Gew.-% und bevorzugt zwischen 0,05 und 2 Gew.-%, besonders be vorzugt zwischen 0,1 und 1,0 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Emulsion, beträgt. 6. O / W emulsions according to one of the preceding claims, characterized in that the content of one or more anionic emulsifiers in the emulsion is from 0.001 to 5.0% by weight and preferably between 0.05 and 2% by weight , particularly preferably between 0.1 and 1.0% by weight, based in each case on the total weight of the emulsion.
7. O/W-Emulsionen nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass der Gehalt an einem oder mehreren nichtionischen Emulgatoren in der Emulsion von 0,001 bis 5,0 Gew.-% und bevorzugt zwischen 0,05 und 3 Gew.-%, besonders be vorzugt zwischen 0,1 und 2,0 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Emulsion, beträgt. 7. O / W emulsions according to one of the preceding claims, characterized in that the content of one or more nonionic emulsifiers in the emulsion from 0.001 to 5.0% by weight and preferably between 0.05 and 3% by weight, particularly preferably between 0.1 and 2.0% by weight, based in each case on the total weight of the emulsion.
8. O/W-Emulsionen nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass als O/W-Emulgatoren lipophile Emulgatoren mit einem HLB-Wert von grö ßer/gleich 8 eingesetzt werden. 8. O / W emulsions according to one of the preceding claims, characterized in that lipophilic emulsifiers with an HLB value of greater than / equal to 8 are used as O / W emulsifiers.
9. O/W-Emulsionen nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass als O/W-Emulgatoren Polyglyceryl-3 Methylglucosedistearat (INCI Polyglyceryl Methyl Glucose Distearate, z. B. Tego Care 450 der Firma Evonik), Kalium Cetylphos- phate, Natrium Cetearylsulfat, Natrium Stearylglutamat, Alkalisalze von gesättigten Fettsäuren der Kettenlänge C14-C22, insbesondere Natrium Stearat und/oder Po- lyethylenglycol(2000)monostearat (INCI; PEG-40 stearate) eingesetzt werden. 9. O / W emulsions according to one of the preceding claims, characterized in that the O / W emulsifiers are polyglyceryl 3 methyl glucose distearate (INCI polyglyceryl methyl glucose distearate, e.g. Tego Care 450 from Evonik), potassium cetyl phosphate , Sodium cetearyl sulfate, sodium stearyl glutamate, alkali salts of saturated fatty acids of chain length C14-C22, in particular sodium stearate and / or polyethylene glycol (2000) monostearate (INCI; PEG-40 stearate) can be used.
10. O/W-Emulsionen nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass als O/W-Emulgatoren ein oder mehrere Polyglycerylfettsäureester gewählt wer den, insbesondere bevorzugt Polyglyceryl-10 Stearat. 10. O / W emulsions according to any one of the preceding claims, characterized in that one or more polyglyceryl fatty acid esters are selected as O / W emulsifiers, particularly preferably polyglyceryl-10 stearate.
EP20760785.4A 2019-08-19 2020-08-17 Cosmetic o/w emulsion containing succinoglucan and lipophilic uv filter substances Pending EP4017598A1 (en)

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