EP3990066A1 - Method of cleaning and coating - Google Patents
Method of cleaning and coatingInfo
- Publication number
- EP3990066A1 EP3990066A1 EP20734035.7A EP20734035A EP3990066A1 EP 3990066 A1 EP3990066 A1 EP 3990066A1 EP 20734035 A EP20734035 A EP 20734035A EP 3990066 A1 EP3990066 A1 EP 3990066A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- plasma
- coating
- cleaning
- container
- mdi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000004140 cleaning Methods 0.000 title claims abstract description 68
- 238000000034 method Methods 0.000 title claims abstract description 61
- 238000000576 coating method Methods 0.000 title claims abstract description 59
- 239000011248 coating agent Substances 0.000 title claims abstract description 56
- 239000008199 coating composition Substances 0.000 claims abstract description 27
- 238000009832 plasma treatment Methods 0.000 claims abstract description 24
- 239000002904 solvent Substances 0.000 claims abstract description 24
- 239000011347 resin Substances 0.000 claims abstract description 18
- 229920005989 resin Polymers 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229940071648 metered dose inhaler Drugs 0.000 claims abstract description 7
- 238000012545 processing Methods 0.000 claims description 22
- 229920002313 fluoropolymer Polymers 0.000 claims description 15
- 239000004811 fluoropolymer Substances 0.000 claims description 15
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 10
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 239000004812 Fluorinated ethylene propylene Substances 0.000 claims description 7
- 229920009441 perflouroethylene propylene Polymers 0.000 claims description 7
- BNXZHVUCNYMNOS-UHFFFAOYSA-N 1-butylpyrrolidin-2-one Chemical compound CCCCN1CCCC1=O BNXZHVUCNYMNOS-UHFFFAOYSA-N 0.000 claims description 6
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 6
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 6
- 239000003945 anionic surfactant Substances 0.000 claims description 6
- 238000001125 extrusion Methods 0.000 claims description 6
- 229940043265 methyl isobutyl ketone Drugs 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- -1 polytetrafluoroethylene Polymers 0.000 claims description 5
- 150000001298 alcohols Chemical class 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 claims description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- 229910000838 Al alloy Inorganic materials 0.000 claims description 3
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 208000028659 discharge Diseases 0.000 claims 2
- 239000000243 solution Substances 0.000 description 19
- 238000004132 cross linking Methods 0.000 description 13
- 235000019441 ethanol Nutrition 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000000443 aerosol Substances 0.000 description 7
- 239000013583 drug formulation Substances 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 229930195733 hydrocarbon Natural products 0.000 description 6
- 150000002430 hydrocarbons Chemical class 0.000 description 6
- 230000001464 adherent effect Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- 239000012298 atmosphere Substances 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 238000001994 activation Methods 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 238000010382 chemical cross-linking Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
- 208000026344 Nasal disease Diseases 0.000 description 1
- 208000030880 Nose disease Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 239000012874 anionic emulsifier Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 230000002844 continuous effect Effects 0.000 description 1
- GLWWLNJJJCTFMZ-UHFFFAOYSA-N cyclanilide Chemical compound C=1C=C(Cl)C=C(Cl)C=1NC(=O)C1(C(=O)O)CC1 GLWWLNJJJCTFMZ-UHFFFAOYSA-N 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical group CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 230000007775 late Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003900 succinic acid esters Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000012855 volatile organic compound Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/10—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by other chemical means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/62—Plasma-deposition of organic layers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/10—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by other chemical means
- B05D3/102—Pretreatment of metallic substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/14—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by electrical means
- B05D3/141—Plasma treatment
- B05D3/142—Pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D5/00—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
- B05D5/08—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain an anti-friction or anti-adhesive surface
- B05D5/083—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain an anti-friction or anti-adhesive surface involving the use of fluoropolymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/14—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to metal, e.g. car bodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B7/00—Cleaning by methods not provided for in a single other subclass or a single group in this subclass
- B08B7/0035—Cleaning by methods not provided for in a single other subclass or a single group in this subclass by radiant energy, e.g. UV, laser, light beam or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/54—Metering valves ; Metering valve assemblies
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/22—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the deposition of inorganic material, other than metallic material
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/50—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
- C23G5/00—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
- C23G5/00—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents
- C23G5/02—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents using organic solvents
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
- C23G5/00—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents
- C23G5/06—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents using emulsions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2202/00—Metallic substrate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2202/00—Metallic substrate
- B05D2202/20—Metallic substrate based on light metals
- B05D2202/25—Metallic substrate based on light metals based on Al
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/22—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to internal surfaces, e.g. of tubes
- B05D7/227—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to internal surfaces, e.g. of tubes of containers, cans or the like
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/40—Specific cleaning or washing processes
- C11D2111/46—Specific cleaning or washing processes applying energy, e.g. irradiation
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
- C23G5/00—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents
- C23G5/02—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents using organic solvents
- C23G5/028—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents using organic solvents containing halogenated hydrocarbons
- C23G5/02806—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents using organic solvents containing halogenated hydrocarbons containing only chlorine as halogen atom
Definitions
- the present invention relates to the production of metered dose inhaler containers (MDI-containers ) , in particular to the cleaning and coating of MDI-containers.
- MDI-containers metered dose inhaler containers
- the invention also re lates to a processing line for cleaning and coating of MDI- containers .
- Drugs for treating respiratory and nasal disorders are fre quently administered in aerosol formulation through the mouth or nose of a patient.
- One widely used method for dispensing such aerosol drug formulations involves preparing a suspension of a solution formulation of the drug and of a liquefied gas known as a propellant.
- the suspension is stored in a sealed container (or canister) capable of withstanding the pressure required to maintain the propellant as a liquid.
- the formula tion may then be dispersed by activating a dose-metering valve fixed to the container.
- Metered dose inhalers are typically used to dispense such drug formulations.
- the container is inserted into the MDI such that the metering valve is received in a nozzle block lo cated at a bottom portion of the inhaler.
- the metering valve of the container is designed to consistently release a fixed predetermined mass of the aerosol drug formulation upon acti vation of the MDI, in particular upon depression of the con tainer against the nozzle block.
- the suspension rapidly exits the nozzle block via a nozzle.
- the suspension Upon exiting the nozzle block the suspension rapidly vaporizes leaving a fast moving plume of very fine particles of the drug formulation. This plume of particles is directed into the mouth of the patient via a mouthpiece of the MDI and is in haled by the patient into his/her lungs.
- the aerosol drug formulation may tend to adhere to and/or chemically react with the inner surfaces of the MDI, including the canister, metering valve and cap. This can lead to the patient receiving significantly less or more than the prescribed amount of drug upon each activation of the MDI.
- Fluorine-containing polymers have been widely used for the coating of an inner surface of MDI container.
- US 6,596,260 relates to an aerosol container for pharmaceuti cally active aerosols that are to be administered in predeter mined amounts and that are supplied in the container in the form of a suspension.
- the inner wall of the container is coat ed with polytetrafluoroethylene, also widely known by the name Teflon .
- the provided method is suitable for cleaning and coating at least one surface of a metered dose inhaler container, the method comprising the steps of: a) cleaning the at least one surface of the container with a cleaning solvent, an aqueous cleaning solution or an alco hol based cleaning solution;
- the following further method step may be carried out: d) subjecting the coated at least one surface to a cross- linking step to provide an adherent continuous coating on the at least one surface of the container.
- atmospheric plasma is suitable to clean and/or activate the at least one surface of the MDI container prior to being coated.
- the term "ac tivate” is understood as increasing the surface tension of a surface. Activating a surface improves wettability of the sur face and the adherence of a later coating thereon.
- the term "atmospheric plasma” is understood as plasma having the pressure of the surrounding atmosphere, i.e. around 101,325 kPa at sea level and at 0°C.
- the use of atmospheric plasma increases wettabilty of the at least one surface of the MDI container to be treated.
- Com pared to a conventional cleaning and coating process in which a cleaning solvent is used and the MDI container has to be heated and cooled thereafter to remove the residual hydrocar bons thereon, the thermal treatment steps, i.e. heating and cooling in a separate oven, can be omitted.
- the time needed to produce each MDI container by use of the method according to the present invention was decreased by a factor ranging from 1,5 to 2, in particular around 1,8. Assuming that a con ventional method would allow a production of 90 cans per mi nute the method according the present invention allows a pro duction of 160 cans per minute.
- the use of atmospheric plasma for cleaning the at least one surface of the MDI container allows the use of mul tiple alternative cleaning solutions such as a cleaning sol vent, an aqueous cleaning solution or an alcohol based clean ing solution.
- atmospheric plasma in a cleaning step al lows removement of any residues left on the at least one sur face from the production process of the MDI container, in par ticular deep drawing or impact extrusion, and/or from the cleaning solutions used.
- the at least one surface is properly prepared for coating re garding its degree of purity and its degree of wettabilty with a coating composition.
- the use of atmospheric plasma allows the coating of the at least one surface with a coating composition con taining a fluoropolymer resin or by use of a plasma coating treatment.
- the coating composition and the plasma coating treatment can be used as alternatives.
- a method and corre sponding device for a plasma coating treatment is for example disclosed in document EP 2 539 082 B1 to which reference is made in its entirety. According to EP 2 539 082 B1 an inner surface of a medicament body is coated with a plasma polymer ised polymer coating.
- the plasma treatment is a low pressure plasma treatment.
- the cleaning solvent com prises chlorinated hydrocarbons.
- the cleaning sol vent is tetrachlorethene (PER) .
- PER tetrachlorethene
- the aqueous cleaning solution comprises an anionic surfactant and emulsifier.
- the surfactant and the emulsifier promote emulsification with wa ter.
- Suitable anionic surfactants include sodium dodecylbenzene sulfonate, alkyl phosphate, alkyl sulfonate, alkyl benzenesulfonate, and sodium di ( 2-ethylhexyl ) sulfosuccinate .
- the anionic surfactant is dodecylbenzene sulfonate.
- the anionic surfactant is used to penetrate the oil film on the preferably deep drawn or impact extruded cans and to emulsify and disperse the oil in the cleaning bath.
- the coating composi tion is solvent based or aqueous based. Both coating composi tions can be used as alternatives and have shown proper adher ence to the at least on surface of the MDI container.
- the solvent based coating composition comprises a solvent chosen from the group consist ing of: n-methyl-2-pyrrolidone (NMP) , n-butyl-2-pyrrolidone (NBP) and methylisobutylketone (MIBK) .
- the aqueous based coating composition comprises 20-40 wt% of the fluoropolymer resin with one or more alcohols as wetting agents and balance water.
- alcohols usable as wetting agents in the practice of the pre sent invention include but are not limited to, n-butyl alcohol (about 2-10 wt%), 2-butoxyethanol (about 2-10 wt%), and/or 2- (dimethylamino) ethanol (about 1-5 wt%), and amyl alcohol, with water as the balance.
- concentration of the fluoropolymer resin is adjusted for optimum spray efficiency, surface fin ish, and thermal desorption, with the optimum between 22 and 27 wt%.
- the fluoropolymer resin is chosen from the group consisting of: polytetrafluoroetylene (PTFE) , fluorinat- ed ethylene propylene (FEP) and perflouroalkoxy polymers (PFA) .
- PTFE polytetrafluoroetylene
- FEP fluorinat- ed ethylene propylene
- PFA perflouroalkoxy polymers
- the atmospheric plasma treatment includes generat ing a concentrated plasma beam of a reactive medium by a plas ma discharge by supplying a working gas and moving the plasma beam over the at least one surface.
- the plasma beam is active in a chemical way such that a surface pre-treatment can be achieved in order to increase wettability of the at least one surface to be treated.
- the temperature of the plasma beam is at such a low level that delicate surfaces are not damaged.
- the plasma beam is provided by a plasma source comprising a plasma head.
- the plasma head may be a static plasma head such as PFW 10 or a rotatable plasma head such as RD 1004.
- the plasma source also comprises a plasma nozzle such as e.g. article-No.: 10147, 10148 or 15029, com- pitchally available for example from the company Plasmatreat GmbH, Steinhagen, Germany.
- the working gas is an oxygen-carrying gas.
- the working gas is air. This reduces costs as no inert atmosphere around the plasma beam has to be created.
- the atmospheric plasma is a low temperature plasma, wherein the plasma beam has a tempera ture of at most 300°C in proximity to the cleaned at least one surface .
- multiple plasma beams of higher reactive medium are collectively moved over the cleaned at least one surface.
- the area which can be treated at once is increased and the time needed to clean the at least one surface of the MDI container is reduced.
- the at least one sur face is an inner surface of the container.
- the inner surface is the surface which comes into contact with the drug formula tion stored in the MDI-container .
- the outer sur face of the MDI container is not treated during the method of the invention.
- the container comprises a material chosen from the group consisting of aluminum, aluminum alloy and stainless steel.
- the material may be chosen depending on the physical properties needed in the respective application, e.g. in order to withstand the corresponding pressure of the solu tion to be used with the MDI container.
- the container is deep drawn from a metal blank or manufactured via impact extrusion.
- the metal blank is deep drawn into the MDI container in multiple drawing steps by use of a deep drawing transfer press having multiple punches and dies.
- the object of the present invention is also achieved by a pro cessing line as defined in claim 15.
- the processing line is configured to process the method as defined above.
- the processing line is configured for cleaning and coating of at least one surface of a metered dose inhaler and comprises a cleaning station for cleaning the at least one surface with a cleaning solvent, an aqueous cleaning solution or an alcohol based cleaning solution.
- the processing line further comprises a plasma treatment station which is configured to subject the cleaned at least one sur face through an atmospheric plasma treatment.
- the processing line further includes a coating station for coating the plasma treated at least one surface with a coating composition con taining a flouropolymer resin or for coating the plasma treat ed at least one surface by a plasma coating treatment.
- the plasma treatment is a low pressure plasma treatment.
- the processing line may further comprise a cross-linking station.
- the cross-linking station may be configured to sub ject the coated at least one surface to a cross-linking step to provide an adherent continuous coating on the at least one surface of the container.
- Figure 1 shows a process flow diagram of a known cleaning and coating method
- Figure 2 shows a process flow diagram of the method according to the present invention
- Figure 3 shows a schematically view of a processing line ac cording to the present invention.
- Figure 1 shows a known method of cleaning and coating at least one surface, in particular an inner surface, of a metered dose inhaler container.
- a first step 1 the MDI container is deep drawn, e.g. from a metal blank, or manufactured via impact extrusion.
- a cleaning solvent such as tretrachlorethene (PER) .
- PER tretrachlorethene
- the cleaning solvent is used in order to remove most of the hydrocarbon lubricants used for the produc tion of the MDI container.
- a third step 3 the MDI container is fed into a bowl feeder in order to be conveyed one by one to subsequent processing stations .
- a fourth method step 4 the MDI container is inserted into an oven (not shown) in order to remove residual hydrocarbons.
- the MDI container is typically heated above 200°C.
- the MDI container is provided to a cooling tower (not shown) in order to cool the container down to room temperature.
- the cleaned inner surface is sub jected to a coating composition containing a flouropolymere resin for example fluorinated ethylene propylene (FEP) .
- FEP fluorinated ethylene propylene
- step 7 the coated inner surface is sub jected to a cross-linking step to provide an adherent continu ous coating on the inner surface of the container.
- the MDI container In particu lar the MDI container is moved into an oven and the MDI con tainer is heated to a temperature that initiates chemical cross-linking of the coating.
- the temperature and time at tem perature are selected based on measurements of coating cross- linking density and desorption of volatile organic compounds based on measurements with gas chromatography/mass spectrome try .
- a further method step 8 the MDI container is cooled in a cooling tower (not shown) . Thereafter, in method step 9, the MDI container is checked in order to insure proper quality of the coating and subsequently in method step 10 packaged into a "good part box".
- Figure 2 shows a method of cleaning and coating according to the present invention.
- a first method step 1 the MDI container is deep drawn from a metal blank in multiple deep drawing steps.
- the container is manufactured via impact extrusion.
- the con tainer comprises a material select from the group consisting of aluminum, aluminum alloy and stainless steel. In particu lar, aluminum is preferred.
- a second step 11 according to the invention the at least one surface, which is an inner surface of the container, is cleaned.
- an outer surface of the MDI container is not treated at all during the method according to the present invention .
- the inner surface of the MDI con tainer is cleaned with a cleaning solvent, an aqueous cleaning solution or an alcohol based cleaning solution. All of the three mentioned cleaning solutions are used as alternatives.
- the cleaning solvent comprises chlorinated hydrocarbons, in particular tetrachlorethene (PER) .
- the aqueous cleaning solu tion comprises an anionic surfactant and an emulsifier.
- the alcohol based cleaning solution is for example a succinic acid ester .
- all method steps of the method according to the present invention are carried out one after another at one single location.
- the first two method steps (1 and 11) and the subsequent method steps are conducted at different locations, e.g. at different production plants.
- a third method step 3 the cleaned MDI container is fed into a bowl feeder in order to be conveyed one by one to subsequent processing stations to undergo further method steps.
- the inner surface is subjected to an atmospheric plasma treatment.
- the atmospheric plasma treatment includes generating a concen trated plasma beam of a reactive medium by plasma discharge while supplying a working gas such as an oxygen-carrying gas, e.g. air, and moving the plasma beam over the at least one surface.
- the atmospheric plasma is a low temperature plasma, wherein the plasma beam has a temperature of at most 300°C in proximity to the cleaned inner surface.
- multiple plasma beams of a reactive medium are collectively moved over the cleaned inner surface of the MDI-container .
- a subsequent method step 13 the plasma treated inner sur face is subjected to a coating composition containing a fluoropolymer resin or alternatively to a plasma coating treatment.
- a method and corresponding device for a plasma coating treatment is for example disclosed in document EP 2 539 082 B1 to which reference is made in its entirety.
- the plasma treatment is a low pressure plasma treatment.
- the coating composition is a solvent based coating composition or alternatively an aqueous based coating composition.
- the solvent based coating composition comprises a solvent chosen from the group consisting of n-methyl-2-pyrolidon (NMP) , n- butyl-2-pyrrolidone (NBP) and methyl isobutyl ketone (MIBK) .
- NMP n-methyl-2-pyrolidon
- NBP n-butyl-2-pyrrolidone
- MIBK methyl isobutyl ketone
- the alternatively used aqueous based coating composition com prises 20 to 40wt% of the fluoropolymer resin with one or more alcohols as wetting agents and the balance water.
- the fluoropolymer resin is chosen from the group consisting of: polytetrafluoroethylene (PTFE) , fluorinated ethylene pro pylene (FEP) and perfluoralkoxy polymeres (PFA) .
- PTFE polytetrafluoroethylene
- FEP fluorinated ethylene pro pylene
- PFA perfluoralkoxy polymeres
- step 7 the coated inner surface of the MDI container is subjected to a cross-linking step to provide an adherent continuous coating on the inner surface of the container.
- the MDI container is heated to a temperature that initiates chemical cross-linking of the coating.
- FIG. 3 shows a processing line 14 for the coating of the in ner surface of a MDI container (now shown) according to the invention.
- the processing line 14 comprises a conveyor 15 by use of which MDI container are conveyed, preferably on a tray (not shown) , from one station of the processing line 14 to subsequent stations.
- the processing line 14 is configured to process the method according to the present invention as de scribed above.
- the processing line 14 comprises a cleaning station 16 for cleaning the inner surface of the MDI container with a clean ing solvent, an aqueous cleaning solution or an alcohol based cleaning solution.
- the processing line 14 further comprises a plasma treatment station 17 which is configured to subject the cleaned inner surface to an atmospheric plasma treatment.
- the processing line 14 further comprises a coating station 18 for coating the plasma treated inner surface with a coating composition containing a fluoropolymer resin or coating the plasma treated inner surface by plasma treatment.
- the plasma treatment is a low pressure plasma treatment.
- the processing line 14 further comprises a cross-linking station 19 (shown in dotted lines) .
- the cross-linking station 19 is configured to subject the coated inner surface to a cross-linking step to provide an adherent continuous coating on the inner surface of the container.
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Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19182370.7A EP3756711A1 (en) | 2019-06-25 | 2019-06-25 | Method of plasma cleaning and coating of mdi cans |
PCT/EP2020/067692 WO2020260386A1 (en) | 2019-06-25 | 2020-06-24 | Method of cleaning and coating |
Publications (1)
Publication Number | Publication Date |
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EP3990066A1 true EP3990066A1 (en) | 2022-05-04 |
Family
ID=67070664
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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EP19182370.7A Withdrawn EP3756711A1 (en) | 2019-06-25 | 2019-06-25 | Method of plasma cleaning and coating of mdi cans |
EP20734035.7A Withdrawn EP3990066A1 (en) | 2019-06-25 | 2020-06-24 | Method of cleaning and coating |
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Application Number | Title | Priority Date | Filing Date |
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EP19182370.7A Withdrawn EP3756711A1 (en) | 2019-06-25 | 2019-06-25 | Method of plasma cleaning and coating of mdi cans |
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EP (2) | EP3756711A1 (en) |
WO (1) | WO2020260386A1 (en) |
Families Citing this family (1)
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WO2023228000A1 (en) * | 2022-05-27 | 2023-11-30 | Precision Concepts (Harrisonburg) Llc | Coated medicament cannister |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6596260B1 (en) | 1993-08-27 | 2003-07-22 | Novartis Corporation | Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol |
DE19532412C2 (en) | 1995-09-01 | 1999-09-30 | Agrodyn Hochspannungstechnik G | Device for surface pretreatment of workpieces |
GB0721739D0 (en) * | 2007-11-06 | 2007-12-19 | 3M Innovative Properties Co | medicinal inhalation devices and components thereof |
AU2008323924B2 (en) * | 2007-11-06 | 2013-01-17 | 3M Innovative Properties Company | Medicinal inhalation devices and components thereof |
EP2227230B1 (en) * | 2007-12-07 | 2017-01-25 | Presspart Gmbh & Co. Kg | Method for cleaning the internal surface of a container and applying a polymer coating thereon |
US8815325B2 (en) * | 2009-05-06 | 2014-08-26 | 3M Innovative Properties Company | Medicinal inhalation device |
CN102460635B (en) * | 2009-05-06 | 2014-12-24 | 3M创新有限公司 | Apparatus and method for plasma treatment of containers |
GB201003273D0 (en) | 2010-02-26 | 2010-04-14 | Portal Medical Ltd | Medicament dispenser device |
FR2978775B1 (en) * | 2011-08-03 | 2014-02-14 | Air Liquide | PROCESS FOR THE PREPARATION OF ALUMINUM SURFACES BY ATMOSPHERIC PLASMA TREATMENT FOR THE DEPOSITION OF COATINGS WITHOUT ADHESIVE PROMOTERS |
-
2019
- 2019-06-25 EP EP19182370.7A patent/EP3756711A1/en not_active Withdrawn
-
2020
- 2020-06-24 EP EP20734035.7A patent/EP3990066A1/en not_active Withdrawn
- 2020-06-24 WO PCT/EP2020/067692 patent/WO2020260386A1/en unknown
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WO2020260386A1 (en) | 2020-12-30 |
EP3756711A1 (en) | 2020-12-30 |
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