EP3980069A4 - METHODS OF TREATMENT OF A SPLENOMEGALY - Google Patents
METHODS OF TREATMENT OF A SPLENOMEGALY Download PDFInfo
- Publication number
- EP3980069A4 EP3980069A4 EP21738476.7A EP21738476A EP3980069A4 EP 3980069 A4 EP3980069 A4 EP 3980069A4 EP 21738476 A EP21738476 A EP 21738476A EP 3980069 A4 EP3980069 A4 EP 3980069A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- splenomegaly
- treating
- treating splenomegaly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010041660 Splenomegaly Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Processing Of Solid Wastes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP22150344.4A EP4000624A1 (en) | 2020-01-08 | 2021-01-08 | Btk inhibitors for treating splenomegaly |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062958632P | 2020-01-08 | 2020-01-08 | |
PCT/US2021/012696 WO2021142257A1 (en) | 2020-01-08 | 2021-01-08 | Methods of treating splenomegaly |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22150344.4A Division-Into EP4000624A1 (en) | 2020-01-08 | 2021-01-08 | Btk inhibitors for treating splenomegaly |
EP22150344.4A Division EP4000624A1 (en) | 2020-01-08 | 2021-01-08 | Btk inhibitors for treating splenomegaly |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3980069A1 EP3980069A1 (en) | 2022-04-13 |
EP3980069A4 true EP3980069A4 (en) | 2022-08-17 |
Family
ID=76788747
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22150344.4A Pending EP4000624A1 (en) | 2020-01-08 | 2021-01-08 | Btk inhibitors for treating splenomegaly |
EP21738476.7A Pending EP3980069A4 (en) | 2020-01-08 | 2021-01-08 | METHODS OF TREATMENT OF A SPLENOMEGALY |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22150344.4A Pending EP4000624A1 (en) | 2020-01-08 | 2021-01-08 | Btk inhibitors for treating splenomegaly |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP4000624A1 (zh) |
JP (1) | JP2023509968A (zh) |
KR (1) | KR20220130151A (zh) |
CN (1) | CN114423457A (zh) |
AU (1) | AU2021205484A1 (zh) |
BR (1) | BR112022013646A2 (zh) |
CA (1) | CA3164063A1 (zh) |
CO (1) | CO2022010592A2 (zh) |
CR (1) | CR20220374A (zh) |
IL (1) | IL294582A (zh) |
JO (1) | JOP20220168A1 (zh) |
MA (1) | MA57226B1 (zh) |
MX (1) | MX2022008490A (zh) |
WO (1) | WO2021142257A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20240024314A1 (en) | 2020-01-08 | 2024-01-25 | Telios Pharma, Inc. | Methods of Treating Splenomegaly |
CN114423457A (zh) * | 2020-01-08 | 2022-04-29 | 泰利奥斯制药公司 | 治疗脾肿大的方法 |
WO2023071973A1 (en) * | 2021-10-26 | 2023-05-04 | Shenzhen Targetrx, Inc. | Fused bicyclic compound for inhibiting activity of tyrosine kinase |
WO2024041614A1 (en) * | 2022-08-25 | 2024-02-29 | Beigene Switzerland Gmbh | Solid forms comprising (s) -7- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahydropyrazolo [1, 5-a] pyrimidine-3-carboxamide, and oxalic acid, compositions and methods of use thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015057992A1 (en) * | 2013-10-16 | 2015-04-23 | Izumi Raquel | Btk inhibitors for hematopoietic mobilization |
WO2016024230A1 (en) * | 2014-08-11 | 2016-02-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 inhibitor |
US20160122365A1 (en) * | 2014-10-03 | 2016-05-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2019243223A1 (en) * | 2018-06-19 | 2019-12-26 | Merck Patent Gmbh | Novel crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-4-fluoro-piperidin-1-yl)-propenone, salt forms thereof, and processes to obtain |
WO2021097213A1 (en) * | 2019-11-14 | 2021-05-20 | Quogue Ip Holdings Llc | Combination of a btk inhibitor and an mdm2 inhibitor for cancer treatment |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114423457A (zh) * | 2020-01-08 | 2022-04-29 | 泰利奥斯制药公司 | 治疗脾肿大的方法 |
-
2021
- 2021-01-08 CN CN202180004918.1A patent/CN114423457A/zh active Pending
- 2021-01-08 WO PCT/US2021/012696 patent/WO2021142257A1/en active Application Filing
- 2021-01-08 AU AU2021205484A patent/AU2021205484A1/en active Pending
- 2021-01-08 IL IL294582A patent/IL294582A/en unknown
- 2021-01-08 MA MA57226A patent/MA57226B1/fr unknown
- 2021-01-08 EP EP22150344.4A patent/EP4000624A1/en active Pending
- 2021-01-08 JO JOP/2022/0168A patent/JOP20220168A1/ar unknown
- 2021-01-08 EP EP21738476.7A patent/EP3980069A4/en active Pending
- 2021-01-08 BR BR112022013646A patent/BR112022013646A2/pt unknown
- 2021-01-08 CR CR20220374A patent/CR20220374A/es unknown
- 2021-01-08 CA CA3164063A patent/CA3164063A1/en active Pending
- 2021-01-08 JP JP2022542216A patent/JP2023509968A/ja active Pending
- 2021-01-08 KR KR1020227027305A patent/KR20220130151A/ko unknown
- 2021-01-08 MX MX2022008490A patent/MX2022008490A/es unknown
-
2022
- 2022-07-28 CO CONC2022/0010592A patent/CO2022010592A2/es unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015057992A1 (en) * | 2013-10-16 | 2015-04-23 | Izumi Raquel | Btk inhibitors for hematopoietic mobilization |
WO2016024230A1 (en) * | 2014-08-11 | 2016-02-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 inhibitor |
US20160122365A1 (en) * | 2014-10-03 | 2016-05-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2019243223A1 (en) * | 2018-06-19 | 2019-12-26 | Merck Patent Gmbh | Novel crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-4-fluoro-piperidin-1-yl)-propenone, salt forms thereof, and processes to obtain |
WO2021097213A1 (en) * | 2019-11-14 | 2021-05-20 | Quogue Ip Holdings Llc | Combination of a btk inhibitor and an mdm2 inhibitor for cancer treatment |
Non-Patent Citations (4)
Title |
---|
ASHANGARI CHANDRALEKHA ET AL: "Hairy Cell Leukemia Variant", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 132, 29 November 2018 (2018-11-29), pages 5562, XP086591091, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2018-99-110192 * |
JAMIE L DARGART ET AL: "Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 95, no. 1, 7 May 2012 (2012-05-07), pages 49 - 56, XP028491144, ISSN: 0166-3542, [retrieved on 20120516], DOI: 10.1016/J.ANTIVIRAL.2012.05.003 * |
MICHAEL L. WANG ET AL: "Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 369, no. 6, 8 August 2013 (2013-08-08), US, pages 507 - 516, XP055484912, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1306220 * |
ON BEHALF OF THE INVESTIGATORS OF THE ITALIAN REGISTRY OF MYELOFIBROSIS WITH MYELOID METAPLASIA AND THE MYELOPROLIFERATIVE DISORDE: "The expression of CXCR4 is down-regulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia", BLOOD CELLS, MOLECULES & DISEASES, LAJOLLA, US, vol. 38, no. 3, 4 April 2007 (2007-04-04), pages 280 - 286, XP022014560, ISSN: 1079-9796, DOI: 10.1016/J.BCMD.2007.01.003 * |
Also Published As
Publication number | Publication date |
---|---|
CA3164063A1 (en) | 2021-07-15 |
MA57226B1 (fr) | 2023-06-28 |
KR20220130151A (ko) | 2022-09-26 |
MA57226A1 (fr) | 2023-02-28 |
MX2022008490A (es) | 2022-10-13 |
BR112022013646A2 (pt) | 2022-10-04 |
JOP20220168A1 (ar) | 2023-01-30 |
JP2023509968A (ja) | 2023-03-10 |
WO2021142257A1 (en) | 2021-07-15 |
EP4000624A1 (en) | 2022-05-25 |
IL294582A (en) | 2022-09-01 |
AU2021205484A1 (en) | 2022-08-18 |
CN114423457A (zh) | 2022-04-29 |
CO2022010592A2 (es) | 2022-10-31 |
EP3980069A1 (en) | 2022-04-13 |
CR20220374A (es) | 2023-01-25 |
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A4 | Supplementary search report drawn up and despatched |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 29/00 20060101ALI20220711BHEP Ipc: A61K 31/519 20060101ALI20220711BHEP Ipc: A61K 31/4985 20060101AFI20220711BHEP |
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