EP3947416A4 - Peptides and compounds that bind to elongation initiation factor 4e - Google Patents

Peptides and compounds that bind to elongation initiation factor 4e Download PDF

Info

Publication number
EP3947416A4
EP3947416A4 EP20782868.2A EP20782868A EP3947416A4 EP 3947416 A4 EP3947416 A4 EP 3947416A4 EP 20782868 A EP20782868 A EP 20782868A EP 3947416 A4 EP3947416 A4 EP 3947416A4
Authority
EP
European Patent Office
Prior art keywords
peptides
bind
compounds
initiation factor
elongation initiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20782868.2A
Other languages
German (de)
French (fr)
Other versions
EP3947416A1 (en
Inventor
Simon Ng
Christopher John Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agency for Science Technology and Research Singapore
Original Assignee
Agency for Science Technology and Research Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency for Science Technology and Research Singapore filed Critical Agency for Science Technology and Research Singapore
Publication of EP3947416A1 publication Critical patent/EP3947416A1/en
Publication of EP3947416A4 publication Critical patent/EP3947416A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP20782868.2A 2019-03-29 2020-03-30 Peptides and compounds that bind to elongation initiation factor 4e Pending EP3947416A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201902892R 2019-03-29
PCT/SG2020/050192 WO2020204828A1 (en) 2019-03-29 2020-03-30 Peptides and compounds that bind to elongation initiation factor 4e

Publications (2)

Publication Number Publication Date
EP3947416A1 EP3947416A1 (en) 2022-02-09
EP3947416A4 true EP3947416A4 (en) 2023-05-31

Family

ID=72667485

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20782868.2A Pending EP3947416A4 (en) 2019-03-29 2020-03-30 Peptides and compounds that bind to elongation initiation factor 4e

Country Status (5)

Country Link
US (1) US20220242906A1 (en)
EP (1) EP3947416A4 (en)
CN (1) CN113646325A (en)
SG (1) SG11202110836SA (en)
WO (1) WO2020204828A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023069332A1 (en) * 2021-10-22 2023-04-27 Merck Sharp & Dohme Llc Cell permeable macrocyclic peptides useful for eif4e cap-binding site inhibition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018073394A1 (en) * 2016-10-19 2018-04-26 Cellectis Cell death inducing chimeric antigen receptors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020162A (en) * 1997-06-13 2000-02-01 The Rockefeller University Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof
CN1339492A (en) * 2000-08-23 2002-03-13 上海博德基因开发有限公司 New polypeptide-human translation initiation factor subunit eIF4E binding protein 17.27 and polynucleotide for encoding such polypeptide
WO2010080248A2 (en) * 2008-12-18 2010-07-15 The Board Of Regents Of The University Of Texas System Peptides that bind eukaryotic translation initiation factor 4e
FR2942798B1 (en) * 2009-03-05 2011-04-08 Centre Nat Rech Scient PEPTIDES USEFUL FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA
WO2010138084A1 (en) * 2009-05-28 2010-12-02 Agency For Science, Technology And Research CRYSTAL STRUCTURE OF CAP-FREE HUMAN eIF4E
US9018348B2 (en) * 2010-04-27 2015-04-28 Agency For Science, Technology And Research eIF4E binding peptides
CN104411715A (en) * 2012-07-09 2015-03-11 霍夫曼-拉罗奇有限公司 Cell penetrating peptides to target eif4e
CN105263950A (en) * 2013-03-21 2016-01-20 新加坡科技研究局 Stapling eif4e interacting peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018073394A1 (en) * 2016-10-19 2018-04-26 Cellectis Cell death inducing chimeric antigen receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FROSI YURI ET AL: "Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE)", RSC CHEMICAL BIOLOGY, vol. 3, no. 7, 6 July 2022 (2022-07-06), pages 916 - 930, XP093039512, Retrieved from the Internet <URL:https://pubs.rsc.org/en/content/articlepdf/2022/cb/d2cb00099g> DOI: 10.1039/D2CB00099G *
See also references of WO2020204828A1 *

Also Published As

Publication number Publication date
EP3947416A1 (en) 2022-02-09
SG11202110836SA (en) 2021-10-28
WO2020204828A1 (en) 2020-10-08
CN113646325A (en) 2021-11-12
US20220242906A1 (en) 2022-08-04

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A4 Supplementary search report drawn up and despatched

Effective date: 20230428

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 35/00 20060101ALI20230421BHEP

Ipc: A61P 31/00 20060101ALI20230421BHEP

Ipc: A61P 25/00 20060101ALI20230421BHEP

Ipc: A61K 38/08 20190101ALI20230421BHEP

Ipc: C07K 7/08 20060101ALI20230421BHEP

Ipc: C07K 7/06 20060101AFI20230421BHEP