EP3924482A4 - ENZYMES WITH RUVC DOMAINS - Google Patents

ENZYMES WITH RUVC DOMAINS Download PDF

Info

Publication number
EP3924482A4
EP3924482A4 EP20756259.6A EP20756259A EP3924482A4 EP 3924482 A4 EP3924482 A4 EP 3924482A4 EP 20756259 A EP20756259 A EP 20756259A EP 3924482 A4 EP3924482 A4 EP 3924482A4
Authority
EP
European Patent Office
Prior art keywords
enzymes
ruvc domains
ruvc
domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20756259.6A
Other languages
German (de)
French (fr)
Other versions
EP3924482A1 (en
Inventor
Brian Thomas
Christopher Brown
Rose KANTOR
Audra DEVOTO
Cristina Butterfield
Lisa ALEXANDER
Daniela S. A. GOLTSMAN
Jason Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metagenomi Therapeutics Inc
Original Assignee
Metagenomi Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metagenomi Inc filed Critical Metagenomi Inc
Publication of EP3924482A1 publication Critical patent/EP3924482A1/en
Publication of EP3924482A4 publication Critical patent/EP3924482A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
EP20756259.6A 2019-02-14 2020-02-14 ENZYMES WITH RUVC DOMAINS Pending EP3924482A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962805878P 2019-02-14 2019-02-14
US201962805899P 2019-02-14 2019-02-14
US201962805868P 2019-02-14 2019-02-14
US201962874414P 2019-07-15 2019-07-15
PCT/US2020/018432 WO2020168291A1 (en) 2019-02-14 2020-02-14 Enzymes with ruvc domains

Publications (2)

Publication Number Publication Date
EP3924482A1 EP3924482A1 (en) 2021-12-22
EP3924482A4 true EP3924482A4 (en) 2023-04-05

Family

ID=72045639

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20756259.6A Pending EP3924482A4 (en) 2019-02-14 2020-02-14 ENZYMES WITH RUVC DOMAINS

Country Status (9)

Country Link
US (1) US20240117330A1 (en)
EP (1) EP3924482A4 (en)
JP (3) JP2022520428A (en)
KR (2) KR20240007322A (en)
CN (2) CN116515797A (en)
AU (3) AU2020223370B2 (en)
CA (2) CA3241703C (en)
MX (2) MX2021009886A (en)
WO (1) WO2020168291A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021178933A2 (en) 2020-03-06 2021-09-10 Metagenomi Ip Technologies, Llc Class ii, type v crispr systems
EP3204496A1 (en) 2014-10-10 2017-08-16 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
AU2019291918B2 (en) 2018-06-29 2025-06-12 Editas Medicine, Inc. Synthetic guide molecules, compositions and methods relating thereto
KR20240007322A (en) * 2019-02-14 2024-01-16 메타지노미, 인크. Enzymes with ruvc domains
US10913941B2 (en) 2019-02-14 2021-02-09 Metagenomi Ip Technologies, Llc Enzymes with RuvC domains
GB2617659B (en) * 2020-02-14 2024-05-01 Metagenomi Inc Enzymes with RuvC domains
CA3177051A1 (en) * 2020-03-31 2021-10-07 Metagenomi, Inc. Class ii, type ii crispr systems
CN116096892A (en) * 2020-05-08 2023-05-09 宏基因组学公司 Enzyme with RuvC domain
WO2021226369A1 (en) * 2020-05-08 2021-11-11 Metagenomi Ip Technologies, Llc Enzymes with ruvc domains
CA3192224A1 (en) 2020-09-11 2022-03-17 Jyun-Liang LIN Base editing enzymes
GB202418708D0 (en) * 2020-09-11 2025-02-05 Metagenomi Inc Base editing enzymes
JP2023546694A (en) * 2020-10-21 2023-11-07 エメンドバイオ・インコーポレイテッド Novel OMNI56, 58, 65, 68, 71, 75, 78 and 84 CRISPR nucleases
EP4240853A2 (en) * 2020-11-03 2023-09-13 Science Solutions LLC Novel class 2 crispr-cas rna-guided endonucleases
CN116964197A (en) * 2021-01-22 2023-10-27 宏基因组学公司 Novel engineered and chimeric nucleases
WO2022159742A1 (en) * 2021-01-22 2022-07-28 Metagenomi, Inc Novel engineered and chimeric nucleases
KR20230134543A (en) * 2021-01-22 2023-09-21 메타지노미, 인크. Novel engineered nucleases and chimeric nucleases
JP7877351B2 (en) * 2021-03-19 2026-06-22 メタゲノミ セラピューティクス，インク． Multiplex editing using CAS enzymes
EP4330386A4 (en) * 2021-04-30 2025-05-14 Metagenomi, Inc. ENZYMES WITH RUVC DOMAINS
CN119452085A (en) * 2021-08-27 2025-02-14 宏基因组学公司 Enzymes with RUVC domain
MX2024005505A (en) 2021-11-05 2024-05-23 Metagenomi Inc BASE EDITING ENZYMES.
KR20240110603A (en) 2021-11-24 2024-07-15 메타지노미, 인크. endonuclease system
WO2023122663A2 (en) * 2021-12-23 2023-06-29 Mammoth Biosciences, Inc. Effector proteins and methods of use
WO2023194359A1 (en) * 2022-04-04 2023-10-12 Alia Therapeutics Srl Compositions and methods for treatment of usher syndrome type 2a
KR20250037788A (en) * 2022-06-15 2025-03-18 빔 테라퓨틱스, 인크. Compositions and methods for reducing complement activation
EP4587564A2 (en) * 2022-09-16 2025-07-23 Alia Therapeutics Srl Enqp type ii cas proteins and applications thereof
AU2024230342A1 (en) * 2023-03-01 2025-10-16 Metagenomi Therapeutics, Inc. Enzymes with ruvc domains
WO2025106934A1 (en) * 2023-11-16 2025-05-22 Metagenomi, Inc. Enzymes with ruvc domains

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018035250A1 (en) * 2016-08-17 2018-02-22 The Broad Institute, Inc. Methods for identifying class 2 crispr-cas systems
US20190264232A1 (en) * 2018-02-23 2019-08-29 Pioneer Hi-Bred International, Inc. Novel cas9 orthologs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105209621B (en) * 2012-12-12 2021-05-25 布罗德研究所有限公司 Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation
US10392607B2 (en) * 2015-06-03 2019-08-27 The Regents Of The University Of California Cas9 variants and methods of use thereof
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
KR20240007322A (en) 2019-02-14 2024-01-16 메타지노미, 인크. Enzymes with ruvc domains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018035250A1 (en) * 2016-08-17 2018-02-22 The Broad Institute, Inc. Methods for identifying class 2 crispr-cas systems
US20190264232A1 (en) * 2018-02-23 2019-08-29 Pioneer Hi-Bred International, Inc. Novel cas9 orthologs

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "GSP:BGS65773", 17 October 2019 (2019-10-17), XP055968889, Retrieved from the Internet <URL:http://ibis.internal.epo.org/exam/dbfetch.jsp?id=GSP:BGS65773> [retrieved on 20221007] *
ANONYMOUS: "GSP:BGS65777", 29 August 2019 (2019-08-29), XP055968896, Retrieved from the Internet <URL:http://ibis.internal.epo.org/exam/dbfetch.jsp?id=GSP:BGS65777> [retrieved on 20221007] *
KOONIN EUGENE V ET AL: "Diversity, classification and evolution of CRISPR-Cas systems", CURRENT OPINION IN MICROBIOLOGY, vol. 37, 9 June 2017 (2017-06-09), pages 67 - 78, XP085276922, ISSN: 1369-5274, DOI: 10.1016/J.MIB.2017.05.008 *
See also references of WO2020168291A1 *
SERGEY SHMAKOV ET AL: "Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems", MOLECULAR CELL, vol. 60, no. 3, 1 November 2015 (2015-11-01), AMSTERDAM, NL, pages 385 - 397, XP055267512, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2015.10.008 *
SHMAKOV SERGEY ET AL: "Diversity and evolution of class 2 CRISPR-Cas systems", NATURE REVIEWS. MICROBIOLOGY, NATURE PUBLISHING GROUP, ENGLAND, vol. 15, no. 3, 1 March 2017 (2017-03-01), pages 169 - 182, XP002767857, ISSN: 1740-1534, DOI: 10.1038/NRMICRO.2016.184 *
UNIPROTKB/TREMBL: "A0A1F0KNW4 . A0A1F0KNW4_9MICC HNHc domain-containing protein . Rothia sp. HMSC066H02", 15 February 2017 (2017-02-15), XP055968869, Retrieved from the Internet <URL:https://rest.uniprot.org/uniprotkb/A0A1F0KNW4.txt> [retrieved on 20221007] *
UNIPROTKB/TREMBL: "A0A1F0PN46 . A0A1F0PN46_9MICC HNH Cas9-type domain-containing protein . Rothia sp. HMSC076D04", 15 February 2017 (2017-02-15), XP055968835, Retrieved from the Internet <URL:https://rest.uniprot.org/uniprotkb/A0A1F0PN46.txt> [retrieved on 20221007] *
UNIPROTKB/TREMBL: "A0A1S1DAD0 . A0A1S1DAD0_9MICC HNH Cas9-type domain-containing protein . Rothia sp. HMSC065C03", 12 April 2017 (2017-04-12), XP055968878, Retrieved from the Internet <URL:https://rest.uniprot.org/uniprotkb/A0A1S1DAD0.txt> [retrieved on 20221007] *

Also Published As

Publication number Publication date
JP2022520428A (en) 2022-03-30
CN113728098A (en) 2021-11-30
KR20240007322A (en) 2024-01-16
MX2021009886A (en) 2021-10-13
CA3241703A1 (en) 2020-08-20
KR20210139254A (en) 2021-11-22
AU2020223370A1 (en) 2021-10-07
JP2024133476A (en) 2024-10-02
CA3130135C (en) 2024-11-19
CA3241703C (en) 2026-02-24
CN116515797A (en) 2023-08-01
AU2025279720A1 (en) 2026-01-15
WO2020168291A1 (en) 2020-08-20
AU2023206079A1 (en) 2023-08-10
AU2020223370B2 (en) 2023-04-20
JP7502537B2 (en) 2024-06-18
CA3130135A1 (en) 2020-08-20
KR102623312B1 (en) 2024-01-09
EP3924482A1 (en) 2021-12-22
MX2023006575A (en) 2023-06-16
US20240117330A1 (en) 2024-04-11
JP2023179468A (en) 2023-12-19

Similar Documents

Publication Publication Date Title
EP3924477A4 (en) ENZYMES WITH RUVC DOMAINS
IL283169A (en) CRISPR-CAS12J enzyme and system
CA3241703A1 (en) Enzymes with ruvc domains
HUE059249T2 (en) Preparations containing bacterial strains
IL279883A (en) Transgenic galactose oxidase variant enzymes
DK3743086T3 (en) COMPOSITIONS INCLUDING BACTERIA STRAINS
EP3762501A4 (en) VAA CHIMERAS
EP3589640A4 (en) PROTEIN PURIFICATION WITH PROTEIN L
PL3609910T3 (en) LACTASE ENZYMES WITH IMPROVED PROPERTIES
DK3385377T3 (en) BACTERIAL MANNAS
EP3874032A4 (en) ENZYMATIC PRODUCTION OF HEXOSES
PL3609908T3 (en) Lactase enzymes with improved properties
EP3859003A4 (en) GLUCOSAMINE ENZYMATIC PREPARATION
EP3478822C0 (en) PRESERVATION OF MICROORGANISMS
EP3821026A4 (en) MODIFIED PHOSPHOPENTOMUTASE VARIANT ENZYMES
HUE053488T2 (en) Preparations containing bacterial strains
HUE054164T2 (en) Preparations containing bacterial strains
EP3840582A4 (en) MODIFICATION OF PROTEIN GLYCOSYLATION IN MICRO-ORGANISMS
EP3846938A4 (en) IMMOBILIZED ENZYMES AND MICROSOMES ON MAGNETIC SCAFFOLDS
PL4001297T3 (en) CHIMERIC PAPILOMAVIRUS L1 PROTEIN
EP4330386A4 (en) ENZYMES WITH RUVC DOMAINS
MA50220A (en) LACTASE ENZYMES WITH ENHANCED ACTIVITY AT LOW TEMPERATURES
HUE052319T2 (en) Preparations containing bacterial strains
EP4392561A4 (en) ENZYMES WITH RUVC DOMAS
EP3673085A4 (en) ENZYME SCREENING METHODS

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210817

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: METAGENOMI, INC.

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40065111

Country of ref document: HK

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/90 20060101ALI20221019BHEP

Ipc: C12N 15/10 20060101ALI20221019BHEP

Ipc: C12N 15/113 20100101ALI20221019BHEP

Ipc: C12N 9/22 20060101AFI20221019BHEP

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/90 20060101ALI20221026BHEP

Ipc: C12N 15/10 20060101ALI20221026BHEP

Ipc: C12N 15/113 20100101ALI20221026BHEP

Ipc: C12N 9/22 20060101AFI20221026BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20230302

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/90 20060101ALI20230224BHEP

Ipc: C12N 15/10 20060101ALI20230224BHEP

Ipc: C12N 15/113 20100101ALI20230224BHEP

Ipc: C12N 9/22 20060101AFI20230224BHEP

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230513

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: METAGENOMI THERAPEUTICS, INC.

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: METAGENOMI THERAPEUTICS, INC.