EP3924375A4 - Universalspenderstammzellen und zugehörige verfahren - Google Patents
Universalspenderstammzellen und zugehörige verfahren Download PDFInfo
- Publication number
- EP3924375A4 EP3924375A4 EP20755906.3A EP20755906A EP3924375A4 EP 3924375 A4 EP3924375 A4 EP 3924375A4 EP 20755906 A EP20755906 A EP 20755906A EP 3924375 A4 EP3924375 A4 EP 3924375A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- stem cells
- related methods
- universal donor
- donor stem
- universal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1114—T cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201916277913A | 2019-02-15 | 2019-02-15 | |
US201916596697A | 2019-10-08 | 2019-10-08 | |
PCT/US2020/018467 WO2020168317A2 (en) | 2019-02-15 | 2020-02-16 | Universal donor stem cells and related methods |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3924375A2 EP3924375A2 (de) | 2021-12-22 |
EP3924375A4 true EP3924375A4 (de) | 2023-03-22 |
Family
ID=72045137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20755906.3A Withdrawn EP3924375A4 (de) | 2019-02-15 | 2020-02-16 | Universalspenderstammzellen und zugehörige verfahren |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP3924375A4 (de) |
JP (1) | JP2022526218A (de) |
KR (1) | KR20210128440A (de) |
CN (1) | CN113906048A (de) |
AU (1) | AU2020223192A1 (de) |
BR (1) | BR112021016178A2 (de) |
CA (1) | CA3130398A1 (de) |
IL (1) | IL285619A (de) |
MX (1) | MX2021009842A (de) |
SG (1) | SG11202108891QA (de) |
WO (1) | WO2020168317A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230338533A1 (en) * | 2020-05-15 | 2023-10-26 | Rxcell Inc. | Hypoimmunogenic Cells and Uses Thereof in Immune Responses |
CN114457021A (zh) * | 2020-10-30 | 2022-05-10 | 未来智人再生医学研究院(广州)有限公司 | 一种表达cd47抗体的多能干细胞及其衍生物与应用 |
CN114525256A (zh) * | 2020-10-30 | 2022-05-24 | 未来智人再生医学研究院(广州)有限公司 | 一种表达Siglec-15阻断物的多能干细胞或其衍生物及应用 |
TW202237826A (zh) | 2020-11-30 | 2022-10-01 | 瑞士商克里斯珀醫療股份公司 | 基因編輯的自然殺手細胞 |
JP2023552816A (ja) * | 2020-12-11 | 2023-12-19 | インテリア セラピューティクス,インコーポレイテッド | 細胞内のmhcクラスiiを低減する組成物及び方法 |
AU2021410751A1 (en) * | 2020-12-23 | 2023-07-13 | Intellia Therapeutics, Inc. | Compositions and methods for genetically modifying ciita in a cell |
JP2024501971A (ja) | 2020-12-31 | 2024-01-17 | サナ バイオテクノロジー,インコーポレイテッド | Car-t活性を調節するための方法及び組成物 |
AU2022283291A1 (en) | 2021-05-27 | 2023-11-02 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
IL310702A (en) | 2021-08-11 | 2024-04-01 | Sana Biotechnology Inc | Inducible systems for altering gene expression in hypoimmunogenic cells |
WO2023122337A1 (en) | 2021-12-23 | 2023-06-29 | Sana Biotechnology, Inc. | Chimeric antigen receptor (car) t cells for treating autoimmune disease and associated methods |
WO2023154578A1 (en) | 2022-02-14 | 2023-08-17 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
WO2023191063A1 (ja) * | 2022-04-01 | 2023-10-05 | 株式会社Logomix | 遺伝子工学、細胞工学、および細胞医薬に適した細胞およびその製造方法 |
WO2024003349A1 (en) | 2022-07-01 | 2024-01-04 | Novo Nordisk A/S | Enhancing neuronal differentiation of ventral midbrain neural progenitor cells |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017079673A1 (en) * | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3294342A4 (de) * | 2015-05-08 | 2018-11-07 | President and Fellows of Harvard College | Universalspenderstammzellen und zugehörige verfahren |
BR112019014257A2 (pt) * | 2017-01-13 | 2020-04-28 | Univ California | método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina |
-
2020
- 2020-02-16 SG SG11202108891QA patent/SG11202108891QA/en unknown
- 2020-02-16 CN CN202080021860.7A patent/CN113906048A/zh active Pending
- 2020-02-16 KR KR1020217029445A patent/KR20210128440A/ko unknown
- 2020-02-16 JP JP2021547755A patent/JP2022526218A/ja active Pending
- 2020-02-16 AU AU2020223192A patent/AU2020223192A1/en not_active Abandoned
- 2020-02-16 CA CA3130398A patent/CA3130398A1/en active Pending
- 2020-02-16 EP EP20755906.3A patent/EP3924375A4/de not_active Withdrawn
- 2020-02-16 WO PCT/US2020/018467 patent/WO2020168317A2/en unknown
- 2020-02-16 MX MX2021009842A patent/MX2021009842A/es unknown
- 2020-02-16 BR BR112021016178A patent/BR112021016178A2/pt unknown
-
2021
- 2021-08-15 IL IL285619A patent/IL285619A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017079673A1 (en) * | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
Non-Patent Citations (1)
Title |
---|
XIAO HAN ET AL: "Generation of hypoimmunogenic human pluripotent stem cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 21, 30 April 2019 (2019-04-30), pages 10441 - 10446, XP055640699, ISSN: 0027-8424, DOI: 10.1073/pnas.1902566116 * |
Also Published As
Publication number | Publication date |
---|---|
JP2022526218A (ja) | 2022-05-24 |
EP3924375A2 (de) | 2021-12-22 |
WO2020168317A8 (en) | 2021-02-25 |
IL285619A (en) | 2021-09-30 |
KR20210128440A (ko) | 2021-10-26 |
WO2020168317A2 (en) | 2020-08-20 |
CN113906048A (zh) | 2022-01-07 |
SG11202108891QA (en) | 2021-09-29 |
AU2020223192A1 (en) | 2021-09-09 |
MX2021009842A (es) | 2021-12-10 |
BR112021016178A2 (pt) | 2021-11-03 |
WO2020168317A3 (en) | 2020-10-29 |
CA3130398A1 (en) | 2020-08-20 |
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Legal Events
Date | Code | Title | Description |
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STAA | Information on the status of an ep patent application or granted ep patent |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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17P | Request for examination filed |
Effective date: 20210902 |
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Ref country code: HK Ref legal event code: DE Ref document number: 40065863 Country of ref document: HK |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20230220 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/113 20100101ALI20230214BHEP Ipc: C12N 5/074 20100101ALI20230214BHEP Ipc: C07K 14/705 20060101ALI20230214BHEP Ipc: C07K 14/74 20060101ALI20230214BHEP Ipc: C12N 5/0735 20100101AFI20230214BHEP |
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18D | Application deemed to be withdrawn |
Effective date: 20230921 |