EP3896165A4 - Mutant strain having enhanced l-glutamic acid producing ability, and l-glutamic acid preparation method using same - Google Patents
Mutant strain having enhanced l-glutamic acid producing ability, and l-glutamic acid preparation method using same Download PDFInfo
- Publication number
- EP3896165A4 EP3896165A4 EP19895465.3A EP19895465A EP3896165A4 EP 3896165 A4 EP3896165 A4 EP 3896165A4 EP 19895465 A EP19895465 A EP 19895465A EP 3896165 A4 EP3896165 A4 EP 3896165A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- glutamic acid
- enhanced
- same
- mutant strain
- producing ability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01182—(R)-Citramalate synthase (2.3.1.182)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/15—Corynebacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
- C12Y203/03013—2-Isopropylmalate synthase (2.3.3.13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020180161190A KR102075160B1 (en) | 2018-12-13 | 2018-12-13 | Mutant strain with enhanced L-glutamic acid productivity and method for preparing L-glutamic acid using the same |
PCT/KR2019/017124 WO2020122505A1 (en) | 2018-12-13 | 2019-12-05 | Mutant strain having enhanced l-glutamic acid producing ability, and l-glutamic acid preparation method using same |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3896165A1 EP3896165A1 (en) | 2021-10-20 |
EP3896165A4 true EP3896165A4 (en) | 2022-04-27 |
Family
ID=69627443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19895465.3A Pending EP3896165A4 (en) | 2018-12-13 | 2019-12-05 | Mutant strain having enhanced l-glutamic acid producing ability, and l-glutamic acid preparation method using same |
Country Status (6)
Country | Link |
---|---|
US (1) | US20220049212A1 (en) |
EP (1) | EP3896165A4 (en) |
JP (2) | JP2022513813A (en) |
KR (1) | KR102075160B1 (en) |
CN (2) | CN117568249A (en) |
WO (1) | WO2020122505A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102075160B1 (en) * | 2018-12-13 | 2020-02-10 | 대상 주식회사 | Mutant strain with enhanced L-glutamic acid productivity and method for preparing L-glutamic acid using the same |
KR102269639B1 (en) * | 2020-02-12 | 2021-06-25 | 대상 주식회사 | Mutant of Corynebacterium glutamicum with enhanced L-glutamic acid productivity and method for preparing L-glutamic acid using the same |
CN112646767B (en) * | 2020-12-30 | 2022-08-09 | 宁夏伊品生物科技股份有限公司 | Strain with enhanced L-glutamic acid productivity and construction method and application thereof |
KR102266230B1 (en) * | 2021-01-27 | 2021-06-17 | 씨제이제일제당 주식회사 | Novel ABC transporter ATP-binding protein variant and a method for producing L-glutamic acid using the same |
KR102277406B1 (en) * | 2021-01-27 | 2021-07-14 | 씨제이제일제당 주식회사 | Novel excinuclease ABC subunit A variant and a method for producing L-glutamic acid using the same |
KR102277405B1 (en) * | 2021-01-27 | 2021-07-14 | 씨제이제일제당 주식회사 | Novel spermidine synthase variant and a method for producing L-glutamic acid using the same |
KR102266233B1 (en) * | 2021-01-27 | 2021-06-17 | 씨제이제일제당 주식회사 | Novel ABC transporter ATP-binding protein variant and a method for producing L-glutamic acid using the same |
WO2022231036A1 (en) * | 2021-04-29 | 2022-11-03 | 씨제이제일제당 (주) | Novel variant, and method for producing l-glutamic acid using same |
CN113512540B (en) * | 2021-05-31 | 2022-07-19 | 廊坊梅花生物技术开发有限公司 | Quinolinate synthase mutant and application thereof |
CN114806987B (en) * | 2022-04-19 | 2023-06-06 | 中国科学院上海高等研究院 | Engineered escherichia coli engineering bacterium and method for producing citramalic acid by same |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015005406A1 (en) * | 2013-07-09 | 2015-01-15 | 味の素株式会社 | Method for manufacturing useful substance |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100630604B1 (en) | 1998-09-25 | 2006-10-04 | 아지노모토 가부시키가이샤 | Process for constructing amino acid-producing bacterium and process for producing amino acid by fermentation method with the use of the thus constructed amino acid-producing bacterium |
JP2000201692A (en) | 1999-01-13 | 2000-07-25 | Ajinomoto Co Inc | Production of l-glutamic acid by fermentation |
CA2590403A1 (en) * | 1999-07-01 | 2001-01-11 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding phosphoenolpyruvate:sugar phospho-transferase system proteins |
ATE474918T1 (en) * | 2002-03-19 | 2010-08-15 | Kyowa Hakko Bio Co Ltd | MUTATED ISOPROPYLMALATISOMERASE |
JP5343303B2 (en) * | 2004-12-28 | 2013-11-13 | 味の素株式会社 | L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
BRPI0519410B1 (en) * | 2004-12-28 | 2020-12-22 | Ajinomoto Co., Inc | method for producing l-glutamic acid |
KR101138289B1 (en) | 2009-09-29 | 2012-04-24 | 대상 주식회사 | Microorganism having glutamic acid-producing activity and process for producing glutamic acid using the same |
CN104302765B (en) * | 2012-04-27 | 2018-09-11 | 赢创工业化学有限公司 | Feed back resistance α-isopropylmalate synthase |
JP2015029474A (en) * | 2013-08-02 | 2015-02-16 | 学校法人東京電機大学 | Production method of purine-derived substance |
CN104480058B (en) * | 2014-12-30 | 2017-07-21 | 福建师范大学 | One plant height produces L leucines engineering bacteria and its application |
CN105695383B (en) * | 2016-03-02 | 2020-06-19 | 廊坊梅花生物技术开发有限公司 | Recombinant strain and application thereof |
US10428359B2 (en) * | 2016-10-03 | 2019-10-01 | Ajinomoto Co, Inc. | Method for producing L-amino acid |
KR101959063B1 (en) * | 2017-06-09 | 2019-03-18 | 대상 주식회사 | Mutant strain with enhanced l-leucine productivity and method for preparing l-leucine using the same |
KR102075160B1 (en) * | 2018-12-13 | 2020-02-10 | 대상 주식회사 | Mutant strain with enhanced L-glutamic acid productivity and method for preparing L-glutamic acid using the same |
CN113135985B (en) * | 2020-01-19 | 2022-11-01 | 中国科学院天津工业生物技术研究所 | Method for producing L-glutamic acid |
KR102269639B1 (en) * | 2020-02-12 | 2021-06-25 | 대상 주식회사 | Mutant of Corynebacterium glutamicum with enhanced L-glutamic acid productivity and method for preparing L-glutamic acid using the same |
JP2024509290A (en) * | 2021-03-09 | 2024-02-29 | デサン・コーポレイション | Corynebacterium glutamicum mutant strain with improved L-lysine production ability and method for producing L-lysine using the same |
-
2018
- 2018-12-13 KR KR1020180161190A patent/KR102075160B1/en active IP Right Grant
-
2019
- 2019-12-05 EP EP19895465.3A patent/EP3896165A4/en active Pending
- 2019-12-05 WO PCT/KR2019/017124 patent/WO2020122505A1/en unknown
- 2019-12-05 CN CN202311504949.0A patent/CN117568249A/en active Pending
- 2019-12-05 JP JP2021533622A patent/JP2022513813A/en active Pending
- 2019-12-05 US US17/413,156 patent/US20220049212A1/en active Pending
- 2019-12-05 CN CN201980082944.9A patent/CN113227381A/en active Pending
-
2023
- 2023-03-03 JP JP2023032941A patent/JP2023071883A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015005406A1 (en) * | 2013-07-09 | 2015-01-15 | 味の素株式会社 | Method for manufacturing useful substance |
Non-Patent Citations (1)
Title |
---|
MICHAEL VOGT ET AL: "Pushing product formation to its limit: Metabolic engineering of Corynebacterium glutamicum for l-leucine overproduction", METABOLIC ENGINEERING, vol. 22, 1 March 2014 (2014-03-01), pages 40 - 52, XP055111480, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2013.12.001 * |
Also Published As
Publication number | Publication date |
---|---|
CN117568249A (en) | 2024-02-20 |
CN113227381A (en) | 2021-08-06 |
EP3896165A1 (en) | 2021-10-20 |
JP2022513813A (en) | 2022-02-09 |
KR102075160B1 (en) | 2020-02-10 |
WO2020122505A1 (en) | 2020-06-18 |
US20220049212A1 (en) | 2022-02-17 |
JP2023071883A (en) | 2023-05-23 |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20220330 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12P 13/00 20060101ALI20220324BHEP Ipc: C12N 9/10 20060101ALI20220324BHEP Ipc: C12N 15/77 20060101AFI20220324BHEP |