EP3886823A1 - Woven, nonwoven, cotton, nonwoven-cotton blended polyethylene and polipropilen and polystyrene mask, wound dressing, panty, bra, handkerchief, pad, scouring pad, disposable surgical dress, disposable sheets with antimicrobial properties - Google Patents
Woven, nonwoven, cotton, nonwoven-cotton blended polyethylene and polipropilen and polystyrene mask, wound dressing, panty, bra, handkerchief, pad, scouring pad, disposable surgical dress, disposable sheets with antimicrobial propertiesInfo
- Publication number
- EP3886823A1 EP3886823A1 EP18941108.5A EP18941108A EP3886823A1 EP 3886823 A1 EP3886823 A1 EP 3886823A1 EP 18941108 A EP18941108 A EP 18941108A EP 3886823 A1 EP3886823 A1 EP 3886823A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- nonwoven
- guanidine
- cotton
- derivatives
- diamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 229920000573 polyethylene Polymers 0.000 title claims abstract description 30
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- 238000009991 scouring Methods 0.000 title claims abstract description 12
- 125000003277 amino group Chemical group 0.000 claims abstract description 30
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract description 25
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- 150000002357 guanidines Chemical class 0.000 claims abstract description 23
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- 150000003839 salts Chemical class 0.000 claims abstract description 12
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000002253 acid Substances 0.000 claims abstract description 11
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract description 11
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- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
- D06M13/402—Amides imides, sulfamic acids
- D06M13/432—Urea, thiourea or derivatives thereof, e.g. biurets; Urea-inclusion compounds; Dicyanamides; Carbodiimides; Guanidines, e.g. dicyandiamides
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/19—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with synthetic macromolecular compounds
- D06M15/37—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- D06M15/53—Polyethers
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/19—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with synthetic macromolecular compounds
- D06M15/37—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- D06M15/564—Polyureas, polyurethanes or other polymers having ureide or urethane links; Precondensation products forming them
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/19—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with synthetic macromolecular compounds
- D06M15/37—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- D06M15/61—Polyamines polyimines
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
- D06M16/003—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic with enzymes or microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- This invention relates to woven, nonwoven, cotton, nonwoven- cotton blended and polystyrene mask, wound dressing, panty, bra, handkerchief, pad, scouring pad, disposable surgical dress, disposable sheets with antimicrobial properties.
- the present invention relates to woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material having antimicrobial activity, and to its uses ranging from wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials, panty, bra, handkerchief, pad, scouring pad, disposable sheets and similar applications where the antimicrobial effects are employed, as well as to a process for the preparation of the woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material.
- the present invention relates to a combination polymeric guanidine derivative based on a diamine containing oxyalkylene chains between two amino groups, with the guanidine derivative representing a product of polycondensation between a guanidine acid addition salt and a diamine containing polyoxyalkylene chains between two amino groups, Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride), Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants like humic acids and some natural products like phytotherapeutic plant extracts for the production of a liqid, powder and tablette form for anti
- Surgical drapes are presently made from woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabrics, and are typically used during surgical procedures to isolate the patient from the operating room personnel and the environment of the operating room. Contact with contaminated liquids through surgical drapes has been considered as a primary source of bacterial contamination for patients. Typically, drapes equipped with chemical antimicrobial agents are employed to avoid this, which typically must be present at a relatively high concentration to achieve the desired level of efficacy.
- the use of antibacterial or antifungal agents in non-woven fabrics is for instance disclosed in U.S. Pat. No. 4,111,922. Unfortunately, however, the required high levels of antimicrobial agents employed are undesired in many cases.
- the use of high levels of certain types of antimicrobial agents may be undesired due to an increased likelihood of contacting sensitive areas, such as wounds.
- most presently employed antimicrobial compositions loose efficacy over time, since the microbiological pathogens develop resistance, such as for instance exemplified by methicilin -resistant staphylococcus aureus (MRS A). This resistance spread is exacerbated by the low number of antibiotics in the development pipeline which could result in a major world-wide public health problem.
- the antimicrobial products which have been developed to date have all the features of dipping process and have short-term stability and weariness, while the method developed in the present invention has the ability to penetrate into the structure of woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene materials to increase effcieny and long term stability.
- antimicrobial effcetivines has not been successfully developed and applied to a substrate having the combination of characteristics described here in, as desired for an effective antimicrobial properties of wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials, panty, bra, handkerchief, pad, scouring pad, , disposable sheets and similar applications as well as to a process for the preparation of the woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material.
- HVAC Heating Ventilating and Air Conditioning
- the microbial contamination frequently found includes fungi such as Aspergillus spp., Fusarium spp., Penicillium chrysogenum and/or Candida albicans, but also Legionella, a pathogenic Gram negative bacterium, including species that cause legionellosis or“Legionnaires' disease”, most notably, Legionella pneumophila, has caused many issues with infections transmitted through HVAC systems.
- the present invention relates to a fabric material having antimicrobial activity, comprising: (a) a woven, non-woven and non woven-cotton fabric material, and (b) fabric material having a thickness of from 5 to 100 nm, 10 to 70 gsm
- antimicrobial activity refers to a material that destroys, inhibits or prevents the propagation, growth and multiplication of unwanted microbial organisms such as bacteria, fungia and viriis.
- microbial organisms or“microbes” includes, but is not limited to, microorganisms, bacteria, undulating bacteria, spirochetes, spores, spore -forming organisms, gram-negative organisms, gram-positive organisms, yeasts, fungi, moulds, viruses, aerobic organisms, anaerobic organisms and mycobacteria.
- Such organisms include the fungi Aspergillus niger, Aspergillus flavus, Rhizopus nigricans, Cladosporium herbarium, Epidermophyton floccosum, Trichophyton mentagrophytes, Histoplasma capsulatum, and the like; bacteria, such as Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Staphylococcus epidermis, Streptococcus faecalis, Klebsiella, Enterobacter aerogenes, Proteus mirabilis, other gram-negative bacteria and other gram-positive bacteria, mycobactin and the like, as well as yeasts, such as Saccharomyces cerevisiae, Candida albicans, and the like.
- the antimicrobial layer lie on on the all surface of woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material and that imparts the antimicrobial activity comprises a combination polymeric guanidine derivative based on a diamine containing oxyalkylene chains between two amino groups, with the guanidine derivative representing a product of polycondensation between a guanidine acid addition salt and a diamine containing polyoxyalkylene chains between two amino groups, hexamethylenediamine (1,6- hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2- (2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent.
- the present invention also advantageously relates to woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material, whereby high cation capacity of synthesiz antimcirobial material inhibited all of the bacteria and fungia nad viriis contaminated surface.
- the present invention refers to fabric materials including to woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material and/or film surfaces.
- Woven or nonwoven fabric materials are usually defined as sheet or web structures bonded together by entangling of fibres or filaments, and/or by perforating films mechanically, thermally or chemically. They are typically flat, porous, sheet like structures that are made from separate fibres, and/or from molten plastic or plastic film. Woven or nonwoven fabrics provide specific functions such as absorbency, liquid repellence, resilience, stretch, softness, strength, flame retardancy, washability, cushioning, filtering, use as a bacterial barrier and sterility.
- Woven fabric according to the present invention may be formed from fibres
- Woven fabrics according to the invention are typically prepare from fibres and/or yam prepared from fibres, such as synthetic fibres, natural fibres, or combinations thereof.
- the process usually involves steps such as weaving or knitting, and it does not necessarily require converting fibres to yam.
- Synthetic fibres include, for example, polyester, acrylic, polyamide, polyolefin, polyaramid, polyurethane, regenerated cellulose, and blends thereof. More specifically, polyester, polyethylene and polipropilen, high impact polystyrene includes, for example, polyethylene terephthalate, polytriphenylene terephthalate, polybutylene terephthalate, polylactic acid, and combinations thereof.
- Polyamide includes, for example, nylon-6, nylon-6.6, and combinations thereof.
- Polyolefins include polypropylene, polyethylene, and combinations thereof.
- Polyaramid includes, for instance poly-p-phenyleneteraphthalamid (i.e., Kevlar (iD), poly-m-phenyleneteraphthalamid (i.e., Nomex (E)), and combinations or variations thereof.
- Natural fibres include, for example, wool, cotton, flax, cellulose and blends thereof.
- the fabric may be formed from fibres or yarns of any size, including microdenier fibres and yams (fibres or yams having less than one denier per filament).
- the fibres or yams may have deniers that range from less than about 1 denier per filament to about 2000 denier per filament or more preferably, from less than about 1 denier per filament to about 500 denier per filament, or even more preferably, from less than about 1 denier per filament to about 300 denier per filament.
- the fabric may be partially or wholly comprised of multi -component or bicomponent fibres or yarns which may be splittable along their length by chemical or mechanical action.
- the fabric may be comprised of fibres such as staple fibre, filament fibre, spun fibre, or combinations thereof.
- the fabric may be of any variety, including but not limited to, woven fabric, knitted fabric, nonwoven fabric, or combinations thereof. They may optionally be coloured by a variety of dyeing techniques, such as high temperature jet dyeing with disperse dyes, thermosol dyeing, pad dyeing, transfer printing, screen printing, or any other technique that is common in the art for comparable, equivalent, traditional textile products. If yams or fibres are treated by the process of the current invention, they may be dyed by suitable methods prior to fabric formation, such as, for instance, by package dyeing or solution dyeing, or after fabric formation as described above, or they may be left undyed.
- suitable methods prior to fabric formation such as, for instance, by package dyeing or solution dyeing, or after fabric formation as described above, or they may be left undyed.
- the film may include thermoplastic materials, thermoset materials, or combinations there of.
- Thermoplastic or thermoset materials may include polyolefin, polyester, polyamide, polyurethane, acrylic, silicone, melamine compounds, polyvinyl acetate, polyvinyl alcohol, nitrile rubber, ionomers, polyvinyl chloride, polyvinylidene chloride, chloroisoprene, or combinations thereof.
- the polyolefin may be polyethylene, polypropylene, ethylvinyl acetate, ethylmethyl acetate, or combinations thereof.
- Polyethylene may include low density or high density polyethylene.
- the film may have a thickness of between 1 and 500 pm, preferably between 2 pm and 250 pm, or even more preferable between about 3 and 100 pm.
- Nonwoven fabrics may be engineered for a single use, limited life or a durable fabric.
- the nonwoven fabric material preferably is a nonwoven web which may include nonwoven webs manufactured by any of the commonly known processes for producing nonwoven webs.
- nonwoven web refers to a fabric that has a structure of individual fibres or filaments which are randomly and/or unidirectionally interlaid in a mat-like fashion.
- the fibrous nonwoven web can be made by carded, air laid, wet laid, spunlaced, spunbonding, electro spinning or melt-blowing techniques, such as melt- spun or melt-blown, or combinations thereof.
- Spunbonded fibres are typically small diameter fibres that are formed by extruding molten thermoplastic polymer as filaments from a plurality of fine, usually circular capillaries of a spinneret with the diameter of the extruded fibres being rapidly reduced.
- meltblown fibres are typically formed by extruding the molten thermoplastic material through a plurality of fine, usually circular, die capillaries as molten threads or filaments into a high velocity, usually heated gas (e.g., air) stream which attenuates the filaments of molten thermoplastic material to reduce their diameter. Thereafter, the meltblown fibres are carried by the high velocity gas stream and are deposited on a collecting surface to from a web of randomly disbursed meltblown fibres. Any of the non woven webs may be made from a single type of fibre or two or more fibres that differ in the type of thermoplastic polymer and/or thickness. Staple fibres may also be present in the web.
- heated gas e.g., air
- staple fibres generally provides a loftier, less dense web than a web of only melt blown microfibers.
- no more than about 20 weight percent staple fibres are present, more preferably no more than about 10 weight percent.
- Webs containing such staple fibre are for instance disclosed in U.S. Pat. No. 4,118,531.
- the nonwoven fabric may advantageously be fashioned or shaped in any suitable article.
- Such an article may optionally further comprise one or more layers of scrim.
- the scrim which is typically a woven or nonwoven reinforcement made from fibres, is included to provide strength to the nonwoven article.
- Suitable scrim materials include, but are not limited to, nylon, polyester, fibreglass, and the like.
- the average thickness of the scrim can vary. Typically, the average thickness of the scrimranges from about 25 to about 100 pm, preferably about 25 to about 50 pm.
- the layer of the scrim may optionally be bonded to the nonwoven article. A variety of adhesive materials can be used to bond the scrim to the polymeric material.
- the scrim may be heat-bonded to the nonwoven.
- the micro fibres of the nonwoven fabric material substrate typically have an effective fibre diameter of from about 0.5 to 15 pm, preferably from about 1 to 6 pm, as calculated according to the method set forth in Davies, C. N.,“The Separation of Airborne Dust and Particles,” Institution of Mechanical Engineers, London, Proceedings IB, 1952.
- the nonwoven fabric material preferably has a basis weight in the range of about 10 to 400 g/m 2 , more preferably about 10 to 100 g/m 2 .
- the average thickness of the nonwoven fabric material is preferably about 0.1 to 10 mm, more preferably about 0.25 to 5 mm for the non-functionalized, and uncalendared fabric material.
- the minimum tensile strength of the nonwoven web is at least 3.0, preferably at least 4.0 Newtons. It is generally recognized that the tensile strength of nonwovens is lower in the machine direction than in the cross-web direction due to better fibre bonding and entanglement in the latter.
- Nonwoven web loft is measured by solidity, a parameter that defines the solids fraction in a volume of web. Lower solidity values are indicative of greater web loft.
- Useful nonwoven fabric materials typically have a solidity of less than 20%, preferably less than 15%, as defined in WO-A-2010151447. Solidity is used herein to refer to the nonwoven fabric material itself and not to the functionalized nonwoven. When a nonwoven fabric material contains mixtures of two or more kinds of fibres, the individual solidities are determined for each kind of fibre using the same L[nonwoven] and these individual solidities are added together to obtain the web's solidity, dt.
- the nonwoven fabric material before calendering or grafting preferably has an average pore size of 14 pm, calculated from a thickness of 0.34 mm, effective fibre diameter of 4.2 um and solidity of 13%. After calendering the nonwoven web will have a thickness of 0.24 mm and solidity of 18% with an average pore size of 8 pm.
- the term“average pore size”, also referred to as average pore diameter is related to the arithmetic median fibre diameter and web solidity and can be determined as disclosed in WO-A-2010/151447.
- the nonwoven fabric material preferably has a mean pore size of 1-40 pm, preferably 2-20 pm.
- Mean pore size may be measured according to ASTM F 316- 03“Standard Test Methods for Pore Size Characteristics of Membrane Filters by Bubble Point and Mean Flow Pore Test Method B” using Freon TFTM as the test fluid.
- the nonwoven fabric material may be formed from any suitable thermoplastic polymeric material.
- Suitable polymeric materials include, but are not limited to, polyolefins, poly(isoprenes), poly(butadienes), fluorinated polymers, chlorinated polymers, polyamides, polyimides, polyethers, poly(ether sulfones), poly(sulfones), poly(vinyl acetates), copolymers of vinyl acetate, such as poly(ethylene)-co-poly(vinyl alcohol), poly(phosphazenes), poly(vinyl esters), poly(vinyl ethers), poly( vinyl alcohols), and poly(carbonates).
- Suitable polyolefins include, but are not limited to, poly(ethylene), poly(propylene), poly(l -butene), copolymers of ethylene and propylene, alpha olefin copolymers (such as copolymers of ethylene or propylene with 1 -butene, 1-hexene, 1-octene, and 1-decene), poly(ethylene-co-l -butene) and poly(ethylene-co-l-butene-co-l- hexene).
- Suitable fluorinated polymers include, but are not limited to, poly(vinyl fluoride), poly(vinylidene fluoride), copolymers of vinylidene fluoride (such as poly(vinylidene fluoride-co-hexafluoropropylene), and copolymers of chlorotrifluoroethylene (such as poly(ethylene-co-chlorotrifluoroethylene).
- Suitable polyamides include, but are not limited to, nylon 6, nylon 6,6, nylon 6, 12 poly(iminoadipoyliminohexamethylene), poly(iminoadipoyliminodecamethylene), and polycaprolactam.
- Suitable polyimides include poly(pyromellitimide).
- Suitable poly(ether sulfones) include, but are not limited to, poly(diphenylether sulfone) and poly(diphenylsulfone-co-diphenylene oxide sulfone).
- Suitable copolymers of vinyl acetate include, but are not limited to, poly(ethylene- co-vinyl acetate) and such copolymers in which at least some of the acetate groups have been hydrolyzed to afford various poly(vinyl alcohols) including, poly(ethylene-co- vinyl alcohol).
- Preferred polymers are inherently hydrophilic and are readily grafted by ionizing radiation, such as by exposure to e-beam or gamma radiation.
- Preferred polymers include of polyamides and ethylene vinyl alcohol polymers and copolymers.
- preferred nonwoven fabric sheets are made from wood pulp; fibres of a thermoplastic polymeric material, including melt-blown polymer fibres, such as melt-blown polypropylene fibres, and synthetic polymer fibres, such as polypropylene, polyester, polyethylene, polyolefin, polyamide polyethylene and polipropilen, high impact polystyrene and nylon fibres; cellulosic nonwoven fibres such as nonwoven rayon; and combinations of these materials.
- thermoplastic is used herein to refer to materials which are solid at room temperature, i.e. from 22° C. to 30° C., but which soften or melt when heated to temperatures above room temperature. Thermoplastic materials are extrudable at temperatures in excess of 50° C. Preferred thermoplastic materials soften or melt at temperatures above about 50° C. and below about 1,000° C., in order that the material will not melt during transportation but be melted by commonly-used surgical lasers. More preferred thermoplastic materials soften or melt at temperatures between 60° C. and 500° C. For surgical drape applications where patient comfort is a factor, preferably at least 10 percent of the nonwoven fibres have lengths greater than about 0.06 cm.
- Nonwoven fabric sheets include a layer of polyethylene film sandwiched between two layers of nonwoven rayon, melt-blown polypropylene fabric; and a combination of wood pulp and polyester fibres.
- Nonwovens are typically manufactured by putting small fibres together in the form of a sheet or web, and then binding them either mechanically as in the case of felt, by interlocking them with serrated needles such that the inter-fibre friction results in a stronger fabric, with an adhesive; thermally; by applying binder, preferably in the form of powder, paste, or polymer melt, and then melting the binder onto the web by increasing temperature.
- the nonwoven fabric material may be a nonwoven web, paper, film, foam, elastomeric material, which may be supplied with the antimicrobial composition.
- the nonwoven fabric has a weblike stmcture, it may preferably be a spunbond web, meltblown web, bonded carded web, airlaid web, coform web, and/or hydraulically entangled web.
- Polymers suitable for making nonwoven webs include, for example, polyolefins, polyesters, polyamides, polycarbonates, copolymers and blends thereof, etc.
- Most embodiments of the laminate of the present invention employ a nonwoven web formed from olefin-based polymers, which are non-polar in nature.
- Suitable polyolefins include polyethylene, such as high density polyethylene, medium density polyethylene, low density polyethylene, and linear low density polyethylene; polypropylene, such as isotactic polypropylene, atactic polypropylene, and syndiotactic polypropylene; polybutylene, such as poly(l- butene) and poly(2-butene); polypentene, such as poly(l-pentene) and poly(2- pentene); poly(3 -methyl -1-pentene); poly(4-methyl-l-pentene); and copolymers and blends thereof.
- polyethylene such as high density polyethylene, medium density polyethylene, low density polyethylene, and linear low density polyethylene
- polypropylene such as isotactic polypropylene, atactic polypropylene, and syndiotactic polypropylene
- polybutylene such as poly(l- butene) and poly(2-butene
- polypentene such as poly(l-pen
- Suitable copolymers include random and block copolymers prepared from two or more different unsaturated olefin monomers, such as ethylene/propylene and ethylene/butylene copolymers. Such polymer(s) may preferably also contain additives, such as processing aids to impart desired properties to the fibres, residual amounts of carriers, pigments or colorants, and so forth.
- the nonwoven fabric may have a multi-layer structure.
- Suitable multi layered materials may include, for instance spunbond/meltblown/spunbond (SMS) laminates and spunbond/meltblown (SM) laminates.
- SMS laminates are described in U.S. Pat. No. 4,041,203, U.S. Pat. No. 5,213,881, U.S. Pat. No. 5,464,688, U.S. Pat. No. 4,374,888 U.S. Pat. No. 5,169,706 and U.S. Pat. No. 4,766,029.
- Nonwoven fabric materials are usually made in at least two steps.
- fibres are cut to a few centimetres length, and then dispersed on a conveyor belt, where they are spread in a uniform web by a wetlaid process or by carding.
- SM or SMS webs nonwoven fabric materials which are strong and offer the intrinsic benefits of fine fibres such as fine filtration, low pressure drop as used in face masks or filters and physical benefits such as acoustic insulation as used in dishwashers, for instance for disposable diaper and hygiene care products.
- Melt blown non woven fibres are typically produced by extruding melted polymer fibres through a spin net or die to form long thin fibres which are stretched and cooled by passing hot air over the fibres as they fall from the die. The resultant web is collected into rolls and subsequently converted to finished products.
- the extremely fine fibres typically differ from other in that they have low intrinsic strength but much smaller size offering.
- Nonwoven fabrics are typically bonded by using either resin or thermally. Bonding can be throughout the web by resin saturation or overall thermal bonding or in a distinct pattern via resin printing or thermal spot bonding.
- the nonwoven fabric may advantageously also contain additional fibrous components.
- a nonwoven fabric may be entangled with a fibrous component using any of a variety of entanglement techniques known to a person skilled in the art, such as cellulosic fibres or glass fibres.
- a typical hydraulic entangling process utilizes high pressure jet streams of water to entangle fibres to form a highly entangled consolidated fibrous structure, e.g., a nonwoven fabric.
- Fibreglass is wetlaid into mats for use in roofing and shingles. Synthetic fibre blends are wetlaid along with cellulose for single -use fabrics.
- the nonwoven fabric may contain an elastomeric polymer, such as natural rubber latex, isoprene polymers, chloroprene polymers, vinyl chloride polymers, styrene-ethylene -butylene-styrene block copolymers, styrene -isoprene- styrene block copolymers, styrene -butadiene-styrene block copolymers, styrene-isoprene block copolymers, styrene -butadiene block copolymers, butadiene polymers, styrene-butadiene polymers, carboxylated styrene -butadiene polymers, acrylonitrile -butadiene polymers, carboxylated acrylonitrile -butadiene polymers, acrylonitrile-styrene
- an elastomeric polymer such as natural rubber latex
- the woven or non-woven fabric materials according to the present invention can be prepared particularly cheaply and in large economical scale with high throughput processes, giving access to comparatively cheap antimicrobial products that may be employed for applications where prior to the invention the use of antimicrobial materials would have been unsuccessful due to the prohibitive costs involved.
- the antimicrobial composition may be tailored according to the use and potential contamination targeted. The economics can be maintained due to the extremely low amounts of metal deposited.
- the metal layer has a high adhesion, while other properties, such as flexibility of the substrate, remain unchanged.
- the subject woven and non-woven antimicrobial materials may advantageously be employed in various applications to inhibit the growth of microorganisms. For example, they may be used in treatments or surroundings where hospital -acquired infections caused by bacteria, viruses, fungi, or parasites.
- the subject woven and non-woven antimicrobial materials preferably have an antibacterial activity of at least 3, more preferably at least 4, yet more preferably at least 5 as determined by the ISO 20743:2007 method, using Staphylococcus aureus ATCC 6538 and/or Klebsiella pneumoniae ATCC 4352. This activity is advantageously measured on the on the metalized surface as described herein below.
- Antimicrobial woven and non-woven fabric materials according to the invention may advantageously be employed in numerous applications, including: hygiene articles, such as diapers, feminine hygiene articles, wet wipes, bandages, facial masks and wound dressings; medical isolation and/or surgical apparel and gowns, surgical drapes and covers, surgical scrub suits, masks, caps and generally disposable clothing; filters for fluids and air, sensitive packaging materials and so on. These filters are typically employed in filtration and processing steps in the pharmaceutical, chemical, food and mineral and oil processing industry, and may be formed into cartridge and bag filters, vacuum bags, and allergen membranes.
- the present invention further also relates to a integrarted syhthezis material to woven or non- woven fabric material such as sheet cloth and its applications as two different technologies which are used in the introduction of the synthesis material to the structure of non-woven material, and while the effect is achieved by immersion method, but a shorter period of time is provided, in the case of entering the material during the production phase, the formation of longer periods than both efficiency and stability is ensured.
- the effect is desirable in high quality air environments such as hospitals and health care facilities, but also public spaces, such as preferably public transport, e.g. underground trains, large office buildings, schools, housing and the like.
- the present invention further relates to a filter comprising the metallised non-woven material with bacterial growth suppressing activity.
- the filter, and cartridges comprising the nonwoven fabric material according to the invention may be employed for air and/or liquid filtration, such as for instance for drinking water. In the latter it may advantageously remove smells, discolouration and chemical contaminants such as chlorine besides its antimicrobial function.
- the antibacterial filter comprising material according to the invention can further positively reduce the microbial load, and hence impact air quality in stand alone ventilation circuits in the automotive and aerospace industries.
- the woven non-woven fabric may be used alone, or in combination with other materials for a further spectrum of products with diverse properties, such as components of apparel, home furnishings, health care, engineering, industrial and consumer goods.
- the (non)woven fabric material substrate may also serve other purposes, such as providing water absorption, barrier properties, etc. Any of a variety of (non)woven fabric material substrates may be applied with the antimicrobial composition in accordance with the present invention. Accordingly, the present invention also relates to the use of the materials according to the invention, or those materials obtainable according to above described process, for the control or restriction of antimicrobial growth.
- Nonwoven abrasive articles used for cleaning can harbor microorganisms such as bacteria and fungi that can thrive and rapidly multiply in moist environments. Consequently, it is desirable to use materials that are effective at cleaning and that control or prevent the growth of unwanted microorganisms on nonwoven abrasive articles.
- various approaches have been taken to try to solve the problem of microbial growth on nonwoven abrasive articles used for cleaning, such approaches have not produced nonwoven abrasive articles that have long lasting effects on a broad spectrum of organisms
- the nonwoven substrate can be of any desired weight.
- the weight of the nonwoven substrate material per unit area can be in a range of about 100 GSM to 500 GSM, such as 150 GSM to 200 GSM, or about 160 GSM to about 180 GSM (i.e., grams per square meter, or g/m 2 ).
- Suitable nonwoven substrates are comprised of fibers that are bound together by various methods or mechanisms, such as typically, by being sprayed with a binder formulation.
- a suitable non-limiting binder composition is shown below in Table A of the Examples.
- the nonwoven substrate material can have any desired suitable loft. In a specific embodiment the loft is 12-14 mm and a weight per unit area within a range of 230-250 GSM.
- the nonwoven substrate material can include one or more binders to adhere and interlock the threads (fibers) of the nonwoven web.
- the binder can include natural or synthetic rubber latex, a large range of acrylic binder, melamine formaldehyde resin, or a combination thereof.
- the nonwoven substrate material is cured and complete prior to application of the first formulation or the second formulation.
- the nonwoven substrate material can have a particular thickness. Thickness can be defined as the minimum exterior dimension of the nonwoven substrate material.
- the nonwoven substrate material can have a thickness that is at least 1 mm, such as at least 5 mm, at least 10 mm, at least 15 mm, at least 20 mm, or even at least 25 mm. In a non-limiting embodiment, the nonwoven substrate material can have a thickness that is not greater than 100 mm, such as not greater than 50 mm, or even not greater than 30 mm. It will be appreciated that the nonwoven substrate material can have a thickness that is within a range of any minimum or maximum value noted above.
- the nonwoven substrate material can have a particular loft.
- the nonwoven substrate material can have a loft of at least 5 mm, such as at least 8 mm, or at least 10 mm.
- the nonwoven substrate material can have a loft that is not greater than 35 mm, such as not greater than 30 mm, not greater than 20 mm, not greater than 15 mm, or even not greater than 12 mm. It will be appreciated that the nonwoven substrate material can have a loft that is within a range of any maximum or minimum value noted above, such as within a range of 8 mm to 14 mm.
- the nonwoven substrate material can have a particular weight per unit area, defined as grams per square meter, or GSM.
- the nonwoven substrate material can have a weight of at least 200 GSM, such as at least 220 GSM, or at least 240 GSM.
- the nonwoven substrate material can have a weight per unit area of not greater than 300 GSM, such as not greater than 270 GSM, or even not greater than 250 GSM. It will be appreciated that the nonwoven substrate material can have a weight per unit area within a range of any minimum or maximum value noted above, such as within a range of 240 GSM to 250 GSM.
- the abrasive article provides abrasive performance and broad spectrum antimicrobial effectiveness against S. aureus, and one or more of K. pneumoniae, Bacillus, and E. coli as defined above with respect to the first antimicrobial agent.
- the broad spectrum antimicrobial effectiveness lasts over an extended period of time and/or extensive usage of the abrasive article.
- the abrasive article possesses broad spectrum effectiveness even after extensive usage, such as even after completing 5000 cycles according to the Cyclic Abrasion Test, which equates to cleaning approximately 500 utensils or approximately 15 days of cleaning with the abrasive article.
- the Cyclic Abrasion Test is described in greater detail below in the Examples.
- the abrasive article possesses broad spectrum effectiveness even after being subjected to three hours of ball milling according to the Accelerated Life Test, which is described in greater detail below in the Examples.
- the abrasive article can have a particular weight, defined as grams per square meter, or GSM. In an embodiment, the abrasive article can have a weight of at least at least 300 GSM, at least 500 GSM, at least 750 GSM, at least 850 GSM, or at least 1050 GSM. In a non-limiting embodiment, the abrasive article can have a weight of not greater than 3000 GSM, such as not greater than 2000 GSM, not greater than 1500 GSM, or not greater than 1300 GSM. It will be appreciated that the abrasive article can have a weight within a range of any minimum or maximum value noted above, such as within a range of 300 GSM to 3000 GSM. IN a particular embodiment, the abrasive can have a weight per unit area within a range of 1050 GSM to 1150 GSM.
- the completed abrasive article can have a particular measure of nonwoven substrate material compared to the total weight of the abrasive article (which includes the combined amount of cured first formulation and cured second formulation disposed on and in the nonwoven substrate material).
- the abrasive article can have a GSM ra tio of the weight of the nonwoven substrate material prior to being impregnated and sprayed with the first ad second formulation (GSMnonwoven) to the weight of the final cured abrasive article (GSM fmai ).
- the abrasive article can have a GSM ratio (i.e., GSM n0nwoven :GSM finai ) of at least 1:2, meaning that the weight in GSM of the final cured abrasive article has at least twice a much weight as the nonwoven substrate material from which it was formed.
- the GSM ratio can be at least 1 :3, at least 1:4, or at least 1:5.
- the GSM ratio C an be not greater than 1:15, such as not greater than 1 :6, or not greater than 1:5. It will be appreciated that the GSM rati0 can be within a range of any minimum or maximum value noted above.
- the GSM ratio can be within a range of 1 :3 to 1 :6, and more particularly within a range of 1 :4 to 1:5.
- a mastectomy surgical removal of the breast
- a biopsy such as an open excisional biopsy (lumpectomy) or needle aspiration may be used to obtain a sample of a suspected tumor for analysis.
- Mastopexy breast lift
- Mammoplasty breast reduction
- Reconstructive surgery may restore the contour of a breast after accident or other surgery, or may be used to amend the contour of a healthy breast to match the contour of a breast changed by other surgery.
- surgeries of the breast share the characteristic that an incision or a penetration of the skin overlying the breast is required.
- surgeries of the breast involve a risk that bacteria or other infectious agents may travel through the skin penetration and cause an infection.
- microbes on the undergarments of a post-surgery patient helps to reduce infection and to improve the emotional well-being of the patient.
- a brassiere is worn continuously for many hours, providing a relatively warm, relatively moist environment in which microbes may multiply.
- the problem posed by microbes is exacerbated in the case of the post-operative breast surgery patient due to the fact that tenderness and loss of arm strength or mobility resulting from the breast surgery may make maintaining a high degree of personal cleanliness difficult for the patient.
- the control of microbes in the brassiere of a post-breast surgery patient further helps to prevent anxiety and to maintain the emotional well being of the patient by preventing odors or discoloration resulting from the presence of the microbes
- the present invention relates to novel, antimicrobial polymers. In another aspect, the present invention relates to antimicrobial pharmaceutical compositions and methods for treatment of microbial infections in a mammal.
- the present invention relates to antimicrobial pharmaceutical compositions and methods for wound management.
- the present invention relates to antimi crobial pharmaceutical compositions and methods for treatment of infections of the skin, oral mucosa and gastrointestinal tract.
- the present invention relates to antimicrobial compositions and methods of preventing, inhibiting, or eliminating the growth, dissemination and accumulation of microorganisms on susceptible surfaces, particularly in a health-related environment.
- the ionene polymers and compositions of the invention are also particularly useful for inhibiting the growth and dissemination, of microorganisms, particularly on surfaces wherein such growth is undesirable.
- the term“inhibiting the growth of microorganisms” means that the growth, dissemination, accumulation, and/or the attachment, e.g. to a susceptible surface, of one or more microorganisms is impaired, retarded, eliminated or prevented.
- the antimicrobial compositions of the inventtions are used in methods for inhibiting the growth of an organism on susceptible surfaces in health-related environments.
- health-related environment as used herein includes all those environments where activities are carried out directly or indirectly, that are implicated in the restoration or maintenance of human health.
- a health -related environment can be a medical environment, where activities are carried out to restore human health.
- An operating room, a doctor’s office, a hospital room, and a factory making medical equipment are all examples of health-related environments.
- Other health-related environments can include industrial or residential sites where activities pertaining to human health are carried out such as activities including food processing, water purification, recreational water maintenance, and sanitation.
- susceptible surface refers to any surface whether in an industrial or medical setting, that provides an interface between an object and the fluid.
- a surface, as understood herein further provides a plane whose mechanical structure, without further treatment, is compatible with the adherence of microorganisms. Microbial growth and/or biofilm formation with health implications can involve those surfaces in all health -related environments.
- Such surfaces include, but are not limited to, scalpels, needles, scissors and other devices used in invasive surgical, therapeutic or diagnostic procedures; implantable medical devices, including artificial blood vessels, catheters and other devices for the removal or delivery of fluids to patients, artificial hearts, artificial kidneys, orthopedic pins, plates and implants; catheters and other tubes (including urological and biliary tubes, endotracheal tubes, peripherally insertable central venous catheters, dialysis catheters, long term tunneled central venous catheters, peripheral venous catheters, pulmonary catheters, Swan-Ganz catheters, urinary catheters, peritoneal catheters), urinary devices (including long term urinary devices, tissue bonding urinary devices, artificial urinary sphincters, urinary dilators), shunts (including ventricular or arterio-venous shunts); prostheses, (including breast implants, penile prostheses, vascular grafting prostheses, heart valves, artificial joints, artificial larynxes, otological implants),
- Other surfaces include the inner and outer surfaces of pieces of medical equipment, medical gear worn or carried by personnel in the health care settings and protective clothing for biohazard or biological warfare applications. Such surfaces can include counter tops and fixtures in areas used for medical procedures or for preparing medical apparatus, tubes and canisters used in respiratory treatments, including the administration of oxygen, solubilized drugs in nebulizers, and anesthetic agents. Additional surfaces include those surfaces intended as biological barriers to infectious organisms such as gloves, aprons and faceshields.
- those reservoirs and tubes used for delivering humidified oxygen to patients can bear biofilms inhabited by infectious agents.
- Dental unit waterlines similarly can bear biofilms on their surfaces, providing a reservoir for continuing contami nation of the system of flowing and aerosolized water used in dentistry.
- Other surfaces related to health include the inner and outer surfaces of equipment used in water purification, water storage and water delivery, and those articles involved in food processing equipment for home use, materials for infant care and toilet bowls.
- a method for preventing, inhibiting or eliminating the growth, dissemination and/or accumulation of microorganisms on a susceptible surface comprises the step of contacting such surface with an antimicrobial agent, or composition thereof of the invention, with an amount sufficient to prevent, inhibit or eliminate such growth, dissemination and/or accumulation, i.e., with an effective amount.
- the antimicrobial agent of the invention is an antimicrobial preservative, attesting to the ability of the formulations of the invention to suppress microbial growth, reduce microbial infestation, treat products or surfaces to improve product resistance to microbial infestation, reduce biofilm, prevent conversion of bacteria to biofilm, prevent or inhibit microbial infection, prevent spoilage, retard or minimize or prevent quorum sensing, and retard microbial reproduction.
- the antimicrobial agent is capable of endowing a product, or the product surface, with a biological resistance to at least one biological effect, which in the absence of such agent would eventually bring about a short-term or long-term damage to the product.
- the antimicrobial agent improves the product's resistance to a certain environmental condition.
- the resistance to such a condition is resistance to biofouling.
- the microorganism is a bacteria, being selected, in some embodiments from Bordetella pertussis, Borrelia burgdorferi. Brucella abortus. Brucella cards. Brucella melitensis. Brucella suis, Campylobacter jejuni. Chlamydia pneumonia.
- Chlamydia psittaci Chlamydia trachomatis, Clostridium botulinum Clostridium difficile, Clostridium perfringens, Clostridium tetani, Corynebacterium diphtheria. Enterococcus faecalis. Enterococcus faecium, Escherichia coll (E. coli), Enterotoxigenic Escherichia coli (ETEC), Enteropathogenic E. coli, Erancisella tularensis, Haemophilus influenza, Helicobacter pylori, Legionella pneumophila, Leptospira interrogans.
- Listeria monocytogenes Mycobacterium leprae, Mycobacterium tuberculosis.
- Mycoplasma pneumonia Neisseria gonorrhoeae. Neisseria meningitidis. Pseudomonas aeruginosa, Rickettsia rickettsii. Salmonella typhi. Salmonella typhimurium. Shigella sonnei. Staphylococcus epidermidis. Staphylococcus saprophyticus. Streptococcus agalactiae. Streptococcus mutans Streptococcus pneumonia. Streptococcus pyogenes. Treponema pallidum. Vibrio cholera, Vibrio harveyi and Yersinia pestis.
- the microorganism is a fungus, selected in some embodiments from Absidia corymbifera, Ajellomyces capsulatus, Ajellomyces dermatitidis, Arthroderma benhamiae, Arthroderma fulvum, Arthroderma gypseum, Arthroderma incurvatum, Arthroderma otae, Arthroderma vanbreuseghemii, Aspergillus flavus, Aspergillus fumigates, Aspergillus niger, Blastomyces dermatitidis, Candida albicans, Candida albicans var.
- Cryptococcus ne of ormans Cunninghamella sp., Epidermophyton floccosum, Exophiala dermatitidis, Eilobasidiella neoformans, Eonsecaea pedrosoi.
- dry fogging refers to the bringing together of the liquid to be treated (e.g., water) and the antimicrobial agent embedded or air diffusion and surface coated onto at least a part of the product's surface in such a way to allow elimination of organisms within the air and contaminated surface.
- the method comprising incorporating the antimicrobial agent of the invention onto said surface.
- the product's surface is surface coated with the antimicrobial agent as described herein.
- the antimicrobial agents are present material impart the antimicrobial properties to the substrate.
- the surface may be associated with the surface in any way, e.g.. Vander Waals forces, ionic bonding, hydrogen bonding, or through a coating linker such as a glue, forming stable coatings that exhibits minimal or no degradation or leaching, e.g., when exposed to an aqueous medium.
- a coating linker such as a glue
- the dry fogging substrates according to the invention may be used for (a) reducing or preventing bacterial infection without the need to use drug materials e.g., antibiotics, to the end product, the substrates may be any region of a storage container or a delivery system for use in food packaging, food and beverage containers, food and beverage preparation or disposing equipment, blood bags, proteins or pharmaceuticals.
- drug materials e.g., antibiotics
- the antimicrobial agents of the invention may be used in the construction of a personal product or an industrial product such as devices used in sporting activities, orthodontic devices, face or breathing masks, pacifiers, contact lenses, adult products, food preparation surfaces, food packaging, surface, air, textile, paint, plastic, silicone and wood, polyethylene, metals and derivatives reusable water containers, hydration systems, water bottles, computer keyboards, telephones, rental car steering wheels, health club equipment, whirlpool spas and humidifiers to provide antimicrobial properties.
- a personal product or an industrial product such as devices used in sporting activities, orthodontic devices, face or breathing masks, pacifiers, contact lenses, adult products, food preparation surfaces, food packaging, surface, air, textile, paint, plastic, silicone and wood, polyethylene, metals and derivatives reusable water containers, hydration systems, water bottles, computer keyboards, telephones, rental car steering wheels, health club equipment, whirlpool spas and humidifiers to provide antimicrobial properties.
- Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride),
- Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine
- TAGDA Triethyleneglycol diamine
- Antimicrobial activity HPP plates with 0.5% and 5% w/w of synthesis material from obtained combination polymeric guanidine derivative based on a diamine containing oxyalkylene chains between two amino groups, with the guanidine derivative representing a product of polycondensation between a guanidine acid addition salt and a diamine containing polyoxyalkylene chains between two amino groups, Hexamethylenediamine (1,6- hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2- (2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride), Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants like humic acids were obtained by injection of the mixture. The mixtures were tested for
- Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives Containing polyoxyalkylene chains between two amino groups, Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent.
- Polietheramine derivatives JEFF AMINE EDR-148
- Polietheramine Triethyleneglycol diamine (TEGDA) enzymes
- PGPR amino acids, antioxidants like humic acids are found to be very effective on antibacterial agent woven, nonwoven-coton blended fabric material having antimicrobial activity, and to its uses ranging from wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials, panty, bra, handkerchief, pad, scouring pad,
- oligo(2-(2- ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as humic acids and some natural products like phytotherapeutic plant extracts as antibacterial agent is found to be effective against said bacteria without loss of taste and without loss of texture both directly application and and/or contamination using antimicrobial surface of touch surface such as polyethylene, metal, plastic.
- the above-mentioned methods and alternative processing techniques as e.g. heat treatment for preservation do not prevent food poisoning as consequences of temperature-abuse and/or contamination.
- Examples of fresh and dry vegetable, fruit and fresh meat are beef, beef steak, beef oxtails, neckbones, short ribs, beef roasts, stew meat, beef briskets, pork, pork chops, por steaks, cutlets, pork roasts, lamb, veal, game goat, filet americain, steak tartar, sushi, or carpaccio, chicken, turkey, duck and other poultry directly and/or contamination using antimicrobial surface of touch surface such as polyethylene, metal, plastic.
- Some of these fresh meat applications are to be consumed raw, while others are consumed after application of only partial heat treatment, intentionally applied as e.g. for medium cooked steak or unintentionally applied due to improper preparation or improper handling of the food products.
- Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent.
- poly(hexamethylendiamine guanidinium chloride) Polietheramine derivatives (JEFF AMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants like humic acids as antibacterial agent ensures food safety even in the case of partial heat -treatment.
- the antibacterial activity not only includes bacteriostatic activity preventing further bacterial growth but also includes for some bacteria bacteriocidal activity that actually reduces the bacterial number containing polyoxyalkylene chains between two amino groups, Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride), Polietheramine derivatives (JEFF AMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants like humic acids of 0.5 to 2 wt% based on total weight of product were found to be effective as antibacterial agent for escheria coli, entereobacter aerogenes, coliform, legionalla and glycine concentrations of 0.5 to
- Combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as humic acids and some natural products like phytotherapeutic plant extracts concentrations of 0.25 to 2 wt% based on total weight of product were found to be effective as antibacterial agent for E.
- Sakazakii and containing polyoxyalkylene chains between two amino groups Hexamethylenediamine (1,6- hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2- (2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent.
- Polietheramine derivatives JEFFAMINE EDR-148
- Polietheramine Triethyleneglycol diamine (TEGDA) enzymes
- PGPR amino acids, antioxidants like humic acids of 0.5 to 1.5 wt% based on total weight of product were found to be suited in ensuring taste of the product.
- Tests showed that a concentration of about 1 to 1.8 wt% of combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as humic acids and some natural products like phytotherapeutic plant extracts based on total weight of product starts to affect the taste of said product. In said product no auxiliary antibacterial agents and no other taste affecting ingredients were present.
- oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as humic acids and some natural products like phytotherapeutic plant extracts concentration in terms of not negatively affecting taste can be increased to concentrations above 1.8 wt% guanidium based on total weight of the product.
- the maximum concentration of combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as humic acids and some natural products like phytotherapeutic plant extracts can also be increased up to a point at which the taste starts to be negatively affected by the presence of gundium derivative.
- guanidium and/or its derivatives according to the invention as antibacterial agent in refrigerated foods and refrigerated drinks may be combined with one or more combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as humic acids and some natural products like phytotherapeutic plant extracts.
- the object of the present invention is to provide a highly effective universal disinfecting, antiseptic and bactericidal, fungicidal or virucidal composition, which is useful in a broad range of positive and negative temperatures and in increasing the term of microbiocidal and disinfectant action.
- a further objective of the invention is to enhance the length of time of the microbiocidal or disinfectant action.
- the present invention relates to woven, nonwoven -coton blended fabric material having antimicrobial activity, and to its uses ranging from wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials, panty, bra, handkerchief, pad, scouring pad, , disposable sheets and similar applications where the antimicrobial effects are employed, as well as to a process for the preparation of the woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material.
- the present invention relates to a combination polymeric guanidine derivative based on a diamine containing oxyalkylene chains between two amino groups, with the guanidine derivative representing a product of polycondensation between a guanidine acid addition salt and a diamine containing polyoxyalkylene chains between two amino groups, Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent., polyfhexamethylendiamine guanidinium chloride), Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants like humic acids and some natural products like phytotherapeutic plant extracts for the production of a liqid, powder and tablette form for anti
- compositions are useful in a wide variety of utility areas. These compositions are useful as topical applications in the treatment of microbiocidal infections in a subject. Applicants’ compositions can be applied to various surfaces and when so applied these compositions serve as sterilizers or sanitizers. Similarly, the present compositions can be used in application areas such as, for example, synthetic surface preservative such as the prevention of microfloral growth on surfaces such as polymers, plastics or poliethylne, ploprophylene, as a hard surface or carpet sanitizer. These compositions are generally useful in controlling and/or elimination of microflora and spores in many industrial, medical, agricultural, veterinary and domestic applications. Additionally, the present compositions can be employed to sterilize or disinfect gaseous environments including, for example, the cleansing of the atmosphere in homes and industrial sites, as well as airplanes, etc.
- the present invention provides novel ionene polymers having antimi- crobial activity“combination polymeric guanidine derivative based on a diamine containing oxyalkylene chains between two amino groups, with the guanidine derivative representing a product of polycondensation between a guanidine acid addition salt and a diamine containing polyoxyalkylene chains between two amino groups, Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride), Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants like humic acids and some natural products like phytotherapeutic
- the synthesis of this invention have been found to be non-irritating and low in toxicity to warm-blooded animals.
- the present invention also provides antimicrobial compositions comprising synthesis product and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention.
- the present invention further provides antimicrobial compositions comprising at least one synthesis and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface such as surface, air, textile, paint, plastic, silicone and wood, polyethylene and derivatives.
- the present invention relates to methods for the protection relates to woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material having antimicrobial activity, and to its uses ranging from wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials and similar applications where the antimicrobial effects are employed, as well as to a process for the preparation of the woven or nonwoven fabric material have been treated before consum with combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as humic acids and some natural products like phytotherapeutic plant extracts.
- woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric material protecting agent composition having a pH of between 5.5 and 7.5 containing at least 0.5%, preferably at least 5% of a combination food protecting agent and guanidinium derivatives, particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), polyfhexamethylendiamine guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as humic acids and some natural products like phytotherapeutic plant extracts.
- the present invention also relates generally to hard surface cleaning wipes and cleaning pads having a more abrasive side and a less abrasive side. More particularly, the present invention relates to two-sided wet wipes and cleaning pads that are disinfecting or sanitizing.
- the invention is also a brassiere to be worn after breast surgery.
- the fabric of the brassiere includes antimicrobial fibers that control microbes on the skin of the woman's breast area both before and after surgical incisions are healed.
- combinations of containing polyoxyalkylene chains between two amino groups Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial agent.
- Polietheramine derivatives JEFFAMINE EDR-148
- Polietheramine Triethyleneglycol diamine (TEGDA) enzymes
- PGPR amino acids, antioxidants like humic acids and some natural products like phytotherapeutic plant extracts can be used to prevent growth of bacteria which cause breast area .
- Nonwoven and woven materials are used to make a variety of products for use in various industries. There remains a need, however, for such materials having antimicrobial properties to eliminate microorganisms in various applications, including applications requiring an antimicrobial barrier (e.g., wound dressings, face masks, etc).
- an antimicrobial barrier e.g., wound dressings, face masks, etc.
- a method for preventing, inhibiting or eliminating the growth, dissemination and/or accumulation of microorganisms on a susceptible surface comprises the step of contacting such surface with an antimicrobial agent, or composition thereof of the invention, with an amount sufficient to prevent, inhibit or eliminate such growth, dissemination and/or accumulation, i.e., with an effective amount on wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials, panty, handkerchief, pad, scouring pad, , disposable sheets and similar applications.
- “contacting” refers to any means for providing the compounds of the invention to a surface to be protected from, microbial growth and/or biofilm formation.
- Contacting can include spraying, wetting, immersing, dipping, painting, bonding, coating, adhering or otherwise providing a surface with a compound or composition in accordance with the invention.
- A“coating” refers to any temporary, semipermanent, or permanent layer, covering a surface.
- a coating can be a gas, vapor, liquid, paste, semi solid or solid.
- a coating can be applied as a liquid and solidify into a hard coating.
- coatings include polishes, surface cleaners, caulks, adhesives, finishes, paints, waxes, polymerizable compositions (including phenolic resins, silicone polymers, chlorinated rubbers, coal tar and epoxy combinations, epoxy resins, polyamide resins vinyl resins, elastomers, acrylate polymers, fluoropolymers, polyesters and polyurethane, latex). Silicone resins, silicone polymers (e.g. RTV polymers) and silicone heat cured rubbers are suitable coatings for use in the invention and described in the art. Coatings can be ablative or dissolvable, so that the dissolution rate of the matrix controls the rate at which the compositions of the invention are delivered to the surface.
- Coatings can also be non-ablative, and rely on diffusion principals to deliver a composition of the invention to the wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials, panty, handkerchief, pad, scouring pad, , disposable sheets and similar applications surface.
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- Engineering & Computer Science (AREA)
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- Health & Medical Sciences (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Nonwoven Fabrics (AREA)
Abstract
Description
Claims
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/TR2018/050753 WO2020112039A1 (en) | 2018-11-30 | 2018-11-30 | Woven, nonwoven, cotton, nonwoven-cotton blended polyethylene and polipropilen and polystyrene mask, wound dressing, panty, bra, handkerchief, pad, scouring pad, disposable surgical dress, disposable sheets with antimicrobial properties |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3886823A1 true EP3886823A1 (en) | 2021-10-06 |
EP3886823A4 EP3886823A4 (en) | 2022-07-06 |
Family
ID=70852543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18941108.5A Withdrawn EP3886823A4 (en) | 2018-11-30 | 2018-11-30 | Woven, nonwoven, cotton, nonwoven-cotton blended polyethylene and polipropilen and polystyrene mask, wound dressing, panty, bra, handkerchief, pad, scouring pad, disposable surgical dress, disposable sheets with antimicrobial properties |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP3886823A4 (en) |
JP (1) | JP2022510997A (en) |
KR (1) | KR20210114398A (en) |
CN (1) | CN113395961A (en) |
AU (1) | AU2018451180A1 (en) |
BR (1) | BR112021010135A2 (en) |
CA (1) | CA3121644A1 (en) |
MX (1) | MX2021006349A (en) |
PH (1) | PH12021551217A1 (en) |
WO (1) | WO2020112039A1 (en) |
ZA (1) | ZA202103184B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US20220193468A1 (en) * | 2020-12-22 | 2022-06-23 | Owners Capital Gmbh | Fibre filter and method of manufacture thereof |
CN114181453B (en) * | 2021-11-04 | 2023-07-18 | 金发科技股份有限公司 | Low-friction-coefficient low-atomization polypropylene material and preparation method and application thereof |
CN114369188A (en) * | 2021-11-18 | 2022-04-19 | 山东志存科技有限公司 | Synthesis process of macromolecular bactericide polyolefin carbamidine |
CN114516961A (en) * | 2021-12-01 | 2022-05-20 | 山东志存科技有限公司 | Synthesis process of polyolefin carbapyrimidine-siloxane modified compound |
CN114479746B (en) * | 2022-01-27 | 2023-08-11 | 万华化学集团股份有限公司 | Preparation method of antibacterial polyurethane adhesive for binding cork particles, adhesive and application thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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AT505102B1 (en) * | 2004-11-05 | 2010-05-15 | Schmidt Oskar | BIOZIDE, ESPECIALLY FUNGICIDE MEANS |
WO2007101445A1 (en) * | 2006-03-08 | 2007-09-13 | Glad, Thomas Christian | Biocidal cleaning compositions |
EP2071954A1 (en) * | 2007-12-19 | 2009-06-24 | Bayer CropScience AG | Use of polymeric guanidine derivatives for combating unwanted micro-organisms in the protection of plants |
AU2007339730A1 (en) * | 2006-12-29 | 2008-07-10 | Aka Technology Gmbh | Use of polymeric guanidines for controlling microorganisms |
CN101461379A (en) * | 2007-12-18 | 2009-06-24 | 李萍 | Composite lysozyme disinfecting liquid |
EP2230259A1 (en) * | 2009-03-18 | 2010-09-22 | Mindinvest Holdings Ltd. | Complex containing a polymeric gaunidin |
US10226405B2 (en) * | 2009-09-18 | 2019-03-12 | International Flavors & Fragrances Inc. | Purified polyurea capsules, methods of preparation, and products containing the same |
US9737628B2 (en) * | 2014-09-25 | 2017-08-22 | International Flavors & Fragrances Inc. | High-coverage, low oder malodor counteractant compounds and methods of use |
GB201505701D0 (en) * | 2015-04-02 | 2015-05-20 | Byotrol Plc | Anti-microbial composition |
CN107243261B (en) * | 2017-05-26 | 2020-10-30 | 天津大学 | Method for preparing antibacterial and anti-pollution separation membrane through surface grafting modification |
EP3833188A4 (en) * | 2018-04-19 | 2022-04-13 | UCAR Health GmbH | Surface, air, textile, paint, plastic, silicone and wood, polyethylene; metal and derivatives antimicrobial properties |
-
2018
- 2018-11-30 KR KR1020217020005A patent/KR20210114398A/en not_active Application Discontinuation
- 2018-11-30 AU AU2018451180A patent/AU2018451180A1/en not_active Abandoned
- 2018-11-30 CA CA3121644A patent/CA3121644A1/en active Pending
- 2018-11-30 BR BR112021010135-7A patent/BR112021010135A2/en not_active Application Discontinuation
- 2018-11-30 EP EP18941108.5A patent/EP3886823A4/en not_active Withdrawn
- 2018-11-30 JP JP2021531373A patent/JP2022510997A/en active Pending
- 2018-11-30 MX MX2021006349A patent/MX2021006349A/en unknown
- 2018-11-30 CN CN201880099850.8A patent/CN113395961A/en active Pending
- 2018-11-30 WO PCT/TR2018/050753 patent/WO2020112039A1/en active Application Filing
-
2021
- 2021-05-11 ZA ZA2021/03184A patent/ZA202103184B/en unknown
- 2021-05-26 PH PH12021551217A patent/PH12021551217A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA202103184B (en) | 2022-03-30 |
JP2022510997A (en) | 2022-01-28 |
WO2020112039A1 (en) | 2020-06-04 |
CN113395961A (en) | 2021-09-14 |
KR20210114398A (en) | 2021-09-23 |
BR112021010135A2 (en) | 2021-08-24 |
EP3886823A4 (en) | 2022-07-06 |
MX2021006349A (en) | 2021-08-11 |
CA3121644A1 (en) | 2020-06-04 |
AU2018451180A1 (en) | 2021-06-03 |
PH12021551217A1 (en) | 2021-12-06 |
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