EP3883691A4 - Vacuum-loaded, droplet-generating microfluidic chips and related methods - Google Patents

Vacuum-loaded, droplet-generating microfluidic chips and related methods Download PDF

Info

Publication number
EP3883691A4
EP3883691A4 EP19877523.1A EP19877523A EP3883691A4 EP 3883691 A4 EP3883691 A4 EP 3883691A4 EP 19877523 A EP19877523 A EP 19877523A EP 3883691 A4 EP3883691 A4 EP 3883691A4
Authority
EP
European Patent Office
Prior art keywords
droplet
loaded
vacuum
related methods
microfluidic chips
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19877523.1A
Other languages
German (de)
French (fr)
Other versions
EP3883691A1 (en
Inventor
Nicolas Arab
Ross Johnson
David BUSSIAN
Jon ISOM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pattern Bioscience Inc
Original Assignee
Pattern Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pattern Bioscience Inc filed Critical Pattern Bioscience Inc
Publication of EP3883691A1 publication Critical patent/EP3883691A1/en
Publication of EP3883691A4 publication Critical patent/EP3883691A4/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/406—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles with gas supply only at the bottom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP19877523.1A 2018-10-22 2019-10-22 Vacuum-loaded, droplet-generating microfluidic chips and related methods Pending EP3883691A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862748919P 2018-10-22 2018-10-22
PCT/US2019/057392 WO2020086549A1 (en) 2018-10-22 2019-10-22 Vacuum-loaded, droplet-generating microfluidic chips and related methods

Publications (2)

Publication Number Publication Date
EP3883691A1 EP3883691A1 (en) 2021-09-29
EP3883691A4 true EP3883691A4 (en) 2022-11-16

Family

ID=68617749

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19877523.1A Pending EP3883691A4 (en) 2018-10-22 2019-10-22 Vacuum-loaded, droplet-generating microfluidic chips and related methods

Country Status (5)

Country Link
US (4) US10486155B1 (en)
EP (1) EP3883691A4 (en)
JP (1) JP7398469B2 (en)
CN (1) CN113438972B (en)
WO (1) WO2020086549A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210031189A1 (en) * 2018-10-22 2021-02-04 Pattern Bioscience, Inc. Droplet-Generating Microfluidic Chips and Related Methods
US10486155B1 (en) 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods
US10953404B1 (en) 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
US20220118447A1 (en) * 2020-10-19 2022-04-21 Pattern Bioscience, Inc. Microfluidic Chips Including a Gutter Having a Trough and a Ridge to Facilitate Loading Thereof and Related Methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010042744A1 (en) * 2008-10-08 2010-04-15 Universite De Strasbourg Microfluidic devices for reliable on-chip incubation of droplets in delay lines
US20120108721A1 (en) * 2009-05-07 2012-05-03 Centre National De La Recherche Scientifique Microfluidic system and methods for highly selective droplet fusion
US20140024023A1 (en) * 2012-07-23 2014-01-23 Bio- Rad Laboratories, Inc Droplet generation system with features for sample positioning
CN106140340A (en) * 2016-08-19 2016-11-23 北京工业大学 Micro-fluidic chip based on flow focusing type microchannel synthesis microemulsion drop

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1259566A (en) 1960-03-18 1961-04-28 Construction panel
DE3218925C2 (en) 1981-08-12 1985-03-07 Mannesmann AG, 4000 Düsseldorf Flame cutting roller table, especially for continuous metal casting plants
US5609828A (en) 1995-05-31 1997-03-11 bio M erieux Vitek, Inc. Sample card
US5762873A (en) 1996-02-21 1998-06-09 Biomerieux Vitek, Inc. Automatic sample testing machine
JP4050870B2 (en) 1998-09-08 2008-02-20 タカラバイオ株式会社 DNA synthesis method
SE0004297D0 (en) 2000-11-23 2000-11-23 Gyros Ab Device for thermal cycling
US7150999B1 (en) * 2001-03-09 2006-12-19 Califer Life Sciences, Inc. Process for filling microfluidic channels
DE10145568A1 (en) 2001-09-14 2003-04-03 Knoell Hans Forschung Ev Process for the cultivation and analysis of microbial single cell cultures
EP2283917B1 (en) 2002-05-09 2021-12-15 The University of Chicago Device for pressure-driven plug transport and reaction
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7341841B2 (en) 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US7029091B2 (en) 2003-08-05 2006-04-18 Hewlett-Packard Development Company, L.P. Inkjet consumable cartridge with integrated nozzle cap
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7759111B2 (en) * 2004-08-27 2010-07-20 The Regents Of The University Of California Cell encapsulation microfluidic device
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
KR20100028526A (en) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. Microfluidic and nanofluidic devices, systems, and applications
US8772046B2 (en) * 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008102065A1 (en) 2007-02-14 2008-08-28 Commissariat A L'energie Atomique Fluorescent emulsions for optical imaging
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20100227767A1 (en) 2007-07-26 2010-09-09 Boedicker James Q Stochastic confinement to detect, manipulate, and utilize molecules and organisms
EP2235210B1 (en) 2007-12-21 2015-03-25 President and Fellows of Harvard College Methods for nucleic acid sequencing
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US9764322B2 (en) * 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
FR2950544B1 (en) 2009-09-29 2011-12-09 Ecole Polytech MICROFLUIDIC CIRCUIT
JP2011147932A (en) 2009-12-24 2011-08-04 Kao Corp Fluid-mixing device
FR2958186A1 (en) 2010-03-30 2011-10-07 Ecole Polytech DEVICE FOR FORMING DROPS IN A MICROFLUID CIRCUIT.
WO2012061444A2 (en) 2010-11-01 2012-05-10 Hiddessen Amy L System for forming emulsions
JP2014505594A (en) 2011-02-07 2014-03-06 プレジデント アンド フェロウズ オブ ハーバード カレッジ System and method for splitting droplets
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
EP3216872B1 (en) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzyme quantification
JP6207007B2 (en) 2012-05-15 2017-10-04 国立大学法人 千葉大学 Liposomes and production methods thereof
FR2996545B1 (en) 2012-10-08 2016-03-25 Ecole Polytech MICROFLUIDIC METHOD FOR PROCESSING AND ANALYZING A SOLUTION CONTAINING BIOLOGICAL MATERIAL, AND CORRESPONDING MICROFLUIDIC CIRCUIT
US9427737B2 (en) 2012-12-14 2016-08-30 Bio-Rad Laboratories, Inc. Methods and compositions for using oils for analysis and detection of molecules
EP3473905B1 (en) * 2013-01-25 2020-07-29 Bio-rad Laboratories, Inc. System and method for performing droplet inflation
GB201313583D0 (en) 2013-07-30 2013-09-11 Sphere Fluidics Ltd Emulsion
US9440233B2 (en) * 2013-08-09 2016-09-13 Shark Kabushiki Kaisha Microfluidic device for serial fluidic operations
US20160257990A1 (en) * 2013-10-18 2016-09-08 The Regents Of The University Of California Method and device for detecting molecules or particles using fractionalized volumes
WO2015160919A1 (en) * 2014-04-16 2015-10-22 President And Fellows Of Harvard College Systems and methods for producing droplet emulsions with relatively thin shells
JP2015211931A (en) 2014-05-01 2015-11-26 学校法人同志社 Method and apparatus for producing microdroplet using microfluidic chip
EP3271058B1 (en) 2015-03-16 2021-10-06 Luminex Corporation Apparatus and methods for multi-step channel emulsification
EP3708256B1 (en) 2015-04-22 2022-11-30 Stilla Technologies Contact-less priming method for loading a solution in a microfluidic device and associated system
GB201511129D0 (en) 2015-06-24 2015-08-05 Linea Ab Q Method of determining antimicrobial susceptibility of a microorganism
JP2017225919A (en) 2016-06-21 2017-12-28 学校法人同志社 Production kit of droplet and production method of droplet
CN106975411B (en) * 2017-05-05 2020-01-10 北京大学 Micro-fluidic chip based on 3D prints and including emulsion generating device of this chip
US10486155B1 (en) * 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010042744A1 (en) * 2008-10-08 2010-04-15 Universite De Strasbourg Microfluidic devices for reliable on-chip incubation of droplets in delay lines
US20120108721A1 (en) * 2009-05-07 2012-05-03 Centre National De La Recherche Scientifique Microfluidic system and methods for highly selective droplet fusion
US20140024023A1 (en) * 2012-07-23 2014-01-23 Bio- Rad Laboratories, Inc Droplet generation system with features for sample positioning
CN106140340A (en) * 2016-08-19 2016-11-23 北京工业大学 Micro-fluidic chip based on flow focusing type microchannel synthesis microemulsion drop

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2020086549A1 *

Also Published As

Publication number Publication date
CN113438972A (en) 2021-09-24
US20200298229A1 (en) 2020-09-24
US10792659B2 (en) 2020-10-06
WO2020086549A1 (en) 2020-04-30
JP7398469B2 (en) 2023-12-14
US10486155B1 (en) 2019-11-26
EP3883691A1 (en) 2021-09-29
US20230108211A1 (en) 2023-04-06
US11344890B2 (en) 2022-05-31
CN113438972B (en) 2023-01-10
US20200197931A1 (en) 2020-06-25
JP2022514118A (en) 2022-02-09

Similar Documents

Publication Publication Date Title
EP3451973A4 (en) Annuloplasty procedures, related devices and methods
EP3436482A4 (en) Antibodies, pharmaceutical compositions and methods
EP3283435A4 (en) Composition, particulate materials and methods for making particulate materials.
EP3325966A4 (en) Chips, detectors, and methods of making and using the same
EP3484499A4 (en) Tgfb antibodies, methods, and uses
EP3495391A4 (en) Antibody against programmed death-ligand 1 (pd-l1), and use thereof
EP3885760A4 (en) Microfluidic chip
EP3501700A4 (en) Cutting tool base, and cutting tool
EP3483928A4 (en) Chip packaging structure, and packaging method thereof
EP3612307A4 (en) Systems, devices and methods for microfluidic analysis
EP3883691A4 (en) Vacuum-loaded, droplet-generating microfluidic chips and related methods
EP3426297A4 (en) Gitr antibodies, methods, and uses
EP3586343A4 (en) Titanium-molybdate and method for making the same
EP3496860A4 (en) Biological sample-analyzing system, components, and methods thereof
EP3521464A4 (en) Slide material and method for manufacturing same, and slide member
EP3873668A4 (en) Microfluidic viscometer and assembly, and methods using the same
EP3467043A4 (en) Heat-conducting member, heat-conducting composition and heat-conducting composition production method
EP3550775A4 (en) Resource determination method and device, and nfvo
EP3617305A4 (en) Genetic testing chip, testing method and manufacturing method therefor, and microfluidic chip system
EP3783846A4 (en) Determination method, determination device and determination program
EP4066942A4 (en) Method for using microfluidic chip, and device thereof
EP3612813A4 (en) Nanoplasmonic instrumentation, materials, methods and system integration
EP3880364A4 (en) Analysis systems with microfluidic devices, microfluidic devices and related methods
EP3932552A4 (en) Microfluidic chip
EP3708531A4 (en) Microfluidic chip and microfluidic device

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210422

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 31/20 20060101ALI20220708BHEP

Ipc: F16L 41/00 20060101ALI20220708BHEP

Ipc: F16K 99/00 20060101ALI20220708BHEP

Ipc: F16K 23/00 20060101ALI20220708BHEP

Ipc: F16K 11/02 20060101ALI20220708BHEP

Ipc: B01L 3/00 20060101AFI20220708BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20221017

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 31/20 20060101ALI20221011BHEP

Ipc: F16L 41/00 20060101ALI20221011BHEP

Ipc: F16K 99/00 20060101ALI20221011BHEP

Ipc: F16K 23/00 20060101ALI20221011BHEP

Ipc: F16K 11/02 20060101ALI20221011BHEP

Ipc: B01L 3/00 20060101AFI20221011BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230731