EP3880176A4 - Pharmazeutische zusammensetzungen mit verzögerter wirkstoffabgabe mit einem therapeutischen mittel zur behandlung von krankheiten infolge verminderter knochendichte oder knorpelverlust und deren verwendungen - Google Patents

Pharmazeutische zusammensetzungen mit verzögerter wirkstoffabgabe mit einem therapeutischen mittel zur behandlung von krankheiten infolge verminderter knochendichte oder knorpelverlust und deren verwendungen Download PDF

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Publication number
EP3880176A4
EP3880176A4 EP19884612.3A EP19884612A EP3880176A4 EP 3880176 A4 EP3880176 A4 EP 3880176A4 EP 19884612 A EP19884612 A EP 19884612A EP 3880176 A4 EP3880176 A4 EP 3880176A4
Authority
EP
European Patent Office
Prior art keywords
sustained
treatment
pharmaceutical compositions
therapeutic agent
bone density
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19884612.3A
Other languages
English (en)
French (fr)
Other versions
EP3880176A1 (de
Inventor
Keelung Hong
Hao-Wen Kao
Yi-Yu Lin
Jonathan FANG
Weiwei FANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiwan Liposome Co Ltd
TLC Biopharmaceuticals Inc
Original Assignee
Taiwan Liposome Co Ltd
TLC Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiwan Liposome Co Ltd, TLC Biopharmaceuticals Inc filed Critical Taiwan Liposome Co Ltd
Publication of EP3880176A1 publication Critical patent/EP3880176A1/de
Publication of EP3880176A4 publication Critical patent/EP3880176A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
EP19884612.3A 2018-11-14 2019-11-13 Pharmazeutische zusammensetzungen mit verzögerter wirkstoffabgabe mit einem therapeutischen mittel zur behandlung von krankheiten infolge verminderter knochendichte oder knorpelverlust und deren verwendungen Withdrawn EP3880176A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862767254P 2018-11-14 2018-11-14
PCT/US2019/061143 WO2020102323A1 (en) 2018-11-14 2019-11-13 Sustained-release pharmaceutical compositions comprising a therapeutic agent for treating diseases due to reduced bone density or cartilage loss and uses thereof

Publications (2)

Publication Number Publication Date
EP3880176A1 EP3880176A1 (de) 2021-09-22
EP3880176A4 true EP3880176A4 (de) 2022-08-03

Family

ID=70730604

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19884612.3A Withdrawn EP3880176A4 (de) 2018-11-14 2019-11-13 Pharmazeutische zusammensetzungen mit verzögerter wirkstoffabgabe mit einem therapeutischen mittel zur behandlung von krankheiten infolge verminderter knochendichte oder knorpelverlust und deren verwendungen

Country Status (5)

Country Link
EP (1) EP3880176A4 (de)
JP (1) JP7431419B2 (de)
CN (1) CN113056259A (de)
TW (1) TWI729562B (de)
WO (1) WO2020102323A1 (de)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101199505A (zh) * 2007-12-20 2008-06-18 沈阳药科大学 维拉帕米脂质体及其制备方法
CN102406606A (zh) * 2011-11-29 2012-04-11 海南美大制药有限公司 富马酸喹硫平脂质体固体制剂
US20130202686A1 (en) * 2010-12-27 2013-08-08 Terumo Kabushiki Kaisha Liposome composition and process for production thereof
WO2017066726A1 (en) * 2015-10-16 2017-04-20 Merrimack Pharmaceuticals, Inc. Stabilizing camptothecin pharmaceutical compositions
WO2017193139A1 (en) * 2016-05-06 2017-11-09 The Brigham And Women's Hospital, Inc. Binary self assembled gels for controlled delivery of encapsulated agents to cartilage
US9877918B2 (en) * 2011-03-25 2018-01-30 Terumo Kabushiki Kaisha Long-lasting controlled-release liposome composition and method for producing same
WO2020023445A1 (en) * 2018-07-24 2020-01-30 Taiwan Liposome Co., Ltd. Sustained-release pharmaceutical compositions comprising a therapeutic agent for treating dementia and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8658203B2 (en) * 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
AU2006302797B2 (en) 2005-03-02 2012-02-02 Merck Canada Inc. Composition for inhibition of cathepsin K
CA2834968C (en) * 2011-01-05 2018-01-09 Livon Laboratories Methods of making liposomes, liposome compositions made by the methods, and methods of using the same
EP2537532A1 (de) 2011-06-22 2012-12-26 J. Stefan Institute Cathepsinbindende Verbindungen, die an ein Nanogerät gebunden sind, und deren diagnostische und therapeutische Verwendung
EP2734500A4 (de) * 2011-07-20 2015-04-08 Gen Hospital Corp Selektive histondeacetylase-6-inhibitoren zur behandlung von knochenerkrankungen
SI2854769T1 (sl) * 2012-07-05 2023-09-29 Taiwan Liposome Company, Ltd. Postopki za zdravljenje artritisa
WO2014121211A2 (en) * 2013-02-01 2014-08-07 Zoneone Pharma, Inc. Remote loading of sparingly water-soluble drugs into liposomes

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101199505A (zh) * 2007-12-20 2008-06-18 沈阳药科大学 维拉帕米脂质体及其制备方法
US20130202686A1 (en) * 2010-12-27 2013-08-08 Terumo Kabushiki Kaisha Liposome composition and process for production thereof
US9877918B2 (en) * 2011-03-25 2018-01-30 Terumo Kabushiki Kaisha Long-lasting controlled-release liposome composition and method for producing same
CN102406606A (zh) * 2011-11-29 2012-04-11 海南美大制药有限公司 富马酸喹硫平脂质体固体制剂
WO2017066726A1 (en) * 2015-10-16 2017-04-20 Merrimack Pharmaceuticals, Inc. Stabilizing camptothecin pharmaceutical compositions
WO2017193139A1 (en) * 2016-05-06 2017-11-09 The Brigham And Women's Hospital, Inc. Binary self assembled gels for controlled delivery of encapsulated agents to cartilage
WO2020023445A1 (en) * 2018-07-24 2020-01-30 Taiwan Liposome Co., Ltd. Sustained-release pharmaceutical compositions comprising a therapeutic agent for treating dementia and uses thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHEN J ET AL: "Preparation and pharmacokinetic investigation of propranolol-loaded elastic liposomes composed of DP-PC and SPC", CHINESE PHARMACEUTICAL JOURNAL, ZHONGGUO YAOXUEHUI ZHUBAN CHUBAN. ZHONGGUO-YAOXUE-ZAZHI BIANJI WEIYUANHUI, CN, vol. 48, no. 20, 22 October 2013 (2013-10-22), pages 1761 - 1765, XP009534476, ISSN: 1001-2494 *
EL-MEZAYEN NESRINE S ET AL: "Hepatic stellate cell-targeted imatinib nanomedicineversusconventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 266, 28 September 2017 (2017-09-28), pages 226 - 237, XP085292753, ISSN: 0168-3659, DOI: 10.1016/J.JCONREL.2017.09.035 *
KIM HYEONGSEOK ET AL: "Anti-inflammatory effect of quetiapine on collagen-induced arthritis of mouse", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 678, no. 1, 23 November 2011 (2011-11-23), pages 55 - 60, XP028891080, ISSN: 0014-2999, DOI: 10.1016/J.EJPHAR.2011.12.017 *
SATO TSUYOSHI ET AL: "Donepezil prevents RANK-induced bone loss via inhibition of osteoclast differentiation by downregulating acetylcholinesterase", HELIYON, vol. 1, no. 1, 1 September 2015 (2015-09-01), GB, pages e00013, XP055935707, ISSN: 2405-8440, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939821/pdf/main.pdf> DOI: 10.1016/j.heliyon.2015.e00013 *
See also references of WO2020102323A1 *
TAKAMATSU AKIRA ET AL: "Verapamil Protects against Cartilage Degradation in Osteoarthritis by Inhibiting Wnt/[beta]-Catenin Signaling", PLOS ONE, vol. 9, no. 3, 21 January 2014 (2014-01-21), pages e92699, XP055935688, DOI: 10.1371/journal.pone.0092699 *
TORU HIRAGA ET AL: "Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals", INTERNATIONAL JOURNAL OF CANCER, vol. 124, no. 1, 1 January 2009 (2009-01-01), US, pages 215 - 222, XP055292283, ISSN: 0020-7136, DOI: 10.1002/ijc.23903 *
ZHANG XINGGUANG ET AL: "Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats", IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH : IJPR, 1 January 2013 (2013-01-01), Iran, pages 557 - 562, XP055935721, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813260/pdf/ijpr-12-557.pdf> [retrieved on 20220627] *

Also Published As

Publication number Publication date
TW202031247A (zh) 2020-09-01
TWI729562B (zh) 2021-06-01
EP3880176A1 (de) 2021-09-22
WO2020102323A1 (en) 2020-05-22
CN113056259A (zh) 2021-06-29
JP2023510658A (ja) 2023-03-15
JP7431419B2 (ja) 2024-02-15

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