EP3849625A1

EP3849625A1 - System for analysing fluids originating from the body or fluids in contact with fluids originating from the body

Info

Publication number: EP3849625A1
Application number: EP19769417.7A
Authority: EP
Inventors: Waldemar Janik; Franco Teltow; Anne Zygmanowski
Original assignee: B Braun Melsungen AG
Current assignee: B Braun Melsungen AG
Priority date: 2018-09-10
Filing date: 2019-09-10
Publication date: 2021-07-21
Also published as: DE102018122024A1; WO2020053212A1

Abstract

The invention relates to a system for analysing fluids originating from the body, having a volume through which the fluid is passed, more particularly having a fluid line (4, 5, 6, 306, 307, 308) and/or a fluid storage volume (1, 2), and having a sensor unit (100, 200) which is integrated in the system and is or can be connected to the volume to detect at least one analyte in the fluid and/or at least one parameter of the fluid, wherein the sensor unit has a test strip (100, 200) having at least one test field (101 - 111), which changes colour in the presence of an analyte to be detected and/or subject to a fluid parameter to be detected.

Description

System for the analysis of liquids coming from or in contact with the body

description

The invention relates to a system for analyzing liquids originating from the body with a volume through which the liquid flows, in particular with a liquid line and / or a liquid storage volume, and a system that is integrated in the system and can be connected or connected to the volume

Sensor unit for the detection of at least one analyte in the liquid and / or at least one parameter of the liquid. It also affects one

Removal device for taking samples of liquids originating from the body with a sample volume, a sensor unit with the

Sample volume is connected or connectable.

Permanent transurethral catheters are one of the most frequently used care utensils in everyday clinical practice. Due to possible flan tract infections, there is a need for regular monitoring. A urine analysis can be carried out, for example, by immersing commercially available test strips in the urine in a test vessel. These test strips have test fields that change their color

Change the presence of the analyte to be examined and its concentration.

In the area of care and medicine, there are many more besides urine

Body fluids, through their analysis important statements about the

Health status of the patient can be taken.

In order to examine urine in a urine bag, in practice this is often filled directly into an open test vessel via an outlet valve on the bag.

A care worker then holds a test strip in this test vessel. The result can usually be read after about a minute. The test vessel containing urine is then emptied and disposed of. From WO 2016 176 603 A1 an analysis device for analyzing urine is known which can be connected to a urine collection container and has: a) a discrete test section for performing a colorimetric test, each test section being designed to carry out a different colorimetric test, b ) a color sensor for reading out the test section and for outputting an indication based on the presence of an analyte and c) an integrated circuit for obtaining a display of the color sensor and calculating a quantity of the analyte in the urine. Solutions of this type with optical sensors are generally quite complex and expensive and are therefore less suitable for day-to-day hospital use with limited costs.

WO 2018 058 077 A1 discloses a sensor connector for connecting a urine bag and a catheter in order to determine the pH value and a nitrite concentration, the connector being a hollow body which forms a passage for the urine and a first end for connecting to the catheter and has a second end for connection to the line of the urine bag, and a pH sensor connected to the connector as a hydrogel and / or a nitrite sensor with plasmonic nanoparticles for detecting bacteria in the urine flowing through the passage, the pH sensor reversibly provides a colorimetric change based on the pH of the urine, and the nitrite sensor provides a colorimetric change based on the nitrite concentration of the urine. A disadvantage of this system is that an exchange of the connector requires an opening of the otherwise closed system, which involves the risk of germs entering the system or the catheter.

Up to now, open test vessels have been used to carry out analyzes using conventional test strips, into which a sample of urine from a urine bag is filled. However, the test vessels disadvantageously represent a potential source of infection for the nursing staff. In addition, when a sample is taken from a urine bag, urine can drip onto the floor, which must then be removed and adversely affect hygiene in the hospital. Such a urine withdrawal, which is currently common in everyday clinical practice, also involves a certain amount This means more work for the nursing staff. Due to time constraints, it is not uncommon that urine analysis does not take place and a possible infection of the patient is recognized too late.

Urine bags or tube systems that are already equipped with test fields have the disadvantage that they have to be replaced quite quickly after contact with liquid, since the test fields can usually only be used once.

Starting from the prior art described above, the present invention is based on the object of eliminating the disadvantages mentioned above, in particular a device for analyzing from the body

available fluids or liquids in contact with them so that a quick, clean, safe and inexpensive analysis can be carried out.

According to the invention, this object is achieved by a system according to claim 1, in particular a system for analyzing liquids originating from the body with a volume through which the liquid flows, in particular with a

Liquid line and / or a liquid storage volume, and an integrated in the system and connected to the volume or connectable

Sensor unit for the detection of at least one analyte of the liquid and / or at least one parameter of the liquid, wherein the sensor unit has or is a test strip with at least one test field, which is in the presence of an analyte to be recorded and / or as a function of a parameter to be recorded Liquid stains. The task is also solved by a

Removal device according to claim 12, in particular a removal device for taking samples of liquids originating from the body with a sample volume, a sensor unit being connected or connectable to the sample volume, the sensor unit having or being a test strip with at least one test field that is in the presence of an analyte to be detected and / or depending on a parameter of the liquid to be detected. Under a liquid coming from the body are next to direct

Body fluids such as urine, cerebrospinal fluid, tear fluid or aqueous humor,

Nasal secretions, sputum (saliva), pleural fluid, gastric juice, pancreatic secretions, bile, vaginal secretions, menstrual fluid, cervical mucus, amniotic fluid,

To understand seminal fluid, blood, lymph, pus, wound secretion in general and sweat also with such body fluids or fluids that have come into contact with the body of a patient. A liquid which does not originate directly from the patient, but which is at least temporarily in contact with him or at least one of its components, is, for example, dialysis liquid or the dialysate during a dialysis treatment.

Parameters that can be determined with the aid of the system according to the invention include nitrite (this is formed by some germs from nitrate and therefore indicates a urinary tract infection), urobilinogen (arises from bilirubin and indicates as a breakdown product of hemoglobin to liver disease) ), Erythrocytes (indicate inflammation of the urinary tract), leukocytes (may occur if the kidney or bladder is inflamed), proteins (including albumin, in particular, indicate kidney disease), pH (an alkaline pH value occurs Urinary tract infections, an acidic pH value indicates diabetes), ketones (indicate increased fat loss in metabolic diseases), glucose (indicates diabetes and can also occur in some types of cancer), density (can include kidney disease) indicate if the density remains low despite low fluid intake), ascorbic acid (does not provide any information on the Health of the patient, but can measure other parameters

affect) as well as blood.

According to the invention, there are in particular in medical collecting bags and / or tubes or sample containers that can be opened or removed or connected, test strips with test fields that change their color in the presence of an analyte to be examined and its concentration.

The invention has the following advantages in particular.

Reduce the risk of infection for medical personnel Saving time for sampling and sample analysis

Any bacterial infection of the patient can be quickly identified by rapid measurement (continuously, quasi-continuously or as required) and thus treated promptly

In one embodiment, the liquid located in a separate sampling and testing device can be used for further analysis, so that additional sampling is not required

Advantageous embodiments of the invention are claimed in the subclaims and are explained in more detail below.

One embodiment of the device is characterized in that the liquid line is a catheter, a line tube for guiding body fluid into a collecting container, a bypass tube, a connector piece for connecting a catheter to a line tube or an extracorporeal blood line. According to the invention, the liquid storage volume can in particular be a

Be a collection container or a container for body fluids. It is preferably a bag, such as a collecting bag or a collecting bag for urine, blood, wound secretions or other. In particular, the liquid line and / or the liquid storage volume can be designed or provided with a bypass in which the test strip is located. If necessary, liquid to be examined can be passed through the bypass so that the test strip

It comes into contact with it as intended and the desired analysis is carried out and the result is displayed via the test field / test fields by changing the color.

According to one embodiment of the invention, the bypass is exchangeably connected to the liquid line or to the liquid storage volume.

As a result, the bypass with the test strip can be exchanged particularly easily without having to separate the catheter from the collecting bag. This is particularly advantageous if the collection bag and catheter are connected to the patient over a longer period of time and the test strip has test fields with an irreversible color change property. A bypass with integrated Test strips can also be part of a connector piece. The bypass is preferably connected to an integrated test strip by penetrating a self-sealing membrane. This has the advantage that the bypass can be removed and replaced without leakage. Alternatively, two valves on the inlet and

Outlet of the branch are used.

A further embodiment of the device is characterized in that the system comprises at least one sample container, one with which the

Liquid flow volume is connected or is connectable and in which the test strip is arranged. In contrast to the volume of the system through which the liquid flows, the volume of the sample container is preferably not permanent, but is only filled with the liquid to be analyzed for the purpose of measurement or analysis. In this way, accidental contact of the

Test strip with liquid and premature consumption of the test strip can be avoided.

The sample container can preferably form a sample volume in which the test strip is arranged or to which the test strip is fluidly connected. The sample volume can in particular be sealed off from the volume of the system through which liquid flows by means of a barrier. The

The sample container can in particular be filled with a preferably isotonic solution. The barrier can in particular be formed or arranged on the liquid storage volume and / or on the liquid line. Preferably that is

Sample volume by user actuation with that of liquid

flowable volume can be fluidically connected. In this way, a measurement / analysis can be carried out in a particularly simple manner to one desired by medical personnel

Time. The barrier is preferably a clamp,

Weld seam, peel seam or adhesive seam or as a membrane, in particular as

pierceable and / or rubber-elastic and / or semipermeable membrane. In the case of cloudy liquids such as blood, in particular, it lies within the scope of the invention of the test strip of the liquid to be examined with a

to separate semipermeable membrane. The pores of this membrane are large enough to to allow the analyte or analytes to pass through, but at the same time small enough to retain interfering substances.

According to a further embodiment, the sample container can consist of rigid, semi-rigid or flexible material. It is preferably arranged directly and immediately on a collection container or collection container for body fluid, in particular collection bags or collection bags for urine, blood, wound secretions or other. The sample container can in particular be a bag, for example a tubular bag. Alternatively, it can be in the form of a protuberance of a liquid storage volume designed as a bag.

According to a particularly advantageous embodiment, the sample container can be separated and removed from the volume through which liquid flows. This has the advantage that no new sampling is necessary if the

Liquid to be examined in the sample container is to be examined in more detail with an external analysis system.

A further embodiment of the invention is characterized in that the sample container is non-positively and / or positively and / or materially connected to the liquid storage volume or to the liquid line. In this way, the sample container can be connected to or separated from the volume of the system through which liquid flows, in a particularly simple manner, which makes the system particularly user-friendly.

According to one embodiment, the sample container is designed as a syringe, in particular a single-use syringe, with a syringe cylinder and a syringe plunger that is movably received therein and limits a variable sample volume.

In other words, the object on which the present invention is based is achieved by a system for analyzing from the body

originating liquids with a fluid line and collecting device (ie, a volume through which liquid flows), which a liquid line, in particular a hose, a liquid storage volume, in particular a Liquid bag, and one the liquid line with the

Liquid storage volume, fluid-connecting hose connector

(Connector piece), and a sensor unit connected or connectable to the fluid line and collection device for detecting at least one analyte in the liquid and / or at least one parameter of the liquid, which sensor unit has or is a test strip with at least one test field that is in Presence of an analyte to be detected and / or depending on a parameter to be detected of the liquid colors, furthermore with at least one attachment (with the sample container) that can be or is mounted fluidically and releasably on the fluid line and collection device, which serves as a carrier for the Sensor unit is formed.

Furthermore, the object is achieved by a sampling device for taking samples of liquids originating from the body with a sample container, in which a sensor unit is arranged, which has or is a test strip with at least one test field, which can be detected in the presence of one

Analytes and / or colors depending on a parameter to be detected of the liquid, the removal device being designed as an attachment which is detachably mounted or mountable on a fluid line and collection device and fluidly connected or connectable thereto.

The cultivation is to be understood in particular in such a way that this one to the

Fluid line and collection device is a separate component. In particular, the attachment is from the fluid line and collection device

Removable / detachable / removable / separable mounted or mountable on it that when removing / releasing / disassembling / separating the extension or when mounting it on or on the fluid line and collection device, operation or use of the fluid line and collection device is not or only slightly is impaired, ie, a liquid flow through or into the fluid line and collection device does not have to be interrupted in order to loosen or mount the attachment. That is, the

Fluid line and collection device is by mounting or loosening the

Cultivation not impaired in their function. The attachment preferably has a single connection at which it connects to the fluid line and collection device is connectable or connected, or the attachment alternatively has exactly two connections in order to connect the attachment with both connections to the fluid line and collection device such that it can be flowed through in the manner of a bypass.

io

The invention is explained in more detail below on the basis of exemplary, non-limiting embodiments shown in the attached figures. It shows:

1 is a schematic representation of a fluid system with a bag for collecting a body fluid with a test strip,

2 shows a schematic representation of a test strip of the system of FIG. 1,

3 shows a schematic representation of a liquid system with a bag for collecting body fluid and a test strip arranged in a liquid line leading to the bag at different positions,

Fig. 4 is a schematic representation of a fluid system with a bag for collecting body fluid and one in a connector

arranged test strips,

5 shows a schematic representation of an alternative embodiment of a bag according to the invention,

Fig. 6 shows a further alternative in a schematic representation

Embodiment of a bag according to the invention,

Fig. 7 shows a further alternative in a schematic representation

Embodiment of a bag according to the invention and

8 shows a schematic representation of a device for extracorporeal blood treatment with a device according to the invention,

9 shows a schematic representation of a fluid system with a bag for collecting body fluid and a test strip arranged in a bypass. FIG. 1 shows an example of a liquid system with a bag 1 for

Fluid, especially for a body fluid such as urine. The bag 1 can be designed as a collecting bag 1 or a collecting bag 1 and forms a liquid space 2, which can also be referred to as a collecting space 2, is provided with a drain valve 3 and via a flexible liquid line 4, here in the form of a hose 4 Connector piece 5 connected. The connector piece 5 is connected to a catheter 6 on the side opposite the hose 4. In the present case, this can in particular be a transurethral

Disposable catheter or a suprapubic bladder catheter or other catheter. The catheter 6, although not shown in this way in the figure, can be in the form of a catheter 6 according to Nelaton, Tiemann, Mercier, Couvelaire, Dufouer, Frohmüller, Pezzer, Casper, Malecot and / or Stöer or modifications thereof. The catheter 6 shown in FIG. 1 is a Foley catheter 6 and has a balloon 7 for fixation in the bladder of a patient. As an alternative to a catheter 6, a condom urinal is also conceivable and is within the scope of the invention.

Liquid can be drained from the liquid space 2 of the bag 1 via the drain valve 3. The drain valve 3 arises at the lower edge of the bag 1 from the bag space 2, into which the hose 4 opens at the upper edge of the bag 1. At least one sensor unit 100 in the form of a test strip 100 is arranged, in particular attached, in the bag space 2. The test strip 100 has at least one test field 101-111 which changes its color in the presence of an analyte to be examined and / or its concentration. Such a test strip 100 is shown by way of example in FIG. 2.

The test strip 100 shown in FIG. 2 has, for example, a test field 101 for determining the pFI value, a further test field 102 for determining nitrite, a further test field 103 for determining urobilinogen, a further test field 104 for determining erythrocytes, and a further test field 105 to determine

Leukocytes, another test field 106 for the determination of proteins, another test field 107 for the determination of ketones, another test field 108 for the determination of glucose, a further test field 109 for determining ascorbic acid, a further test field 110 for displaying blood and a further test field 111 for

Determination of density. It should be noted that the above

Compilation of test fields is exemplary and in particular the number of test fields as well as the parameters detected by means of these can vary within the scope of the invention. In particular, only a part of these test fields on the

Test strips or a redundant design are available. FIG. 2 shows the test fields 101-111 on the test strip 100 in row form, but an arrangement of test fields 100 in matrix form is also within the scope of the invention. In addition, a design of the test strip 100 in the form of a ring is within the scope of the invention. This embodiment of the test strip 100 is particularly advantageous when the test strip 100 is in a cylindrical container.

To assess the color change of a test field 101-111, a

Reference color chart can be used, with which it can be compared whether and if so in what concentration an analyte is present in the liquid to be examined. The same applies to the pFI value and the density of the liquid.

The reference color chart is preferably located in the vicinity of the test strip or is arranged in the vicinity of the test strip.

FIG. 3 shows a modified embodiment of the liquid system 1, which essentially corresponds to the embodiment according to FIG. 1, so that reference is made to the relevant description and only deviations are described below. In the liquid system 1 of FIG. 3 there are two

different positions for the test strip 100 are shown, of which only one or both can be provided with a test strip 100. Accordingly, a first test strip (100a) can be arranged in the liquid line 4, also here as a hose 4, between the bag 1 and the connector piece 5.

Alternatively or additionally, a second test strip 100b can be arranged directly on the catheter 6 itself. A further embodiment, not shown in the figures, has the test strip 100 in the bag 1, the first test strip 100a in the tube 4 and the second test strip 100b in the catheter 6. A further embodiment is shown in FIG. 4, in which the test strip 100 is arranged on a connector / connector piece 5 or is integrated into the connector 5 as a component thereof. The connector 5 and thus also the test strip 100 are thus arranged between the tube 4 and the catheter 6. At this

An embodiment is advantageous in that conventional collecting bags 1 and catheters 6 can continue to be used. The connector 5 can advantageously be designed as a separate consumable.

A further embodiment, which enables medical personnel to carry out a quick measurement when required or, for example, when a bacterial infection is suspected, is shown in FIG. 5. In this embodiment, the collecting bag 1 is designed or equipped with sample containers 8a, 8b, 8c. In each of the

Sample containers 8a, 8b, 8c, a sensor unit 200 is arranged in the form of a test strip 200a, 200b, 200c, each with at least one test field. Each of the

Sample containers 8a, 8b, 8c can be made of rigid or semi-rigid or flexible

Be formed material and has a sample volume that compared to

Liquid space 2 of the bag 1 is sealed in a liquid-tight manner. For example, a sealing section or a barrier between the sample volume and the

Liquid space in the form of a weld seam, peel seam, adhesive seam or the like. If necessary, the seal between the liquid space 2 and the respective sample volume of the sample containers 8a, 8b, 8c can be removed and a liquid connection can be formed, so that the sample volume is

Liquid space 2 is open and liquid to be examined can flow in

The bag 1 shown in FIG. 5 has three sample containers 8a, 8b, 8c on one side, each of which contains a test strip 200a, 200b, 200c, each with variable test fields. The contents of the bag from the liquid space 2 can only get into one of the sample containers 8a, 8b, 8c when a fluidic connection has been brought about by an operator. Basically, one can stand out

described sample container 8a, 8b, 8c on any side of the bag 1 and / or on the tube 4 and / or connector 5 and / or catheter 6. Another embodiment, which is shown in FIG. 6, has a removable sample container 9. This has the advantage that no new sampling is necessary if the sample in the sample container is to be examined

Liquid should be examined in more detail with an external analysis system. Figure 6 shows an example of a bag 1 with a bag space 2 or liquid space 2, an optional drain valve 3 and a connector unit 10. A removable sample container 9 with an integrated test strip 200 is compatible with the connector unit 10 and can be attached to or with the Bag space 2 are connected. The connection between the connector unit 10 and the sample container 9 can be non-positive and / or positive and / or material. The connector unit 10 may advantageously have a rubber-elastic membrane. This can be pierced by the sample container 9 and effect a seal between the latter and the connector unit 10. After filling and removal of the sample container 9, the membrane can contract again due to its rubber-elastic properties and preferably seal the connector unit 10 independently, so that a

uncontrolled leakage of liquid in the bag 1 after removing the sample container can be safely avoided. Alternatively, the

Connector unit 10 can be closed manually by means of a clamp, not shown in the figures. The at least one connector unit 10 can be located at any point on the bag 1 and / or on the tube 4 and / or connector 5 and / or catheter 6.

FIG. 7 shows a further embodiment of the invention with a removable sample container with integrated test strip 200. The sample container is designed here as a particularly connectable removal device in the form of a syringe with a piston 12 and a syringe cylinder 11. It can already be integrated in the bag 1 by the manufacturer, or it can only be connected to the bag 1 by the user before a sample is taken. The removal device is or is connected to the liquid space 2 of the bag 1 by means of a preferably self-sealing connector unit 10. By pulling out the piston 12, liquid is sucked into the syringe barrel 11. A test strip 200 is arranged in the syringe cylinder 11 and, depending on the presence of an analyte to be detected, the color of its changes at least one test field. It should be pointed out that in this embodiment the connector unit 10 can also be located at any point on the bag 1 and / or on the tube 4 and / or connector 5 and / or catheter 6.

In addition, the invention and in particular such a type of

Withdrawal device in other areas of medical technology, such as used in the context of an extracorporeal blood treatment. FIG. 8 shows a simplified arrangement for extracorporeal blood treatment. Blood is withdrawn from a patient 300 with the aid of a blood pump 302 and passed through an arterial blood line 301, here in the form of an arterial tube 301, into a dialyzer 303, where it is freed from excess water and substances that require urine and thus cleaned. The blood travels back to the patient 300 via a venous blood line 304, here in the form of a venous tube 304. The blood treatment machine 305 produces dialysis fluid for the duration of the therapy.

Dialysis fluid line / fluid line 306 flows counter to the blood direction and flows through the dialyzer 303 separately through a semipermeable membrane. Excess water and urinary substances are removed by the

Dialysis fluid is added, which then leaves the dialyser 303 as a so-called dialysate through a line / dialysate line / liquid line 307.

The dialysate is fed via a dialysate line / liquid line 308 into a drain, not shown in detail. Although the fluids in the lines 306, 307, 308 can be in contact with extracorporeal blood, these are strictly intracorporeal fluid lines. The dialysate is therefore a liquid which is in contact with a liquid from the body, the blood, via the dialyzer 303 and its membrane.

Similar to FIG. 7, a connectable removal device 309a, 309b can be used as a sample container in order to examine the dialysate. A suitable sampling point is located, for example, in line 307. If such a sampling point is not available, the sampling device 309b can also be used directly at the machine exit in order to take and examine a dialysate sample. Line 306 represents another tapping point. In the area Acute and peritoneal dialysis bags are often used

Contain body fluids or liquids that are or have been in contact with the body fluids. According to the above-mentioned embodiments, these bags can also be equipped with test strips, sample containers or

Removal devices are equipped.

In the case of cloudy liquids such as blood in particular, it is within the scope of the invention to separate the test strip from the liquid to be examined with a semipermeable membrane. The pores of this membrane are large enough to allow the analyte or analytes to pass through, but at the same time small enough to be disruptive

Withhold substances. The sample containers 8a, 8b, 8c can in the

Embodiment of Figure 5 be prefilled with a preferably isotonic solution, so that an analyte, if present in the liquid in the liquid space 2, then passes through the membrane by means of diffusion.

If a syringe-like removal device is used as in the embodiment of FIG. 7, a passage in the syringe cylinder 11 being provided with a membrane, a pre-filling is not necessary, since the piston 12 does not diffuse, but convection is the driving force due to the piston 12 moving in the syringe cylinder 11 is to convey any substance to the test strip.

FIG. 9 shows a modified embodiment of the liquid system 1, which essentially corresponds to the embodiment according to FIG. 1, so that reference is made to the relevant description and only deviations are described below. In the liquid system 1 of FIG. 9, the test strip 100 is in a bypass 13. Accordingly, a test strip 100 can be arranged in the bypass 13, which is designed here as a bypass line. The bypass 13 is interchangeable with the liquid line 4, but can also on any other

Position, e.g. in the connector 5 or the catheter 6.

As a result, the bypass 13 with the test strip 100 can be exchanged in a particularly simple manner without the catheter 6 having to be separated from the collecting bag 1. The bypass 13 is connected to an integrated test strip 100 preferably via penetration of a connection point 14 which has a self-sealing membrane or a valve.

Reference numerals

1 bag, collecting bag, collecting bag

2 liquid space, bag volume

3 drain valve

4 liquid line, hose

5 connector, connector piece

6 catheters

7 balloon

8a, 8b, 8c sample container

9 sample container

10 connector unit

1 1 syringe barrel

12 syringe plungers

13 bypass

14 connection point

100 test strips

101 - 1 1 1 test field

200 test strips

200a test strips

200b test strips

200c test strips

300 patient

301 arterial blood line, arterial tube

302 blood pump

303 dialyzer

304 venous blood line, venous tube

305 blood treatment machine

306 (dialysis fluid) line

307 (dialysate) line

308 dialysate line

309a removal device

309b removal device

Claims

1. System for analyzing fluids from the body with

a fluid line and collection device, which a

Liquid line (4, 5, 6, 306, 307, 308), in particular a hose, a liquid storage volume (1, 2), in particular a liquid bag, and the liquid line (4, 5, 6, 306, 307, 308) with the

Liquid storage volume (1, 2) connecting fluid-conducting

Has hose connector (5), and

a sensor unit (100, 200) connected or connectable to the fluid line and collection device for detecting at least one analyte in the liquid and / or at least one parameter of the

Liquid, which sensor unit has or is a test strip (100, 200) with at least one test field (101-111) that colors in the presence of an analyte to be detected and / or as a function of a parameter of the liquid to be detected,

characterized by at least one attachment, which can be mounted or mounted on the fluid line and collection device in a fluid-conducting and detachable manner, which is designed as a support for the sensor unit (100, 200).

2. System according to claim 1, characterized in that the

Liquid line (4, 5, 6, 306, 307, 308) a catheter (6)

Line hose (4) for guiding body fluid into a

Collection container (1), a dialysis fluid line (306) or one

Dialysate line (307, 308).

3. System according to claim 1 or 2, characterized in that the

Liquid storage volume (1, 2) a collecting container (1) or

Is a collection container (1) for body fluid, in particular a bag, such as a collection bag or a collection bag for urine, blood, wound secretions or other.

4. System according to any one of the preceding claims, characterized in that the attachment comprises at least one sample container (8a, 8b, 8c, 9) external to the fluid line and collecting device, in which the test strip is arranged.

5. System according to claim 4, characterized in that the

Sample container (8a, 8b, 8c, 9) forms a sample volume, in which the test strip (100, 200) is arranged or with which the test strip (100, 200) is fluidly connected, the sample volume by means of a barrier to the fluid line and Collecting device of the system is sealed and can be fluidly connected in particular by actuation by the user to the fluid line and collecting device.

6. System according to claim 5, characterized in that the barrier is designed as a weld seam, peel seam or adhesive seam.

7. System according to any one of claims 4 to 6, characterized in that the sample container (8a, 8b, 8c, 9) consists of rigid, semi-rigid or flexible material and on a liquid storage volume (1) or

Collection container for body fluid, in particular collection bags or collection bags for urine, blood, wound secretions or other, is arranged.

8. System according to claim 7, characterized in that the

Sample container (8a, 8b, 8c, 9) a parallel to the liquid line (4, 5, 6, 306, 307, 308) is mounted or can be mounted on the fluid line and collection system.

9. System according to any one of claims 4 to 8, characterized in that the sample container (8a, 8b, 8c, 9) from the fluid line and

Collecting device is separable and removable.

10. System according to claim 9, characterized in that the

Sample container (8a, 8b, 8c, 9) non-positively and / or positively with the Liquid storage volume (1, 2) or with the liquid line (4, 5, 6,

306, 307, 308) is connected.

11. System according to one of claims 4 to 10, characterized in that the sample container (8a, 8b, 8c, 9) is designed as a syringe, with a

Syringe barrel (11) and a syringe plunger (12) which is movably received therein and limits a variable sample volume.

12. Removal device (309a, 309b) for taking samples of liquids originating from the body with a sample container (8a, 8b, 8c, 9), in which a sensor unit (100, 200) is arranged, which one

Has or is test strips (100, 200) with at least one test field (101-111) which is in the presence of an analyte to be detected and / or in

Dependence on a parameter of the liquid to be recorded,

characterized in that the removal device is designed as an attachment, which is detachably mounted or mountable on a fluid line and collection device and fluidly connected or connectable thereto.

13. removal device (309a, 309b) according to claim 12, characterized

characterized in that the sample container (8a, 8b, 8c, 9) consists of semi-rigid or flexible material and / or that it is designed as a syringe, in particular as a disposable syringe.