EP3846815A4 - Pharmazeutische zubereitungen von sebacoyl-dinalbuphin und acetaminophen und verfahren zur schmerzbehandlung - Google Patents

Pharmazeutische zubereitungen von sebacoyl-dinalbuphin und acetaminophen und verfahren zur schmerzbehandlung Download PDF

Info

Publication number
EP3846815A4
EP3846815A4 EP18932827.1A EP18932827A EP3846815A4 EP 3846815 A4 EP3846815 A4 EP 3846815A4 EP 18932827 A EP18932827 A EP 18932827A EP 3846815 A4 EP3846815 A4 EP 3846815A4
Authority
EP
European Patent Office
Prior art keywords
acetaminophen
methods
pharmaceutical preparations
treating pain
sebacoyl dinalbuphine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18932827.1A
Other languages
English (en)
French (fr)
Other versions
EP3846815A1 (de
Inventor
Oliver Yoa-Pu Hu
Yen-Lun Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jacob Biotech Ltd
Original Assignee
Jacob Biotech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jacob Biotech Ltd filed Critical Jacob Biotech Ltd
Publication of EP3846815A1 publication Critical patent/EP3846815A1/de
Publication of EP3846815A4 publication Critical patent/EP3846815A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP18932827.1A 2018-09-03 2018-09-03 Pharmazeutische zubereitungen von sebacoyl-dinalbuphin und acetaminophen und verfahren zur schmerzbehandlung Pending EP3846815A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/103786 WO2020047703A1 (en) 2018-09-03 2018-09-03 Pharmaceutical preparations of sebacoyl dinalbuphine and acetaminophen and methods for treating pain

Publications (2)

Publication Number Publication Date
EP3846815A1 EP3846815A1 (de) 2021-07-14
EP3846815A4 true EP3846815A4 (de) 2022-05-04

Family

ID=69721971

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18932827.1A Pending EP3846815A4 (de) 2018-09-03 2018-09-03 Pharmazeutische zubereitungen von sebacoyl-dinalbuphin und acetaminophen und verfahren zur schmerzbehandlung

Country Status (11)

Country Link
EP (1) EP3846815A4 (de)
JP (2) JP7318987B2 (de)
KR (1) KR102700501B1 (de)
CN (1) CN113164469A (de)
AU (1) AU2018440280B2 (de)
CA (1) CA3111271A1 (de)
CL (1) CL2021000309A1 (de)
IL (1) IL280822A (de)
SG (1) SG11202101974WA (de)
WO (1) WO2020047703A1 (de)
ZA (1) ZA202102209B (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237140A (en) * 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US6225321B1 (en) * 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
AU2003296954A1 (en) * 2002-12-13 2004-07-09 The Regents Of The University Of California Analgesic combination comprising nalbuphine
EP1964552B1 (de) * 2007-03-02 2009-08-26 Flamek Corp OÜ Analgesische Zusammensetzung von topisch angewendeten, nichtsteroiden und entzündungshemmenden Arzneimitteln und Opioiden
EP3069733B1 (de) 2013-11-13 2022-08-10 National Defense Education and Research Foundation Neue acetaminophenverbindungszusammensetzung ohne nebenwirkungen für die leber

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
SG11202101974WA (en) 2021-03-30
CL2021000309A1 (es) 2021-07-19
EP3846815A1 (de) 2021-07-14
IL280822A (en) 2021-04-29
JP7318987B2 (ja) 2023-08-01
JP2021535216A (ja) 2021-12-16
CN113164469A (zh) 2021-07-23
JP2023078480A (ja) 2023-06-06
ZA202102209B (en) 2022-03-30
AU2018440280A1 (en) 2021-03-18
KR102700501B1 (ko) 2024-08-28
CA3111271A1 (en) 2020-03-12
WO2020047703A1 (en) 2020-03-12
KR20210054560A (ko) 2021-05-13
AU2018440280B2 (en) 2022-11-03

Similar Documents

Publication Publication Date Title
EP3801625A4 (de) Produktformulierungen auf seidenbasis und verwendungsverfahren
EP4072593A4 (de) Bioaktivierbare arzneimittel auf cytokinbasis und verwendungsverfahren dafür
EP3681479A4 (de) Verabreichungs- und behandlungsverfahren
EP3749344A4 (de) Verfahren zur therapeutischen verwendung von exosomen und y-rnas
EP3682884A4 (de) Kristallform von gsk1278863 sowie herstellungsverfahren und pharmazeutische verwendung davon
EP3437637A4 (de) Pharmazeutische zubereitung von palbociclib und herstellungsverfahren dafür
EP3991173A4 (de) Systeme und verfahren zur verordnung und dosierung therapeutischer stimuli mithilfe aufgezeichneter garantien
EP3694832A4 (de) Pharmazeutische formulierung mit verlängerter freisetzung und verfahren zur behandlung
EP3790425A4 (de) Applikator und system für pharmazeutische zubereitung und verwendungsverfahren
EP3891175A4 (de) Modifizierte proteine und zugehörige behandlungsverfahren
EP3654961A4 (de) Verfahren und zusammensetzungen zur behandlung von schmerzen mit capsaicin
EP3976093A4 (de) Antibakterielle pharmazeutische zusammensetzungen mit breitem spektrum mit lysozym und verfahren zur verwendung davon
EP3972647A4 (de) Wirkstoffkonjugate und verfahren zu ihrer verwendung
EP3760191A4 (de) Pharmazeutische zusammensetzung, herstellungsverfahren dafür sowie verwendung davon
EP3570835A4 (de) Verfahren und pharmazeutische zusammensetzungen zur prävention oder behandlung von immunentzündlichen dermalen erkrankungen
EP3468540A4 (de) Pharmazeutische zusammensetzungen und verfahren zur schmerzbehandlung
EP3860570A4 (de) Formulierungen und verfahren zur transdermalen verabreichung von ketonen
EP4017493A4 (de) Behandlungsverfahren mit bcn057 und bcn512
EP3880183A4 (de) Pharmazeutische zubereitung von fruquintinib und verwendung davon
EP3777849A4 (de) Pharmazeutische zusammensetzung mit polmacoxib und pregabalin zur schmerzbehandlung
EP3885033A4 (de) Verfahren und system zur behandlung von materialien
EP3790603A4 (de) Therapeutisches hydrogelmaterial und verfahren zur verwendung davon
EP3781082A4 (de) Medizinisches haltesystem und verfahren zur erleichterung der herstellung von implantierbaren elementen
EP3801484A4 (de) Arzneimittel auf biobasis und verfahren zur erhöhung der compliance eines patienten
EP3576761A4 (de) Kräutermineralformulierung zur behandlung von krebs und verfahren zur herstellung davon

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210401

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20220331

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/12 20060101ALI20220325BHEP

Ipc: A61K 9/16 20060101ALI20220325BHEP

Ipc: A61K 9/20 20060101ALI20220325BHEP

Ipc: A61K 9/48 20060101ALI20220325BHEP

Ipc: A61K 9/10 20060101ALI20220325BHEP

Ipc: A61K 9/08 20060101ALI20220325BHEP

Ipc: A61K 9/06 20060101ALI20220325BHEP

Ipc: A61K 9/00 20060101ALI20220325BHEP

Ipc: A61P 25/04 20060101ALI20220325BHEP

Ipc: A61K 31/167 20060101ALI20220325BHEP

Ipc: A61K 31/485 20060101AFI20220325BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20240611