EP3820854A1 - Method for preparation of 1,4-sorbitan - Google Patents
Method for preparation of 1,4-sorbitanInfo
- Publication number
- EP3820854A1 EP3820854A1 EP19758597.9A EP19758597A EP3820854A1 EP 3820854 A1 EP3820854 A1 EP 3820854A1 EP 19758597 A EP19758597 A EP 19758597A EP 3820854 A1 EP3820854 A1 EP 3820854A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- done
- dehydreac
- step3
- step2
- sorbitan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 44
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 title claims abstract description 22
- 229940084778 1,4-sorbitan Drugs 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 35
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 35
- 229960002920 sorbitol Drugs 0.000 claims abstract description 35
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000006297 dehydration reaction Methods 0.000 claims abstract description 12
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 17
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 claims description 11
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 claims description 10
- 101100345673 Xenopus laevis mix-b gene Proteins 0.000 claims description 8
- 101100184148 Xenopus laevis mix-a gene Proteins 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 230000035484 reaction time Effects 0.000 claims description 3
- 230000018044 dehydration Effects 0.000 abstract description 9
- 238000007363 ring formation reaction Methods 0.000 abstract description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 18
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000000600 sorbitol Substances 0.000 description 15
- 238000002425 crystallisation Methods 0.000 description 11
- 230000008025 crystallization Effects 0.000 description 11
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 11
- 238000002955 isolation Methods 0.000 description 9
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 101000927799 Homo sapiens Rho guanine nucleotide exchange factor 6 Proteins 0.000 description 7
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 description 7
- 102100033202 Rho guanine nucleotide exchange factor 6 Human genes 0.000 description 7
- 229960002479 isosorbide Drugs 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 101000927796 Homo sapiens Rho guanine nucleotide exchange factor 7 Proteins 0.000 description 5
- 102100033200 Rho guanine nucleotide exchange factor 7 Human genes 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 239000003054 catalyst Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000001953 recrystallisation Methods 0.000 description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 238000010533 azeotropic distillation Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000004042 decolorization Methods 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 2
- -1 Isosorbide compound Chemical class 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000282344 Mellivora capensis Species 0.000 description 1
- 239000003377 acid catalyst Substances 0.000 description 1
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- CETRZFQIITUQQL-UHFFFAOYSA-N dmso dimethylsulfoxide Chemical compound CS(C)=O.CS(C)=O CETRZFQIITUQQL-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
Definitions
- the invention discloses a method for preparation of 1 ,4-sorbitan by dehydration of D-sorbitol, wherein one equivalent of water is removed and a cyclization occurs, followed by a treatment with ethanol and isopropanol.
- l,4-Sorbitan is used for the production of pharmaceuticals, such as certain prostaglandin analogues, and for the production of excipients used in formulation of pharmaceuticals, such as Polysorbate 80.
- US 2002/0002284 Al discloses a method for preparation of 1 ,4-sorbitan by dehydration of 4 kg D-sorbitol in the presence of sulfuric acid and water at l04°C for ca. 52 h, the method has a recrystallization step from ethanol as a last step, reported yield is 1.693 kg, the calculated molar yield is 47.0%.
- sulfuric acid also Na 2 C0 3 , isopropanol, Na 2 S0 4 , ethanol, activated charcoal and toluene are used in considerable amounts.
- the method comprises 3 filtration steps besides the dehydration step and the recrystallization step.
- CN 101948451 A discloses a method for preparation of high-purity 1 ,4-sorbitan, which is characterized by taking sorbitol as a raw material through two times of dehydration and three times of crystallization. Already after the second dehydration, a base is added to the reactiom mixture for neutralization, then the reaction mixture is filtered to remove an acid catalyst used in the second dehydration reaction, the a decolourization is done by addition of activated carbon, which again necessitates a filtration for removing the activated carbon. The crystallization is done with methanol, after each crystallization step a filtration is done.
- CN 106167476 A discloses in [0028] Sl a preparation of l,4-Sorbitan from a melt of sorbitol with a catalyst which is composed of tetrabutylammonium bromide and p-toluene sulfonic acid. No yield and also no analytical data is given of any amounts of sorbitol or of isosorbide in the product.
- Example 1 discloses in Example 1 the dehydration of Sorbitol to provide 1 ,4-sorbitan. The reported yield of 35% is significantly lower than the yield of 52.6 % of inventive Example 1.
- Example 1 of US’277 Reworking of this Example 1 of US’277, as reported herein under Comparative Example 2, was not possible. In particular the crystallization of the reported residue after the reaction from cold methanol was not possible even though the procedure as reported in Example 1 US'277 up to this point was follow literally.
- the analysis of the this residue shows a significantly higher relative content of sorbitol and a significantly lower relative content of 1 ,4 sorbitan compared to the analysis of the equivalent intermediate in the clear solution in ethanol in the inventive example 1. This difference in the relative amounts of 1,4 sorbitan and sorbitol correlates well with the reported significantly lower yield of Example 1 of US’277.
- the reaction in Example 1 of US’277 is done under a pressure of 50 bar.
- Any use of a compound for or in pharmaceutical applications requires a defined purity and usually also a high purity.
- % percent are percent by weight (wt%), if not stated otherwise
- Subject of the invention is a method for preparation of l,4-sorbitan with four consecutive steps STEP1, STEP2, STEP3 and STEP4, wherein
- STEP1 D-sorbitol is dehydrated in a dehydration reaction DEHYDREAC in the presence of p-toluenesulfonic acid and tetrabutylammonium bromide, STEP1 provides a mixture MIX1;
- STEP3 isopropanol is mixed with MIX2, STEP3 provides a mixture MIX3; in STEP4 l,4-sorbitan is isolated from MIX3.
- the p-toluene sulfonic acid is used in form of p-toluenesulfonic acid monohydrate; so in any embodiment where p-toluene sulfonic acid is mentioned, the preferred embodiment is p-toluenesulfonic acid monohydrate.
- no solvent is present in or used for DEHYDREAC.
- DEHYDREAC is done neat, that is only the three components D-sorbitol, p- toluenesulfonic acid and tetrabutylammonium bromide are used for and are charged for DEHYDREAC.
- the molar equivalent of p-toluenesulfonic acid in DEHYDREAC acid is from 0.2 to 1.6%, more preferably from 0.4 to 1.4%, even more preferably from 0.6 to 1.2%, especially from 0.6 to 1.0%, of the molar equivalents of D-sorbitol.
- the molar equivalent of tetrabutylammonium bromide in DEHYDREAC acid is from 1.0 to 3.6%, more preferably from 1.2 to 3.2%, even more preferably from 1.4 to 2.8%, especially from 1.6 to 2.4%, more especially from 1.6 to 2.0%, of the molar equivalents of D-sorbitol.
- the weight of ethanol mixed in STEP2 is from 0.2 to 5 fold, more preferably from 0.2 to 2 fold, even more preferably from 0.2 to 1 fold, especially from 0.2 to 0.8 fold, more especially from 0.2 to 0.6 fold, even more especially from 0.3 to 0.5 fold, of the weight of D-sorbitol.
- the weight of isopropanol mixed in STEP2 is from 0.2 to 5 fold, more preferably from 0.2 to 2 fold, even more preferably from 0.2 to 1 fold, especially from 0.2 to 0.8 fold, more especially from 0.2 to 0.6 fold, even more especially from 0.3 to 0.5 fold, of the weight of D-sorbitol.
- DEHYDREAC is done at a temperature TEMP1, TEMP1 is from 95 to 130 °C, more preferably from 95 to l20°C, even more preferably from 100 to 1 l5°C, especially from 105 to H5°C, in particular H0°C.
- reaction time TIME1-1 of DEHYDREAC is from 3 to 12 h, more preferably from 4 to 12 h, even more preferably from 5 to 10 h, especially from 5 to 8 h, more especially from 5 to 7 h, in particular 6 h.
- TIME 1-1 is preferably from 6 to 10 h, more preferably from 7 to 9 h.
- DEHYDREAC is done at a pressure PRESS 1 of 500 mbar or below, more
- preferably of 250 mbar or below even more preferably of 100 mbar or below, especially of 50 mbar or below, more especially of 25 mbar or below, even more especially of 15 mbar or below, in particular of 10 mbar or below.
- the lower limit of the pressure may be anything which is technically feasible. Examples for a lower limit of the pressure may be 0.1 mbar, or 0.5 mbar, or 1 mbar, or 2 mbar.
- DEHYDREAC is done at PRESS 1 of from 0.001 to 500 mbar
- STEP2, STEP3 and STEP4 are done at atmospheric pressure.
- Water is formed by DEHYDREAC as the reaction is a dehydration, which removes 1 equiv of water.
- the p-toluene sulfonic acid is used in form of p-toluenesulfonic acid monohydrate, it can also be a source of water during DEHYDREAC.
- water is removed during DEHYDREAC.
- STEP2 is done at a temperature TEMP2 of from 60 to 90°C, more preferably of from 60 to 85°C, even more preferably of from 65 to 80°C, in particular of from 70 to 75°C.
- STEP1 comprises a cooling COOL1 after DEHYDREAC, where MIX1 is cooled from TEMP 1 to TEMP2.
- COOL1 is done in a time TIME 1-2, TIME 1-2 is from 10 min to 10 h, more
- STEP2 comprises a stirring STIRR2 of MIX2 for a time TIME2-1, TIME2-1 is from 30 min to 10 h, more preferably of from 1 to 8 h, even more preferably of from 1 to 6 h, especially from 1 to 4 h, more especially from 1.5 to 3 h, in particular 2 h.
- STEP3 is done at a temperature TEMP3-1 of from 10 to 30°C, more preferably of from 15 to 25°C, even more preferably of from 17.5 to 22.5°C, in particular 20°C.
- STEP2 comprises a cooling COOL2, where MIX2 is cooled from TEMP1 or
- COOL2 is done after STIRR2.
- COOL2 is done from TEMP2 to TEMP3-1.
- COOL2 is done in a time TIME2-2, TIME2-2 is from 1 to 10 h, more preferably from 1 to 8 h, even more preferably from 1 to 6 h, especially from 1 to 4 h, more especially from 2 to 4 h, in particular 3 h.
- COOL3 is done in a time TIME3-1, TIME3-1 is from 30 min to 10 h, more
- STEP3 comprises a stirring STIRR3 of MIX3, STIRR3 is done for a time TIME3- 2, TIME3-2 is from 1 to 12 h, more preferably from 1 to 10 h, even more preferably from 2 to 8 h, especially from 2 to 6 h, more especially from 3 to 5 h, in particular 4 h.
- STIRR3 is done after COOL3.
- the isolation in STEP4 of 1 ,4-sorbitan from MIX3 can be done by any means known to the skilled person, such as evaporation of any liquids in MIX3, filtration, centrifugation, drying, or a combination thereof, preferably the isolation is done by filtration or centrifugation of MIX3, more preferably by filtration, preferably followed by drying of the provided isolated solid product.
- l,4-sorbitan is isolated in STEP4 from MIX3 by filtration providing a presscake, preferably followed by washing the presscake with isopropanol, preferably followed by drying of the washed presscake, preferably the drying is done at a temperature of from 30 to 70°C, more preferably of from 40 to 60°C, in particular 50°C.
- STEP2 comprises after the mixing of ethanol consecutively STIRR2 and COOL2;
- STEP3 comprises after the mixing of isopropanol consecutively COOL3 and STIRR3;
- STEP4 comprises an isolation of l,4-sorbitan by a filtration of MIX3, preferably followed by washing and drying.
- isopropanol is charged to MIX2 providing MIX3.
- STEP2 and STEP3 are done consecutively without isolation, such as by filtration, of the l,4-sorbitan between STEP2 and STEP3.
- STEP1, STEP2 and STEP3 are done consecutively without isolation, such as by filtration, of the l,4-sorbitan between STEP1 and STEP2 and without isolation, such as by filtration, of the l,4-sorbitan between STEP2 and STEP3.
- STEP1, STEP2 and STEP3 are done consecutively in one and the same reactor.
- camphorsulfonic acid sulfuric acid, Na 2 C0 3 , Na 2 S0 4 , activated
- camphorsulfonic acid is used in STEP1, STEP2, STEP3 or STEP4.
- no Na 2 C0 3 , Na 2 S0 4 , activated charcoal or toluene are used in STEP2 or STEP3; more preferably no Na 2 C0 3 , Na 2 S0 4 , activated charcoal or toluene are used in STEP2, STEP3 or STEP4; even more preferably no Na 2 C0 3 , Na 2 S0 4 , activated charcoal or toluene are used in STEP1, STEP2, STEP3 or STEP4.
- the method of instant invention does not use azeotropic removal of water, more preferably azeotropic removal of water facilitated by the presence of toluene during the azeotropic removal of water for providing the azeotrope.
- none of the steps STEP1, STEP2, STEP3 and STEP4 comprise a
- Ratel Final 1; Time 1 8°C/min; 350°C; keep lOmin
- the resulting mixture was stirred at 70 to 75 °C for 2 hours and formed a clear solution. Then the solution was cooled to 20 °C in 3 hours. A yellow suspension was formed. Isopropanol (150 mL) was charged. The mixture was cooled to 0 °C in 1 hour. The mixture was slurry at 0 °C for 4 hours. The mixture was filtered, and the cake was washed with isopropanol (150 mL). The cake was dried at 50 °C for 16 hours under vacuum to provide 142.2 g of product as white solid.
- D-Sorbitol (20 g, 110 mmol) and 0.1% (mol/mol) camphor sulfonic acid are added in a 150 ml stainless steel autoclave.
- the reactor is sealed hermetically, purged with hydrogen three times and then hydrogen was introduced up to a pressure of 50 bar.
- the system is then heated to 140° C. and shaken with a mechanical shaker for 15 hours. After cooling to room temperature, the hydrogen pressure was released and the white foam was diluted in ethanol (200 ml) in order to obtain a yellow homogeneous mixture. Solvent is evaporated under reduced pressure.
- Example 1 of US'277 can be compared with the product obtained in Example 1 of this invention at the following point in the procedure of Example 1 of this invention:
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
Abstract
Description
Claims
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2018102509 | 2018-08-27 | ||
US201862736060P | 2018-09-25 | 2018-09-25 | |
EP18196446 | 2018-09-25 | ||
EP19151606 | 2019-01-14 | ||
EP19176534 | 2019-05-24 | ||
EP19000293 | 2019-06-14 | ||
EP19187318 | 2019-07-19 | ||
EP19187974 | 2019-07-24 | ||
PCT/EP2019/072661 WO2020043639A1 (en) | 2018-08-27 | 2019-08-26 | Method for preparation of 1,4-sorbitan |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3820854A1 true EP3820854A1 (en) | 2021-05-19 |
Family
ID=67777303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19758597.9A Withdrawn EP3820854A1 (en) | 2018-08-27 | 2019-08-26 | Method for preparation of 1,4-sorbitan |
Country Status (8)
Country | Link |
---|---|
US (1) | US11174236B2 (en) |
EP (1) | EP3820854A1 (en) |
JP (1) | JP7148732B2 (en) |
KR (1) | KR102312129B1 (en) |
CN (1) | CN112585122B (en) |
CA (1) | CA3110034A1 (en) |
SG (1) | SG11202101706WA (en) |
WO (1) | WO2020043639A1 (en) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6639067B1 (en) * | 1998-09-09 | 2003-10-28 | Willard C. Brinegar | Continuous process for the production of anhydrosugar alcohols |
US6441196B2 (en) * | 2000-05-19 | 2002-08-27 | Alcon, Inc. | Processes and novel intermediates for 11-oxa prostaglandin synthesis |
CN101948451B (en) | 2010-08-18 | 2013-03-06 | 南京威尔化工有限公司 | Preparation method of high-purity 1,4-sorbitan |
FR3007031B1 (en) * | 2013-06-14 | 2015-07-24 | Syral Belgium Nv | PROCESS FOR THE PREPARATION OF ALKYL LONG CHAINS CYCLIC ACETALS BASED ON SUGAR |
CN106167476B (en) * | 2016-07-20 | 2018-01-12 | 广州嘉德乐生化科技有限公司 | A kind of preparation method of Sorbitan Oleate |
US20220064135A1 (en) | 2019-01-16 | 2022-03-03 | Lonza Guangzhou Pharmaceutical Ltd. | Method for Preparation of 1,4-Sorbitan in Aqueous Medium |
-
2019
- 2019-08-26 JP JP2021536155A patent/JP7148732B2/en active Active
- 2019-08-26 WO PCT/EP2019/072661 patent/WO2020043639A1/en unknown
- 2019-08-26 EP EP19758597.9A patent/EP3820854A1/en not_active Withdrawn
- 2019-08-26 KR KR1020217007579A patent/KR102312129B1/en active IP Right Grant
- 2019-08-26 US US17/265,939 patent/US11174236B2/en active Active
- 2019-08-26 CA CA3110034A patent/CA3110034A1/en not_active Abandoned
- 2019-08-26 SG SG11202101706WA patent/SG11202101706WA/en unknown
- 2019-08-26 CN CN201980054956.0A patent/CN112585122B/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20210261514A1 (en) | 2021-08-26 |
SG11202101706WA (en) | 2021-03-30 |
CA3110034A1 (en) | 2020-03-05 |
US11174236B2 (en) | 2021-11-16 |
KR20210036977A (en) | 2021-04-05 |
JP2021535929A (en) | 2021-12-23 |
JP7148732B2 (en) | 2022-10-05 |
WO2020043639A1 (en) | 2020-03-05 |
KR102312129B1 (en) | 2021-10-14 |
CN112585122B (en) | 2023-04-04 |
CN112585122A (en) | 2021-03-30 |
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