EP3805370A4 - Hla gene-deleted, human induced pluripotent stem cell-derived mesenchymal stem cell and preparation method therefor - Google Patents

Hla gene-deleted, human induced pluripotent stem cell-derived mesenchymal stem cell and preparation method therefor Download PDF

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Publication number
EP3805370A4
EP3805370A4 EP19812038.8A EP19812038A EP3805370A4 EP 3805370 A4 EP3805370 A4 EP 3805370A4 EP 19812038 A EP19812038 A EP 19812038A EP 3805370 A4 EP3805370 A4 EP 3805370A4
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EP
European Patent Office
Prior art keywords
stem cell
deleted
preparation
method therefor
induced pluripotent
Prior art date
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Application number
EP19812038.8A
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German (de)
French (fr)
Other versions
EP3805370A1 (en
Inventor
Kyung-Sun Kang
Kwang Won Seo
Hee-Jin Ahn
Daekee KWON
Mi-Jung Han
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Kangstem Biotech Co Ltd
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Kangstem Biotech Co Ltd
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Publication of EP3805370A1 publication Critical patent/EP3805370A1/en
Publication of EP3805370A4 publication Critical patent/EP3805370A4/en
Pending legal-status Critical Current

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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EP19812038.8A 2018-05-30 2019-05-30 Hla gene-deleted, human induced pluripotent stem cell-derived mesenchymal stem cell and preparation method therefor Pending EP3805370A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20180062166 2018-05-30
PCT/KR2019/006536 WO2019231266A1 (en) 2018-05-30 2019-05-30 Hla gene-deleted, human induced pluripotent stem cell-derived mesenchymal stem cell and preparation method therefor

Publications (2)

Publication Number Publication Date
EP3805370A1 EP3805370A1 (en) 2021-04-14
EP3805370A4 true EP3805370A4 (en) 2022-04-27

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ID=68697049

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EP19812038.8A Pending EP3805370A4 (en) 2018-05-30 2019-05-30 Hla gene-deleted, human induced pluripotent stem cell-derived mesenchymal stem cell and preparation method therefor

Country Status (4)

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US (1) US20210222127A1 (en)
EP (1) EP3805370A4 (en)
KR (1) KR102304549B1 (en)
WO (1) WO2019231266A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021169017A1 (en) * 2020-02-25 2021-09-02 上海大学 Use of mesenchymal stem cells in treatment of severe covid-19 pneumonia
KR102560588B1 (en) * 2020-03-18 2023-07-28 가톨릭대학교 산학협력단 HLA class I and MICA/MICB null cell line constructed from multiplex CRISPR-Cas9 system and use thereof
CN115701285A (en) * 2020-04-28 2023-02-07 菲克特生物科学股份有限公司 Mesenchymal stem cell therapy
JP2023537364A (en) * 2020-08-06 2023-08-31 カンステム バイオテック カンパニー リミテッド Method for producing highly functional artificial organs using aptamers
KR20230020351A (en) * 2021-07-28 2023-02-10 의료법인 성광의료재단 Genetically engineered stem cells with inhibited expression of the B2M gene and use thereof
WO2023090589A1 (en) * 2021-11-22 2023-05-25 주식회사 미래셀바이오 Pluripotent stem cell-based composition for prevention or treatment of hypersensitive immune response-induced skin disease
WO2023191709A2 (en) * 2022-03-31 2023-10-05 Agency For Science, Technology And Research Method

Citations (2)

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WO2014139443A1 (en) * 2013-03-14 2014-09-18 浙江大学 Low immunogenicity human cell and preparation method therefor
US20180142262A1 (en) * 2016-11-22 2018-05-24 Regents Of The University Of Minnesota Method for correcting a genetic sequence

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US20110091862A1 (en) * 2007-11-14 2011-04-21 Osteosphere, Llc Generation of an hla-negative osteogenic precursor cell line
US20140134195A1 (en) * 2011-04-20 2014-05-15 University Of Washington Through Its Center For Commercialization Beta-2 microglobulin-deficient cells
JP6933898B2 (en) * 2014-04-24 2021-09-08 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System Application of induced pluripotent stem cells to manufacture adoptive cell therapy products
CN106536721B (en) * 2014-08-06 2020-12-04 车医科学大学校产学协力团 Nuclease-mediated generation of immune-compatible cells by editing HLA-encoding genes
AU2016261600B2 (en) * 2015-05-08 2021-09-23 President And Fellows Of Harvard College Universal donor stem cells and related methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014139443A1 (en) * 2013-03-14 2014-09-18 浙江大学 Low immunogenicity human cell and preparation method therefor
US20180142262A1 (en) * 2016-11-22 2018-05-24 Regents Of The University Of Minnesota Method for correcting a genetic sequence

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HIROKI TORIKAI ET AL: "Toward eliminating HLA class I expression to generate universal cells from allogeneic donors", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 122, no. 8, 5 June 2013 (2013-06-05), pages 1341 - 1349, XP002719612, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2013-03-478255 *
JUNG YUNJOON ET AL: "Concise Review: Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells: Progress Toward Safe Clinical Products", STEM CELLS, vol. 30, no. 1, 1 January 2012 (2012-01-01), pages 42 - 47, XP055897554, ISSN: 1066-5099, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784250/pdf/nihms512851.pdf> DOI: 10.1002/stem.727 *
See also references of WO2019231266A1 *
SUNG-HWAN MOON ET AL: "Differentiation of hESCs into Mesodermal Subtypes: Vascular-, Hematopoietic-and Mesenchymal-lineage Cells", INTERNATIONAL JOURNAL OF STEM CELLS, 1 January 2011 (2011-01-01), XP055093794, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840970/pdf/ijsc-04-24.pdf> [retrieved on 20131217], DOI: 10.15283/ijsc.2011.4.1.24 *

Also Published As

Publication number Publication date
WO2019231266A1 (en) 2019-12-05
KR20190137010A (en) 2019-12-10
KR102304549B1 (en) 2021-09-27
EP3805370A1 (en) 2021-04-14
US20210222127A1 (en) 2021-07-22

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