EP3793982A4 - Inhibiteurs à petites molécules de la translocation nucléaire du récepteur des androgènes pour traiter le cancer de la prostate résistant à la castration - Google Patents
Inhibiteurs à petites molécules de la translocation nucléaire du récepteur des androgènes pour traiter le cancer de la prostate résistant à la castration Download PDFInfo
- Publication number
- EP3793982A4 EP3793982A4 EP19803487.8A EP19803487A EP3793982A4 EP 3793982 A4 EP3793982 A4 EP 3793982A4 EP 19803487 A EP19803487 A EP 19803487A EP 3793982 A4 EP3793982 A4 EP 3793982A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- castration
- treatment
- prostate cancer
- small molecule
- androgen receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862671254P | 2018-05-14 | 2018-05-14 | |
PCT/US2019/032033 WO2019222105A1 (fr) | 2018-05-14 | 2019-05-13 | Inhibiteurs à petites molécules de la translocation nucléaire du récepteur des androgènes pour traiter le cancer de la prostate résistant à la castration |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3793982A1 EP3793982A1 (fr) | 2021-03-24 |
EP3793982A4 true EP3793982A4 (fr) | 2022-05-11 |
Family
ID=68541064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19803487.8A Withdrawn EP3793982A4 (fr) | 2018-05-14 | 2019-05-13 | Inhibiteurs à petites molécules de la translocation nucléaire du récepteur des androgènes pour traiter le cancer de la prostate résistant à la castration |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3793982A4 (fr) |
JP (1) | JP2021523207A (fr) |
CA (1) | CA3099739A1 (fr) |
WO (1) | WO2019222105A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022140464A1 (fr) * | 2020-12-22 | 2022-06-30 | Immunomolecular Therapeutics, Inc. | Composés et méthodes de traitement de troubles auto-immuns par ciblage de hla-dq2 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017165822A1 (fr) * | 2016-03-24 | 2017-09-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Inhibiteur de type petite molécule de la translocation nucléaire du récepteur aux androgènes pour le traitement du cancer de la prostate résistant à la castration |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10980806B2 (en) * | 2016-03-24 | 2021-04-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
-
2019
- 2019-05-13 JP JP2020564224A patent/JP2021523207A/ja active Pending
- 2019-05-13 WO PCT/US2019/032033 patent/WO2019222105A1/fr unknown
- 2019-05-13 EP EP19803487.8A patent/EP3793982A4/fr not_active Withdrawn
- 2019-05-13 CA CA3099739A patent/CA3099739A1/fr active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017165822A1 (fr) * | 2016-03-24 | 2017-09-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Inhibiteur de type petite molécule de la translocation nucléaire du récepteur aux androgènes pour le traitement du cancer de la prostate résistant à la castration |
Non-Patent Citations (2)
Title |
---|
PAOLA CIAPETTI AND BRUNO GIETHLEN ED - CAMILLE GEORGES WERMUTH: "Chapter 15 - Molecular Variations Based on Isosteric Replacements", 1 January 2008, THE PRACTICE OF MEDICINAL CHEMISTRY (THIRD EDITION), ELSEVIER, NL, PAGE(S) 290 - 342, ISBN: 978-0-12-374194-3, XP009142466 * |
See also references of WO2019222105A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2021523207A (ja) | 2021-09-02 |
CA3099739A1 (fr) | 2019-11-21 |
EP3793982A1 (fr) | 2021-03-24 |
WO2019222105A1 (fr) | 2019-11-21 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20211220BHEP Ipc: A61K 31/498 20060101ALI20211220BHEP Ipc: A61K 31/496 20060101ALI20211220BHEP Ipc: A61K 31/495 20060101ALI20211220BHEP Ipc: A61K 31/407 20060101ALI20211220BHEP Ipc: A61K 31/403 20060101ALI20211220BHEP Ipc: A61K 31/40 20060101ALI20211220BHEP Ipc: A61K 31/165 20060101ALI20211220BHEP Ipc: A61K 31/12 20060101ALI20211220BHEP Ipc: C07D 487/04 20060101ALI20211220BHEP Ipc: C07D 233/61 20060101ALI20211220BHEP Ipc: C07D 207/08 20060101ALI20211220BHEP Ipc: C07D 207/06 20060101ALI20211220BHEP Ipc: C07D 409/02 20060101ALI20211220BHEP Ipc: C07C 49/563 20060101ALI20211220BHEP Ipc: C07D 209/52 20060101ALI20211220BHEP Ipc: C07D 295/185 20060101AFI20211220BHEP |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20220412 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20220406BHEP Ipc: A61K 31/498 20060101ALI20220406BHEP Ipc: A61K 31/496 20060101ALI20220406BHEP Ipc: A61K 31/495 20060101ALI20220406BHEP Ipc: A61K 31/407 20060101ALI20220406BHEP Ipc: A61K 31/403 20060101ALI20220406BHEP Ipc: A61K 31/40 20060101ALI20220406BHEP Ipc: A61K 31/165 20060101ALI20220406BHEP Ipc: A61K 31/12 20060101ALI20220406BHEP Ipc: C07D 487/04 20060101ALI20220406BHEP Ipc: C07D 233/61 20060101ALI20220406BHEP Ipc: C07D 207/08 20060101ALI20220406BHEP Ipc: C07D 207/06 20060101ALI20220406BHEP Ipc: C07D 409/02 20060101ALI20220406BHEP Ipc: C07C 49/563 20060101ALI20220406BHEP Ipc: C07D 209/52 20060101ALI20220406BHEP Ipc: C07D 295/185 20060101AFI20220406BHEP |
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Effective date: 20221115 |