EP3758851A4 - Integrated rotor devices for autonomous analytical centrifugation, integrated cell devices for autonomous analytical centrifugation, and methods of assembly and operation of same - Google Patents

Integrated rotor devices for autonomous analytical centrifugation, integrated cell devices for autonomous analytical centrifugation, and methods of assembly and operation of same Download PDF

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Publication number
EP3758851A4
EP3758851A4 EP19758305.7A EP19758305A EP3758851A4 EP 3758851 A4 EP3758851 A4 EP 3758851A4 EP 19758305 A EP19758305 A EP 19758305A EP 3758851 A4 EP3758851 A4 EP 3758851A4
Authority
EP
European Patent Office
Prior art keywords
analytical centrifugation
integrated
devices
autonomous
assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19758305.7A
Other languages
German (de)
French (fr)
Other versions
EP3758851A1 (en
Inventor
Christopher A. SUCATO
Mario Dipaola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Higher Order Tech LLC
Higher Order Technologies LLC
Original Assignee
Higher Order Tech LLC
Higher Order Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Higher Order Tech LLC, Higher Order Technologies LLC filed Critical Higher Order Tech LLC
Publication of EP3758851A1 publication Critical patent/EP3758851A1/en
Publication of EP3758851A4 publication Critical patent/EP3758851A4/en
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/08—Rotary bowls
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0332—Cuvette constructions with temperature control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G01N2015/045—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates by optical analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G01N21/455—Schlieren methods, e.g. for gradient index determination; Shadowgraph

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
EP19758305.7A 2018-02-26 2019-02-26 Integrated rotor devices for autonomous analytical centrifugation, integrated cell devices for autonomous analytical centrifugation, and methods of assembly and operation of same Pending EP3758851A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862635514P 2018-02-26 2018-02-26
PCT/US2019/019691 WO2019165478A1 (en) 2018-02-26 2019-02-26 Integrated rotor devices for autonomous analytical centrifugation, integrated cell devices for autonomous analytical centrifugation, and methods of assembly and operation of same

Publications (2)

Publication Number Publication Date
EP3758851A1 EP3758851A1 (en) 2021-01-06
EP3758851A4 true EP3758851A4 (en) 2022-01-26

Family

ID=67687937

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19758305.7A Pending EP3758851A4 (en) 2018-02-26 2019-02-26 Integrated rotor devices for autonomous analytical centrifugation, integrated cell devices for autonomous analytical centrifugation, and methods of assembly and operation of same

Country Status (5)

Country Link
US (1) US20210107015A1 (en)
EP (1) EP3758851A4 (en)
JP (2) JP2021516348A (en)
CA (1) CA3128974A1 (en)
WO (1) WO2019165478A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11465160B2 (en) 2016-09-16 2022-10-11 Fenwal, Inc. Blood separation systems and methods employing centrifugal and spinning membrane separation techniques
EP3705146A3 (en) 2019-03-05 2020-11-25 Fenwal, Inc. Collection of mononuclear cells and peripheral blood stem cells
EP4238595A3 (en) 2019-05-23 2023-11-29 Fenwal, Inc. Adjustment of target interface location between separated fluid components in a centrifuge
EP4238596A3 (en) 2019-05-23 2023-12-13 Fenwal, Inc. Centrifugal separation and collection of red blood cells or both red blood cells and plasma
EP3791904B1 (en) 2019-09-16 2022-02-09 Fenwal, Inc. Dynamic adjustment of algorithms for separation and collection of blood components
EP3834858A1 (en) 2019-12-12 2021-06-16 Fenwal, Inc. Systems enabling alternative approaches to therapeutic red blood cell exchange and/or therapeutic plasma exchange
DE102020109382A1 (en) 2020-04-03 2021-10-07 Gea Mechanical Equipment Gmbh Centrifuge and method of operating a centrifuge
CN111751341B (en) * 2020-06-24 2023-06-02 新乡市食品药品检验所 Traditional Chinese medicine component fluorescence analysis detector and analysis detection method
EP4347137A1 (en) * 2021-05-31 2024-04-10 Cytena Gmbh Centrifuge for rotating a sample carrier

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060205581A1 (en) * 2005-03-09 2006-09-14 Jacques Chammas Automated system and method for blood components separation and processing
EP2484391A1 (en) * 2011-02-04 2012-08-08 Fenwal, Inc. Control of interface between separated blood components under lipemic and hemolytic conditions
US20140371047A1 (en) * 2013-06-18 2014-12-18 L.U.M. Gmbh Centrifuge rotor
WO2016160962A1 (en) * 2015-04-01 2016-10-06 Weatherford Technology Holdings, Llc Centrifuge having onboard imaging system

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US1648369A (en) 1923-09-10 1927-11-08 Svedberg Theodor Analytical centrifuge
US2340825A (en) 1941-09-09 1944-02-01 Research Corp Centrifuge
GB812309A (en) 1956-03-14 1959-04-22 Beckman Instruments Inc Improvements in or relating to centrifuging
US3487994A (en) * 1968-05-08 1970-01-06 Canal Ind Corp Analytical ultracentrifuge cell
US4226537A (en) 1978-04-15 1980-10-07 Fisons Limited Analytical centrifuge with improved signal/noise ratio
JP3409463B2 (en) * 1994-10-07 2003-05-26 日立工機株式会社 Ultracentrifuge for analysis
AU2001261756A1 (en) * 2000-05-19 2001-12-03 Large Scale Proteomics Corporation Precision fluid gradient formation
KR100818274B1 (en) * 2006-09-05 2008-04-01 삼성전자주식회사 Apparatus and method of controlling the microfluidic system, and the microfluidic system
US8491454B2 (en) * 2008-12-02 2013-07-23 President And Fellows Of Harvard College Spinning force apparatus
CN201532349U (en) * 2009-10-16 2010-07-21 广东医学院 Detection device for nanopartical size
US9039992B2 (en) * 2011-06-06 2015-05-26 Abbott Laboratories Apparatus for closed tube sampling and open tube sampling for automated clinical analyzers
CN105378103B (en) * 2012-12-27 2018-01-16 成均馆大学校产学协力团 Using temperature-sensitive polymers compound body nucleic acid amplification disk device and utilize its analysis method
US20180304277A1 (en) * 2014-11-26 2018-10-25 Flsmidth A/S Methods and apparatus for the continuous monitoring of wear and pressure in centrifugal concentrators
DE112015006428T5 (en) * 2015-04-08 2017-12-21 Mann + Hummel Gmbh centrifugal
EP3312586B1 (en) * 2015-06-16 2020-12-16 Tascom Co., Ltd. Biological material measuring instrument

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060205581A1 (en) * 2005-03-09 2006-09-14 Jacques Chammas Automated system and method for blood components separation and processing
EP2484391A1 (en) * 2011-02-04 2012-08-08 Fenwal, Inc. Control of interface between separated blood components under lipemic and hemolytic conditions
US20140371047A1 (en) * 2013-06-18 2014-12-18 L.U.M. Gmbh Centrifuge rotor
WO2016160962A1 (en) * 2015-04-01 2016-10-06 Weatherford Technology Holdings, Llc Centrifuge having onboard imaging system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019165478A1 *

Also Published As

Publication number Publication date
US20210107015A1 (en) 2021-04-15
WO2019165478A1 (en) 2019-08-29
JP2021516348A (en) 2021-07-01
JP2024022589A (en) 2024-02-16
CA3128974A1 (en) 2019-08-29
EP3758851A1 (en) 2021-01-06

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