EP3718632B1 - Probe fluid analyzer system - Google Patents
Probe fluid analyzer system Download PDFInfo
- Publication number
- EP3718632B1 EP3718632B1 EP19167611.3A EP19167611A EP3718632B1 EP 3718632 B1 EP3718632 B1 EP 3718632B1 EP 19167611 A EP19167611 A EP 19167611A EP 3718632 B1 EP3718632 B1 EP 3718632B1
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- EP
- European Patent Office
- Prior art keywords
- probe fluid
- analyzer system
- sensor
- fluid analyzer
- probe
- Prior art date
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Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/023—Sending and receiving of information, e.g. using bluetooth
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
Definitions
- the disclosure relates to the field of analyzing probe fluids, and in particular to determining chemical, biochemical or physical quantities of a probe fluid collected in a container.
- WO 2016/010959 A1 discloses a probe fluid analyzer system which comprises a sample collecting cup, a cartridge serving as a lid of the cup and an electronic reader.
- the cartridge includes a fluid sample area and is used as a closure of the sample collecting cup. It is outfitted with metal electrodes that come in contact with the sample fluid trapped in the chamber.
- US 2018/0257068 A1 discloses a portable free-standing biological sample analysis device having a cover in which a data collection and analysis unit is integrated. A data analysis and display unit is mounted atop the cover and electrically connected to the data collection and analysis unit by wires.
- a probe fluid analyzer system includes a lid element for a container.
- a sensor is mounted or is mountable to the lid element.
- the sensor is configured to determine measurement data of a probe fluid to be stored in the container.
- An electronic circuitry electrically connected or connectable to the sensor is configured to generate a radio transmission signal carrying information based on the measurement data for transmission to an external radio receiver.
- the probe fluid analyzer system includes an antenna for transmitting the radio transmission signal to an external radio receiver.
- the antenna and the electronic circuitry are mounted on a support member which is permanently affixed to the lid element and acts as an intermediate holding structure to mount the sensor to the lid element.
- the terms “attached”, “mounted”, “connected”, “coupled” and/or “electrically connected/electrically coupled” are not meant to mean that the elements or layers must directly be contacted together; intervening elements may be provided between the “attached”, “mounted”, “connected”, “coupled” and/or “electrically connected/electrically coupled” elements, respectively.
- the above-mentioned terms may, optionally, also have the specific meaning that the elements are directly contacted together, i.e. that no intervening elements are provided between the "attached”, “mounted”, “connected”, “coupled” and/or “electrically connected/electrically coupled” elements, respectively.
- an embodiment of a probe fluid analyzer system 100 includes a lid element 110 for a container.
- the lid element 110 may, e.g., have a plate-shaped design. It can be placed on the container 150, which may but does not need to form a part of the probe fluid analyzer system 110.
- the container 150 is therefore illustrated by a dashed dotted line in Figure 1 .
- the container 150 is configured to store a probe fluid 160 to be analyzed.
- probe fluids 160 could be used for the probe fluid analyzer system 110.
- the probe fluid 160 may be a body-fluid such as, e.g., urine or blood.
- the probe fluid 160 may alternatively be a fluid such as, e.g., water or a liquid extracted from food products such as juice, oils, milk products, baby food, etc.
- the container 150 may be a special container such as, e.g., a beaker (urine beaker), a test tube (such as, e.g., a blood or urine tube) etc.
- the container 150 typically matches with the lid element 110 in some way, e.g. in size, in having a mutually engaging closure mechanics or even in terms of electrical connections between the lid element 110 and the container 150.
- the container 150 may also be a simple "everyday" container such as, e.g., a drinking glass, a bottle, a plastic cup, a pot (e.g. jam pot a baby food pot), etc.
- Such containers 150 need not to have any technical or structural relationship to the lid element 110, except, e.g., their size.
- the probe fluid analyzer system 100 further includes a sensor 120.
- the sensor 120 is mounted or is mountable to the lid element 110.
- the intermediate holding structure is typically equipped with a sensor socket or receptacle (not shown in Figure 1 ), which allows to remove the sensor 120 and allows to attach a new one, if desired.
- the probe fluid analyzer system 100 may be designed only for single use, if the sensor 120 is a non-exchangeable sensor, the probe fluid analyzer system 100 may, e.g., also be designed for multiple use, if, e.g., an exchangeable sensor 120 is provided. In general, however, depending on the type of the sensor 120, it may also be possible that a multiple use probe fluid analyzer system 100 uses the same, non-exchangeable sensor 120 (e.g. if the sensor 120 is an optical sensor or if the sensor could be cleaned and reused after operation).
- the senor 120 may be an electrochemical sensor, a biochemical sensor, a sensor configured to sense one or more physical properties, e.g. a sensor to sense temperature, optical properties such as color, reflectivity, etc.
- the sensor 120 may determine measurement data of the probe fluid 160 indicative of one or more of a glucose concentration, a ph-value, a salt concentration, a potassium concentration, a concentration of a chemical substance, a concentration of a biochemical substance, or an electrical conductivity value of the probe fluid 160.
- the senor 120 may be configured to determine the concentration of one or more proteins such as, e.g., of the connecting peptide (C-peptide) which is known to be used for the diagnosis of diseases such as, e.g., diabetes or other metabolic disorders. Further, concentrations of antibodies, hormones, or other probe fluid ingredients indicative of the body condition or indicative of the probe fluid quality (e.g. water quality, food product quality) could be sensed by the sensor 120.
- the concentration of one or more proteins such as, e.g., of the connecting peptide (C-peptide) which is known to be used for the diagnosis of diseases such as, e.g., diabetes or other metabolic disorders.
- concentrations of antibodies, hormones, or other probe fluid ingredients indicative of the body condition or indicative of the probe fluid quality e.g. water quality, food product quality
- the sensor 120 is configured to determine measurement data of the probe fluid 160.
- the measurement data is communicated to an electronic circuitry 130.
- the electronic circuitry 130 is configured to generate a radio transmission signal which carries information based on the measurement data.
- the probe fluid analyzer system 100 includes an antenna 140, which is configured to transmit the radio transmission signal to an external radio receiver (not shown).
- the external radio receiver (also termed as an external reader) may, e.g., be a cellular phone, a personal computer, a tablet personal computer, or a watch.
- Figure 2 illustrates a block diagram of the electronic circuitry 130 coupled to the sensor 120 and to the antenna 140.
- the electronic circuitry 130 may include a first interface (IF) 130_1 interfacing the electronic circuitry 130 to the sensor 120, and may include a second interface (IF) 130_2 interfacing the electronic circuitry 130 to the antenna 140.
- the electronic circuitry 130 may include an integrated circuit (IC) such as, e.g., a microprocessor 130_3.
- IC integrated circuit
- the electronic circuitry 130 may be realized as a monolithic circuit, e.g. as a single semiconductor chip. It is also possible that the electronic circuitry 130 is realized by two or more semiconductor chips, e.g. by a signal processor or baseband chip, which provides for sensor signal interfacing and which processes and/or evaluates the measurement data, and by a RF (Radio Frequency) chip, which provides for radio transmission signal generation and wireless communication standard protocol interfacing. Further, the sensor 120 may be integrated in the same semiconductor chip in which the electronic circuit 130 or a portion of the electronic circuit 130 is implemented.
- the first interface 130_1 may receive (e.g. analog) measurement data from the sensor 120.
- the first interface 130_1 may, e.g., be configured to convert the analog measurement data into digital measurement data.
- the microprocessor 130_3 may process the (analog or digital) measurement data. Data processing may include evaluation of the measurement signals to determine the measurement quantities such as, e.g., concentrations of the various ingredients, temperature, optical or other physical properties, etc.
- the microprocessor 130_3 may be configured to evaluate the measurement data received from the sensor 120 via the first interface 130_1 in accordance with the function of the probe fluid analyzer system 100.
- the second interface 130_2 is a wireless communication interface configured to generate a radio transmission signal based on the measurement data (e.g. on the processed measurement data provided by the microprocessor 130_3 as described above). To that end, the second interface 130_2 operates in accordance with a wireless communication standard such as, e.g., the NFC (Near Field Communication) standard, the RFID (Radio Frequency Identification) standard or any other appropriate wireless data communication standard.
- a wireless communication standard such as, e.g., the NFC (Near Field Communication) standard, the RFID (Radio Frequency Identification) standard or any other appropriate wireless data communication standard.
- NFC is a short range technology that enables devices to communicate when they are brought into close proximity of only a few centimeters distance. NFC enables two devices to share power and data using magnetic field induction at short range.
- the external radio receiver may be an active tag (transponder), wherein active means that the device has an own power source (battery).
- the electronic circuitry 130 may, e.g., be a passive tag (transponder). In this case, the electronic circuitry 130 does not have an own power source (battery). Rather, the energy to operate the electronic circuitry 130 and the sensor 120 is then wirelessly provided by the reader (i.e. the external radio receiver) and is harvested in the electronic circuitry 130 for operation.
- RFID is a wireless communication standard which is similar to NFC.
- the reader cannot act as tag (transponder), i.e. data exchange is only possible from the electronic circuitry 130 to the external radio receiver (reader).
- RFID tag is powered by the reader to harvest the energy for operation if the RFID tag (i.e. the electronic circuitry 130) is a passive tag (i.e. without own power source).
- any wireless data communication technology and/or standard may be used for transmitting the radio transmission signal to the external radio receiver and, optionally, for data exchange between the external radio receiver and the electronic circuitry 130 (as it is, e.g., also possible in NFC).
- the second interface 130_2 may be a wireless data communication interface 130_2 configured to exchange data between the electronic circuitry 130 via the antenna 140 with the external radio receiver and configured to harvest energy provided by the external radio receiver via the antenna 140 for operating the electronic circuitry 130 (which may represent a passive transponder).
- FIG 3 illustrates an exemplary probe fluid analyzer system 300.
- the probe fluid analyzer system 300 is similar to the probe fluid analyzer system 100, and reference is made to the description above in order to avoid reiteration.
- the antenna 140 is mounted on the lid element 110.
- the antenna 140 may be mounted on an upper surface 110A of the lid element 110.
- the antenna 140 may be shaped as a coil which runs along the edge of the lid element 110.
- the electronic circuitry 130 may, e.g., also be mounted on the upper surface 110A of the lid element 110.
- the sensor 120 may comprise a strip-shaped carrier element 122 supporting a plurality of electrodes 120_1, 120_2.
- the electrodes 120_1, 120_2 may, e.g., be formed out of a structured electrode layer disposed on the carrier element 120.
- the carrier element 120 may be fixedly or detachably connected to the lid element 110 via an intermediate member as described in more detail further below.
- Conducting paths 124_1, 124_2 running on the carrier element 122 may electrically connect the electrodes 120_1, 120_2 to the electronic circuitry 130.
- the electronic circuitry 130 is arranged at the outside of the probe fluid volume defined by the container 150 and the lid element 110. However, it is also possible that the electronic circuitry 130 is arranged in the interior of this volume. To this end, the electronic circuitry 130 may be mounted on the lower surface 110B of the lid element 110. Further, it is possible that the electronic circuitry 130 is located at a place where it is immersed in the probe fluid during determination of measurement data. This option allows the electronic circuitry 130 to also collect measurement data, e.g. temperature data (since the electronic circuitry 130 is in many cases already equipped with a temperature sensor).
- measurement data e.g. temperature data (since the electronic circuitry 130 is in many cases already equipped with a temperature sensor).
- the senor 120 and the electronic circuitry are monolithically integrated in the same semiconductor chip.
- FIGS 4, 5 and 6 illustrate various views of a probe fluid analyzer system 400.
- the probe fluid analyzer system 400 is similar to the probe fluid analyzer system 300, and reference is made to the above disclosure to avoid reiteration.
- the probe fluid analyzer system 400 may be a urine beaker.
- the container 150 may be transparent and/or may be provided with a screw closure (not shown) at its upper rim.
- the lid element 110 can be tightly screwed on the container 150 so as to hermetically seal the lid 110 to the container 150.
- the circular antenna 140 and the electronic circuitry 130 is mounted on a support member 420, e.g. a common printed circuit board (PCB), which might be a flexible PCB.
- the support member 420 (e.g. PCB) is used as an intermediate holding structure to mount the sensor 120 to the lid element 110.
- the carrier 122 of the sensor 120 is fixedly or detachably attached to the support member 420, see Figure 6 , which is permanently affixed (e.g. glued, laminated, etc.) to the lid element 110, e.g. the upper surface 110A thereof, see Figures 4 and 5 .
- the sensor 120 may reach into the container 150 through an opening 610 in the lid element 110.
- the opening 610 may either open into a measuring chamber as will be described in more detail further below or directly into the container 150.
- Figure 7 illustrates an exemplary probe fluid analyzer system 700.
- the probe fluid analyzer system 700 may be implemented in any of the aforementioned probe fluid analyzer systems 100, 300, 400. Therefore, features of the probe fluid analyzer system 700 described in the following can readily be applied to the probe fluid analyzer systems 100, 300, 400 and vice versa.
- the probe fluid analyzer system 700 is (optionally) provided with a measuring chamber 760.
- the measuring chamber 760 may be arranged at the lid element 110.
- the measuring chamber 760 may be integrally formed with the lid element 110.
- the measuring chamber 760 may be bordered by a chamber wall 710 separating the measuring chamber 760 from the residual interior of the container 150.
- the chamber wall 710 may, e.g., be integrally formed with the lid element 110, i.e. the lid element 110 and the chamber wall 710 may be formed in one piece, e.g. in one plastic piece.
- the chamber wall 710 may be shaped as depression of the lid element 110.
- the support member 420 or any other element does not carry the electronic circuitry 130 and the antenna 140 may be used to hermetically seal the measuring chamber 760 at its opening 610 in the lid element 110.
- the lid element 110 may, e.g., have a rim 112, which is, e.g., equipped with a closure mechanics (e.g. screw closure) configured to hermetically connect the lid element 110 to the container 150.
- the closure mechanics of the probe fluid analyzer system 700 or any other probe fluid analyzer system disclosed herein may be designed in a manner that it cannot be re-opened without damage. Such protection against reopening the probe fluid analyzer system may be useful in cases of hazardous probe fluids or to prevent unlawful opening (e.g. as in the case of doping tests).
- the measuring chamber 760 is configured to receive probe fluid from the container 150 in order to determine the measurement data from the probe fluid 160 in the measuring chamber 760.
- An exemplary process to feed the measuring chamber 760 with probe fluid 160 from the container 150 is illustrated in Figures 8 to 10 .
- the measuring chamber 760 may be configured to be automatically filled by the probe fluid 160 once the lid element 110 is placed on the container 150. Moreover, in various examples, the measuring chamber 760 may be configured to be filled by a predetermined volume of probe fluid 160.
- the lid element 110 is placed (e.g. screwed) on the container 150.
- the chamber wall 710 may have a probe fluid intake 712.
- the probe fluid intake 712 may be located on a specific height over the bottom of the measuring chamber 760. The height of the probe fluid intake 712 may control the automatic filling process and may accurately determine the amount of probe fluid 160 which enters the measuring chamber 760 during the filling process as, e.g., shown in Figures 8 to 10 .
- the probe fluid intake 712 may simply be a hole in the chamber wall 710. In other examples, the probe fluid intake 712 may be configured to suppress discharge of the probe fluid 160 from the measuring chamber 760 back into the container 150.
- the probe fluid intake 712 may be a mechanical filter, a diffusion barrier, a valve or a combination of these elements.
- a mechanical filter may, e.g., be used to prevent suspended bodies or particles to enter the measuring chamber 760. Suspended bodies or particles could impair the measurement, if they physically engage with the sensor 120 or, in particular, with the electrodes 120_1, 120_2 of the sensor 120.
- a diffusion barrier and/or a valve could, in particular, be useful if the measuring chamber 760 simultaneously acts as a reaction chamber.
- one or more reaction substances may be deposited in the measuring chamber 760.
- the sensor 120 and, in particular, the electrodes 120_1, 120_2 of the sensor 120 may be covered with reaction substances such as, e.g., antibodies or enzymes.
- the operation of the probe fluid analyzer system 700 may then rely on the measurement of the concentration of reaction products generated by the reaction between the reaction substances deposited in the measuring chamber 760 and ingredients of the probe fluid 160. Such measurements may rely both on the exact knowledge of the probe fluid diagnosis volume in the measuring chamber 760 and/or on the prevention of ongoing probe fluid exchange between the measuring chamber 760 and the container 150 during measurement.
- Figure 9 illustrates a stage during the automatic filling of the measuring chamber 760 shortly before the sensor 120 is immersed in the probe fluid 160.
- Figure 10 illustrates a final state of the filling process.
- a predetermined filling level is obtained because the probe fluid 160 in the measuring chamber 760 traps the air above the probe fluid 160 once the filling level exceeds the probe fluid intake 712.
- the residual air trapped over the probe fluid in the measuring chamber 760 may also serve to keep the carrier element 122 and/or the conducting paths 124_1, 124_2 dry and clean.
- a concentration of an ingredient of the probe fluid 160 is directly determined by the sensor 120 and/or that a quantity of the probe fluid 160 is determined which does not rely on a certain dosage volume and/or the prevention of fluid exchange between the measuring chamber 760 and the container 150.
- a simple through hole or a mechanical filter may be sufficient to serve as the probe fluid intake 712 to the measuring chamber 760, or the measuring chamber 760 may completely be avoided.
- the measuring chamber 760 may be applied with a vacuum which controls the filling process.
- a puncturing device such as, e.g., a hollow needle 1012 may be provided in the container 150, e.g. mounted at the bottom of the container 150. The puncturing device may cause the measuring chamber 760 to be punctured once the lid element 110 is placed (e.g. screwed or otherwise fixedly closed) on the container 150.
- the probe fluid 160 may then be sucked into the measuring chamber 760.
- the amount of probe fluid 160 sucked into the measuring chamber 760 may be controlled by the pressure of the vacuum and/or by the size of the measuring chamber 760 (e.g. if the measuring chamber 760 is completely filled with probe fluid 160).
- an external radio receiver 1050 such as, e.g., a cellular phone or a smartphone or any other reader device may be brought into proximity to the lid element 110 of the probe fluid analyzer system 700. For instance, the external radio receiver may simply be put down on the lid element 110. As already described above, the external radio receiver 1050 may then power the electronic circuitry 130 and the sensor 120 via the antenna 140 and may read out the information based on the measurement data. A software application program running on the external radio receiver 1050 may be used to control the communication with the electronic circuitry 130 and to display, manage and/or store the received information data.
- a software application program running on the external radio receiver 1050 may be used to control the communication with the electronic circuitry 130 and to display, manage and/or store the received information data.
- FIGs 12A and 12B illustrate further examples of a probe fluid analyzer system 1200.
- a measuring chamber 1260 may be provided in a space directly below the lower surface 110B of the lid element 110.
- the measuring chamber 1260 may be formed as an integral part of the lid element 110.
- the measurement chamber 1260 may be defined by a chamber wall 1210 which may form a part of the lid element 110.
- the vertical dimension of the measurement chamber 1260 may in this example be relatively small, e.g. equal to or less than a few (say 2, 3, 4, 5 or 10) millimeters.
- the chamber wall 1210 may be provided with a probe fluid intake 1212, which may be designed similar as the probe fluid intake 712, and reference is made to the above disclosure in order to avoid reiteration.
- the electronic circuitry 130 may be located outside of the measuring chamber 1260, while in the example of Figure 12B the electronic circuitry 130 is located in the interior of the measuring chamber 1260 together with the sensor 120. In the latter case, as mentioned before, the electronic circuitry 130 can contribute to the determining of measurement data such as, e.g., temperature data.
- the measuring chamber 1260 may be completely filled by probe fluid 160. Therefore, the probe fluid analyzer system 1200 can also provide for a predetermined volume of probe fluid 160 to be analyzed as required in some applications.
- Figures 13 to 17 illustrate exemplary operation stages of a probe fluid analyzer system 1200.
- probe fluid 160 has been collected in the container 150. Again, all kinds of probe fluid 160 and/or containers 150 may be used.
- the container 150 is then closed by the lid assembly as, e.g., illustrated in Figures 12A or 12B .
- the term probe fluid analyzer system 1200 may again either relate only to the lid assembly, as for instance illustrated in Figures 12A and 12B , or to the combination of the container 150 and the lid assembly as shown in Figure 14 .
- the measuring chamber 1260 may then be completely filled.
- the fluid analyzer system 1200 may be turned upside down to completely fill the measuring chamber 1260 with probe fluid 160.
- Other possibilities to completely fill the measuring chamber 1260 with probe fluid 160 may rely on applying the measuring chamber 1260 with a vacuum and puncturing the measuring chamber 1260, e.g. by a hollow needle (see Figure 11 ).
- the measuring chamber 1260 may be completely filled by probe fluid 160 without the need of turning the probe fluid analyzer system 1200 upside down.
- the measuring chamber 1260 may be completely filled by gravity. Then, as illustrated in Figure 16 , the probe fluid analyzer system 1200 is a second time turned upside down. The probe fluid 160 remains in the measuring chamber 1260. This may be achieved either due to the effect of capillary forces and the small amount of probe fluid pressuring against the probe fluid intake 1212 (even if the probe fluid intake 1212 is merely a hole) or may be supported by additional features such as a specific design (e.g. filter, diffusion barrier, valve, etc.) of the probe fluid intake 1212 as already mentioned.
- the probe fluid analyzer system 1200 completely excludes any possibility of fluid exchange between the measuring chamber 1260 and the container 150 after completion of the filling process.
- the probe fluid measuring chamber 760, 1260 may be a sterile volume which might be filled with a protective gas or vacuum.
- Figure 17 corresponds to the wireless data communication process of Figures 10 and 11 , and reference is made to the above description for the sake of brevity.
- Waste disposal of the probe fluid analyzer systems described herein may depend on the specific application (in particular the kind of probe fluid 160) and the specific design of the probe fluid analyzer system. However, it is believed that existing waste disposal management processes may at least partly be applicable to the probe fluid analyzer systems disclosed herein.
- a further aspect of the disclosure involves the return of the filled probe fluid analyzer systems to the producer.
- the producer may then use laboratory analytics to verify the measurement data and/or the information based on the measurement data as computed by the electronic circuitry 130.
- These quantities may be stored in a non-volatile memory of the electronic circuitry 130 and could be used to develop and refine the acquisition, evaluation and/or interpretation of the measurement data for product advancements.
- the probe fluid analyzer system disclosed herein allows for a simple and inexpensive probe fluid analysis on the ground. There is not much the user can do wrong and the user does not need to come into contact with the probe fluid sample.
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Description
- The disclosure relates to the field of analyzing probe fluids, and in particular to determining chemical, biochemical or physical quantities of a probe fluid collected in a container.
- Chemical or biochemical analysis of fluids such as body-fluids, food products, beverages, water etc. is typically carried out in laboratories. This involves collecting the fluid to be analyzed in a container, sealing the container, transferring the container to the laboratory, performing the analysis and communicating the analysis result back to the remitter. This process is well established, mostly avoids any possible risk of contamination and allows highly accurate analysis results. However, it is time consuming and expensive.
- Therefore, on-site testing of fluids has gained increasing importance over the past years. On-site testing allows to obtain analysis results swiftly and in an autonomous manner. However, on-site testing is typically challenged by low accuracy of analysis results, significant risk of contamination and possible hygienic shortcomings. Further, the handling of on-site test kits can be inconvenient or difficult for some people.
WO 2016/010959 A1 discloses a probe fluid analyzer system which comprises a sample collecting cup, a cartridge serving as a lid of the cup and an electronic reader. The cartridge includes a fluid sample area and is used as a closure of the sample collecting cup. It is outfitted with metal electrodes that come in contact with the sample fluid trapped in the chamber. -
US 2018/0257068 A1 discloses a portable free-standing biological sample analysis device having a cover in which a data collection and analysis unit is integrated. A data analysis and display unit is mounted atop the cover and electrically connected to the data collection and analysis unit by wires. - According to an aspect, a probe fluid analyzer system includes a lid element for a container. A sensor is mounted or is mountable to the lid element. The sensor is configured to determine measurement data of a probe fluid to be stored in the container. An electronic circuitry electrically connected or connectable to the sensor is configured to generate a radio transmission signal carrying information based on the measurement data for transmission to an external radio receiver. The probe fluid analyzer system includes an antenna for transmitting the radio transmission signal to an external radio receiver. The antenna and the electronic circuitry are mounted on a support member which is permanently affixed to the lid element and acts as an intermediate holding structure to mount the sensor to the lid element.
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Figure 1 is a schematic illustration of an exemplary probe fluid analyzer system. -
Figure 2 is a block diagram of an electronic circuitry coupled to a sensor and an antenna. -
Figure 3 is an illustration of an exemplary probe fluid analyzer system. -
Figure 4 is a perspective view of an exemplary probe fluid analyzer system. -
Figure 5 is a top view on the exemplary probe fluid analyzer system ofFigure 4 . -
Figure 6 is a perspective view of the exemplary probe fluid analyzer system ofFigure 4 where the sensor, the electronic circuitry and the antenna are disassembled from the lid element. -
Figure 7 is a sectional view of an exemplary probe fluid analyzer system equipped with a measuring chamber. -
Figure 8 is a sectional view of the exemplary probe fluid analyzer system ofFigure 7 further including a container for the probe fluid. -
Figure 9 is a sectional view of the exemplary probe fluid analyzer system ofFigure 8 during the process of filling the measuring chamber with probe fluid. -
Figure 10 is a sectional view of the exemplary probe fluid analyzer system ofFigure 9 after completion of the process of filling the measuring chamber with probe fluid and during transmission of the information based on the measurement data to a radio receiver. -
Figure 11 is a sectional view of a further exemplary probe fluid analyzer system including a tool for opening an intake to the measuring chamber for filling the measuring chamber with probe fluid. -
Figures 12A-B are sectional views of further exemplary probe fluid analyzer systems equipped with a measuring chamber. -
Figure 13 is a sectional view of an exemplary container for the probe fluid after probe fluid collection. -
Figure 14 is a sectional view of the exemplary probe fluid analyzer system ofFigure 12A combined with the container ofFigure 13 . -
Figure 15 is a sectional view of the exemplary probe fluid analyzer system ofFigure 14 during the process of filling the measuring chamber with probe fluid by turning the probe fluid analyzer system upside down. -
Figure 16 is a sectional view of the exemplary probe fluid analyzer system ofFigure 15 after completion of the process of filling the measuring chamber with probe fluid and after turning the probe fluid analyzer system a second time upside down. -
Figure 17 is a sectional view of the exemplary probe fluid analyzer system ofFigure 16 during transmission of the information based on the measurement data to a radio receiver. - It is to be understood that the features of the various exemplary embodiments and examples described herein may be combined with each other, unless specifically noted otherwise. Further, identical or similar parts are referenced by the same reference numerals throughout the various embodiments and examples.
- As used in this specification, the terms "attached", "mounted", "connected", "coupled" and/or "electrically connected/electrically coupled" are not meant to mean that the elements or layers must directly be contacted together; intervening elements may be provided between the "attached", "mounted", "connected", "coupled" and/or "electrically connected/electrically coupled" elements, respectively. However, in accordance with the disclosure, the above-mentioned terms may, optionally, also have the specific meaning that the elements are directly contacted together, i.e. that no intervening elements are provided between the "attached", "mounted", "connected", "coupled" and/or "electrically connected/electrically coupled" elements, respectively.
- Referring to
Figure 1 , an embodiment of a probefluid analyzer system 100 includes alid element 110 for a container. Thelid element 110 may, e.g., have a plate-shaped design. It can be placed on thecontainer 150, which may but does not need to form a part of the probefluid analyzer system 110. Thecontainer 150 is therefore illustrated by a dashed dotted line inFigure 1 . - The
container 150 is configured to store aprobe fluid 160 to be analyzed. A variety ofprobe fluids 160 could be used for the probefluid analyzer system 110. By way of example, theprobe fluid 160 may be a body-fluid such as, e.g., urine or blood. Theprobe fluid 160 may alternatively be a fluid such as, e.g., water or a liquid extracted from food products such as juice, oils, milk products, baby food, etc. - Hence, the
container 150 may be a special container such as, e.g., a beaker (urine beaker), a test tube (such as, e.g., a blood or urine tube) etc. In this case, thecontainer 150 typically matches with thelid element 110 in some way, e.g. in size, in having a mutually engaging closure mechanics or even in terms of electrical connections between thelid element 110 and thecontainer 150. On the other hand, thecontainer 150 may also be a simple "everyday" container such as, e.g., a drinking glass, a bottle, a plastic cup, a pot (e.g. jam pot a baby food pot), etc.Such containers 150 need not to have any technical or structural relationship to thelid element 110, except, e.g., their size. - The probe
fluid analyzer system 100 further includes asensor 120. Thesensor 120 is mounted or is mountable to thelid element 110. As will be described in more detail further below, this means that thesensor 120 may be permanently fixed at thelid element 110 by using an intermediate holding structure or may be anexchangeable sensor 120 which could be detached from the intermediate holding structure to be replaced by anew sensor 120. In the latter case, the intermediate holding structure is typically equipped with a sensor socket or receptacle (not shown inFigure 1 ), which allows to remove thesensor 120 and allows to attach a new one, if desired. - Differently put, while the probe
fluid analyzer system 100 may be designed only for single use, if thesensor 120 is a non-exchangeable sensor, the probefluid analyzer system 100 may, e.g., also be designed for multiple use, if, e.g., anexchangeable sensor 120 is provided. In general, however, depending on the type of thesensor 120, it may also be possible that a multiple use probefluid analyzer system 100 uses the same, non-exchangeable sensor 120 (e.g. if thesensor 120 is an optical sensor or if the sensor could be cleaned and reused after operation). - A variety of
sensors 120 and/or sensing functions could be provided within the scope of this disclosure. By way of example, thesensor 120 may be an electrochemical sensor, a biochemical sensor, a sensor configured to sense one or more physical properties, e.g. a sensor to sense temperature, optical properties such as color, reflectivity, etc. For example, thesensor 120 may determine measurement data of theprobe fluid 160 indicative of one or more of a glucose concentration, a ph-value, a salt concentration, a potassium concentration, a concentration of a chemical substance, a concentration of a biochemical substance, or an electrical conductivity value of theprobe fluid 160. In particular, thesensor 120 may be configured to determine the concentration of one or more proteins such as, e.g., of the connecting peptide (C-peptide) which is known to be used for the diagnosis of diseases such as, e.g., diabetes or other metabolic disorders. Further, concentrations of antibodies, hormones, or other probe fluid ingredients indicative of the body condition or indicative of the probe fluid quality (e.g. water quality, food product quality) could be sensed by thesensor 120. - The
sensor 120 is configured to determine measurement data of theprobe fluid 160. The measurement data is communicated to anelectronic circuitry 130. Theelectronic circuitry 130 is configured to generate a radio transmission signal which carries information based on the measurement data. Further, the probefluid analyzer system 100 includes anantenna 140, which is configured to transmit the radio transmission signal to an external radio receiver (not shown). As will be described in more detail further below, the external radio receiver (also termed as an external reader) may, e.g., be a cellular phone, a personal computer, a tablet personal computer, or a watch. -
Figure 2 illustrates a block diagram of theelectronic circuitry 130 coupled to thesensor 120 and to theantenna 140. Theelectronic circuitry 130 may include a first interface (IF) 130_1 interfacing theelectronic circuitry 130 to thesensor 120, and may include a second interface (IF) 130_2 interfacing theelectronic circuitry 130 to theantenna 140. Further, theelectronic circuitry 130 may include an integrated circuit (IC) such as, e.g., a microprocessor 130_3. - The
electronic circuitry 130 may be realized as a monolithic circuit, e.g. as a single semiconductor chip. It is also possible that theelectronic circuitry 130 is realized by two or more semiconductor chips, e.g. by a signal processor or baseband chip, which provides for sensor signal interfacing and which processes and/or evaluates the measurement data, and by a RF (Radio Frequency) chip, which provides for radio transmission signal generation and wireless communication standard protocol interfacing. Further, thesensor 120 may be integrated in the same semiconductor chip in which theelectronic circuit 130 or a portion of theelectronic circuit 130 is implemented. - The first interface 130_1 may receive (e.g. analog) measurement data from the
sensor 120. The first interface 130_1 may, e.g., be configured to convert the analog measurement data into digital measurement data. The microprocessor 130_3 may process the (analog or digital) measurement data. Data processing may include evaluation of the measurement signals to determine the measurement quantities such as, e.g., concentrations of the various ingredients, temperature, optical or other physical properties, etc. In other words, the microprocessor 130_3 may be configured to evaluate the measurement data received from thesensor 120 via the first interface 130_1 in accordance with the function of the probefluid analyzer system 100. - The second interface 130_2 is a wireless communication interface configured to generate a radio transmission signal based on the measurement data (e.g. on the processed measurement data provided by the microprocessor 130_3 as described above). To that end, the second interface 130_2 operates in accordance with a wireless communication standard such as, e.g., the NFC (Near Field Communication) standard, the RFID (Radio Frequency Identification) standard or any other appropriate wireless data communication standard.
- NFC is a short range technology that enables devices to communicate when they are brought into close proximity of only a few centimeters distance. NFC enables two devices to share power and data using magnetic field induction at short range. By way of example, the external radio receiver (reader) may be an active tag (transponder), wherein active means that the device has an own power source (battery). The
electronic circuitry 130 may, e.g., be a passive tag (transponder). In this case, theelectronic circuitry 130 does not have an own power source (battery). Rather, the energy to operate theelectronic circuitry 130 and thesensor 120 is then wirelessly provided by the reader (i.e. the external radio receiver) and is harvested in theelectronic circuitry 130 for operation. - RFID is a wireless communication standard which is similar to NFC. However, in RFID the reader cannot act as tag (transponder), i.e. data exchange is only possible from the
electronic circuitry 130 to the external radio receiver (reader). Similar to NFC the electronic circuitry 130 (RFID tag) is powered by the reader to harvest the energy for operation if the RFID tag (i.e. the electronic circuitry 130) is a passive tag (i.e. without own power source). - In general, any wireless data communication technology and/or standard may be used for transmitting the radio transmission signal to the external radio receiver and, optionally, for data exchange between the external radio receiver and the electronic circuitry 130 (as it is, e.g., also possible in NFC).
- Hence, the second interface 130_2 may be a wireless data communication interface 130_2 configured to exchange data between the
electronic circuitry 130 via theantenna 140 with the external radio receiver and configured to harvest energy provided by the external radio receiver via theantenna 140 for operating the electronic circuitry 130 (which may represent a passive transponder). -
Figure 3 illustrates an exemplary probefluid analyzer system 300. The probefluid analyzer system 300 is similar to the probefluid analyzer system 100, and reference is made to the description above in order to avoid reiteration. Moreover, in the probefluid analyzer system 300, theantenna 140 is mounted on thelid element 110. As shown inFigure 3 , theantenna 140 may be mounted on anupper surface 110A of thelid element 110. Theantenna 140 may be shaped as a coil which runs along the edge of thelid element 110. Theelectronic circuitry 130 may, e.g., also be mounted on theupper surface 110A of thelid element 110. - The
sensor 120 may comprise a strip-shapedcarrier element 122 supporting a plurality of electrodes 120_1, 120_2. The electrodes 120_1, 120_2 may, e.g., be formed out of a structured electrode layer disposed on thecarrier element 120. Thecarrier element 120 may be fixedly or detachably connected to thelid element 110 via an intermediate member as described in more detail further below. Conducting paths 124_1, 124_2 running on thecarrier element 122 may electrically connect the electrodes 120_1, 120_2 to theelectronic circuitry 130. - It is to be noted that in the exemplary probe
fluid analyzer system 300 shown inFigure 3 , theelectronic circuitry 130 is arranged at the outside of the probe fluid volume defined by thecontainer 150 and thelid element 110. However, it is also possible that theelectronic circuitry 130 is arranged in the interior of this volume. To this end, theelectronic circuitry 130 may be mounted on thelower surface 110B of thelid element 110. Further, it is possible that theelectronic circuitry 130 is located at a place where it is immersed in the probe fluid during determination of measurement data. This option allows theelectronic circuitry 130 to also collect measurement data, e.g. temperature data (since theelectronic circuitry 130 is in many cases already equipped with a temperature sensor). And still further, as mentioned earlier, it is possible that thesensor 120 and the electronic circuitry (or a portion of theelectronic circuitry 130 such as, e.g., IF 130_1 and/or IC 130_2 and/or IF 130_3) are monolithically integrated in the same semiconductor chip. -
Figures 4, 5 and 6 illustrate various views of a probefluid analyzer system 400. The probefluid analyzer system 400 is similar to the probefluid analyzer system 300, and reference is made to the above disclosure to avoid reiteration. - As an example and without loss of generality, the probe
fluid analyzer system 400 may be a urine beaker. In this and many other cases, thecontainer 150 may be transparent and/or may be provided with a screw closure (not shown) at its upper rim. Thelid element 110 can be tightly screwed on thecontainer 150 so as to hermetically seal thelid 110 to thecontainer 150. Thecircular antenna 140 and theelectronic circuitry 130 is mounted on asupport member 420, e.g. a common printed circuit board (PCB), which might be a flexible PCB. The support member 420 (e.g. PCB) is used as an intermediate holding structure to mount thesensor 120 to thelid element 110. More specifically, thecarrier 122 of thesensor 120 is fixedly or detachably attached to thesupport member 420, seeFigure 6 , which is permanently affixed (e.g. glued, laminated, etc.) to thelid element 110, e.g. theupper surface 110A thereof, seeFigures 4 and 5 . Thesensor 120 may reach into thecontainer 150 through anopening 610 in thelid element 110. Theopening 610 may either open into a measuring chamber as will be described in more detail further below or directly into thecontainer 150. -
Figure 7 illustrates an exemplary probefluid analyzer system 700. The probefluid analyzer system 700 may be implemented in any of the aforementioned probefluid analyzer systems fluid analyzer system 700 described in the following can readily be applied to the probefluid analyzer systems - The probe
fluid analyzer system 700 is (optionally) provided with a measuringchamber 760. The measuringchamber 760 may be arranged at thelid element 110. In particular, the measuringchamber 760 may be integrally formed with thelid element 110. - The measuring
chamber 760 may be bordered by achamber wall 710 separating the measuringchamber 760 from the residual interior of thecontainer 150. Thechamber wall 710 may, e.g., be integrally formed with thelid element 110, i.e. thelid element 110 and thechamber wall 710 may be formed in one piece, e.g. in one plastic piece. Thechamber wall 710 may be shaped as depression of thelid element 110. - The
support member 420 or any other element does not carry theelectronic circuitry 130 and theantenna 140 may be used to hermetically seal the measuringchamber 760 at itsopening 610 in thelid element 110. Further, thelid element 110 may, e.g., have arim 112, which is, e.g., equipped with a closure mechanics (e.g. screw closure) configured to hermetically connect thelid element 110 to thecontainer 150. - Optionally, the closure mechanics of the probe
fluid analyzer system 700 or any other probe fluid analyzer system disclosed herein may be designed in a manner that it cannot be re-opened without damage. Such protection against reopening the probe fluid analyzer system may be useful in cases of hazardous probe fluids or to prevent unlawful opening (e.g. as in the case of doping tests). - The measuring
chamber 760 is configured to receive probe fluid from thecontainer 150 in order to determine the measurement data from theprobe fluid 160 in the measuringchamber 760. An exemplary process to feed the measuringchamber 760 withprobe fluid 160 from thecontainer 150 is illustrated inFigures 8 to 10 . - In various examples, the measuring
chamber 760 may be configured to be automatically filled by theprobe fluid 160 once thelid element 110 is placed on thecontainer 150. Moreover, in various examples, the measuringchamber 760 may be configured to be filled by a predetermined volume ofprobe fluid 160. In this context, referring to the example ofFigure 8 , thelid element 110 is placed (e.g. screwed) on thecontainer 150. Thechamber wall 710 may have aprobe fluid intake 712. Theprobe fluid intake 712 may be located on a specific height over the bottom of the measuringchamber 760. The height of theprobe fluid intake 712 may control the automatic filling process and may accurately determine the amount ofprobe fluid 160 which enters the measuringchamber 760 during the filling process as, e.g., shown inFigures 8 to 10 . - In one example, the
probe fluid intake 712 may simply be a hole in thechamber wall 710. In other examples, theprobe fluid intake 712 may be configured to suppress discharge of theprobe fluid 160 from the measuringchamber 760 back into thecontainer 150. For instance, theprobe fluid intake 712 may be a mechanical filter, a diffusion barrier, a valve or a combination of these elements. A mechanical filter may, e.g., be used to prevent suspended bodies or particles to enter the measuringchamber 760. Suspended bodies or particles could impair the measurement, if they physically engage with thesensor 120 or, in particular, with the electrodes 120_1, 120_2 of thesensor 120. A diffusion barrier and/or a valve could, in particular, be useful if the measuringchamber 760 simultaneously acts as a reaction chamber. For example, one or more reaction substances may be deposited in the measuringchamber 760. In some cases, thesensor 120 and, in particular, the electrodes 120_1, 120_2 of thesensor 120 may be covered with reaction substances such as, e.g., antibodies or enzymes. The operation of the probefluid analyzer system 700 may then rely on the measurement of the concentration of reaction products generated by the reaction between the reaction substances deposited in the measuringchamber 760 and ingredients of theprobe fluid 160. Such measurements may rely both on the exact knowledge of the probe fluid diagnosis volume in the measuringchamber 760 and/or on the prevention of ongoing probe fluid exchange between the measuringchamber 760 and thecontainer 150 during measurement. -
Figure 9 illustrates a stage during the automatic filling of the measuringchamber 760 shortly before thesensor 120 is immersed in theprobe fluid 160. -
Figure 10 illustrates a final state of the filling process. A predetermined filling level is obtained because theprobe fluid 160 in the measuringchamber 760 traps the air above theprobe fluid 160 once the filling level exceeds theprobe fluid intake 712. The residual air trapped over the probe fluid in the measuringchamber 760 may also serve to keep thecarrier element 122 and/or the conducting paths 124_1, 124_2 dry and clean. - It is also possible that a concentration of an ingredient of the probe fluid 160 (i.e. not a reaction product) is directly determined by the
sensor 120 and/or that a quantity of theprobe fluid 160 is determined which does not rely on a certain dosage volume and/or the prevention of fluid exchange between the measuringchamber 760 and thecontainer 150. In these and other cases, a simple through hole or a mechanical filter may be sufficient to serve as theprobe fluid intake 712 to the measuringchamber 760, or the measuringchamber 760 may completely be avoided. - Other solutions to fill the measuring
chamber 760 with a predefined volume ofprobe fluid 160 are also feasible. By way of example, the measuringchamber 760 may be applied with a vacuum which controls the filling process. Referring toFigure 11 , a puncturing device such as, e.g., ahollow needle 1012 may be provided in thecontainer 150, e.g. mounted at the bottom of thecontainer 150. The puncturing device may cause the measuringchamber 760 to be punctured once thelid element 110 is placed (e.g. screwed or otherwise fixedly closed) on thecontainer 150. - By virtue of the vacuum, the
probe fluid 160 may then be sucked into the measuringchamber 760. The amount ofprobe fluid 160 sucked into the measuringchamber 760 may be controlled by the pressure of the vacuum and/or by the size of the measuring chamber 760 (e.g. if the measuringchamber 760 is completely filled with probe fluid 160). - As illustrated in
Figures 10 and11 , anexternal radio receiver 1050 such as, e.g., a cellular phone or a smartphone or any other reader device may be brought into proximity to thelid element 110 of the probefluid analyzer system 700. For instance, the external radio receiver may simply be put down on thelid element 110. As already described above, theexternal radio receiver 1050 may then power theelectronic circuitry 130 and thesensor 120 via theantenna 140 and may read out the information based on the measurement data. A software application program running on theexternal radio receiver 1050 may be used to control the communication with theelectronic circuitry 130 and to display, manage and/or store the received information data. -
Figures 12A and 12B illustrate further examples of a probefluid analyzer system 1200. Referring toFigure 12A , a measuringchamber 1260 may be provided in a space directly below thelower surface 110B of thelid element 110. The measuringchamber 1260 may be formed as an integral part of thelid element 110. - The
measurement chamber 1260 may be defined by achamber wall 1210 which may form a part of thelid element 110. The vertical dimension of themeasurement chamber 1260 may in this example be relatively small, e.g. equal to or less than a few (say 2, 3, 4, 5 or 10) millimeters. Thechamber wall 1210 may be provided with aprobe fluid intake 1212, which may be designed similar as theprobe fluid intake 712, and reference is made to the above disclosure in order to avoid reiteration. - In the example of
Figure 12A theelectronic circuitry 130 may be located outside of the measuringchamber 1260, while in the example ofFigure 12B theelectronic circuitry 130 is located in the interior of the measuringchamber 1260 together with thesensor 120. In the latter case, as mentioned before, theelectronic circuitry 130 can contribute to the determining of measurement data such as, e.g., temperature data. - Moreover, the measuring
chamber 1260 may be completely filled byprobe fluid 160. Therefore, the probefluid analyzer system 1200 can also provide for a predetermined volume ofprobe fluid 160 to be analyzed as required in some applications. -
Figures 13 to 17 illustrate exemplary operation stages of a probefluid analyzer system 1200. - Referring to
Figure 13 ,probe fluid 160 has been collected in thecontainer 150. Again, all kinds ofprobe fluid 160 and/orcontainers 150 may be used. - The
container 150 is then closed by the lid assembly as, e.g., illustrated inFigures 12A or 12B . As noted previously, the term probefluid analyzer system 1200 may again either relate only to the lid assembly, as for instance illustrated inFigures 12A and 12B , or to the combination of thecontainer 150 and the lid assembly as shown inFigure 14 . - The measuring
chamber 1260 may then be completely filled. Various options are available. For instance, referring for example toFigure 15 , thefluid analyzer system 1200 may be turned upside down to completely fill themeasuring chamber 1260 withprobe fluid 160. Other possibilities to completely fill themeasuring chamber 1260 withprobe fluid 160 may rely on applying the measuringchamber 1260 with a vacuum and puncturing the measuringchamber 1260, e.g. by a hollow needle (seeFigure 11 ). In this and other cases, the measuringchamber 1260 may be completely filled byprobe fluid 160 without the need of turning the probefluid analyzer system 1200 upside down. - Returning to the example of
Figure 14 , the measuringchamber 1260 may be completely filled by gravity. Then, as illustrated inFigure 16 , the probefluid analyzer system 1200 is a second time turned upside down. Theprobe fluid 160 remains in the measuringchamber 1260. This may be achieved either due to the effect of capillary forces and the small amount of probe fluid pressuring against the probe fluid intake 1212 (even if theprobe fluid intake 1212 is merely a hole) or may be supported by additional features such as a specific design (e.g. filter, diffusion barrier, valve, etc.) of theprobe fluid intake 1212 as already mentioned. The probefluid analyzer system 1200 completely excludes any possibility of fluid exchange between the measuringchamber 1260 and thecontainer 150 after completion of the filling process. - The probe
fluid measuring chamber -
Figure 17 corresponds to the wireless data communication process ofFigures 10 and11 , and reference is made to the above description for the sake of brevity. - Waste disposal of the probe fluid analyzer systems described herein may depend on the specific application (in particular the kind of probe fluid 160) and the specific design of the probe fluid analyzer system. However, it is believed that existing waste disposal management processes may at least partly be applicable to the probe fluid analyzer systems disclosed herein.
- A further aspect of the disclosure involves the return of the filled probe fluid analyzer systems to the producer. The producer may then use laboratory analytics to verify the measurement data and/or the information based on the measurement data as computed by the
electronic circuitry 130. These quantities may be stored in a non-volatile memory of theelectronic circuitry 130 and could be used to develop and refine the acquisition, evaluation and/or interpretation of the measurement data for product advancements. - In conclusion, the probe fluid analyzer system disclosed herein allows for a simple and inexpensive probe fluid analysis on the ground. There is not much the user can do wrong and the user does not need to come into contact with the probe fluid sample.
Claims (17)
- A probe fluid analyzer system, comprising:a lid element (110) for a container (150);a sensor (120) mounted or mountable to the lid element (110), the sensor (120) being configured to determine measurement data of a probe fluid (160) to be stored in the container (150);an electronic circuitry (130) electrically connected or connectable to the sensor (120) and configured to generate a radio transmission signal carrying information based on the measurement data; andan antenna (140) for transmitting the radio transmission signal to an external radio receiver (1050), wherein the antenna (140) and the electronic circuitry (130) are mounted on a support member (420) characterized in that the support member (420) is permanently affixed to the lid element (110) and acts as an intermediate holding structure to mount the sensor (120) to the lid element (110).
- The probe fluid analyzer system of claim 1, wherein the lid element (110) has a plate-shaped design.
- The probe fluid analyzer system of claim 1 or 2, further comprising:
a closure element configured to hermetically seal the lid element (110) to the container (150). - The probe fluid analyzer system of any of the preceding claims, further comprising:
a measuring chamber (760, 1260) provided at the lid element (110) and configured to receive probe fluid (160) from the container (150), wherein the sensor (120) is configured to determine measurement data from the probe fluid (160) in the measuring chamber (760, 1260). - The probe fluid analyzer system of claim 4, wherein the measuring chamber (760, 1260) is configured to be automatically filled by the probe fluid (160) once the lid element (110) is placed on the container (150).
- The probe fluid analyzer system of claim 4, wherein the measuring chamber (760, 1260) is configured to be filled by the probe fluid (160) once the lid element (110) is placed on the container (150) and turned upside down.
- The probe fluid analyzer system of one of claims 4 to 6, wherein the measuring chamber (760, 1260) has a probe fluid intake (712), the probe fluid intake (712) is configured to suppress discharge of the probe fluid (160) from the measuring chamber (760, 1260) back into the container (150).
- The probe fluid analyzer system of one of claims 4 to 7, wherein the measuring chamber (760, 1260) is applied with a vacuum, a protective gas or an air dehumidifier agent.
- The probe fluid analyzer system of one of claims 4 to 8, wherein the measuring chamber (760, 1260) accommodates a reaction agent.
- The probe fluid analyzer system of one of claims 4 to 8, wherein the measuring chamber (760, 1260) is configured to receive a predetermined volume of probe fluid (160).
- The probe fluid analyzer system of any of the preceding claims, wherein the sensor (120) is an electrochemical and/or biochemical sensor and/or a sensor configured to sense a physical property, in particular a temperature sensor and/or an optical sensor.
- The probe fluid analyzer system of any of the preceding claims, wherein the sensor (120) comprises a strip-shaped carrier element (122) supporting a plurality of electrodes (120_1, 120_2).
- The probe fluid analyzer system of any of the preceding claims, wherein the sensor (120) is an exchangeable sensor (120) detachably mounted on the support member (420).
- The probe fluid analyzer system of any of the preceding claims, wherein the electronic circuitry (130) is located at a place where it is immersed in the probe fluid (160) during determination of measurement data.
- The probe fluid analyzer system of any of the preceding claims, wherein the electronic circuitry (130) comprises a non-volatile memory for storing the measurement data and/or the information based on the measurement data.
- The probe fluid analyzer system of any of the preceding claims, wherein the electronic circuitry (130) is wirelessly powered by the external radio receiver (1050).
- The probe fluid analyzer system of any of the preceding claims, further comprising:
the container (150) for the probe fluid (160).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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EP19167611.3A EP3718632B1 (en) | 2019-04-05 | 2019-04-05 | Probe fluid analyzer system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP19167611.3A EP3718632B1 (en) | 2019-04-05 | 2019-04-05 | Probe fluid analyzer system |
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EP3718632B1 true EP3718632B1 (en) | 2022-01-12 |
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US11071977B2 (en) * | 2017-03-13 | 2021-07-27 | William Brinton | Biological sample analysis device |
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