EP3706731A4 - Formulations améliorées de médicaments - Google Patents

Formulations améliorées de médicaments Download PDF

Info

Publication number
EP3706731A4
EP3706731A4 EP18876425.2A EP18876425A EP3706731A4 EP 3706731 A4 EP3706731 A4 EP 3706731A4 EP 18876425 A EP18876425 A EP 18876425A EP 3706731 A4 EP3706731 A4 EP 3706731A4
Authority
EP
European Patent Office
Prior art keywords
drug formulations
improved drug
improved
formulations
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18876425.2A
Other languages
German (de)
English (en)
Other versions
EP3706731A1 (fr
Inventor
Dave A. Miller
Daniel J. ELLENBERGER
Sandra U. SCHILLING
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Austinpx LLC
Original Assignee
Dispersol Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dispersol Technologies LLC filed Critical Dispersol Technologies LLC
Publication of EP3706731A1 publication Critical patent/EP3706731A1/fr
Publication of EP3706731A4 publication Critical patent/EP3706731A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP18876425.2A 2017-11-10 2018-11-09 Formulations améliorées de médicaments Pending EP3706731A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762584321P 2017-11-10 2017-11-10
PCT/US2018/059974 WO2019094688A1 (fr) 2017-11-10 2018-11-09 Formulations améliorées de médicaments

Publications (2)

Publication Number Publication Date
EP3706731A1 EP3706731A1 (fr) 2020-09-16
EP3706731A4 true EP3706731A4 (fr) 2021-08-18

Family

ID=66431148

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18876425.2A Pending EP3706731A4 (fr) 2017-11-10 2018-11-09 Formulations améliorées de médicaments

Country Status (6)

Country Link
US (1) US20190142756A1 (fr)
EP (1) EP3706731A4 (fr)
JP (1) JP7378393B2 (fr)
CN (1) CN111511365A (fr)
CA (1) CA3081358A1 (fr)
WO (1) WO2019094688A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022094817A1 (fr) * 2020-11-04 2022-05-12 Janssen Pharmaceuticals, Inc. Formulation pharmaceutique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130029957A1 (en) * 2011-07-28 2013-01-31 Chandrashekar Giliyar 17-Hydroxyprogesterone Ester-Containing Oral Compositions and Related Methods
TW201311245A (zh) * 2011-09-02 2013-03-16 Abbott Lab 醫藥組成物
US20130142877A1 (en) * 2010-05-10 2013-06-06 Evonik Roehm Gmbh Pharmaceutical dosage form comprising one or more antiretroviral active ingredients
WO2016038532A1 (fr) * 2014-09-09 2016-03-17 Mylan Laboratories Limited Tréprostinil diéthanolamine amorphe
WO2016073421A1 (fr) * 2014-11-03 2016-05-12 Dispersol Technologies, Llc Formulations améliorées de vemurafenib et leurs procédés de fabrication

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5655370A (en) * 1979-10-13 1981-05-15 Kyorin Pharmaceut Co Ltd Amorphous nicomol
US5490840A (en) * 1994-09-26 1996-02-13 General Electric Company Targeted thermal release of drug-polymer conjugates
DE19856432A1 (de) * 1998-12-08 2000-06-15 Basf Ag Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen
DE60023465T2 (de) * 1999-03-24 2006-07-20 R.P. Scherer Technologies, Inc., Las Vegas Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
DE19918434A1 (de) * 1999-04-23 2000-10-26 Basf Ag Feste Pharmazeutische Formulierungen von säurelabilen Protonenpumpenblockern
US20080305173A1 (en) * 2001-07-31 2008-12-11 Beuford Arlie Bogue Amorphous drug beads
DE04801160T1 (de) * 2003-12-01 2007-08-09 Lifecycle Pharma A/S Pharmazeutische zusammensetzungen mit lercanidipin
CA3076115C (fr) * 2007-08-21 2022-06-28 Board Of Regents, The University Of Texas System Melange thermocinetique pour des applications pharmaceutiques
PT2203181T (pt) * 2007-10-16 2018-05-10 Biocon Ltd Uma composição farmacêutica sólida para administração por via oral e o seu processo de fabrico
WO2009140479A1 (fr) * 2008-05-15 2009-11-19 Sanofi-Aventis Dispersions solides amorphes
US20120022087A1 (en) * 2008-08-11 2012-01-26 Ratiopharm Gmbh Amorphous ambrisentan
SI2691083T1 (sl) * 2011-03-29 2017-12-29 Krka, D.D., Novo Mesto Farmacevtski sestavek sitagliptina
EP2744573A2 (fr) * 2011-08-18 2014-06-25 Hetero Research Foundation Mélange amorphe de lopinavir et ritonavir coprécipité sur la copovidone
EP2872122A1 (fr) * 2012-07-16 2015-05-20 Vertex Pharmaceuticals Incorporated Compositions pharmaceutiques de (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide et son administration
CA2891502A1 (fr) * 2012-11-19 2014-05-22 Dr. Reddy's Laboratories Ltd. Compositions pharmaceutiques d'inhibiteurs de cetp
WO2015071248A1 (fr) * 2013-11-15 2015-05-21 Synthon B.V. Composition pharmaceutique à libération prolongée, non détournable, contenant du tapentadol
WO2015152433A1 (fr) * 2014-03-31 2015-10-08 Hanmi Pharm. Co., Ltd. Dispersion solide amorphe comprenant du paclitaxel, comprimé la comprenant, et son procédé de préparation
WO2015175505A1 (fr) * 2014-05-15 2015-11-19 Lundbeck Llc Formulation à libération modifiée de tétrabenazine
CA2989145A1 (fr) * 2015-06-17 2016-12-22 Dispersol Technologies, Llc Formulations ameliorees de deferasirox et leurs procedes de fabrication
WO2017196712A1 (fr) * 2016-05-09 2017-11-16 Dispersol Technologies, Llc Formulations de médicaments améliorées

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130142877A1 (en) * 2010-05-10 2013-06-06 Evonik Roehm Gmbh Pharmaceutical dosage form comprising one or more antiretroviral active ingredients
US20130029957A1 (en) * 2011-07-28 2013-01-31 Chandrashekar Giliyar 17-Hydroxyprogesterone Ester-Containing Oral Compositions and Related Methods
TW201311245A (zh) * 2011-09-02 2013-03-16 Abbott Lab 醫藥組成物
WO2016038532A1 (fr) * 2014-09-09 2016-03-17 Mylan Laboratories Limited Tréprostinil diéthanolamine amorphe
WO2016073421A1 (fr) * 2014-11-03 2016-05-12 Dispersol Technologies, Llc Formulations améliorées de vemurafenib et leurs procédés de fabrication

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KEEN JUSTIN M. ET AL: "Effect of Tablet Structure on Controlled Release from Supersaturating Solid Dispersions Containing Glyceryl Behenate", MOLECULAR PHARMACEUTICS, vol. 12, no. 1, 25 November 2014 (2014-11-25), US, pages 120 - 126, XP055821441, ISSN: 1543-8384, DOI: 10.1021/mp500480y *

Also Published As

Publication number Publication date
EP3706731A1 (fr) 2020-09-16
JP7378393B2 (ja) 2023-11-13
CA3081358A1 (fr) 2019-05-16
US20190142756A1 (en) 2019-05-16
WO2019094688A1 (fr) 2019-05-16
CN111511365A (zh) 2020-08-07
JP2021502384A (ja) 2021-01-28

Similar Documents

Publication Publication Date Title
EP3582755A4 (fr) Préparations
EP3638215A4 (fr) Formulations d'arn
EP3102190A4 (fr) Nouvelles formulations pharmaceutiques
EP3641771A4 (fr) Compositions pharmaceutiques
EP3513809A4 (fr) Composition médicinale
EP3541385A4 (fr) Formulations pharmaceutiques
EP3603642A4 (fr) Préparation pharmaceutique
EP3389628A4 (fr) Formulations pharmaceutiques de comprimés mous à mâcher
EP3454847A4 (fr) Formulations de médicaments améliorées
AU2018302170A1 (en) Pharmaceutical compositions comprising entrectinib
EP3590514A4 (fr) Préparation pharmaceutique
EP3581183A4 (fr) Composition pharmaceutique pour oncothérapie
EP3265059A4 (fr) Formulations pharmaceutiques liposomales en combinaison
ZA202006570B (en) Pharmaceutical formulations
EP3402470A4 (fr) Composition pharmaceutique stable
EP3583943A4 (fr) Composition pharmaceutique
EP3646866A4 (fr) Préparation pharmaceutique
AU2016218074B2 (en) Pharmaceutical formulation
EP3590515A4 (fr) Produit médicamenteux
EP3886820B8 (fr) Formulations de capsules
EP3337463A4 (fr) Formulations pharmaceutiques
EP3383371A4 (fr) Formulation pharmaceutique
EP3720844A4 (fr) Compositions de médicaments
EP3716766A4 (fr) Composés de benzoxaborole et leurs formulations
EP3646867A4 (fr) Composition pharmaceutique

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200609

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20210720

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/192 20060101AFI20210715BHEP

Ipc: A61K 9/14 20060101ALI20210715BHEP

Ipc: A61K 9/20 20060101ALI20210715BHEP

Ipc: A61K 31/4196 20060101ALI20210715BHEP

Ipc: A61K 31/427 20060101ALI20210715BHEP

Ipc: A61K 31/496 20060101ALI20210715BHEP

Ipc: A61K 31/505 20060101ALI20210715BHEP

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AUSTINPX, LLC

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20231213

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN